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Thursday, 20 July

22:07

Florida university fires criminology professor blemished by retractions Retraction Watch

Florida State University last week terminated a criminology professor accused of research misconduct, Retraction Watch has learned, capping a years-long, highly publicized saga the school says has caused almost catastrophic damage to its standing.

In a termination letter obtained by Retraction Watch, the university accused the former professor, Eric A. Stewart, of extreme negligence and incompetence. It also asserted that, due to Stewarts actions, decades of research once believed to be at the forefront of criminology has been shown to contain numerous erroneous and false narratives.

The details of problematic data management, false results, and the numerous publication retractions have negatively affected the discipline on a national level, FSU Provost James J. Clark wrote in the letter, dated July 13. 

Clark added that the debacle had also affected recruitment of faculty and students and caused the universitys researchers to worry about their chances of...

21:42

PRO-KENNEDY SUPERPAC LAUNCHES THE KENNEDY BEACON Age of Autism The Rebel Alliance!

Lighthouse usaNote: We do not endorse candidates. Our readers are international, and come from all walks of life and political persuasions.  Below is a press release from American Values 2024.

Thank you.

###

New Substack will Provide Daily Headlines of all Kennedy Media, Combat Censorship, Misinformation and Boost Candidates Positive Vision for America

Will Feature Expert Guest Authors Including Jeffrey Sachs, David Talbot, Colonel Douglas Macgregor, John Leake

NEW YORK, NY World-leading economist Jeffrey Sachs, bestselling author and historian David Talbot and Ukraine war critic Colonel Douglas Macgregor are among the expert guest authors to be featured in The Kennedy Beacon, a new Substack launched today to support the candidacy of Robert F. Kennedy Jr.

The publication comes courtesy of American Values 2024, the pro-Robert F. Kennedy superPAC. It will combat censorship while highlighting Kennedys positive vision for America. In addition, The Kennedy Beacon will feature guest columns, regular columnists, and a staff of writers covering issues about which Kennedy most cares: censorship, peace, homelessness, federal government corruption, mass incarceration, drug addiction, and the environment.

The SuperPAC American Values 2024 raised more than $10 million to dat...

21:00

Journal editors resign, strike in dispute with Wiley over business model that maximises profit Retraction Watch

The editor in chief of a Wiley journal has resigned, saying the publisher recently has seemed to emphasize cost-cutting and margins over good editorial practice. 

Most of the journals associate editors are in the midst of a work stoppage protesting the same issues. After Wiley responded to the associate editors in a way they found troubling, the editors replied with a list of 12 demands, and a deputy editor in chief tendered her resignation. 

Editorial boards of at least three other journals have recently resigned en masse, or threatened to resign, amid similar disputes. 

Michael Dawson, editor in chief of the Journal of Biogeography, published a blog post announcing his resignation on June 21. In it, he wrote: 

It is becoming increasingly hard to stave off the undesirable consequences of the primary motivations of the the for-profit scientific publishing industry.

He listed several concerns from his resignation letter, including proposed growth targets, equity issues in adopting an open access model in which authors pay fees to publish their work, and compensation for the editors. He wrote: 

In trying to initiate discussions with Wiley about these issues, and being rebuffed multiple times, I came to the conclusion that the opportunities for improvement at the journal that appeared available until late-2022, had receded. What Wiley has failed to understand is that our interests are their interests. These issues seemed symptomatic of larger problems with the for-profit scientific publishing industry. I concluded I could do more by leaving than by staying.

In mid-Octob...

12:47

Spontaneous remission of metastatic castration-resistant prostate cancer. GreenMedInfo

PMID:  Cureus. 2022 Dec ;14(12):e32505. Epub 2022 Dec 14. PMID: 36654621 Abstract Title:  Spontaneous Remission of Metastatic Castration-Resistant Prostate Cancer: Coley's Toxin Revisited? Abstract:  Metastatic castration-resistant prostate cancer (mCRPC) is an incurable disease associated with poor survival outcomes. Immunotherapy was first pioneered by William Coley in the early 20th century with the injection of live and heat-killed bacteria. Despite the recent emergence of cancer immunotherapy, mCRPC remains an elusive immune target. Spontaneous remission of mCRPC following microbial infection has not been described in the literature to date. We present evidence of spontaneous biochemical and radiologic regression in a patient with mCRPC following multiple episodes of sepsis.

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12:43

Neonatal exposure to bisphenol analogues disrupts genital development in male mice. GreenMedInfo

PMID:  Environ Pollut. 2023 Aug 1 ;330:121783. Epub 2023 May 8. PMID: 37164221 Abstract Title:  Neonatal exposure to bisphenol analogues disrupts genital development in male mice. Abstract:  The public concern and governmental regulations on bisphenol A (BPA) have stimulated the development and production of alternative analogues to replace BPA in a myriad of applications. Given the endocrine disrupting activities of BPA and potentially other analogues, the present study investigated and compared the effects of neonatal exposure to BPA, BPB, BPE, BPF, and BPS on the genital development in male mice. Pups were injected subcutaneously on the right shoulder in the mornings of postnatal days P0.5, P2, P4, and P6, resulting in a low dose of 0.05 g/g body weight (bw)/day and a high dose of 10 g/g bw/day. Mice were sacrificed at predetermined time and evaluated for gene expression levels (3 days after birth or P3), steroid hormone levels (P5), and morphological changes (P21). The results demonstrated that BPA, BPB, BPE, or BPF significantly shortened glans penis length and anogenital distance, while BPS didn't. Testis weight and anogenital distance were also significantly affected by BPA, BPE or BPF. The results also revealed that bisphenol analogues exposure significantly reduced testosterone levels, and altered the expression levels of developmental genes networks in developing penis of mice. Our data demonstrate that selected bisphenol analogues may possess similar endocrine disrupting effects compared to BPA, and exposure to these analogues could affect reproductive development of male mice. This raises the concern on the environmental and health safety of bisphenol analogues applied as industrial BPA replacements.

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12:24

Prenatal bisphenol S exposure induces hepatic lipid deposition in male mice offspring. GreenMedInfo

PMID:  J Hazard Mater. 2023 Jul 5 ;453:131410. Epub 2023 Apr 12. PMID: 37088024 Abstract Title:  Prenatal bisphenol S exposure induces hepatic lipid deposition in male mice offspring through downregulation of adipose-derived exosomal miR-29a-3p. Abstract:  The increased usage of bisphenol S (BPS) results in wide distribution in pregnant women. In this study, pregnant mice were given multiple-dose BPS during gestation. Results showed that prenatal BPS exposure (50 g/kg/day) induced increased weight gain, dyslipidemia, higher liver triglyceride (TG), adipocyte hypertrophy, and hepatic lipid deposition in male offspring. Exosomes play important roles in regulating lipid metabolism. Here, serum exosomes and adipose miRNA sequencing of male offspring indicated a remarkable decrease in miR-29a-3p expression. To clarify whether adipocyte-derived exosomes mediate hepatic lipid deposition, exosomes were extracted from BPS-treated adipocytes and co-cultured with hepatocytes. These exosomes could be taken up by hepatocytes and promoted lipid deposition, and notably, exosomal miR-29a-3p was downregulated. Furthermore, miR-29a-3p knockdown in adipocyte-derived exosomes promoted hepatocyte lipid deposition, whereas overexpression led to the opposite effect. Also, the role of miR-29a-3p was demonstrated in hepatocytes by overexpressing or knocking it down. Subsequent studies have shown that miR-29a-3p can promote lipid deposition by directly targeting Col4a1. Taken together, prenatal BPS exposure could lead to lower miR-29a-3p yield in adipocyte-derived exosomes and decrease miR-29a-3p content transported to hepatocytes, which further negatively regulate Col4a1 and promote hepatic lipid deposition. Our findings provided clues to maternal environmental exposure-induced liver metabolic diseases.

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11:24

Occurrence of multiple bisphenol S analogues in children from Shantou, China. GreenMedInfo

PMID:  Environ Int. 2023 Apr ;174:107926. Epub 2023 Apr 10. PMID: 37075580 Abstract Title:  Occurrence of multiple bisphenol S analogues in children from Shantou, China. Abstract:  Emerging bisphenol S analogues (BPSs) have gained their application perspectives to replace bisphenol A (BPA) and BPA analogues (BPAs). However, the extent of human exposure and potential health risk from BPSs is rarely known yet. We hypothesized that children living in Shantou, China, a well-known e-waste recycling city, may expose to emerging BPSs together with BPA and BPAs. In this study, BPA, six commonly used BPAs and 11 emerging BPSs were determined simultaneously in 240 urine samples collected from children residing in Shantou. BPA, BPS, bisphenol F, bisphenol AF and three BPSs of 2,4'-bis(hydroxyphenyl)sulfone, 4-((4-(allyloxy)phenyl)sulfonyl)phenol and diphenylsulfone (DPS) were the urinary predominant bisphenols with detection frequencies of 67-100% in the children. BPA was found at the highest median concentration (3.36 g/g creatinine) followed by BPS (0.313) and DPS (0.187). It is interesting to find that the girls and children in the younger group (2  age 

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10:42

Vitamin C protects retinal ganglion cells via SPP1 in glaucoma and after optic nerve damage. GreenMedInfo

PMID:  Life Sci Alliance. 2023 Aug ;6(8). Epub 2023 May 9. PMID: 37160307 Abstract Title:  Vitamin C protects retinal ganglion cells via SPP1 in glaucoma and after optic nerve damage. Abstract:  Glaucoma is a common neurodegenerative disorder characterized by retinal ganglion cell death, astrocyte reactivity in the optic nerve, and vision loss. Currently, lowering the intraocular pressure (IOP) is the first-line treatment, but adjuvant neuroprotective approaches would be welcome. Vitamin C possesses neuroprotective activities that are thought to be related to its properties as a co-factor of enzymes and its antioxidant effects. Here, we show that vitamin C promotes a neuroprotective phenotype and increases gene expression related to neurotropic factors, phagocytosis, and mitochondrial ATP production. This effect is dependent on the up-regulation of secreted phosphoprotein 1 (SPP1) in reactive astrocytes via the transcription factor E2F1. SPP1astrocytes in turn promote retinal ganglion cell survival in a mouse model of glaucoma. In addition, oral administration of vitamin C lowers the IOP in mice. This study identifies an additional neuroprotective pathway for vitamin C and suggests a potential therapeutic role of vitamin C in neurodegenerative diseases such as glaucoma.

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10:35

The neuroprotective effect of ascorbic acid against imidacloprid-induced neurotoxicity. GreenMedInfo

PMID:  Front Neurol. 2023 ;14:1130575. Epub 2023 Apr 20. PMID: 37153653 Abstract Title:  The neuroprotective effect of ascorbic acid against imidacloprid-induced neurotoxicity and the role of HO-1 in mice. Abstract:  Imidacloprid (IMI) is not only a neurotoxic agricultural pesticide but also a possible food contaminant. The aims of this study were to (1) explore the relationship between recurrent IMI administration and neuronal toxicity in mice and (2) evaluate the potential neuroprotective effect of ascorbic acid (AA), a substance with significant free radical scavenger and having property to block the inflammatory pathways. Mice were categorized as nave controls (administered vehicles for 28 days); the IMI-treatment animal group (administered po 45-mg/kg body weight of IMI per day for 28 days); and the IMI + AA treatment animal group (administered the same IMI dose + 200 mg/kg of AA orally for 28 days). On day 28, memory losses were assessed using the Y-maze and novel target identification behavioral tests. Mice were sacrificed 24 h after the final IMI treatments, as well as hippocampus tissues, were utilized to determine histological assessments, oxidative stress biomarkers, and Heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) gene expression levels. The findings demonstrated that IMI-treated mice had substantial impairment of spatial and non-spatial memory functions, as well as reduced antioxidant enzyme and acetylcholinesterase activity. The AA neuroprotective action was achieved through the suppression of the HO-1 expression as well as the stimulation of Nrf2 expression in hippocampal tissues. In summary, recurrent IMI exposure causes oxidative stress and neurotoxicity in mice, and the administration of AA significantly reduces the IMI toxicity possibly by the activation of the HO-1/Nrf2 pathway.

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10:14

A pro-oxidant property of vitamin C to overcome the burden of latent Mycobacterium tuberculosis infection. GreenMedInfo

PMID:  Front Cell Infect Microbiol. 2023 ;13:1152269. Epub 2023 Apr 19. PMID: 37153159 Abstract Title:  A pro-oxidant property of vitamin C to overcome the burden of latentinfection: A cross-talk review with Fenton reaction. Abstract:  Tuberculosis (TB), caused by the bacillus, is one of the deadliest infectious illnesses of our day, along with HIV and malaria.Chemotherapy, the cornerstone of TB control efforts, is jeopardized by the advent ofstrains resistant to many, if not all, of the existing medications.Isoniazid (INH), rifampicin (RIF), pyrazinamide, and ethambutol are used to treat drug-susceptible TB for two months, followed by four months of INH and RIF, but chemotherapy with potentially harmful side effects is sometimes needed to treat multidrug-resistant (MDR) TB for up to two years. Chemotherapy might be greatly shortened by drugs that killmore quickly while simultaneously limiting the emergence of drug resistance.Regardless of their intended target, bactericidal medicines commonly kill pathogenic bacteria (gram-negative and gram-positive) by producing hydroxyl radicalsthe Fenton reaction.Researchers have concentrated on vitamins with bactericidal properties to address the rising cases globally and have discovered that these vitamins are effective when given along with first-line drugs. The presence of elevated iron content, reactive oxygen species (ROS) generation, and DNA damage all contributed to VC's sterilizing action on. Moreover, it has a pleiotropic effect on a variety of biological processes such as detoxification, protein folding - chaperons, cell wall processes, information pathways, regulatory, virulence, metabolism etc.In this review report, the authors extensively discussed the effects of VC on, such as the generation of free radicals and bactericidal mechanisms with existing treatments, and their further drug development based on ROS production.

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10:00

Can Probiotics Ease Major Depressive Disorder? Articles

Research published in JAMA Psychiatry1 adds more support to the importance of probiotics for mental health. The study, by researchers with the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London, found supplementing with probiotics led to greater improvements in symptoms of depression compared to placebo, along with relieving anxiety symptoms as well.2

The beneficial results were achieved after just eight weeks of daily supplementation, showing the microbiota-gut-brain axis remains an important target in depression. As it stands, about 60% of people with major depressive disorder (MDD) dont respond to first-line treatments like antidepressants, while one-third still experience symptoms even with treatment.3

By supporting gut health with beneficial bacteria, more people with depression may be able to find effective, natural relief.

Probiotics Relieve Depression Symptoms

The study involved 50 patients with major depressive disorder who were taking an antidepressant. They were randomly assigned to take either four capsules daily of probiotic or a placebo. The probiotics contained 14 different strains that had previously shown antidepressant effects:4

Bacillus subtilis

Bifidobacterium bifidum

Bifidobacterium breve

Bifidobacterium infantis

Bifidobacterium longum

Lactobacillus acidophilus

Lactobacillus delbrueckii subsp bulgaricus

Lactobacillus casei

Lactobacillus plantarum

Lactobacillus rhamnosus

Lactobacillus helveticus

Lactobacillus salivarius

Lactococcus lactis

Streptococcus thermophilus

While depression symptoms improved in both groups, by week four there was a greater improvement among the probiotics group. "It has been suggested that probiotics may be beneficial as adjunctive treatment as they may help alleviate presentations that antidepressants are less effective against (e.g., anxious, somatic)," the researchers wrote.5

They added that the improvements to anx...

Brushing, Flossing Could Help Protect Against Dementia Articles

Dementia has been added to the long list of health problems potentially associated with poor oral health. The finding, published in Neurology,1 suggests dental health is associated with hippocampal atrophy shrinkage of the hippocampus brain region that serves as a marker for Alzheimers disease.2

In short, Retaining more healthy teeth without periodontal disease may help to protect brain health, study author Satoshi Yamaguchi, an associate professor at Tohoku University Graduate School of Dentistry in Sendai, Japan, explains.3

Since periodontal disease is also linked with systemic inflammation and bacteria in the bloodstream, leading to chronic disease, keeping your teeth, mouth and gums healthy is a key way to boost your overall health, as well.

Brain Shrinkage Linked to an Unhealthy Mouth

Without proper oral hygiene, gingivitis can develop. This is an inflammatory disease caused by an accumulation of plaque, or bacteria, on your teeth that often leads to bleeding gums. If left untreated, it can lead to periodontitis, which is a more serious infection that can lead to teeth loss.

Periodontitis, or gum disease, has been suggested as a potential risk factor for Alzheimers since at least 2015, when researchers with the University of Bristol noted periodontal pathogens are possible contributors to neural inflammation and SLOAD [sporadic late onset Alzheimer's disease].4

The Neurology study involved 172 people aged 55 years and over who had no cognitive decline at the start of the study. The participants had dental exams and took memory tests, while brain scans were used to measure hippocampus volume at the start of the study and four years later.

Both gum disease and number of teeth were linked to brain changes. Those with mild gum disease and fewer teeth had a faster rate of shrinkage in the left hippocampus. Among this group, having one less tooth increased brain shrinkage at a rate equivalent to nearly one year of brain aging.5

For those with severe gum disease, having more teeth was linked to a faster rate of brain shrinkage, with one more tooth akin to 1.3 years of brain aging.6 Yamaguchi said in a news release:

Tooth loss and gum disease, which is inflammation of the tissue around the teeth that can cause shrinkage of the gums and loosening of the teeth, are very common, so evaluating a potential link with dementia is incredibly important. Our study foun...

Go Grass Fed Organic AGA Certified Articles

Editor's Note: This article is a reprint. It was originally published January 16, 2018.

Choosing organic foods is a straightforward way to lower your exposure to pesticides and GMOs (genetically modified organisms), but an even better option is to look for foods, particularly meat and dairy, that are organic and grass fed.

Cows are designed to eat grass, but the majority of beef and dairy products in the U.S. come from cows that eat corn and grain, perpetuating the unethical, unhealthy and environmentally devastating concentrated animal feeding operations (CAFOs) that dominate industrial agriculture.

In exchange for cheap meat and dairy, we're paying a hefty price, one that may be infinite in the damage it's causing via pollution and damage to human health. On the other hand, farms producing grass fed meat and dairy products are able to naturally regenerate the soil and maintain ecological balance without relying on chemical fertilizers and pesticides.

Meanwhile, grass fed products such as milk and cheese are valued for their seasonal variations in flavor, along with their superior nutritional profile. While the market is still small labeled grass fed beef makes up just 1% of the U.S. beef market it's growing fast. Sales of labeled grass fed beef reached $272 million in 2016, up from $17 million in 2012 which means sales have doubled each year.1

Grass Fed Foods Are Better for You

From a health standpoint alone, there's good reason to go organic and grass fed as much as possible. Milk from cows raised primarily on pasture has been shown to be higher in many nutrients, including vitamin E, beta-carotene and the healthy fats omega-3 and conjugated linoleic acid (CLA).2 Grass fed beef is better for you too, with CLA levels increasing by two- to threefold when cattle are grass finished as opposed to grain finished.3

This is a significant benefit, as CLA is associated with a lower risk of cancer and heart disease and optimized cholesterol levels. The ratio of dietary fats is also healthier in grass fed beef. According to Back to Grass: The Market Potential for U.S. Grassfed Beef, a report produced by a collaboration between sustainable agriculture and ecological farming firms:4

"Although the exact physiologic mechanisms behind these benefits are...

09:54

Prenol of fruit binds to SARS-CoV-2 spike S1 to inhibit viral entry. GreenMedInfo

PMID:  J Immunol. 2023 May 5. Epub 2023 May 5. PMID: 37144841 Abstract Title:  Prenol, but Not Vitamin C, of Fruit Binds to SARS-CoV-2 Spike S1 to Inhibit Viral Entry: Implications for COVID-19. Abstract:  Fruit consumption may be beneficial for fighting infection. Although vitamin C is the celebrity component of fruit, its role in COVID-19 is unclear. Because spike S1 of SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) on host cells to enter the cell and initiate COVID-19, using an-screen-based assay, we screened vitamin C and other components of fruit for inhibiting the interaction between spike S1 and ACE2. We found that prenol, but neither vitamin C nor other major components of fruit (e.g., cyanidin and rutin), reduced the interaction between spike S1 and ACE2. Thermal shift assays indicated that prenol associated with spike S1, but not ACE2, and that vitamin C remained unable to do so. Although prenol inhibited the entry of pseudotyped SARS-CoV-2, but not vesicular stomatitis virus, into human ACE2-expressing HEK293 cells, vitamin C blocked the entry of pseudotyped vesicular stomatitis virus, not SARS-CoV-2, indicating the specificity of the effect. Prenol, but not vitamin C, decreased SARS-CoV-2 spike S1-induced activation of NF-B and the expression of proinflammatory cytokines in human A549 lung cells. Moreover, prenol also decreased the expression of proinflammatory cytokines induced by spike S1 of N501Y, E484K, Omicron, and Delta variants of SARS-CoV-2. Finally, oral treatment with prenol reduced fever, decreased lung inflammation, enhanced heart function, and improved locomotor activities in SARS-CoV-2 spike S1-intoxicated mice. These results suggest that prenol and prenol-containing fruits, but not vitamin C, may be more beneficial for fighting against COVID-19.

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09:50

Vitamin C as a potential ameliorating agent against hepatotoxicity among alcoholic abusers. GreenMedInfo

PMID:  Eur Rev Med Pharmacol Sci. 2023 Apr ;27(8):3322-3335. PMID: 37140282 Abstract Title:  Vitamin C as a potential ameliorating agent against hepatotoxicity among alcoholic abusers. Abstract:  OBJECTIVE: Drug and substance abuse remains a major medical problem globally. Alcohol consumption, particularly heavy drinking, is an important risk factor for many health problems and is a major contributor to the global burden of disease. Vitamin C has proven to be defensive against toxic substances and provides antioxidant and cytoprotective activity to hepatocytes. The aim of this study was to investigate vitamin C as a potential ameliorating agent against hepatotoxicity among alcohol abusers.PATIENTS AND METHODS: This study was a cross-sectional study that included eighty male hospitalized alcohol abusers and twenty healthy people as a control group. Alcohol abusers received standard treatment plus vitamin C. Total protein, albumin, total Bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and 8-hydroxhguanosine (8-OHdG) were investigated.RESULTS: This study reported that, in the alcohol abuser group, there was a significant increase in the total protein, bilirubin, AST, ALT, ALP, TBARS, SOD and 8-OHdG; on the other hand, there was a significant decrease in albumin, GSH and CAT compared with the control group. The alcohol abuser group treated with vitamin C showed a significant decrease in total protein, bilirubin, AST, ALT, ALP, TBARS, SOD and 8-OHdG; on the other hand, there was a significant increase in albumin, GSH and CAT compared with the control group.CONCLUSIONS: This study's findings suggest that alcohol abuse induces significant alterations in various hepatic biochemical parameters and oxidative stress and that vitamin C has a partial protective role in countering alcohol abuse-induced hepatotoxicity. Using vitamin C as an adjunctive supplement to standard treatment may be helpful in minimizing the toxic side effects of alcohol abuse.

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08:36

Breathing exercises increased superoxide dismutase and glutathione activities and decreased malondialdehyde content. GreenMedInfo

PMID:  Front Med (Lausanne). 2023 ;10:1121036. Epub 2023 Apr 5. PMID: 37122322 Abstract Title:  Effect of breathing exercises on oxidative stress biomarkers in humans: A systematic review and meta-analysis. Abstract:  BACKGROUND: Breathing exercises improve oxidative stress in healthy young adults and patients with diabetes, hypertension, and chronic obstructive pulmonary disease. Furthermore, the mechanism of respiratory intervention is controversial. Therefore, in this meta-analysis, we aimed to systematically evaluate the effects of breathing exercises on oxidative stress biomarkers in humans and provide evidence for the clinical application of breathing exercises.METHODS: The Embase, PubMed, Cochrane Library, Web of Science, CNKI, and WANFANG databases were searched for studies about the effects of breathing exercises on human oxidative stress levels, with no restraints regarding time, race, or language. The experimental group included various breathing exercises, and the outcome index included malondialdehyde, superoxide dismutase, and glutathione, nitric oxide, vitamin C, or total antioxidant capacity levels from a randomized controlled trial. Data were extracted by more than two authors and reviewed by one author.RESULTS: Ten studies were included from five countries. Data from patients with no disease, chronic obstructive pulmonary disease, hypertension, or diabetes were included. Participants who performed breathing exercises had greater changes in the included biomarkers than those who did not, suggesting that these biomarkers can be used to evaluate oxidative stress after respiratory interventions.CONCLUSION: Breathing exercises increased SOD and GSH activities and decreased MDA content.SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337119, identifier CRD42022337119.

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08:02

Various breathing exercises for COPD patients confer benefits that manifest in diverse ways. GreenMedInfo

PMID:  Arch Phys Med Rehabil. 2023 May 6. Epub 2023 May 6. PMID: 37150427 Abstract Title:  Effects of Breathing Exercises in Patients With Chronic Obstructive Pulmonary Disease: A Network Meta-analysis. Abstract:  OBJECTIVE: A network meta-analysis of randomized controlled trials (RCTs) was conducted to compare and rank the effectiveness of various breathing exercises for patients with chronic obstructive pulmonary disease (COPD).DATA SOURCES: We searched PubMed, Web of Science, Embase, and the Cochrane Library databases to determine the articles.STUDY SELECTION: Publications investigating the effect of breathing exercises on exercise capacity (six-minute walk test [6MWT]), pulmonary function (the ratio of the first second forced expiratory volume of forced vital capacity [FEV/FVC]), quality of life (St George's Respiratory Questionnaire [SGRQ]), inspiratory muscle pressure (maximum inspiratory pressure [PI]), and dyspnea (Borg scale) were searched.DATA EXTRACTION: Data extracted by 2 researchers were entered into predesigned tables for data extraction. The quality of the literature was assessed using the Cochrane Collaboration's tool.DATA SYNTHESIS: A total of 43 RCTs involving 1977 participants were analyzed. To boost exercise capacity, the top 2 exercises were inspiratory muscle training (75%), Chinese traditional fitness exercises (13%); To improve pulmonary function, the top 2 exercises were Chinese traditional fitness exercises (32%), diaphragm breathing (30%); To raise patients' quality of life, the top 2 exercises were yoga (52%), diaphragm breathing (28%); To increase inspiratory muscle pressure, the top 2 exercises were pursed-lip breathing (47%), Chinese traditional fitness exercises (25%); To improve dyspnea, the top 2 exercises were yoga (44%), inspiratory muscle training (22%).CONCLUSIONS: Various breathing exercises for COPD patients confer benefits that manifest in diverse ways. Pulmonary rehabilitation specialists could administer personalized breathing exercises tailored to each patient's condition to attain optimal therapeutic outcomes.

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07:55

The integration of yoga breathing techniques in cognitive behavioural therapy for post-traumatic stress disorder. GreenMedInfo

PMID:  Front Psychiatry. 2023 ;14:1101046. Epub 2023 Apr 17. PMID: 37139325 Abstract Title:  The integration of yoga breathing techniques in cognitive behavioral therapy for post-traumatic stress disorder: A pragmatic randomized controlled trial. Abstract:  INTRODUCTION: In trauma-focused Cognitive Behavioral Therapy (TF-CBT), stabilization techniques are used before confrontation ones to increase stress/affect tolerance and thus effectiveness of CBT. This study investigated the effects of pranayama, meditative yoga breathing and breath holding techniques, as a complimentary stabilization technique in patients with post-traumatic stress disorder (PTSD).METHODS: Seventy-four PTSD-patients (84% female, 44.213years) were randomized to receive either pranayama at the beginning of each TF-CBT session or TF-CBT alone. The primary outcome was self-reported PTSD severity after 10 sessions of TF-CBT. Secondary outcomes included quality of life, social participation, anxiety, depression, distress tolerance, emotion regulation, body awareness, breath-holding duration, acute emotional reaction to stress, and adverse events (AEs). Intention-to-treat (ITT) and exploratory per-protocol (PP) analyses of covariance with 95% confidence intervals (CI) were performed.RESULTS: ITT analyses revealed no significant differences on primary or secondary outcomes, except for breath-holding duration in favor of pranayama-assisted TF-CBT (20.81s, 95%CI=13.05|28.60). PP analyses of 31 patients without AEs during pranayama revealed significantly lower PTSD severity (-5.41, 95%CI=-10.17|-0.64) and higher mental quality of life (4.89, 95%CI=1.38|8.41) than controls. In contrast, patients with AEs during pranayama breath holding reported significantly higher PTSD severity (12.39, 95%CI=5.08|19.71) than controls. Concurrent somatoform disorders were found to be a significant moderator of change in PTSD severity (=0.029).CONCLUSION: In PTSD patients without concurrent somatoform disorders, the integration of pranayama into TF-CBT might reduce post-traumatic symptoms and increase mental quality of life more efficiently than TF-CBT alone. The results remain preliminary until they can be replicated by ITT analyses.CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT03748121.

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07:53

Wounded Children Are Running the World: Our Inner Child and Political Activism Mad In America

From Kindred Media: Listen to Robin Grille, author of Parenting for a Peaceful World and his latest book, Inner Child Journeys, share insights into how:

1. Its our inner child who is casting the votes for parenting figures we recognize, according to science.

2. Wounded children are driving the direction of the planet.

3. We create public policy based on our inner childs unmet needs.

***

Robin Grille: A lot of activism tends to be about blame; it tends to be laced with the energy of blame, [the] language [and] the rhetoric of blame, and its about tearing down the building. So theres a lot of attack that happens in activism. But even, you know, the so-called non-violent activism, which is Im glad that weve made that transition, that marches are peaceful and . . . theres definitely been, unmistakably, a great movement towards non-physically violent activism in the world, and the thing that we identify as activism, which is usually lots of people out in the street, right. But anger absolutely theres a lot to be angry about, but anger and attack and blame are two completely separate things. You know, I hope everyone is angry about the destruction of our environment its killing people, Australias on fire and people have died and you know, we should be scared being scared means youre waking up to whats going on and angry; that does not mean attack.

I know for me, Ive put a lot of energy over my life [into] being mad at corporations, and corporations are bad, or this aspect of capitalism is bad or etc. And if I really pay attention to my voice, I feel like in that mode Im kind of Im a teenager. And really in my body I feel straight away the connection to how I would fight with my father as a teenager. That I so passionately resented his authoritarian ways, his refusal to listen to my side, his imposition of his world view, which felt completely poisonous to me. And so I got caught up in trying to tear down and bring down my dad as the sort of looming male that was blocking out the sunlight for me. And I mean, Im a little sad about that as I say it because I also love my dad profoundly, and hes gone now, hes been gone for about seven or eight years. But that has stayed within me, and I still can almost feel this sort of adolescent pleasure at pointing the finger and saying, Bad. And I think that that aspect of activism is undermining; its polarizing, its exacerbatin...

07:31

Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity. GreenMedInfo

PMID:  Front Pharmacol. 2023 ;14:1167398. Epub 2023 Apr 24. PMID: 37168997 Abstract Title:  Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats. Abstract:  Microgravity experienced during space flight is known to exert several negative effects on the learning ability and memory of astronauts. Few effective strategies are currently available to counteract these effects. Rg1 and Rb1, the major steroidal components of ginseng, have shown potent neuroprotective effects with a high safety profile. The present study aimed to investigate the effects of Rg1 and Rb1 on simulated microgravity-induced learning and memory dysfunction and its underlying mechanism in the hindlimb suspension (HLS) rat model. Administration of Rg1 (30 and 60 mol/kg) and Rb1 (30 and 60 mol/kg) for 2 weeks resulted in a significant amelioration of impaired spatial and associative learning and memory caused by 4-week HLS exposure, measured using the Morris water maze and Reward operating conditioning reflex (ROCR) tests, respectively. Furthermore, Rg1 and Rb1 administration alleviated reactive oxygen species production and enhanced antioxidant enzyme activities in the prefrontal cortex (PFC). Rg1 and Rb1 also assisted in the recovery of mitochondrial complex I (NADH dehydrogenase) activities, increased the expression of Mfn2 and decreased the fission marker dynamin-related protein (Drp)-1expression. Additionally, Rg1 and Rb1 treatment increased the SYN, and PSD95 protein expressions and decreased the ratio of Bax:Bcl-2 and reduced the expression of cleaved caspase-3 and cytochrome C. Besides these, the BDNF-TrkB/PI3K-Akt pathway was also activated by Rg1 and Rb1 treatment. Altogether, Rg1 and Rb1 treatment attenuated cognitive deficits induced by HLS, mitigated mitochondrial dysfunction, attenuated oxidative stress, inhibited apoptosis, increased synaptic plasticity, and restored BDNF-TrkB/PI3K-Akt signaling.

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07:17

Higher alcohol consumption may increase risk of colorectal cancer Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

A new population-based study shows that higher alcohol consumption may increase the risk of early-onset colorectal cancer.

Skeptical Raptor

07:08

Ginsenoside Rc from Panax ginseng ameliorates palmitate-induced UB/OC-2 cochlear cell injury. GreenMedInfo

PMID:  Int J Mol Sci. 2023 Apr 16 ;24(8). Epub 2023 Apr 16. PMID: 37108509 Abstract Title:  Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury. Abstract:  By 2050, at least 700 million people will require hearing therapy while 2.5 billion are projected to suffer from hearing loss. Sensorineural hearing loss (SNHL) arises from the inability of the inner ear to convert fluid waves into neural electric signals because of injury to cochlear hair cells that has resulted in their death. In addition, systemic chronic inflammation implicated in other pathologies may exacerbate cell death leading to SNHL. Phytochemicals have emerged as a possible solution because of the growing evidence of their anti-inflammatory, antioxidant, and anti-apoptotic properties. Ginseng and its bioactive molecules, ginsenosides, exhibit effects that suppress pro-inflammatory signaling and protect against apoptosis. In the current study, we investigated the effects of ginsenoside Rc (G-Rc) on UB/OC-2 primary murine sensory hair cell survival in response to palmitate-induced injury. G-Rc promoted UB/OC-2 cell survival and cell cycle progression. Additionally, G-Rc enhanced the differentiation of UB/OC-2 cells into functional sensory hair cells and alleviated palmitate-induced inflammation, endoplasmic reticulum stress, and apoptosis. The current study offers novel insights into the effects of G-Rc as a potential adjuvant for SNHL and warrants further studies elucidating the molecular mechanisms.

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06:19

Heat treatment enhances the neuroprotective effects of crude ginseng saponin by increasing minor ginsenosides. GreenMedInfo

PMID:  Int J Mol Sci. 2023 Apr 13 ;24(8). Epub 2023 Apr 13. PMID: 37108384 Abstract Title:  Heat Treatment Enhances the Neuroprotective Effects of Crude Ginseng Saponin by Increasing Minor Ginsenosides. Abstract:  Ginsenoside is the primary active substance of ginseng and has many pharmacological effects, such as anti-cancer, immune, regulating sugar and lipid metabolism, and antioxidant effects. It also protects the nervous and cardiovascular systems. This study analyzes the effects of thermal processing on the bioactivities of crude ginseng saponin. Heat treatment increased the contents of minor ginsenosides in crude saponins, such as Rg3, and heat-treated crude ginseng saponin (HGS) had better neuroprotective effects than non-treated crude saponin (NGS). HGS reduced glutamate-induced apoptosis and reactive oxygen species generation in pheochromocytoma 12 (PC12) cells, significantly more than NGS. HGS protected PC12 cells against glutamate-induced oxidative stress by upregulating Nrf2-mediated antioxidant signaling and downregulating MAPK-mediated apoptotic signaling. HGS has the potential for the prevention and treatment of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease.

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05:39

Ginsenoside Rg1 protects cardiac mitochondrial function. GreenMedInfo

PMID:  Free Radic Biol Med. 2023 Aug 1 ;204:54-67. Epub 2023 Apr 25. PMID: 37105420 Abstract Title:  Ginsenoside Rg1 protects cardiac mitochondrial function via targeting GSTP1 to block S-glutathionylation of optic atrophy 1. Abstract:  Mitochondrial dysfunction is a fundamental challenge in myocardial injury. Ginsenoside Rg1 (Rg1) is a bioactive compound with pharmacological potential for cardiac protection. Optic atrophy 1 (OPA1) acts as a mitochondrial inner membrane protein that contributes to the structural integrity and function of mitochondria. This study investigated the protective role of Rg1 in septic cardiac injury from the perspective of OPA1 stability. Rg1 protected cardiac contractive function against endotoxin injury in mice by maintaining mitochondrial cristae structure. In cardiomyocytes, lipopolysaccharide (LPS) evoked mitochondrial fragmentation and destruction of mitochondrial biogenesis, which were prevented by Rg1, possibly due to the preservation of the integrity of cristae structure. In support, the beneficial effects of Rg1 on cardioprotection and mitochondrial biogenesis were diminished by OPA1 deficiency subjected to the LPS challenge. Mechanistically, LPS stimulation triggered intracellular glutathione destabilization that promoted S-glutathionylation of OPA1 at Cys551, leading to the dissociation of OPA1-Mitofilin. Rg1 interacted with Glutathione S-transferase pi (GSTP1) to inhibit its mediated S-glutathionylation of OPA1, thereby promoting OPA1-Mitofilin interaction and protecting mitochondrial cristae structure. These findings suggest that GSTP1/OPA1 axis may be a beneficial strategy for the treatment of myocardial injury, and expand the clinical application of Rg1.

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05:26

Ginsenoside Rg1 can reverse fatigue behaviour in chronic fatigue syndrome. GreenMedInfo

PMID:  Front Pharmacol. 2023 ;14:1163638. Epub 2023 Apr 10. PMID: 37101547 Abstract Title:  Ginsenoside Rg1 can reverse fatigue behavior in CFS rats by regulating EGFR and affecting Taurine and Mannose 6-phosphate metabolism. Abstract:  Chronic fatigue syndrome (CFS) is characterized by significant and persistent fatigue. Ginseng is a traditional anti-fatigue Chinese medicine with a long history in Asia, as demonstrated by clinical and experimental studies. Ginsenoside Rg1 is mainly derived from ginseng, and its anti-fatigue metabolic mechanism has not been thoroughly explored.We performed non-targeted metabolomics of rat serum using LC-MS and multivariate data analysis to identify potential biomarkers and metabolic pathways. In addition, we implemented network pharmacological analysis to reveal the potential target of ginsenoside Rg1 in CFS rats. The expression levels of target proteins were measured by PCR and Western blotting.Metabolomics analysis confirmed metabolic disorders in the serum of CFS rats. Ginsenoside Rg1 can regulate metabolic pathways to reverse metabolic biases in CFS rats. We found a total of 34 biomarkers, including key markers Taurine and Mannose 6-phosphate. AKT1, VEGFA and EGFR were identified as anti-fatigue targets of ginsenoside Rg1 using network pharmacological analysis. Finally, biological analysis showed that ginsenoside Rg1 was able to down-regulate the expression of EGFR.Our results suggest ginsenoside Rg1 has an anti-fatigue effect, impacting the metabolism of Taurine and Mannose 6-phosphate through EGFR regulation. This demonstrates ginsenoside Rg1 is a promising alternative treatment for patients presenting with chronic fatigue syndrome.

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05:09

Ginsenoside Rb3 reduces ox-LDL-induced injury in human aortic endothelial cells. GreenMedInfo

PMID:  Adv Clin Exp Med. 2023 Apr 24. Epub 2023 Apr 24. PMID: 37093091 Abstract Title:  Ginsenoside Rb3 reduces ox-LDL-induced injury in human aortic endothelial cells by regulating the miR-513a-5p/ZBTB20 axis. Abstract:  BACKGROUND: Atherosclerosis (AS) is a common vascular disease, and its main influencing factor is endothelial damage caused by oxidized low-density lipoprotein (ox-LDL). As one of the main active ingredients of ginseng, ginsenoside Rb3 has anti-inflammatory and anti-oxidative effects. However, the role of ginsenoside Rb3 in endothelial injury induced by ox-LDL is not clear.OBJECTIVES: This study aimed to evaluate the effect and potential mechanism of ginsenoside Rb3 action on ox-LDL-treated human aortic endothelial cells (HAECs).MATERIAL AND METHODS: The HAECs treated with ox-LDL were used to establish an in vitro AS model. The viability of the HAECs was analyzed with Cell Counting Kit-8 (CCK-8). Flow cytometry was performed to assess the apoptosis. Oxidative stress, inflammation and endothelial dysfunction were evaluated using enzyme-linked immunosorbent assay (ELISA) and western blotting. The levels of miR-513a-5p were assessed using quantitative real-time polymerase chain reaction (qPCR). A dual-luciferase assay was performed to analyze the relationship between miR-513a-5p and a zinc finger and BTB domain-containing protein (ZBTB20).RESULTS: Exposure of HAECs to ox-LDL (50g/mL) reduced cell viability, superoxide dismutase (SOD) activity and endothelial nitric oxide synthase (eNOS) expression, while increasing the levels of malondialdehyde (MDA), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-), and soluble intercellular adhesion molecule-1 (sICAM-1). The pretreatment with Rb3 markedly enhanced cell viability and decreased ox-LDL-induced oxidative stress, inflammation and endothelial dysfunction in HAECs. The ox-LDL decreased the level of miR-513a-5p, which was reversed by Rb3 pretreatment. The ZBTB20 was a target of miR-513a-5p in HAECs, and ox-LDL upregulated ZBTB20 expression, which was reversed by Rb3 pretreatment. The protective effect of Rb3 on ox-LDL-induced HAECs was diminished by miR-513a-5p inhibition, which was reversed by ZBTB20 knockdown.CONCLUSIONS: Ginsenoside Rb3 reduces the effects of ox-LDL on HAECs by regulating the miR-513a-5p/ZBTB20 axis, which provides a theoretical basis for the treatment of AS.

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04:51

Vax-Unvax: Let the Science Speak Children's Health Defense

This book is based on over one hundred studies in the peer-reviewed literature that consider vaccinated versus unvaccinated populations. Each study is analyzed, and health differences among infants, children, and adults who have been vaccinated and those who have not are presented and put in context. Readers will find information on:

  • The infant/child vaccination schedule
  • Thimerosal in vaccines
  • Live virus vaccines
  • The human papillomavirus (HPV) vaccine
  • Vaccination and Gulf War illness
  • Influenza (flu) vaccines
  • Hepatitis B vaccination
  • The COVID-19 vaccine
  • Vaccines during pregnancy

Given the massive push to vaccinate the entire global population, this book is timely and necessary for individuals to make informed choices for themselves and their families.

The post Vax-Unvax: Let the Science Speak appeared first on Children's Health Defense.

04:42

Tart Cherries Relieve Osteoarthritis Pain GreenMedInfo

Tart Cherries Relieve Osteoarthritis Pain

If you are among the millions of Americans suffering from joint pain and arthritis, there's good news about a favorite summer treat. According to research from Oregon Health & Science University, tart cherries help reduce the chronic inflammation that leads to pain.[1]

In fact, the Oregon researchers declared that tart cherries have the "highest anti-inflammatory content of any food" and can help osteoarthritis patients manage their condition.

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Wednesday, 19 July

22:08

Yet Another Alzheimers Drug Science-Based Medicine

A third drug either FDA approved or showing clinical benefit for Alzheimer's disease confirms that the world of AD treatment has changed forever.

The post Yet Another Alzheimers Drug first appeared on Science-Based Medicine.

20:01

Sharon Lambert and Naoise CaoilteMental Health Podcasts: A Force for Good in a Contested Field Mad In America

According to Edison Research, there are more podcast listeners than ever, with 64% of the US 12+ population having ever listened to a podcast. With over half a million active podcasts available, more time is being devoted to mental health discussions. However, little is known about the motivation and experiences of people listening to mental health related material in podcasts.

Joining us today are Dr. Sharon Lambert and Naoise Caoilte from University College Cork in Ireland, who have studied the motivations and experiences of mental health-related podcast listeners. Their recent paper is entitled Podcasts as a Tool for Enhancing Mental Health Literacy: An Investigation of Mental Health-Related Podcasts, and it appears in the journal Mental Health & Prevention.

In this interview, we discuss the importance of mental health literacy and ask if the need for honest mental health experiences is being met from the recording studio rather than the consulting room.

The transcript below has been edited for length and clarity. Listen to the audio of the interview here.

 

James Moore: Sharon and Naoise, thank you so much for joining me today for the Mad in America podcast. Before we get to talk about your fascinating study, could I ask you both to introduce yourselves and say a little about what you do at University College Cork?

Dr. Sharon Lambert: I am a psychologist and academic researcher. I research and teach applied psychology at UCC and my areas of interest are the relationship between psychological trauma and traumatic experiences in a very broad sense. So, that includes things like poverty and social exclusion, and how that impacts thinking, learning, and behavior. Im particularly interested in how people design and deliver services so that everybody can use them and that came from working in the community with socially-excluded groups.

Naoise Caoilte: I am a recent graduate of the Masters at University College Cork in applied psychology and mental health and it was there that we started this piece of research. Sharon and I became interested in exploring some of the podcast listeners experiences. At the moment, I work for the Health Service Executive here in Ireland,...

20:00

Journal asks scientist to step down from editorial board after sleuths comments linked him to paper mill Retraction Watch

Masoud Afrand

An engineering researcher has stepped down from an editorial board at the request of a journals leadership following a sleuths comment on a Retraction Watch post linking him to paper mill activity. 

Masoud Afrand, an assistant professor of engineering at the Islamic Azad University in Iran, was, until recently, on the editorial board of the journal Engineering Analysis with Boundary Elements. He also was listed on the website of Scientific Reports as a member of the journals editorial board in the subject of mechanical engineering. 

He now has neither position. He has not responded to our requests for comment. 

In our original story with Undark, Alexander Magazinov, a scientific sleuth and software engineer based in Kazakhstan, said Afrand was likely part of a paper mill operation for a special issue in Mathematical Methods in the Applied Sciences, where Afrand was cited over 130 times. 

Magazinov had cited Afrands association with Scientific Reports as an example of researchers seemingly associated with paper mills attaining editorial roles with reputable journals. 

Following our reporting, Scientific Reports removed Afrand from the webpage with its editorial board members. Rafal Marszalek, its chief editor, told us that the journal had parted ways with Afrand in March 2022, after an internal audit uncovered irregularities in how he handled papers. Afrand had still been listed on the webpage due to an oversight, and the journal updated the page after our story brought attention to it. 

In a...

11:01

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells. GreenMedInfo

PMID:  Acta Biochim Biophys Sin (Shanghai). 2023 Apr 19 ;55(4):587-600. PMID: 37092860 Abstract Title:  Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells. Abstract:  Ginsenoside Rh3 (GRh3) is a seminatural product obtained by chemical processing after isolation from Chinese herbal medicine that has strong antitumor activity against human tumors. However, its antitumor role remains to be elucidated. The aim of this study is to explore the mechanisms underlying the tumor suppressive activity of GRh3 from the perspective of pyroptosis and ferroptosis. GRh3 eliminates colorectal cancer (CRC) cells by activating gasdermin D (GSDMD)-dependent pyroptosis and suppressing solute carrier family 7 member 11 (SLC7A11), resulting in ferroptosis activation through the Stat3/p53/NRF2 axis. GRh3 suppresses nuclear factor erythroid 2-related factor 2 (NRF2) entry into the nucleus, leading to the decrease of heme oxygenase 1 (HO-1) expression, which in turn promotes NOD-like receptor thermal protein domain associated protein 3 (NLRP3) and caspase-1 expression. Finally, caspase-1 activates GSDMD-dependent pyroptosis. Furthermore, GRh3 prevents NRF2 from entering the nucleus, which suppresses SLC7A11, causing the depletion of glutathione (GSH) and accumulation of iron, lipid reactive oxygen species (ROS) and malondialdehyde (MDA), and eventually leading to ferroptosis in CRC cells. In addition, GRh3 effectively inhibits the proliferation of CRC cellsand in nude mouse models. Collectively, GRh3 triggers pyroptotic cell death and ferroptotic cell death in CRC cells via the Stat3/p53/NRF2 axis with minimal harm to normal cells, showing great anticancer potential.

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10:58

Ginsenosides are promising medicine for tumor and inflammation. GreenMedInfo

PMID:  Am J Chin Med. 2023 ;51(4):883-908. Epub 2023 Apr 17. PMID: 37060192 Abstract Title:  Ginsenosides are Promising Medicine for Tumor and Inflammation: A Review. Abstract:  Ginseng is a valuable medicinal plant in Asian countries with thousands of years of history. Ginsenosides, one of the active components of ginseng, are considered to be of potential value in the treatment of various diseases. The antitumor effects of ginsenosides, such as Rg3, Rh2, Rg5, and CK, are well known, and their potential mechanisms are thought to be related to inducing apoptosis, enhancing the immune response, reversing drug resistance to chemotherapy, and regulating signaling pathways, such as MAPK, PI3K/Akt/mTOR, Wnt/[Formula: see text]-catenin, NF-[Formula: see text]B, ASK-1/JNK, AMPK, and EGFR/Akt/SOX2. On the other hand, ginsenosides also have anti-inflammatory effects, including reducing the release of inflammatory factors, regulating the balance of immune cells, regulating the diversity of intestinal flora, and activating MAPK, NF-[Formula: see text]B, and NLRP3 inflammasomes. These data suggest that ginsenosides may provide new insights as promising drugs for the treatment of malignant tumors and inflammatory diseases.

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10:39

Ginsenoside Rb1 interfered with macrophage activation by activating PPAR to inhibit insulin resistance in obesity. GreenMedInfo

PMID:  Molecules. 2023 Mar 30 ;28(7). Epub 2023 Mar 30. PMID: 37049846 Abstract Title:  Ginsenoside Rb1 Interfered with Macrophage Activation by Activating PPARto Inhibit Insulin Resistance in Obesity. Abstract:  Type 2 diabetes (T2D) is characterized by insulin resistance (IR), often accompanied by inflammation. Macrophage activation acts as an inflammatory response, which is characterized by macrophage recruitment in the initial stage. Ginsenoside Rb1 (Rb1) is a main active ingredient, which is known for its fat-reducing, anti-inflammatory effects. To clarify that Rb1 regulates macrophage activation in adipose tissue and improves tissue inflammation, network pharmacology and molecular docking were used for target prediction and preliminary validation. By constructing the co-culture model of adipose-derived stem cells (ADSC) and primary macrophage (PM), the body adipose tissue microenvironment was simulated to observe the adipogenesis degree of adipocytes under the effect of Rb1. The levels of cytokines, macrophage polarization, and protein or RNA expression in the inflammatory signaling pathway were finally detected. The results showed that 89 common targets of T2D-Rb1 were obtained after their intersection. Furthermore, according to the results of the KEGG pathway and PPI analysis, PTGS2 (COX-2) is the downstream protein of PPAR-NF-B. The molecular binding energy of PPAR-Rb1 is -6.8 kcal/mol. Rb1 significantly inhibited the increase in MCP-1, TNF-, and IL-1induced by hypertrophic adipocytes supernatant and promoted the expression of IL-10. Rb1 inhibited the activation of inflammatory macrophages and PM migration and upregulated PPARexpression with the blocking of NF-B activation. Additionally, Rb1 promoted the expression of IRS1 and PI3K in the insulin signal pathway, which had a similar effect with ROS. Therefore, Rb1 might affect macrophage activation through PPAR, which might alleviate obese insulin resistance in T2D early stage.

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10:23

Inhibitory effects of ginsenoside compound K on lipopolysaccharide-stimulated inflammatory responses in macrophages. GreenMedInfo

PMID:  Nutrients. 2023 Mar 27 ;15(7). Epub 2023 Mar 27. PMID: 37049466 Abstract Title:  Inhibitory Effects of Ginsenoside Compound K on Lipopolysaccharide-Stimulated Inflammatory Responses in Macrophages by Regulating Sirtuin 1 and Histone Deacetylase 4. Abstract:  Inflammation, an innate immune response mediated by macrophages, has been a hallmark leading to the pathophysiology of diseases. In this study, we examined the inhibitory effects of ginsenoside compound K (CK) on lipopolysaccharide (LPS)-induced inflammation and metabolic alteration in RAW 264.7 macrophages by regulating sirtuin 1 (SIRT1) and histone deacetylase 4 (HDAC4). LPS suppressed SIRT1 while promoting HDAC4 expression, accompanied by increases in cellular reactive oxygen species accumulation and pro-inflammatory gene expression; however, the addition of CK elicited the opposite effects. CK ameliorated the LPS-induced increase in glycolytic genes and abrogated the LPS-altered genes engaged in the NAD+ salvage pathway. LPS decreased basal, maximal, and non-mitochondrial respiration, reducing ATP production and proton leak in macrophages, which were abolished by CK. SIRT1 inhibition augmentedexpression along with increased LPS-induced inflammatory and glycolytic gene expression, while decreasing genes that regulate mitochondrial biogenesis; however, its activation resulted in the opposite effects. Inhibition of HDAC4 enhancedexpression and attenuated the LPS-induced inflammatory gene expression. In conclusion, CK exerted anti-inflammatory and antioxidant properties with the potential to counteract the alterations of energy metabolism, including glycolysis and mitochondrial respiration, through activating SIRT1 and repressing HDAC4 in LPS-stimulated macrophages.

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10:08

New Documentary on Medically Kidnapped Girl Whose Mother Committed Suicide is the Most Powerful Film Ever Produced Exposing Medical Kidnapping Medical Kidnap

by Brian Shilhavy
Editor, Health Impact News

Last night I watched the new documentary that was released by Netflix last month (June, 2023), Take Care of Maya.

This is, by far, the best documentary I have ever watched that exposes the criminal enterprise allowed to operate in this country, and which I have been covering as a journalist for about a decade now, medical kidnapping.

Here is the Netflix trailer:

The documentary shows the true story of the Kowalski family of Florida, a medical kidnapping horror story that we have covered in previous articles. See:

Florida Group Homes in Foster Care are Pimping and Sexually Trafficking Children

Has Florida Become the Top State in the U.S. for Medical Kidnapping and Child Trafficking?

The documentary was produced by Caitlin Keating, who also writes for People Magazine.

Here is an excerpt from People that was published just before the film was released on Netflix.

An Allegation of Munchausen by Proxy, a Moms Suicide, a Daughters Pain: Take Care of Maya Exclusive Clip

Maya Kowalski tells PEOPLE how a hospitalization for her painful and rare neurological condition led to her mothers suicide, ahead of the premiere of the new Netflix documentary

By Abby Roedel

Maya Kowalski was rushed to the ER at Johns Hopkins All Childrens Hospital in St. Petersburg, Fla., in the early morning of October 7, 2016. She had crippling stomach pain (so severe, her knees were going up to her chest, and she was screaming, says her father, Jack,) related to the rare neurological condition complex regional pain syndrome or CRPS....

10:07

Ginsenoside Rh4 inhibits breast cancer growth through targeting histone deacetylase 2. GreenMedInfo

PMID:  Bioorg Chem. 2023 Jun ;135:106537. Epub 2023 Apr 9. PMID: 37043883 Abstract Title:  Ginsenoside Rh4 inhibits breast cancer growth through targeting histone deacetylase 2 to regulate immune microenvironment and apoptosis. Abstract:  High expression of histone deacetylase 2 (HDAC2) is recognized as a marker of invasive breast cancer (BC). HDAC2 is not only responsible for enhancing tumor cell growth, development, and anti-apoptosis, but also plays a significant role in regulating PD-L1 on the surface of tumor cells. Continuous expression of PD-L1 allows tumor cells to escape immune surveillance. There is not much research on how HDAC2 affects the immune system in breast cancer. Ginsenoside Rh4 (Rh4) is a major rare saponin in heat-treated ginseng, which is widely applied in treating and preventing various diseases because of its potent medicinal value and stable safety. However, it is unclear how Rh4 affects the tumor immune microenvironment in breast cancer. Therefore, this paper aims to investigate the effect of Rh4 on HDAC2 in breast cancer, specifically the effect of HDAC2 on apoptosis and the immune microenvironment to inhibit breast cancer growth. According to our study, ginsenoside Rh4 has been shown to significantly suppress breast cancer cell proliferation without any adverse effects. The molecular docking results of Rh4 and HDAC2 indicate a binding energy of -6.06 kcal/mol, suggesting the potential of Rh4 as a targeting modulator of HDAC2. Mechanistically, Rh4 induces apoptosis of breast cancer cells by the HDAC2-mediated caspase pathway and inhibits the HDAC2-mediated JAK/STAT pathway to regulate the immune microenvironment, which inhibits breast cancer growth. Specifically, Rh4 was shown for the first time to blockade immune checkpoints (PD-1/PD-L1) and increase levels of T-lymphocytes in the tumor. In a word, our study establishes a theoretical framework for applying Rh4 as an immune checkpoint inhibitor as part of breast cancer treatment.

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10:07

New Documentary on Medically Kidnapped Girl Whose Mother Committed Suicide is the Most Powerful Film Ever Produced Exposing Medical Kidnapping Vaccine Impact

by Brian Shilhavy
Editor, Health Impact News

Last night I watched the new documentary that was released by Netflix last month (June, 2023), Take Care of Maya.

This is, by far, the best documentary I have ever watched that exposes the criminal enterprise allowed to operate in this country, and which I have been covering as a journalist for about a decade now, medical kidnapping.

Here is the Netflix trailer:

The documentary shows the true story of the Kowalski family of Florida, a medical kidnapping horror story that we have covered in previous articles. See:

Florida Group Homes in Foster Care are Pimping and Sexually Trafficking Children

Has Florida Become the Top State in the U.S. for Medical Kidnapping and Child Trafficking?

The documentary was produced by Caitlin Keating, who also writes for People Magazine.

Here is an excerpt from People that was published just before the film was released on Netflix.

An Allegation of Munchausen by Proxy, a Moms Suicide, a Daughters Pain: Take Care of Maya Exclusive Clip

Maya Kowalski tells PEOPLE how a hospitalization for her painful and rare neurological condition led to her mothers suicide, ahead of the premiere of the new Netflix documentary

By Abby Roedel

Maya Kowalski was rushed to the ER at Johns Hopkins All Childrens Hospital in St. Petersburg, Fla., in the early morning of October 7, 2016. She had crippling stomach pain (so severe, her knees were going up to her chest, and she was screaming, says her father, Jack,) related to the rare neurological condition complex regional pain syndrome or CRPS....

10:00

Messenger RNA Vaccines in Meat Animals Articles

Messenger ribonucleic acid (mRNA) vaccines became a household term during the COVID-19 pandemic. But many are unaware that these experimental shots may be used in livestock intended for food.

Concerns that mRNA injections could end up "in the global protein supply chain" prompted warnings from cattle producers and calls for mandatory country of origin labeling (MCOOL) so consumers can choose meat from countries that dont allow mRNA shots in meat animals.Backlash quickly ensued, with media spinning a familiar tune and trying to paint the valid concerns as "conspiracy theories," "fearmongering" and "misinformation."2

Cattle Groups Calls for Caution Over mRNA in Beef

In an April 2023 news release, Ranchers-Cattlemen Action Legal Fund United Stockgrowers of America (R-CALF USA), a nonprofit that represents interests of independent U.S. cattle producers, shared concerns about the use of mRNA shots in meat animals.

Max Thornsberry, DVM, R-CALFs animal health committee chair, met with medial doctors and a molecular biologist before briefing the R-CALF USA board:3

"Thornsberry reported that some researchers have found that mRNA and its coded virus is likely passed from an injected human to a noninjected human, and to humans who have consumed dairy products or meat from an mRNA-injected animal.

He said that because the research on mRNA is still in its infancy, no one really knows the full impact it has on either humans or animals, particularly its long-term impact. He said this itself warrants more extensive mRNA research focused on safety, heightened public vigilance, and greater transparency."

In a commentary, R-CALF CEO Bill Bullard also urged caution regarding mRNA injections, stating:4

"Its not a vaccine as we typically understand vaccines. So, for the rest of this discussion, Ill refer to it as an injection. Its an injection of a laboratory-produced substance into humans or livestock that is coded with a particular virus, such as COVID-19, that produces an immune response against the particular virus.

And what does mRNA do? Well, it hijacks living cells, tricking them into producing some level of immunity against human viruses like COVID-19 and livestock viruses such as foot-and-mouth disease or lumpy skin disease. It does this by rewriting the instructions from the bodys DNA. And what are the potential risks to humans and livestock?

The truthful answer is we dont...

What Is Oil Pulling? Articles

Editor's Note: This article is a reprint. It was originally published August 3, 2016.

The history of oil pulling dates back nearly 3,000 years. Before modern medicine, elders in India developed Ayurveda, a form of mind-body health system. The basic tenet of Ayurveda is that when balanced, your body has amazing powers to heal itself.

Practitioners recommend you provide your body support through a healthy diet, adequate sleep, reduced stress, strong digestive process and living in tune with your natural constitution.1

One of the practices of Ayurveda is oil pulling, or the act of swishing and rinsing your mouth with oil. Oil pulling has been used in traditional Indian folk remedies to prevent tooth decay, bad breath, bleeding gums and to strengthen your teeth and gums.2

Benefits to Your Oral Health

Some believe oil pulling may have more extensive benefits to your health. I can't support all of those claims, but I have first-hand knowledge of how oil pulling benefits oral health as I have been pulling consistently since 2011.

Oil pulling is an effective mechanical method of cleansing your teeth and the smallest crevices along your molars that the bristles of your brush cannot reach. Your dentist may have recommended using sealants on your teeth to help prevent decay from forming in these tiny areas.

In the past, popular oils for pulling were sesame and sunflower oils. However, those are high in omega-6 fats, which you likely get enough of each day. Cold-pressed, virgin coconut oil is my oil of choice for a couple of reasons.

Bacteria is the root cause of both bad breath and cavity formation in your teeth. They have membranes that are fat-soluble and break down with the mechanical action of swishing and pulling oil. Research demonstrates that pulling oils improves the saponification, or breakdown of bacterial membranes.3

While sesame and sunflower oils may functionally break down bacteria, coconut oil adds another advantage. Coconut oil is a medium-chain fatty acid found to inhibit Streptococcus mutans, the chief bacteria responsible for cavities.4,5

Coconut oil also protects against yeast infections in the mouth, generally referred to as thrush.6,7 This condition is more common if your immune system is compromised, or may be experienced by infants and nursing mothers....

Is Climate Engineering Real? Articles

In the video above, U.S. presidential candidate Robert F. Kennedy Jr. interviews Dane Wigington, founder of GeoengineeringWatch.org, about climate engineering and its hidden role in climate change. Wigington also produced the documentary The Dimming.

While Wigington has tried to raise awareness about the reality of climate engineering for the last two decades, his work is now gaining traction after the White House announced its backing a plan to block sunlight in a climate engineering effort.

White House Considers Measure to Block Sunlight

As reported by the Daily Mail, July 1, 2023:1

The White House has opened the door to an audacious plan to block sunlight from hitting the surface of the Earth in a bid to halt global warming.

Despite some scientists warning the effort could have untold side effects from altering the chemical makeup of the atmosphere, President Joe Biden's administration has admitted they're open to the idea, which has never been attempted before.

In a report2 released Friday by the White House, officials suggested limiting sunlight to rapidly cool the planet, a process known as solar radiation modification (SRM) ...

The report noted several ways authorities could look to achieve SRM, all of which come with potentially devastating consequences if they backfire ... undertaking the mammoth task could have severe ramifications weather patterns and food supplies, which would in turn impact biodiversity, geopolitics, and health.

Policymakers in the European Union recently called for an international assessment of geoengineering risks, noting that:3

"These technologies introduce new risks to people and ecosystems, while they could also increase power imbalances between nations, spark conflicts and raises a myriad of ethical, legal, governance and political issues.

Supercomputer to Determine Effects

According to Scientific American, a supercomputer called Derecho will help climate scientists decide whether to block the sun:4

A new supercomputer for climate research will help scientists study the effects of solar geoenginee...

09:59

The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer. GreenMedInfo

PMID:  Medicine (Baltimore). 2023 Apr 7 ;102(14):e33463. PMID: 37026927 Abstract Title:  The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer: A systematic review and meta-analysis of randomized controlled trials. Abstract:  BACKGROUND: The occurrence and development of non-small cell lung cancer (NSCLC) are closely related to the immune status of the tumor-host. The immunosuppression caused by tumor cells and toxic side effects produced by chemotherapeutic drugs results in a decrease in immune function, ultimately leading to the failure of clinical chemotherapy treatment. Ginsenoside Rg3 has been clinically reported to have positive effects in enhancing immune function in patients. Thus, we screened and evaluated the quality of the evidence regarding the benefits of ginsenoside Rg3 and conducted a meta-analysis to assess the impact on improving immune function in NSCLC.METHODS: The PubMed, EMBASE, Cochrane Library, CNKI, Weipu (VIP), and Wanfang databases were searched in this study, all from the time of library construction to January 2023.RESULTS: In total,12 trials with a sample size of 1008 cases were included based on the eligible criteria. The results showed that compared with first-line chemotherapy alone, the combination of ginsenoside Rg3 and first-line chemotherapy could better improve level of the CD3+ T lymphocytes [mean difference (MD) = 4.72; 95% confidence intervals (CI): 3.92, 5.53; P

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09:44

Ginsenoside Rg1 treatment alleviates renal fibrosis. GreenMedInfo

PMID:  Ren Fail. 2023 Dec ;45(1):2197075. PMID: 37017270 Abstract Title:  Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4-MAPK pathway in T2DM mice. Abstract:  Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis of DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to improve DKD, but the mechanism is unclear. NADPH oxidase 4 (NOX4) is an essential reactive oxygen species (ROS) source in the kidney. The mitogen-activated protein kinase (MAPK) signaling may exacerbate renal fibrosis. Therefore, we hypothesized that Rg1 might alleviate renal injury and fibrosis by inhibiting NOX4 and MAPK signaling in T2DM-induced DKD. We found that Rg1 significantly improves lipid deposition, fibrosis, and ROS production and reduces NOX4, p22phox, p47phox, p-ERK, p-JNK, and p-P38 MAPK expressions in the T2DM mice kidneys. We also found that the high-fat diet treatment in mice and the palmitate (PA) and PA+HG (high glucose) exposure in human mesangial cells could significantly induce lipid deposition, ROS production, fibrosis, and the activation of NOX4-MAPK signaling. The results suggest that high lipid and glucose may play a significant role in DKD progression, while Rg1 may attenuate renal fibrosis by inhibiting NOX4-MAPK signaling.

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09:13

New Documentary on Medically Kidnapped Girl Whose Mother Committed Suicide is the Most Powerful Film Ever Produced Exposing Medical Kidnapping Health Impact News

by Brian Shilhavy
Editor, Health Impact News

Last night I watched the new documentary that was released by Netflix last month (June, 2023), Take Care of Maya.

This is, by far, the best documentary I have ever watched that exposes the criminal enterprise allowed to operate in this country, and which I have been covering as a journalist for about a decade now, medical kidnapping.

Here is the Netflix trailer:

The documentary shows the true story of the Kowalski family of Florida, a medical kidnapping horror story that we have covered in previous articles. See:

Florida Group Homes in Foster Care are Pimping and Sexually Trafficking Children

Has Florida Become the Top State in the U.S. for Medical Kidnapping and Child Trafficking?

The documentary was produced by Caitlin Keating, who also writes for People Magazine.

Here is an excerpt from People that was published just before the film was released on Netflix.

An Allegation of Munchausen by Proxy, a Moms Suicide, a Daughters Pain: Take Care of Maya Exclusive Clip

Maya Kowalski tells PEOPLE how a hospitalization for her painful and rare neurological condition led to her mothers suicide, ahead of the premiere of the new Netflix documentary

By Abby Roedel

Maya Kowalski was rushed to the ER at Johns Hopkins All Childrens Hospital in St. Petersburg, Fla., in the early morning of October 7, 2016. She had crippling stomach pain (so severe, h...

09:06

New Details Emerge About How White House Colluded With Twitter to Censor RFK Jr. and CHD GreenMedInfo

New "Twitter Files" reveal how the White House and Twitter flag social media posts that contradicted the official government narrative on COVID-19

09:05

New Details Emerge About How White House Colluded With Twitter to Censor RFK Jr. and CHD GreenMedInfo


Originally published on www.childrenshealthdefense.org by Michael Nevradakis, Ph.D.

New "Twitter Files" released today by investigative journalist Paul D. Thacker reveal how a "dark money group" helped the White House and Twitter flag social media posts by Robert F. Kennedy Jr. and Children's Health Defense that contradicted the official government narrative on COVID-19.

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08:32

Ginsenoside Rb1 alleviated concanavalin A-induced hepatocyte pyroptosis. GreenMedInfo

PMID:  Food Funct. 2023 Apr 24 ;14(8):3793-3803. Epub 2023 Apr 24. PMID: 37000511 Abstract Title:  Ginsenoside Rb1 alleviated concanavalin A-induced hepatocyte pyroptosis by activating mitophagy. Abstract:  Pyroptosis is characterized as gasdermin-mediated programmed death and has received substantial attention in recent years. Excessive hepatocyte pyroptosis could induce acute liver injury, and there is a lack of efficient natural compounds to alleviate it. Ginsenoside Rb1 is the most prevalent ginsenoside in ginseng with a variety of biological activities and is usually added to functional foods. In spite of the numerous beneficial effects ginsenoside Rb1 exerts, its role in hepatocyte pyroptosis is yet unknown. In this study, we found that ginsenoside Rb1 alleviated concanavalin A-induced hepatocyte pyroptosis and inhibited NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, which is critical for the process of pyroptosis. Furthermore, with the addition of the mitophagy inhibitor cyclosporin A, we proved that ginsenoside Rb1 promoted PINK1/Parkin-mediated mitophagy to alleviate hepatocyte pyroptosis. The further mechanism was that ginsenoside Rb1 activated mitophagy to eliminate damaged mitochondria. With the clearance of damaged mitochondria, reactive oxygen species production decreased, and then NLRP3 inflammasome expression was inhibited. Our finding demonstrated that ginsenoside Rb1 could alleviate hepatocyte pyroptosis by activating mitophagy, which could provide a basis for formulating effective dietary therapy or dietary recommendation.

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08:00

This Week with Glenn Ellison Dr. Tenpenny

07-18-2023 Listen to interview here. If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-18-23-HHr-GlennEllison.mp4 This interview is one that parent will want to listen and []

07:51

The Looming Addiction Crisis Fueled by AI Mad In America

From Insider: The first Adderall ad appeared in my Instagram feed during the height of pandemic isolation. I thought the slick 30-second video promising me a super easy way to get ADHD medication was another gimmick. But after the algorithm pushed a few more plugs my way, I started to get curious. The drugs, to my surprise, were real. Unlike countless sketchy ads for black-market supplements, Cerebral, the then-hot telehealth startup behind the ads, offered a legal path to prescription medications.

It was indeed a super easy path too easy. My intake process to get prescribed a potentially addictive amphetamine turned out to be easier than getting Taylor Swift tickets or an appointment with my primary-care physician. Even as I doubted that I met the clinical criteria for ADHD, I could honestly answer the vague, brief self-assessment (e.g., How often do you have difficulty paying attention when you are doing boring or repetitive work?) and receive the same result as tens of thousands of AI-targeted customers: You have some symptoms consistent with ADHD. We suggest further evaluation. When I spoke to a Cerebral nurse practitioner for all of 13 minutes, the experience was much the same. Answering that, yes, my concentration was strained in the middle of a once-in-a-century pandemic got me an official diagnosis and prescription. Like its many telehealth competitors, including DoneKlarityadhdonline.com, and...

07:28

Golden rice anti-GMO activists keeping it away from children Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Golden rice, which contains more vitamin A, is being blocked by environmental activists because it is genetically modified.

Skeptical Raptor

07:20

Ginsenoside Rg1 improves inflammation and autophagy of the pancreas and spleen in streptozotocin-induced type 1 diabetes. GreenMedInfo

PMID:  Int J Endocrinol. 2023 ;2023:3595992. Epub 2023 Mar 14. PMID: 36960388 Abstract Title:  Ginsenoside Rg1 Improves Inflammation and Autophagy of the Pancreas and Spleen in Streptozotocin-Induced Type 1 Diabetic Mice. Abstract:  BACKGROUND: Ginsenoside Rg1 (Rg1) is one of the key bioactive components of the precious Traditional Chinese Medicine that has been used to treat diabetes in China. Ginsenosides have been reported to protect diabetics from tissue damage, inflammation, and insulin resistance. Type 1 diabetes (T1D) is an organ-specific autoimmune disease that occurred frequently among adolescents over the world, its development was related to inflammation and-cells immunodeficiency. The aim of this study is to explore the biological mechanism of Rg1 on inflammation and autophagy of-cells in T1D and its therapeutic potential.METHODS: The model of T1D mice was established by injecting Streptozotocin (STZ) (55mg/kg) or citric acids once a day for 5days and from the fourth day of injection, mice were administered with Rg1 (20mg/kg) or saline by gavage once a day for 12days. Hematoxylin-eosin staining, immunofluorescence, ELISA, quantitative real-time PCR, and Western blot were used to observe the histopathological changes, inflammatory factor levels, and autophagy markers after administration of ginsenoside Rg1.RESULTS: Compared to the T1D mice, Rg1 improved the weight (

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06:30

RFK Jrs family condemns his views on vaccines and anti-semitism Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

The Kennedy family is publicly disagreeing with RFK Jr's false claims about vaccines. I hope they keep making these statements.

Skeptical Raptor

06:00

Ep 493 Your gut and a reason why you feel exhausted Dr Ron Unfiltered Uncensored

Are you doing everything right, like sleeping, eating organic, drinking purified water exercising, etc. but still have that feeling of being tired and exhausted? May it is the microbiome (3rd brain) and the mitochondria connection. Tune in.

04:49

Tragic Comedy by Navratra Mad In America

Whenever I do something good,
my mother says,
I am just like her,
my father says,
I am just like him
They feel so proud on themselves
and start loving me so much
as if they are mobile phones
and I am their SIM

But you just need to wait
for a misconduct by me,
how drastically the scene changes,
Youll be able to see

My mother will say,
I am just like my father
My father will say,
I am like my mother
though none of them scolds me much
as, by some divine intervention,
they still love each other

Yes, I have read a bit of biology
but genes changes with deeds
never read this in my life!
The question is:
Is my resemblance something biological,
or just a matter of husband-wife?!

****

Navratra is a young poetess(writer), public speaker and artist from Jaipur, India. Her poems have been published in various national and international journals like Sahitya Kunj, Indian Periodical, Ode to a poetess, Spillwords, Setu Magazine, The Criterion, Madras Courier, InkPantry and elsewhere

****

Back to Poetry Gallery

The post Tragic Comedy by Navratra appeared first on Mad In America.

04:46

On Becoming a Butterfly by Michael Robin Mad In America

On Becoming a Butterfly

Little did I know,
the end was just the beginning
Like the caterpillar,
I shed my old skin as if I was supposed to die.
Reduced to a puddle of muck,
I fought hard to get out of the cocoon.
Had someone intervened to help me escape,
I would have died.
I learned like the caterpillar,
that my struggle had to be vigorous yet patient.
Transformed into a brightly colored butterfly,
I fly along the robins of spring.
Like the butterfly, Ive endured pain and loss,
to become a better person.

****

Michael is recovering from a suicide attempt from ten years ago. Part of his story is reflected in his piece, A Patient Reads His Psychiatrist in Mad in America, June 30, 2023.

****

Back to Poetry Gallery

The post On Becoming a Butterfly by Michael Robin appeared first on Mad In America.

04:43

The Malingerer Goes To the Movies by Scott Norman Rosenthal Mad In America

The Malingerer Goes to the Movies,
(a Dis-Ability Coming-Out poem,
for Colin Kempner, and Judith Wright)

1.
Youre sitting there,
and its getting harder to breathe.
It feels as if a little man, like a gnome,
has crept up the back of your seat,
and dropped a net into your head,
over your brain

You glance at the woman sitting next to you,
and she isnt there
You look at the screen, and it seems unreal,
like a bad film

Are you in a theater at all?
Are you in a room filled with water?
ARE THERE ANY PEOPLE HERE!?

2.
Shows over, youre out in the parking lot,
wondering how to get home

(Scott Norman Rosenthal, Autumn 82)

****

This poem was the first attempt to record the bizarre symptomatology of my debilitating neuro-metabolic imbalance.

****

Back to Poetry Gallery

The post The Malingerer Goes To the Movies by Scott Norman Rosenthal appeared first on Mad In America.

03:45

Morning Coffee Jul 18 Dr. Tenpenny

07-18-2023 Audio Track:   If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-18-23-MorningCoffee-bone.mp4 In this episode, the audience wanted to know about bone health with []

03:41

Children's Health Defense Report: Grassroots Backlash Helps Defeat D.C. Schools COVID Vaccine Mandate Age of Autism The Rebel Alliance!

No voice no choiceGrassroots Backlash Helps Defeat D.C. Schools COVID Vaccine Mandate, CHD Attorney Says

The District of Columbia announced the school vaccine mandate in July 2022 shortly after the U.S. Food and Drug Administration approval for ages 12-15, but low compliance, grassroots pushback and threats of more lawsuits may have led to its cancellation before implementation.

The District of Columbia last week ended its plan to mandate the COVID-19 vaccine for children to attend school this upcoming academic year.

In announcing the decision, the Council of the District of Columbia noted that no state has mandated the COVID-19 vaccine for schoolchildren, that the public health emergency has ended and that not attending school has detrimental effects for children.

Commenting on the news, Kim Mack Rosenberg, acting general counsel for Childrens Health Defense (CHD), told The Defender, While I believe that mandates whether in D.C. or elsewhere were legally problematic from the outset, the councils decision to now remove the mandate is an important step to remedy a mandate that should never have been imposed.

Rosenberg added:

However, parents need to be vigilant in the future to protect their children from similar attempts to control access to education and the classroom by essentially forcing children to take unwanted medical treatments.

Education is essential to childrens success, and to condition access to education, especially by mandating an experimental product is, simply put, unacceptable.

...

03:00

Borderline Personality Disorder and Survivor Injustice Mad In America

Authors Note: Content warnings for trauma, abuse, sexual abuse, child sexual abuse, victim-blaming, sanism and involuntary psychiatric incarceration.

I grew up in an abusive family. It took me decades to realise this, and to be able to name the child sexual abuse I endured.

It also took decades for the memories of it to fully return, stuffed down into the deepest recesses of my mind as they were, as trauma memories can be.

When the memories finally formed, the first things that I remember feeling were immense pain and terror.

I could still hear the sounds sometimes; they came to me as intrusive thoughts. And I could still see images, like flashes, as though everything was happening all over again.

Out of that pain grew rage towards my mother, the person responsible for all of this unbearable, life-altering trauma that had driven me out of my own body for most of my life, had made it the site of this trauma and an unsafe place for me to occupy.

A white woman's face. A man's hand over her mouth.

My mother, in an attempt to deflect accountability for the harms that she had caused, positioned herself as the victim and told people that I was full of all this inexplicable rage towards her, citing decontextualised examples of my rage and the psychiatric diagnosis of borderline personality disorder that I had been given as corroboration that my rage was a sign that I was mentally ill.

In our last exchange before I ended contact, she wrote to me, You turn your rage and anger on me with no provocation. I tried my best to do everything to please you, but it never helped. You need professional help.

She didnt mention to anyone her own rage that I had learned to fear or the severe abuse that I had endured for so long under her. She didnt mention the fact that I had grown up in a house full of domestic abuse and death threats...

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Tuesday, 18 July

20:00

Econ study retracted after researchers find undocumented alterations in the code Retraction Watch

Adrien Matray

An economics study has been retracted after other researchers identified several inconsistencies in the studys code and submitted a comment to the journal. 

Those critics say the flaws drove the papers main findings, but an author of the study says they had no major effect and stands by the results.

The original paper, Dividend Taxes and the Allocation of Capital, was published in the American Economic Review in September 2022. It examined the impact of a 2013 increase in the tax rate on dividends in France, concluding an increased rate can encourage the accumulation of capital. The study has been cited four times, according to Clarivates Web of Science. 

The retraction is only the second in the journals history. As Retraction Watch has previously reported, research shows that it is less common for economics papers to be retracted than research in other fields. 

The retraction notice published this month states, in part: 

The authors are retracting the paper because Figure 4 of the published paper, which pertains to the second result on the increase in investment and which plots the event study difference-in-difference coefficients of the within-firm change in year-to-year investment flows by treated firms, relative to control firms, differs from the figure that was conditionally accepted by the handling editor in two ways. 

The first difference, the authors write in the retraction notice, was that the firm size control variable in the conditionally accepted manuscript was coded in changes...

17:03

Madonna !?! Science-Based Medicine

Remembering the old days of Madonna, courting, and naloxone use.

The post Madonna !?! first appeared on Science-Based Medicine.

11:30

Tanshinone IIA ameliorates experimental diabetic cardiomyopathy. GreenMedInfo

PMID:  Phytother Res. 2023 May 1. Epub 2023 May 1. PMID: 37128721 Abstract Title:  Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1. Abstract:  Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism is a critical factor that affects the occurrence and development of DCM. Additionally, the upregulation/activation of silent information regulation 2 homolog-1 (SIRT1) has been shown to protect against DCM. Tanshinone II A (Tan IIA), the main active component of Salviae miltiorrhizae radix et rhizome (a valuable Chinese medicine), has protective effects against cardiovascular disease and diabetes. However, its role and mechanisms in diabetes-induced cardiac dysfunction remain unclear. Therefore, we explored whether Tan IIA alleviates ERS-mediated DCM via SIRT1 and elucidated the underlying mechanism. The results suggested that Tan IIA alleviated the pathological changes in the hearts of diabetic mice, ameliorated the cytopathological morphology of cardiomyocytes, reduced the cell death rate, and inhibited the expression of ERS-related proteins and mRNA. The SIRT1 agonist inhibited the activities of glucose-regulated protein 78 (GRP78). Furthermore, the opposite results under the SIRT1 inhibitor. SIRT1 knockdown was induced by siRNA-SIRT1 transfection, and the degree of GRP78 acetylation was increased. Cumulatively, Tan IIA ameliorated DCM by inhibiting ERS and upregulating SIRT1 expression.

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11:24

Apocynin infusion before ischemia or at reperfusion protected the heart. GreenMedInfo

PMID:  Pharmaceuticals (Basel). 2023 Mar 27 ;16(4). Epub 2023 Mar 27. PMID: 37111249 Abstract Title:  Effects of Apocynin, a NADPH Oxidase Inhibitor, in the Protection of the Heart from Ischemia/Reperfusion Injury. Abstract:  Ischemia and perfusion (I/R) induce inflammation and oxidative stress, which play a notable role in tissue damage. The aim of this study was to investigate the role of an NADPH oxidase inhibitor (apocynin) in the protection of the heart from I/R injury. Hearts isolated from Wistar rats (n = 8 per group) were perfused with a modified Langendorff preparation. Left ventricular (LV) contractility and cardiovascular hemodynamics were evaluated by a data acquisition program, and infarct size was evaluated by 2,3,5-Triphenyl-2H-tetrazolium chloride (TTC) staining. Furthermore, the effect of apocynin on the pro-inflammatory cytokines (IL-1, IL-6 and TNF-) and anti-inflammatory cytokine (IL-10) was evaluated using an enzyme linked immunosorbent assay (ELISA). Hearts were subjected to 30 min of regional ischemia, produced by ligation of the left anterior descending (LAD) coronary artery, followed by 30 min of reperfusion. Hearts were infused with apocynin before ischemia, during ischemia or at reperfusion. To understand the potential pathways of apocynin protection of the heart, a nitric oxide donor (S-nitroso-N-acetylpenicillamine, SNAP), nitric oxide blocker (N (gamma)-nitro-L-arginine methyl ester, L-Name), nicotinic acid adenine dinucleotide phosphate (NAADP) inhibiter (Ned-K), cyclic adenosine diphosphate ribose (cADPR) agonist, or CD38 blocker (Thiazoloquin (az)olin (on)e compound, 78c) was infused with apocynin. Antioxidants were evaluated by measuring superoxide dismutase (SOD) and catalase (CAT) activity. Apocynin infusion before ischemia or at reperfusion protected the heart by normalizing cardiac hemodynamics and decreasing the infarct size. Apocynin treatment resulted in a significant (

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11:21

Apocynin ameliorates monosodium glutamate induced testis damage. GreenMedInfo

n/a PMID:  Life (Basel). 2023 Mar 17 ;13(3). Epub 2023 Mar 17. PMID: 36983977 Abstract Title:  Apocynin Ameliorates Monosodium Glutamate Induced Testis Damage by Impaired Blood-Testis Barrier and Oxidative Stress Parameters. Abstract:  BACKGROUND: the aim of this study was to investigate the effects of apocynin (APO) on hormone levels, the blood-testis barrier, and oxidative biomarkers in monosodium glutamate (MSG) induced testicular degeneration. METHODS: Sprague Dawley male rats (150-200 g; n = 32) were randomly distributed into four groups: control, APO, MSG, and MSG + APO. MSG and MSG + APO groups were administered MSG (120 mg/kg) for 28 days. Moreover, the APO and MSG + APO groups received APO (25 mg/kg) during the last five days of the experiment. All administrations were via oral gavage. Finally, biochemical analyses were performed based on the determination of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD), as well as light and transmission electron microscopic examinations, assessment of sperm parameters, ZO-1, occludin, NOX-2, and TUNEL immunohistochemistry were evaluated. RESULTS: MSG increased both the oxidative stress level and apoptosis, decreased cell proliferation, and caused degeneration in testis morphology including in the blood-testis barrier. Administration of apocynin reversed all the deteriorated morphological and biochemical parameters in the MSG + APO group. CONCLUSIONS: apocynin is considered to prevent testicular degeneration by maintaining the integrity of the blood-testis barrier with balanced hormone and oxidant/antioxidant levels.

11:16

Protective effects of crocin and gallic acid on the liver damage. GreenMedInfo

PMID:  Gastroenterol Hepatol Bed Bench. 2023 ;16(1):499-508. PMID: 37070111 Abstract Title:  Protective effects of crocin and gallic acid on the liver damage induced by methylglyoxal in male mice: role of inflammatory factors. Abstract:  AIM: This study aims to evaluate whether biochemical alterations caused by methylglyoxal (MG), improves by the administration of gallic acid (GA), crocin (Cr), and metformin (MT) in the liver.BACKGROUND: MG is produced naturally through various physiological processes, but high levels of MG cause inflammation in hepatocytes. Normal liver function is essential for maintaining glucose homeostasis. Gallic acid and crocin can reduce inflammation.METHODS: This experiment was done in 5 weeks. 50 male NMRI mice were randomly divided into 5 groups (n=10): 1) Control, 2) MG (600 mg/Kg/d, p.o.), 3) MG+GA (30 mg/kg/day, p.o.), 4) MG+Cr (60 mg/kg/day, p.o.), 5) MG+MT (150 mg/kg/day, p.o.). After one week of habituation, MG was administered for four weeks. Gallic acid, crocin, and metformin were administered in the last two weeks. Biochemical and histologic evaluations were assessed after plasma collection and tissue sample preparation.RESULTS: Gallic acid and crocin-received groups significantly reduced fasting blood glucose, total cholesterol, triglyceride levels, and elevated insulin sensitivity. Administration of MG exerted a marked increase in the levels of hepatic enzymes. Treatment with gallic acid, crocin, and metformin significantly decreased them. The altered levels of inflammatory factors in the diabetic group were significantly improved in the diabetic-treated groups. High levels of steatosis and red blood cells (RBCs) accumulation in the MG group markedly recovered in other treated mice.CONCLUSION: Harmful effects of accumulated MG in the liver of diabetic mice were effectively attenuated by using gallic acid and crocin.

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11:05

Gallic acid treatment protects intestinal tissue against ischemia-reperfusion. GreenMedInfo

PMID:  Folia Morphol (Warsz). 2023 May 15. Epub 2023 May 15. PMID: 37183516 Abstract Title:  Gallic acid treatment protects intestinal tissue against ischemia-reperfusion. Abstract:  BACKGROUND: This study aimed to investigate the protective effects of gallic acid (GA) in the rat intestine against ischemia-reperfusion (IR) injury.MATERIALS AND METHODS: Thirty male Wistar albino rats with a mean weight of 200-250 g were used. Animals were categorized into the sham, IR, and IR+GA groups. Ischemia of the intestine was induced for 3 h by occluding the superior mesenteric artery (SMA) and then left for 3 h of reperfusion. In the IR+GA group, after ischemia induction, 50 mg/kg GA was orally administered to the animals. Blood samples were collected for biochemical assays. Intestinal tissues were excised for histopathologic and immunohistochemical processing.RESULTS: Malondialdehyde (MDA) levels were increased, and catalase (CAT) and glutathione (GSH) levels were decreased in the IR group compared to the sham group. After GA treatment, MDA levels decreased and CAT and GSH levels increased in the GA-treated group compared to the IR group. In the sham group, normal intestinal histology was observed. In the IR group, the villi structures were completely degenerated. In the IR+GA group, histology was improved after GA treatment. In the sham group, the Caspase-3 reaction was generally negative in the epithelium and glands. In the IR group, the Caspase-3 reaction increased in apoptotic bodies and inflammatory cells. The Caspase-3 reaction was negative in goblet cells and the epithelium. A moderate Caspase-3 reaction was observed in the IR+GA group. The Beclin-1 reaction was negative in epithelial cells and goblet cells in villi in the sham group. In the IR group, the Beclin-1 reaction was positive in the degenerated villi. An intense Beclin-1 reaction was also observed in some inflammatory cells. After GA treatment, the Beclin-1 reaction was positive in a few cells. In general, moderate Beclin-1 positivity was observed.CONCLUSIONS: GA, with its antioxidative effect, inhibited the apoptotic pathway (Caspase-3) through Beclin-1 regulation.

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10:41

Gallic acid restores the sulfonamide sensitivity of multidrug-resistant Streptococcus suis. GreenMedInfo

PMID:  J Agric Food Chem. 2023 May 10 ;71(18):6894-6907. Epub 2023 May 1. PMID: 37125728 Abstract Title:  Gallic Acid Restores the Sulfonamide Sensitivity of Multidrug-Resistantvia Polypharmaceology Mechanism. Abstract:  Due to the large amount of antibiotics used for human therapy, agriculture, and even aquaculture, the emergence of multidrug-resistant() led to serious public health threats. Antibiotic-assisted strategies have emerged as a promising approach to alleviate this crisis. Here, the polyphenolic compound gallic acid was found to enhance sulfonamides against multidrug-resistant. Mechanistic analysis revealed that gallic acid effectively disrupts the integrity and function of the cytoplasmic membrane by dissipating the proton motive force of bacteria. Moreover, we found that gallic acid regulates the expression of dihydrofolate reductase, which in turn inhibits tetrahydrofolate synthesis. As a result of polypharmacology, gallic acid can fully restore sulfadiazine sodium activity in the animal infection model without any drug resistances. Our findings provide an insightful view into the threats of antibiotic resistance. It could become a promising strategy to resolve this crisis.

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10:26

Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye. GreenMedInfo

PMID:  Eye Vis (Lond). 2023 May 1 ;10(1):17. Epub 2023 May 1. PMID: 37122017 Abstract Title:  Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye: in vitro and in vivo studies. Abstract:  BACKGROUND: To investigate the anti-inflammatory and antioxidative effects of gallic acid (GA) on human corneal epithelial cells (HCECs) and RAW264.7 macrophages as well as its therapeutic effects in an experimental dry eye (EDE) mouse model.METHODS: A cell counting kit-8 (CCK-8) assay was used to test the cytotoxicity of GA. The effect of GA on cell migration was evaluated using a scratch wound healing assay. The anti-inflammatory and antioxidative effects of GA in vitro were tested using a hypertonic model (HCECs) and an inflammatory model (RAW264.7 cells). The in vivo biocompatibility of GA was detected by irritation tests in rabbits, whereas the preventive and therapeutic effect of GA in vivo was evaluated using a mouse model of EDE.RESULTS: In the range of 0-100 M, GA showed no cytotoxicity in RAW264.7 cells or HCECs and did not delay the HCECs monolayer wound healing within 24 h. Ocular tolerance to GA in the in vivo irritation test was good after seven days. In terms of antioxidative activity, GA significantly reduced the intracellular reactive oxygen species (ROS) in lipopolysaccharide (LPS) activated RAW264.7 macrophages and HCECs exposed to hyperosmotic stress. Furthermore, after pre-treatment with GA, the expression levels of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NADPH quinone oxidoreductase-1 (NQO-1) were significantly upregulated in RAW264.7 macrophages. GA also exhibits excellent anti-inflammatory properties. This is mainly demonstrated by the ability of GA to effectively downregulate the nuclear transcription factor-B (NF-B) pathway in LPS-activated RAW264.7 macrophages and to reduce inflammatory factors, such as nitric oxide (NO), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-). In vivo efficacy testing results in a mouse model of EDE showed that GA can effectively prevent and inhibit the apoptosis of corneal epithelial cells (CECs), reduce inflammatory factors in the cornea and conjunctiva as well as protect goblet cells.CONCLUSION: In vitro and in vivo results indicate that GA possesses potent anti-inflammatory and antioxidative properties with no apparent cytotoxicity within the range of 0-100 M. It is a promising eye drop formulation for the effective prevention and treatment of dry eye disease (DED).

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10:09

Antibiofilm effects of punicalagin against Staphylococcus aureus in vitro. GreenMedInfo

PMID:  Front Microbiol. 2023 ;14:1175912. Epub 2023 Apr 14. PMID: 37125156 Abstract Title:  Antibiofilm effects of punicalagin against. Abstract:  is a common foodborne pathogen which can form biofilms to help them resist to antimicrobials. It brings great harm to human health. Punicalagin has good antimicrobial activities against, but its effect on biofilm formation has not been clearly illustrated. The aim of this study was to explore the antibiofilm effects of punicalagin against. Results showed that punicalagin did not significantly interfere with the growth ofat the concentrations of 1/64 MIC to 1/16 MIC. The biomass and metabolic activity of biofilms were significantly reduced when exposed to sub-inhibitory concentrations of punicalagin. The number of viable cells in the biofilms was also decreased after punicalagin treatment. Scanning electron microscopy and confocal laser scanning microscopy images confirmed that punicalagin damaged the structure of biofilms. The antibiofilm mechanism was partly due to the modification of the cell surface which led to the reduction of cell surface hydrophobicity. These findings suggest that punicalagin has the potential to be developed as an alternative to controlbiofilms.

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10:05

Bavachinin protects the liver in NAFLD by promoting regeneration. GreenMedInfo

PMID:  J Adv Res. 2023 Feb 16. Epub 2023 Feb 16. PMID: 36801384 Abstract Title:  Bavachinin protects the liver in NAFLD by promoting regeneration via targeting PCNA. Abstract:  INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease all over the world, and no drug is approved for the treatment of NAFLD. Bavachinin (BVC) is proven to possess liver-protecting effect against NAFLD, but its mechanism is still blurry.OBJECTIVES: With the use of Click Chemistry-Activity-Based Protein Profiling (CC-ABPP) technology, this study aims to identify the target of BVC, and investigate the mechanism by which BVC exerts its liver-protecting effect.METHODS: The high fat diet induced hamster NAFLD model is introduced to investigate BVC's lipid-lowering and liver-protecting effects. Then, a small molecular probe ofBVC is designed and synthesized based on theCC-ABPP technology, and BVC's target is fished out. A series of experiments are performed to identify the target, including competitive inhibition assay, surface-plasmon resonance (SPR), cellular thermal shift assay (CETSA), drug affinity responsive target stability (DARTS) assay, and co-immunoprecipitation (Co-IP). Afterward, the pro-regeneration effects of BVC are validated in vitro and in vivo through flow cytometry, immunofluorescence, and the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL).RESULT: In the hamster NAFLD model, BVC shows lipid-lowing effect and improvement on the histology. PCNA is identified as the target of BVC with the method mentioned above, and BVC facilitates the interaction between PCNA and DNA polymerase delta. BVC promotes HepG2 cells proliferation which is inhibited by T2AA, an inhibitor suppresses the interaction between PCNA and DNA polymerase delta. In NAFLD hamsters, BVC enhances PCNA expression and liver regeneration, reduces hepatocyte apoptosis.CONCLUSION: This study suggests that, besides the anti-lipemic effect, BVC binds to the pocket of PCNA facilitating its interaction with DNA polymerase delta and pro-regeneration effect, thereby exerts the protective effect against HFD induced liver injury.

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10:00

Save the Bees Articles

More than 130 fruits, vegetables and nuts,1 and 35% of the worlds crops depend on pollinators.2 The USDA estimates thats 1 out of every 3 bites of food that go into your mouth, and likely more than that if you eat a whole food diet.

One of the primary pollinators is honeybees, which have suffered drastic population losses in the past decade and last year was no different.3 Farmers are unable to grow certain crops, such as blueberries, almonds, apples and other fruits, without bees. The loss of wild bees has meant farmers must rely on rented bees from commercial beekeepers who move their hives from one location to the next to help farmers pollinate their crops.4

Hail Bennett of Bennett Orchards in Frankford, Delaware, is one such farmer who rents bees.5 He has millions of flowers across 6 acres of blueberries, and "each flower has to be visited six to eight times by a honeybee in order to be fully pollinated," he told NPR. "It's pretty amazing how much work the bees have to do."

Most crops benefit from a variety of pollinators, so farmers are encouraged to nurture those that live around the farm. However, as is demonstrated by the rapidly declining population of bees, relying on one pollinator is a financially and environmentally risky business.

Renting honeybees for pollination may be insurance against crop failure, but it is only a stopgap process. It is essential that native pollinators are nurtured, and resilience is built in those populations to ensure a stable food supply, and that includes honeybees.

48% of Bee Colonies Lost in the Year Ending April 1, 2023

Information from a survey by the University of Maryland and Auburn University found that 48% of the honeybee colonies were lost from April 2022 to April 2023.6 The survey also found that in the summer of 2022, an estimated 24.9% of honeybee colonies managed in the U.S. were lost.7 However, the summer loss rate was only slightly higher than the previous 12 years of colony losses.

It was the rising 2022 to 2023 winter losses that were the second highest loss since experts began tracking honeybee colony losses. Commercial beekeepers rank an acceptable winter loss rate as 21.3%, yet the losses during the winter of 2022 to 2023 were an estimated 37.4%.

Over the year from April 1, 2022, to April 1, 2023, it's estimated 48.2% of the managed honeybee colonie...

Study: 74% of Post-Jab Deaths Caused by the Shot Articles

July 5, 2023, Dr. Peter McCullough, Dr. Harvey Risch, Dr. Roger Hodkinson, an expert clinical pathologist, and several other colleagues published a systematic review of autopsy findings in people who died after receiving a COVID shot on The Lancet journals preprint server.1

Disturbingly, but not surprisingly, they concluded that 62.5% to 73.9% of post-jab deaths were likely caused by the injection. Previous autopsy reviews have also concluded that the mRNA COVID jabs are a causative factor in sudden cardiac deaths.2

Nearly Three-Quarters of Post-Jab Deaths Caused by the Shot

As explained by the authors:3

The aim of this systematic review is to investigate possible causal links between COVID-19 vaccine administration and death using autopsies and post-mortem analysis ... We searched for all published autopsy and necropsy reports relating to COVID-19 vaccination up until May 18th, 2023.

We initially identified 678 studies and, after screening for our inclusion criteria, included 44 papers that contained 325 autopsy cases and one necropsy case. Three physicians independently reviewed all deaths and determined whether COVID-19 vaccination was the direct cause or contributed significantly to death.

The most implicated organ system in COVID-19 vaccine-associated death was the cardiovascular system (53%), followed by the hematological system (17%), the respiratory system (8%), and multiple organ systems (7%). Three or more organ systems were affected in 21 cases.

The mean time from vaccination to death was 14.3 days. Most deaths occurred within a week from last vaccine administration. A total of 240 deaths (73.9%) were independently adjudicated as directly due to or significantly contributed to by COVID-19 vaccination ...

Among adjudicators, there was complete independent agreement (all three physicians) of vaccination causing or contributing to death in 203 cases (62.5%). The one necropsy case was judged to be linked to vaccination with complete agreement ...

The consistency seen among cases in this review with known COVID-19 vaccine adverse events, their mechanisms, and related excess death, coupled with autopsy confirmation and physician-led death adjudication, suggests there is a high likelihood of a causal link between COVID-19 vaccines and death in most cases.

The Lancet Censors Pa...

Billionaire Stands to Make Millions From Addiction Treatment Articles

Editor's Note: This article is a reprint. It was originally published September 26, 2018.

An estimated 202,600 Americans died from opioid overdoses between 2002 and 2015,1 and drug overdoses are now the leading cause of death among Americans under the age of 50.2 Chronic opioid use also accounted for 20% of the increase in male unemployment between 1999 and 20153 and, remarkably, 74% of farmers report being addicted to opioids, or know someone who is.4

Aside from the staggering death toll, addiction to narcotic pain relievers also places an enormous economic burden on society, costing the U.S. an estimated $504 billion each year (2.8% of gross domestic product), according to a November 2017 White House report.5,6

Opioid Epidemic Is No Random Fluke

Adding insult to injury, evidence suggests opioid makers are directly responsible. They knew exactly what they were doing when they claimed opioids which are chemically very similar to heroin have an exceptionally low addiction rate when taken for pain.

In fact, the massive increase in opioid sales and subsequent addiction rates have been traced back to an orchestrated marketing plan aimed at misinforming doctors about the drug's addictive potential, and it is this false advertising campaign that seeded the current opioid epidemic an epidemic so great it has even lowered the national life expectancy.

Purdue Pharma, owned by the Sackler family, was one of the most successful in this regard, driving sales of OxyContin up from $48 million in 1996 to $1.5 billion in 2002.7

Studies now show addiction affects about 26% of those using opioids for chronic non-cancer pain, and 1 in 550 patients on opioid therapy dies from opioid-related causes within 2.5 years of their first prescription.8

Meanwhile, Purdue's sales representatives were extensively coached on how to downplay the drug's addictive potential, claiming addiction was occurring in less than 1% of patients being treated for pain.

Evidence also shows Sackler family members were intimately involved with the marketing machi...

09:51

Acupuncture can ameliorate depressive-like behaviours by promoting the recovery of neural plasticity functions. GreenMedInfo

PMID:  Neural Plast. 2023 ;2023:1474841. Epub 2023 May 2. PMID: 37179843 Abstract Title:  Acupuncture Alleviates CUMS-Induced Depression-Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity. Abstract:  PURPOSE: To explore the therapeutic efficiency of acupuncture and the related molecular mechanism of neural plasticity in depression.METHODS: Chronic unpredictable mild stress- (CUMS-) induced rats were established for the depression animal model. There were a total of four rat groups, including the control group, the CUMS group, the CUMS+acupuncture group, and the CUMS+fluoxetine group. The acupuncture group and the fluoxetine group were given a 3-week treatment after the modeling intervention. The researcher performed the open-field, elevated plus maze, and sucrose preference tests to evaluate depressive behaviors. The number of nerve cells, dendrites' length, and the prefrontal cortex's spine density were detected using Golgi staining. The prefrontal cortex expression, such as BDNF, PSD95, SYN, and PKMZ protein, was detected using the western blot and RT-PCR.RESULTS: Acupuncture could alleviate depressive-like behaviors and promote the recovery of the neural plasticity functions in the prefrontal cortex, showing the increasing cell numbers, prolonging the length of the dendrites, and enhancing the spine density. The neural plasticity-related proteins in the prefrontal cortex, including BDNF, PSD95, SYN, and PKMZ, were all downregulated in the CUMS-induced group; however, these effects could be partly reversed after being treated by acupuncture and fluoxetine (

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09:37

acupuncture improved the health-related quality of life in patients receiving maintenance hemodialysis. GreenMedInfo

PMID:  Healthcare (Basel). 2023 May 8 ;11(9). Epub 2023 May 8. PMID: 37174896 Abstract Title:  Effectiveness of Acupuncture on Health-Related Quality of Life in Patients Receiving Maintenance Hemodialysis. Abstract:  Patients with kidney failure (KF) receiving maintenance hemodialysis (HD) experience numerous symptoms that impair their health-related quality of life (HRQOL) and contribute to high mortality rates. Acupuncture is often used for symptom enhancement and HRQOL. This blinded, randomized, controlled patient-assessor trial evaluated the effectiveness of acupuncture compared with sham acupuncture on patients' HRQOL receiving maintenance HD as a secondary analysis. Seventy-two participants were randomly assigned to verum acupuncture (VA), sham acupuncture (SA), or waiting-list (WL) groups. The outcome was an improvement in HRQOL, assessed using the (KDQOL-SFv1.3) at baseline, after treatment, and at 12-week follow-up. Non-parametric tests were used for statistical analysis. Of the 72 randomized patients, 67 were included in the complete analysis set. As for the changes between baseline and after treatment, the VA group showed significantly increased scores on most of the KDQOL-SFv1.3 scales compared to SA or WL groups (0.05). Compared to the sham treatment, acupuncture improved the HRQOL in patients receiving maintenance HD after treatment but not at follow-up.

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09:28

Veterans on Patrol has Rescued Thousands of Children Sexually Trafficked in the U.S. Appeals for More Volunteers Medical Kidnap

by Brian Shilhavy
Editor, Health Impact News

I have written 2 articles on the blockbuster movie Sound of Freedom, a movie that has already grossed over $85 million in less than two weeks since its release on the big screen, and these articles have received tens of thousands of readers in the past few days, even though the movie does not expose child sex trafficking in the U.S., does not name the names of those funding this child sex trafficking network, and has no call to action to stop it. See:

Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It

Sound of Freedom Movie Allegedly Funded by Billionaire Philanthropists with Ties to Human Trafficking

By way of contrast, I have exposed where much of the child sex trafficking in the U.S. is happening, with a recently published story of a man who pleaded guilty to sexually abusing young children through the foster care system, as well as an update on the ongoing lawsuits against Jeffrey Epsteins child sex trafficking network, which DOES name names, and these two articles have received far fewer views than the Sound of Freedom film articles. See:

New Mexico Foster Parent Confesses Guilt of Sexually Abusing Children for Years but Does No Jail Time, 8-Year-Old Girl Awarded $485 Million

...

09:28

Veterans on Patrol has Rescued Thousands of Children Sexually Trafficked in the U.S. Appeals for More Volunteers Vaccine Impact

by Brian Shilhavy
Editor, Health Impact News

I have written 2 articles on the blockbuster movie Sound of Freedom, a movie that has already grossed over $85 million in less than two weeks since its release on the big screen, and these articles have received tens of thousands of readers in the past few days, even though the movie does not expose child sex trafficking in the U.S., does not name the names of those funding this child sex trafficking network, and has no call to action to stop it. See:

Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It

Sound of Freedom Movie Allegedly Funded by Billionaire Philanthropists with Ties to Human Trafficking

By way of contrast, I have exposed where much of the child sex trafficking in the U.S. is happening, with a recently published story of a man who pleaded guilty to sexually abusing young children through the foster care system, as well as an update on the ongoing lawsuits against Jeffrey Epsteins child sex trafficking network, which DOES name names, and these two articles have received far fewer views than the Sound of Freedom film articles. See:

New Mexico Foster Parent Confesses Guilt of Sexually Abusing Children for Years but Does No Jail Time, 8-Year-Old Girl Awarded $485 Million

...

09:00

On Your Health-Jul 17 2023 Tom Haviland Dr. Tenpenny

07-17-2023 Listen to audio of interview here.   Click on the video below to watch this episode:   https://drtenpenny.b-cdn.net/2023/07-17-23-OYH.mp4 Tom Haviland, a retired U.S. Air Force Major, Defense Contractor, and []

08:33

Veterans on Patrol has Rescued Thousands of Children Sexually Trafficked in the U.S. Appeals for More Volunteers Health Impact News

by Brian Shilhavy
Editor, Health Impact News

I have written 2 articles on the blockbuster movie Sound of Freedom, a movie that has already grossed over $85 million in less than two weeks since its release on the big screen, and these articles have received tens of thousands of readers in the past few days, even though the movie does not expose child sex trafficking in the U.S., does not name the names of those funding this child sex trafficking network, and has no call to action to stop it. See:

Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It

Sound of Freedom Movie Allegedly Funded by Billionaire Philanthropists with Ties to Human Trafficking

By way of contrast, I have exposed where much of the child sex trafficking in the U.S. is happening, with a recently published story of a man who pleaded guilty to sexually abusing young children through the foster care system, as well as an update on the ongoing lawsuits against Jeffrey Epsteins child sex trafficking network, which DOES name names, and these two articles have received far fewer views than the Sound of Freedom film articles. See:

New Mexico Foster Parent Confesses Guilt of Sexually Abusing Children for Years but Does No Jail Time, 8-Year-Old Girl Awarded $485 Million

...

08:12

The Lost Patients of Washingtons Abandoned Psychiatric Hospital Mad In America

From The Seattle Times: Lillian Massie pinches the floppy brim of her hat between her fingers and stares at the camera. At 24 years old, Lillian is a mother to two children. Shes slim, with wavy hair cropped at the ears and is once again pregnant or has possibly just given birth to a third child. She stands on what appears to be a train platform, a belt cinched above her belly. Sun washes over her face. Its 1925, and this is the last known photograph ever taken of her.

For the next nine years until her death, Lillian will be confined at Northern State Hospital, the now-shuttered Washington mental institution folded into a lush valley enclosed by dark mountain peaks an hours drive north of Seattle.

. . . Northern State Hospital took in tens of thousands of people like Lillian, most from the Seattle area. Today, theres scant evidence these patients ever existed. But as the 50-year anniversary of Northern States closure approaches this summer, family members and neighbors of the abandoned institution are fighting to recover them.

. . . Much of the country is now considering a push for more psychiatric care to get people off the street, such as Californias and New York Citys plans to expand involuntary treatment. Some fed up with the current mental health system look to places like Northern State with nostalgia. Many others see institutions as prisons for people with mental illnesses.

Between the two narratives are missing graves and ghost stories.

Article

***

Back to Around the Web

The post The Lost Patients of Washingtons Abandoned Psychiatric Hospital appeared first on...

08:09

Effectiveness of Acupuncture for relieving chemotherapy-induced bone marrow suppression. GreenMedInfo

PMID:  J Integr Complement Med. 2023 May 10. Epub 2023 May 10. PMID: 37163212 Abstract Title:  Effectiveness of Acupuncture for Relieving Chemotherapy-Induced Bone Marrow Suppression: A Systematic Review with a Meta-analysis and Trial Sequential Analysis. Abstract:  Bone marrow suppression is the most common side effect of chemotherapy that may lead to discontinuation for treatment pertaining to patients during the therapy course. Acupuncture may relieve bone marrow suppression with regulation hematopoietic function during chemotherapy. The purpose of this study is to evaluate the effectiveness of acupuncture in relieving chemotherapy-induced bone marrow suppression and determine the effects of acupuncture on bone marrow function.PubMed, Embase, Cochrane Library, Medline OVID, CINAHL Plus, Web of Science, and Chinese articles in the Airiti Library and China National Knowledge Infrastructure databases were searched up to February 2023. Publications in both English and Chinese were eligible for inclusion without any limitations on the publication date. Only randomized controlled trials investigating the impact of acupuncture on chemotherapy-induced bone marrow suppression were considered. In addition, a trial sequential analysis was performed to assess the adequacy of the current sample size.A total of 25 studies met the inclusion criteria. Acupuncture was found to increase the levels of hematopoietic cytokine granulocyte colony-stimulating factor (G-CSF) (Hedges'=0.79,

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07:31

Acupuncture could effectively improve tobacco withdrawal syndrome. GreenMedInfo

PMID:  Zhongguo Zhen Jiu. 2023 May 12 ;43(5):575-83. PMID: 37161812 Abstract Title:  [Acupuncture for treatment of tobacco withdrawal syndrome: systematic review and Meta-analysis]. Abstract:  OBJECTIVE: To systematically review the efficacy of acupuncture for the treatment of tobacco withdrawal syndrome.METHODS: The randomized controlled trials (RCTs) regarding acupuncture for treatment of tobacco withdrawal syndrome were searched in CNKI, Wanfang, VIP, SinoMed, PubMed, Cochrane, Medline and EMbase databases. The search period was from January 1st of 2011 to December 31st of 2021. After data extraction and bias risk assessment of the included literature, the Meta-analysis was performed using RevMan5.4.1 software.RESULTS: Totally 23 RCTs were included, including 2 120 patients. The Meta-analysis results showed that compared with medication, acupuncture showed no significant difference at improving Fagerstrm test for nicotine dependence (FTND) score (=0.16, 95%: -0.08, 0.41), heaviness of smoking index (HSI) score (=0.11, 95%: -0.13, 0.36), Minnesota nicotine withdrawal scale (MNWS) score (=0.12, 95%: -0.11, 1.35), questionnaire of smoking urges (QSU) score (=-0.30, 95%: -2.78, 2.18), Hamilton depression scale (HAMD) score (=0.76, 95%: -1.54, 3.06), abstinence rate (=0.95, 95%: 0.82, 1.10) and effective rate (=1.01, 95%: 0.95, 1.07). Acupuncture was superior to sham acupuncture in reducing MNWS score (=-4.88, 95%: -5.21, -4.55,

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07:21

Eriodictyol regulated ferroptosis, mitochondrial dysfunction and cell viability via Nrf2/HO-1/NQO1 signaling pathway in ovarian cancer. GreenMedInfo

PMID:  J Biochem Mol Toxicol. 2023 Apr 5:e23368. Epub 2023 Apr 5. PMID: 37020356 Abstract Title:  Eriodictyol regulated ferroptosis, mitochondrial dysfunction, and cell viability via Nrf2/HO-1/NQO1 signaling pathway in ovarian cancer cells. Abstract:  This study aimed to investigate the antitumor effect and the underlying molecular mechanism of eriodictyol on ovarian cancer cells. CaoV3 and A2780 were exposed to eriodictyol at different concentrations of 0-800M. Cell apoptosis and viability were determined by TdT-mediated dUTP Nick-End Labeling (TUNEL) assay and Cell Counting Kit-8 (CCK-8) assay, respectively. Mitochondrial membrane potential was evaluated by flow cytometers with a JC-1 detection kit. Fecontent was evaluated using an iron assay kit. The section of tumor tissues was observed using hematoxylin-eosin (H&E) staining and nuclear factor erythroid 2-related factor 2 (Nrf2) expression was detected by immunohistochemistry (IHC) staining. Eriodictyol suppressed cell viability and induced cell apoptosis of CaoV3 and A2780 cells. Half maximal inhibitory concentration (IC) value of CaoV3 at 24 and 48h was (229.745.13)M and (38.444.68)M, and ICvalue of A2780 at 24 and 48h was (248.322.54)M and (64.283.19)M. Fecontent and reactive oxygen species production were increased and protein levels of SLC7A11 and GPX4 were decreased by eriodictyol. Besides, eriodictyol reduced the ratio of JC-1 fluorescence ratio, glutathione and malondialdehyde contents but elevated Cytochrome C level. Nrf2 phosphorylation were obviously downregulated by eriodictyol. Finally, eriodictyol suppressed tumor growth, aggravated mitochondrial dysfunction and downregulated Nrf2 expression in tumor tissue in mice. Eriodictyol regulated ferroptosis, mitochondrial dysfunction and cell viability via Nrf2/HO-1/NQO1 signaling pathway in ovarian cancer.

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06:40

Get the flu vaccine for the 2023-24 flu season Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

All the information you need about the flu vaccine for the 2023-24 flu season. The vaccine saves lives, and that's the most important point.

Skeptical Raptor

06:35

Fact Check: No, RFK, Jr. Did Not Say COVID Was an Ethnically Targeted Bioweapon that Spared Jews GreenMedInfo

The internet is ablaze with a story that claims RFK, Jr. said COVID was an ethnically targeted bioweapon that were engineered to spare Jews and Chinese people, but is it true?

06:33

Fact Check: No, RFK, Jr. Did Not Say COVID Was an Ethnically Targeted Bioweapon that Spared Jews GreenMedInfo


Originally published on www.naturalnews.com by Mike Adams

The internet is ablaze with a story that claims RFK, Jr. said COVID was an ethnically targeted bioweapon that were engineered to spare Jews and Chinese people. This headline from the NY Post captures the meme that's going wild: "RFK Jr. says COVID was 'ethnically targeted' to spare Jews."

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05:23

Eriodictyol: a review of its pharmacological activities and molecular mechanisms related to ischemic stroke. GreenMedInfo

PMID:  Food Funct. 2023 Feb 21 ;14(4):1851-1868. Epub 2023 Feb 21. PMID: 36757280 Abstract Title:  Eriodictyol: a review of its pharmacological activities and molecular mechanisms related to ischemic stroke. Abstract:  Ischemic stroke (IS) is characterized by a prominent mortality and disability rate, which has increased the burden on the global economy to a certain extent. Meanwhile, patients benefit little from the limited clinical strategies of intravenous alteplase and thrombectomy due to the limited therapeutic window. Given this, it is urgent to study new therapeutic methods to intervene in these patients. Eriodyctiol (ERD) is a major natural flavonoid, which widely exists in fruits, vegetables, and medicinal herbs, and has various pharmacological properties. It has been reported that ERD can maintain homeostasis in organisms by exerting neuroprotective and vascular protective effects. Therefore, more and more studies have focused on the pharmacological activity and mechanism of ERD in IS. This paper provides an overview of the plant sources, phytochemical properties, pharmacokinetics, and pathogenesis, as well as the pharmacological effects and mechanisms of ERD in IS. To date, preclinical studies on ERD in diverse cell lines and animal models have established the idea of ERD as a feasible agent capable of specifically ameliorating IS. The molecular mechanisms of ERD to prevent or reduce IS are mainly based on the inhibition of inflammation, oxidative stress, autophagy and apoptosis. Nevertheless, the mechanism of ERD against IS is flawed and needs more exploration by the research community. Moreover, well-designed clinical trials are needed to increase the scientific validity of the beneficial effects of ERD against IS.

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05:02

Effects of isosakuranetin on cerebral infarction and blood brain barrier damage from cerebral ischemia/reperfusion injury. GreenMedInfo

PMID:  J Biomol Struct Dyn. 2023 Apr 28:1-8. Epub 2023 Apr 28. PMID: 37114509 Abstract Title:  Effects of isosakuranetin on cerebral infarction and blood brain barrier damage from cerebral ischemia/reperfusion injury in a rat model. Abstract:  This study investigated the effects of isosakuranetin (5,7-dihydroxy-4'-methoxyflavanone) on cerebral infarction and blood brain barrier (BBB) damage in cerebral ischemia and reperfusion (I/R) in a rat model. The right middle cerebral artery was occluded for 2h followed by reperfusion. The experimental rats were divided into five groups: a sham, or control group; vehicle group; and 5mg/kg, 10mg/kg, and 20mg/kg bodyweight isosakuranetin-treated I/R groups. After 24h of reperfusion, the rats were tested using a six-point neurological function score. The percentage of cerebral infarction was evaluated using 2,3,5-triphenyltetrazolium chloride (TTC) staining. BBB leakage was determined by Evan Blue injection assay and brain morphology changes were observed under light microscopy following staining with hematoxylin and eosin (H&E). The results of neurological function score revealed that isosakuranetin reduced the severity of neurological damage. A dose of 10 and 20mg/kg bodyweight of isosakuranetin significantly decreased the infarct volume. All three doses of isosakuranetin significantly decreased Evan Blue leakage. The penumbra area of the I/R brains revealed the characteristics of apoptotic cell death. Therefore, isosakuranetin-treated I/R attenuated the brain damage from cerebral I/R injury and further investigation of the mechanisms warrant further investigation to assist in the development of protective strategies against cerebral I/R injury in clinical trials.Communicated by Ramaswamy H. Sarma.

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04:54

Computational approaches to define poncirin from Magnolia champaka leaves as a novel multi-target inhibitor of SARS-CoV-2. GreenMedInfo

PMID:  J Biomol Struct Dyn. 2023 Jan 25:1-20. Epub 2023 Jan 25. PMID: 36695109 Abstract Title:  Computational approaches to define poncirin fromleaves as a novel multi-target inhibitor of SARS-CoV-2. Abstract:  Phytochemical-based drug discovery against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been the focus of the current scenario. In this context, we aimed to perform the phytochemical profiling of Magnolia champaka, an evergreen tree from thefamily, in order to perform a virtual screening of its phytoconstituents against different biological targets of SARS-CoV-2. The phytochemicals identified from the ethanol extract ofleaves using liquid chromatography-mass spectroscopy (LC-MS) technique were screened against SARS-CoV-2 spike glycoprotein (PDB ID: 6M0J), main protease/Mpro (PDB ID: 6LU7), and papain-like protease/PLpro (PDB ID: 7CMD) through computational tools. The experimentation design included molecular docking simulation, molecular dynamics simulation, and binding free energy calculations. Through molecular docking simulation, we identified poncirin as a common potential inhibitor of all the above-mentioned target proteins. In addition, molecular dynamics simulations, binding free energy calculations, and PCA analysis also supported the outcomes of the virtual screening. By the virtue of all theresults obtained, poncirin could be taken for in vitro andstudies in near future.Communicated by Ramaswamy H. Sarma.

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04:53

Neurodiversity in a World of Disability Age of Autism The Rebel Alliance!

Cui bono
By Anne Dachel

I recently posted 15 stories on Loss of Brain Trust from over three days, July 10th to 12th, and all were about places becoming sensory friendly and neurodiverse.

They were cheery pieces from the U.S., Ireland, the U.K., about a restaurant, a library, a water park, a hospital, a summer camp, a store and lots of other places, ALL providing accommodations for autism and the other neurological conditions kids are living with today. Everyone was extremely happy about it.

Its clear; autism is no longer seen as a disability. Kids with autism are just differently-abled and we need to provide for them. Then everything will be fine.

Thats the message

All I could think, seeing these stories, was that there is a master plan here.

IMAGINE that you produced a medical product that was universally accepted as beneficial AND essential, but this product also had serious, pervasive side effects, including one that was highly visible.

WHAT would you do, especially if you didnt want there to be widespread recognition of the damage?

HOW would you continue marketing the product and keep the profits coming while downplaying the injury?

---------------

FIRST OF ALL, youd get total control of the narrative.

You would ingrain the benefits of this product into the general population: It saves lives and is absolutely safe.

ANYONE disparaging your product would be attacked as dangerous. There must be no dissent.

SECOND, you would have to disprove the damage that resulted from your product. That could be done by using the media to promote phony studies testifying to product safety. The media could also be helpful in discrediting any naysayers.

THIRD, you would have to rationalize product side effects as something else. You could claim the injuries were nothing new, professionals were simply better at noticing them.

FOURTH, you would downplay the damage as merely mild differences from typical people. You could do this by highlighting the resulting condition as something to celebrate. Perhaps even have a whole month dedicated to the damage. An easily recognized emblem could make...

04:42

Poncirin ameliorates cardiac ischemia-reperfusion injury. GreenMedInfo

PMID:  Eur J Pharmacol. 2022 Feb 15 ;917:174759. Epub 2022 Jan 12. PMID: 35032487 Abstract Title:  Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1signaling. Abstract:  Poncirin, a flavonoid glycoside derivative extracted from the fruits of Poncirus trifoliata (trifoliate orange or Chinese bitter orange), has a variety of documented bioactivities, including anti-tumor, anti-inflammatory, and antioxidant effects. Oxidative stress is a major underlying factor in the pathogenesis of cardiac ischemia-reperfusion (I/R) injury. Therefore, we investigated the protective efficacy of poncirin on primary cardiomyocytes subjected to anoxia-reoxygenation (A/R) injury in vitro, and on rat hearts subjected to ischemia-reperfusion (I/R) injury in vivo. Poncirin pretreatment enhanced cardiomyocyte survival, inhibited A/R-induced oxidative stress by upregulating cellular antioxidant capacity, suppressed mitochondrial depolarization, and ultimately inhibited apoptosis. Similarly, systemic poncirin treatment significantly reduced cardiomyocyte apoptosis and infarct size in rat hearts. In addition, activity of the PI3K/AKT/PGC-1pathway was significantly increased by poncirin pretreatment in both A/R and I/R injury models, while PI3K and PGC-1inhibitors abolished all poncirin related effects, suggesting that this pathway is essential for the cardioprotective effects of poncirin. Pretreatment with the PGC-1inhibitor reversed effects of poncirin without affecting p-AKT expression, indicating that PGC-1is downstream of AKT. In conclusion, both in vitro and in vivo studies suggested that poncirin alleviates cardiac ischemia-reperfusion injury by mitigating oxidative stress, which is dependent on activation of the PI3K/AKT/PGC-1signaling pathway.

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03:44

Families join fluoride lawsuit against city of Buffalo Fluoride Action Network

BUFFALO, N.Y. Eight families with a total of 26 plaintiffs have now joined a class action lawsuit against the city of Buffalo for removing fluoride from the water in 2015.

One plaintiff, Rahwa Ghirmatzion, has a 10-year-old son who she says is dealing with oral health complications due to a lack of fluoride over the years.

Honestly, it was a very painful response, Ghirmatzion said. I just was like, viscerally emotional. Emotional because when you have a kid as a parent the only thing you want to do is take care of that kid and make sure that they are taken care of in every way.

Fluoridating drinking water became standard across the United States in the 1950s and it is something Buffalo did up until 2015 when the Water Authority said they were undergoing a study and equipment upgrades. However, the fluoride was never added back.

Ghirmatzion said her prime complaint is that the city is alleged to have never told residents, who could have sought supplements from their dentist. A spokesperson for the city says they do not comment on pending litigation, but supplied this statement to Spectrum News 1:

Buffalo Water will submit a permit application, including plans, to the Erie County Department of Health within two weeks. Following a Health Department Review, Buffalo Water expects to begin construction and testing within six weeks. Essential items, such as flow metering equipment, has already been ordered to help ensure timely construction.

A note about the water was included in the citys annual water report, but Ghirmatzion and the families suing the city believe more should have been done to inform residents.

This past winter, when Spectrum News 1 reached out the Water Board, Chairperson Oluwole A. McFoy, P.E. responded in a statement saying:

Buffalo is committed to fluoridation of our drinking water, which is why we have invested over $1 million to study and upgrade our current system. The plan was for the project to be completed several years ago, but like many things, was slowed during the pandemic and is scheduled to...

03:09

Video: Simple Running Suture Demo

For more than a decade, Ive been teaching basic suturing to the preparedness community. Usually, the classes are introductory with discussion and hands-on work on pigs feet in the classic single-suture instrument tie. Once youve gotten that solidly under your belt, and practiced like you should, you might consider saving time by perform a continuous[Read More]

The post Video: Simple Running Suture Demo first appeared on .

03:00

Critical Psychiatry Textbook, Chapter 8: Depression and Mania (Affective Disorders) (Part Twelve) Mad In America

Editors Note: Over the next several months, Mad in Gtzsches book, Critical Psychiatry Textbook. In this blog, he discusses that depression pills increase mortality, and that psychiatry mistakes withdrawal effects for relapse. Each Monday, a new section of the book is published, and all chapters are archived here.

Depression pills increase total mortality substantially

In 2015, I tried to find out how many people are killed by the three major drug groups, depression pills, benzodiazepines and similar drugs, and psychosis pills.7:307 I used the most reliable research I could find and restricted my analyses to patients at least 65 years of age. The estimated number of drug deaths in Denmark (population 5.8 million) based on current usage was 2831 for depression pills, 721 for minor tranquillisers, and 141 for major tranquillisers. I estimated that fluoxetine alone had killed 311,000 people worldwide in the age group 65 and above up to 2004.

Illustration depicting a person with a megaphone running up an increasing red bar graph as if it was stepsThe high number of deaths on depression pills may be surprising. It is partly due to the fact that so many elderly people take them (12% in the age group 65 to 79 and 19% in those at least 80 years old).7:310 A UK cohort study of 60,746 patients older than 65 showed that SSRIs lead to falls more often than if the depression isnt treated, and that the drugs kill 3.6% of patients treated for one year.447 The study was very carefully done, e.g. the patients were their own control in one of the analyses, which is a good way to remove the effect of confounders.

A textbook advised that in the elderly, we should try a depression pill even on a vague suspicion of depression because it can be difficult to d...

02:10

Specific Vaccines and the Diseases They Trigger (with references) The Healthy Home Economist

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The post Specific Vaccines and the Diseases They Trigger (with references) appeared first on The Healthy Home Economist.

02:06

Common Dry Cleaning Chemical Linked to 500% Increased Risk of Parkinsons Disease Healthy Holistic Living

Used across numerous industries and military applications, TCE is an industrial pollutant and solvent, known for its degreasing properties and utility in spot dry cleaning2. Although the usage of TCE has seen a decline, it remains deeply embedded in various industrial processes. The situation becomes direr when we consider the widespread contamination caused by TCE. It has permeated into half of the most toxic Superfund sites identified by the Environmental Protection Agency (EPA)2. Moreover, several military bases, including Camp Lejeune, bear the brunt of this contamination. The omnipresence of TCE necessitates a profound understanding of its impact on public health.

In an unsettling revelation that will prompt us to reconsider the choices we make daily, a growing body of scientific research has linked the widely used chemical, trichloroethylene (TCE), to Parkinsons disease[1]. Parkinsons, a degenerative disorder affecting the nervous system, has seen an alarming global upsurge. The connection between this neural condition and TCE, a chemical ubiquitously found in industries such as dry cleaning and metal degreasing, is, indeed, deeply worrying [2].

>>>Exposure to chemicals in our daily life is at an all time high our bodies have reached a tipping point and it shows in the massive increase in chronic disease, cancer and more consider detoxing as part of your daily regiment.

The Pervasive Threat: Trichloroethylene (TCE)

Used across numerous industries and military applications, TCE is an industrial pollutant and solvent, known for its degreasing properties and utility in spot dry cleaning [2]. Although the usage of TCE has seen a decline, it remains deeply embedded in various industrial processes. The situation becomes direr when we consider the...

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