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Thursday, 15 June

20:00

Plague of anomalies in conference proceedings hint at systemic issues Retraction Watch

Hundreds of conference papers published by the U.S.-based Institute of Electrical and Electronic Engineers (IEEE) show signs of plagiarism, citation fraud and other types of scientific misconduct, according to data sleuths.

I am concerned that the issue with these particular conferences is widespread enough such that it indicates systemic issues with their peer review systems, Kendra Albert wrote last August in an email to IEEE that Retraction Watch has seen.

Albert is a clinical instructor at Harvard Law School and a lecturer in women, gender, and sexuality at Harvard University. On the side, Albert has been working with Guillaume Cabanac, a professor of computer science at the University of Toulouse, in France, to ferret out research misconduct using a computer system called the Problematic Paper Screener.

The tool flags tortured phrases, which suggest a publications authors have copied work from other researchers and tried to disguise the offense by using paraphrasing software that also renders scientific terminology near-unintelligible. Breast cancer might become bosom peril, for instance, whereas artificial intelligence could turn into counterfeit consciousness.

IEEE keeps publishing proceedings riddled with tortured papers and other anomalies, Cabanac told Retraction Watch.

The publisher said it believes its preventive measures and efforts identify almost all papers submitted to us that do not meet our standards, and told Retraction Watch that it is currently evaluating the papers in question.

IEEE ha...

13:04

Certain natural compounds could help minimize the neuro- aspects of long covid. GreenMedInfo

PMID: Cells. 2023 Feb 22 ;12(5). Epub 2023 Feb 22. PMID: 36899824 Abstract Title: Role of SARS-CoV-2 Spike-Protein-Induced Activation of Microglia and Mast Cells in the Pathogenesis of Neuro-COVID. Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a few months after the initial infection and develop post-acute sequelae of SARS-CoV-2 (PASC), referred to as "Long-COVID," characterized by persistent physical and mental fatigue. However, the exact pathogenetic mechanisms affecting the brain are still not well-understood. There is increasing evidence of neurovascular inflammation in the brain. However, the precise role of the neuroinflammatory response that contributes to the disease severity of COVID-19 and long COVID pathogenesis is not clearly understood. Here, we review the reports that the SARS-CoV-2 spike protein can cause blood-brain barrier (BBB) dysfunction and damage neurons either directly, or via activation of brain mast cells and microglia and the release of various neuroinflammatory molecules. Moreover, we provide recent evidence that the novel flavanol eriodictyol is particularly suited for development as an effective treatment alone or together with oleuropein and sulforaphane (ViralProtek), all of which have potent anti-viral and anti-inflammatory actions.

10:41

U.S. Government Bypassing 4th Amendment by Buying Your Personal Information from Data Brokers Medical Kidnap

US: Yep, Were Buying Your Data, Including Your Embarrassing Secrets

Digital information can be purchased from commercial data brokers and deanonymized to ID the person its tied to, including US citizens, the Office of the Director of National Intelligence says.

by Michael Kan
PCMag.com

Excerpts:

The US has been buying large amounts of commercially available data on internet users for the purposes of spying, according to a new government report.

The Office of the Director of National Intelligence (ODNI) on Friday declassified(Opens in a new window) a report from January 2022 that outlines the US governments approach to using Commercially Available Information (CAI), which can come from data brokers working in the internet ad and analytics industries. The purchased information includes details from users smartphones and social media accounts. Although the data is usually stripped of personal details, the report notes: It is often possible (using other CAI) to deanonymize and identify individuals, including US persons.

The ODNI declassified the report to offer some transparency of the surveillance practice, following years of reports(Opens in a new window) about how US agencies have been buying the information from commercial data brokers. In March, Sen. Ron Wyden (D-Oregon) also asked Director of National Intelligence Avril Haines to offer more transparency around the government purchases.

The commercially bought data can be a major asset for US law enforcement and intel-gathering. The report points out the government would never have been permitted to compel billions of people to carry location tracking devices on their persons at all times Yet smartphones, connected cars, web tracking technologies, the Internet of Things, an...

10:41

U.S. Government Bypassing 4th Amendment by Buying Your Personal Information from Data Brokers Vaccine Impact

US: Yep, Were Buying Your Data, Including Your Embarrassing Secrets

Digital information can be purchased from commercial data brokers and deanonymized to ID the person its tied to, including US citizens, the Office of the Director of National Intelligence says.

by Michael Kan
PCMag.com

Excerpts:

The US has been buying large amounts of commercially available data on internet users for the purposes of spying, according to a new government report.

10:32

Effect of the olive leaf extract in chronic spinal cord injury model. GreenMedInfo

PMID: Ann Med Surg (Lond). 2023 Mar ;85(3):365-372. Epub 2023 Mar 9. PMID: 36923747 Abstract Title: Effect of the olive leaf extract in chronic spinal cord injury model: an experimental research. Abstract: UNLABELLED: Posttraumatic myelopathy is defined as a spinal cord injury (SCI) that results in varying degrees of motor and sensory deficits. The degree of 'secondary damage,' which is caused by a variety of cellular, molecular, and biochemical cascades is linked to the outcome of SCI. According to research, the beneficial effects of oleuropein and its derivatives have been linked to radical scavenging/antioxidant actions and anti-inflammatory effects.MATERIALS AND METHODS: This study was divided into six groups: control negative (sham-operated) group, control positive 1 and 2 (early chronic and chronic), treatment groups 1, 2, and 3 (prophylactic, concomitant, and late). Olive leaf extract (OLE) given dose was 350 mg/kg body weight. Blood was taken from the left corotic artery before the animals were terminated, seromarker assessment, enzyme-linked immunosorbent assay of IL-6, TNF-, brain-derived neurotrophic factor (BDNF), and assessment of functional motoric outcome before the animal was terminated.RESULTS: Chronic spinal cord compression increased serum levels of IL-6, TNF-, and decreased serum level of BDNF. OLE 350 mg/kg body weight decreased serum levels of IL-6, TNF-and increased functional motoric outcome, especially in prophylactic and concomitant therapy.DISCUSSION: These findings indicate that OLE may be effective in protecting chronic SCI model.CONCLUSION: Oleuropein has a potential effect to reduce the IL-6 and TNF-in rabbit model of SCI, and the BDNF value risen after the administration of Oleuropein.

10:30

Molecular mechanisms of the protective effects of olive leaf polyphenols against Alzheimer's disease. GreenMedInfo

PMID: Int J Mol Sci. 2023 Feb 22 ;24(5). Epub 2023 Feb 22. PMID: 36901783 Abstract Title: Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer's Disease. Abstract: Alzheimer's Disease (AD) is the cause of around 60-70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees () are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-B and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD.

10:29

U.S. Government Bypassing 4th Amendment by Buying Your Personal Information from Data Brokers Health Impact News

US: Yep, Were Buying Your Data, Including Your Embarrassing Secrets

Digital information can be purchased from commercial data brokers and deanonymized to ID the person its tied to, including US citizens, the Office of the Director of National Intelligence says.

by Michael Kan
PCMag.com

Excerpts:

The US has been buying large amounts of commercially available data on internet users for the purposes of spying, according to a new government report.

The commercially bought da...

10:00

Improving Your Health by Ditching Desks and Chairs Articles

Editor's Note: This article is a reprint. It was originally published November 27, 2016.

Kelly Starrett, who has a Ph.D. in physical therapy, is the author of "Deskbound: Standing Up to a Sitting World." It's a real eye-opener, and has helped me address some of my own movement challenges.

I read about 150 books a year and last year the best book I read was "The Metabolic Theory of Cancer." This year I would have to give that honor to Kelly's book. I have read many books on posture and movement, but his was the best.

If you have a desk job, this book is a veritable gold mine of helpful guidance that can improve your health and well-being. Kelly is one of the leaders in the CrossFit movement and stresses the importance of proper body mechanics, both in and outside the gym.

His first book, "Becoming a Supple Leopard," addresses biomechanical inadequacies that might increase your risk of injury.

"[A]s I was addressing football teams and soldiers, we were seeing the same sequel of problems a lot of forward [leaning] head or neck, stiff upper back, and inability to put the arms over the head lower back dysfunction, short hips and over striding," Kelly says.

"What we realized [is that] most were engaged in an activity that went against physiology [W]hat's happening today, because of the changing environment, we're sitting a lot more. We have a lot more technology We commute more.

We're making this very basic adaptation error, and that is we're not moving enough. What's interesting about the sitting versus standing conversation is it's really the wrong conversation. The right conversation is moving versus not moving

When we stand up, we [upregulate] the whole physical being. That really ends up being the most important conversations bringing the consciousness to the fact that, as modern humans, we may not be able to move the way we were designed."

Optional Versus Non-Optional Sitting

In "Deskbound," Kelly quotes research from Dr. James Levine showing that for every hour you sit down, your life expectancy decreases by two hours. For comparison, every cigarette smoked reduces life expectancy by 11 minutes.

That means sitting down is far more hazardous to your health than smoking a shocking revela...

Is CAFO Animal Waste the Dirty Secret of Organic Foods? Articles

Farmers have used manure as a natural, nutrient-rich fertilizer for thousands of years. In fact, theres evidence that early farmers used manure to fertilize cereal grains and pulse seeds up to 7,900 years ago. They likely noticed enhanced crop growth in areas where manure naturally accumulated, then tried the method in other areas.¹

Today, many farmers still depend on manure to help their crops grow. This includes organic farmers² and those using permaculture and regenerative methods.³ When chickens are raised on pasture, their manure is spread across the land and worked into the soil naturally via pecking and scratching.⁴

This beneficial practice that works in concert with nature bears little resemblance to the use of poultry litter or chicken feces, sometimes mixed with urine, sawdust, feathers and other materials and other animal waste from concentrated animal feeding operations (CAFOs) as fertilizer. Yet, this latter practice is common, even among some organic farms.⁵

Chicken Litter Contains Bacteria, Viruses and Other Pathogens

Chicken litter used as an organic fertilizer is considered the cheapest and most environmentally safe method of disposing of the volume generated from the rapidly expanding poultry industry worldwide.⁶

But a review, published in the International Journal of Environmental Research and Public Health, raises an important point little is known about the safety of chicken litter for land application and general release into the environment.⁷

The research team, from Kyambogo and Makerere Universities in Uganda and the University of Florida, set out to remedy this. They conducted a meta-analysis of technical reports, conference proceedings, peer-reviewed journal articles and internet texts, noting that the available data was scattered and disjointed making it difficult to access and interpret.

They consolidated the data they did find, however, revealing that direct land application of chicken litter could be harming animal, human, and environmental health.⁸ The review revealed, for instance:⁹

Counts of pathogenic strains of E. coli and coliform b...

Can Taking a Multivitamin Improve Your Memory? Articles

It was once a widely held belief that brain function was at its best during early adulthood and slowly declined as you age, leading to lapses in memory and brain fog. After all, who hasn't walked into a room and forgotten exactly why they went there in the first place? A 2023 study¹ demonstrated that older adults taking a multivitamin supplementation may experience memory improvements.

While its not uncommon to have difficulty recalling names and phone numbers, according to the Alzheimer's Association,² between 12% and 18% of people 60 years and older have mild cognitive impairment (MCI). This is the early stage of memory loss or loss of other cognitive abilities.

Older people must maintain memory and cognitive abilities to live independently. When asked, nearly 90% of Americans 50 and older wanted to stay at home as they age.³ Yet, the same survey also showed that very few of those asked were aware of how to safely maintain their independence.

Unfortunately, for many over the age of 50, they may say they're having a "senior moment" when they can't remember or forget something. Yet the truth is that the majority of memory issues people in that age group have are not related to age and aging. As the featured study finds, multivitamin supplementation may help reduce the challenges associated with short-term recall.

Multivitamin Supplements Were Effective in Older Adults

Using multivitamin supplementation has a history of controversy. The results in past studies have been mixed. Some have shown benefits and others show little to no changes. However, the 2023 study⁴ published by scientists from Harvard Medical School and Columbia University showed memory improvement and slowed cognitive decline.⁵

Data was gathered from the COcoa Supplement and Multivitamin Outcomes Study Web (COSMOS-Web), which was an ancillary study of COSMOS. In this group of 3,562 older adults, participants either received a multivitamin supplement (Centrum Silver) or a placebo.⁶

The researchers identified the primary outcome measure as a change in episodic memory after one year of taking the vitamin. They identified secondary outcome measures as further changes over three years of follow-up. The participants were evaluated at baseline and each year using a battery of neuropsychological tests administered over the Internet.

The data showed that participants taking the multivitamin supplement had better immediate recall at t...

09:49

Oleuropein may represent a novel therapeutic approach against glioblastoma cells. GreenMedInfo

PMID: Life (Basel). 2023 Feb 8 ;13(2). Epub 2023 Feb 8. PMID: 36836827 Abstract Title: Leaf Phenolics Oleuropein, Hydroxytyrosol, Tyrosol, and Rutin Induce Apoptosis and Additionally Affect Temozolomide against Glioblastoma: In Particular, Oleuropein Inhibits Spheroid Growth by Attenuating Stem-like Cell Phenotype. Abstract: The effects ofleaf extract (OLE) phenolics, including oleuropein (OL), hydroxytyrosol (HT), tyrosol (TYR), and rutin against glioblastoma (GB), independently and in combination with temozolomide (TMZ), were investigated in T98G and A172 cells. Cell growth was assessed by WST-1, real-time cell analysis, colony formation, and cell cycle distribution assays. A dual acridine orange propidium iodide (AO/PI) staining and annexin V assay determined cell viability. A sphere-forming assay, an intracellular oxidative stress assay, and the RNA expression of CD133 and OCT4 investigated the GB stem-like cell (GSC) phenotype. A scratch wound-healing assay evaluated migration capacity. OL was as effective as OLE in terms of apoptosis promotion (

09:42

Hydroxytyrosol attenuates ethanol-induced liver injury. GreenMedInfo

PMID: Redox Rep. 2023 Dec ;28(1):2187564. PMID: 36932927 Abstract Title: Hydroxytyrosol attenuates ethanol-induced liver injury by ameliorating steatosis, oxidative stress and hepatic inflammation by interfering STAT3/iNOS pathway. Abstract: Hydroxytyrosol (HT) is a polyphenol with a wide range of biological activities. Excessive drinking can lead to oxidative stress and inflammation in the liver, which usually develop into alcohol liver disease (ALD). At present, there is no specific drug to treat ALD. In this paper, the protection effect of HT on ALD and the underline mechanism were studied.HepG2 cells were exposed to ethanoland C57BL/6J mice were fed with a Lieber-DeCarli ethanol liquid diet.triglyceride (TG) level in serum and the expression of fatty acid synthase (FASN) were reduced significantly by the treatment with HT The acetaldehyde dehydrogenase (ALDH) activity was increased, the serum level of malondialdehyde (MDA) was decreased, catalase (CAT) and glutathione (GSH) were increased, suggesting that HT may reduce its oxidative damage to the body by promoting alcohol metabolism. Furthermore, according to the mRNA levels of tnf-, il-6 and il-1, HT inhibited ethanol-induced inflammation significantly. The anti-inflammatory mechanism of HT may be related to suppress the STAT3/iNOS pathway.Our study showed that HT could ameliorate ethanol-induced hepatic steatosis, oxidative stress and inflammation and provide a new candidate for the prevention and treatment of ALD.

09:26

Association of hydroxytyrosol enriched olive oil with vascular function in chronic coronary disease. GreenMedInfo

PMID: Eur J Clin Invest. 2023 Jul ;53(7):e13983. Epub 2023 Mar 24. PMID: 36912212 Abstract Title: Association of hydroxytyrosol enriched olive oil with vascular function in chronic coronary disease. Abstract: BACKGROUND: Hydroxytyrosol reduces low-density lipoprotein oxidation, contributing to prevention of atherosclerosis progression.METHODS: In a prospective, crossover, double-blind, placebo-controlled trial, 30 chronic coronary artery syndrome (CCAS) patients were randomized to 4 capsules/day, containing 412.5 mg olive oil with 2.5 mg hydroxytyrosol (OOHT) each one or placebo for 1month and then were crossed over to the alternate treatment (placebo or OOHT). We measured (a) perfused boundary region (PBR) of the sublingual arterial microvessels (increased PBR indicates reduced glycocalyx thickness), (b) flow-mediated dilation (FMD), (c) Coronary Flow Reserve (CFR) and markers of LV diastolic function by Doppler echocardiography, (d) pulse wave velocity (PWV), and (e) oxidative stress, inflammatory biomarkers and blood lipids at baseline and after treatment.RESULTS: Treatment with OOHT improved PBR, FMD, CFR and PWV compared to baseline (1.8 .3 vs. 1.7 .4 m, p =.040, 3.7 2.1 vs. 6.5%2.3%, p

09:16

Effects of hydroxytyrosol in endothelial functioning. GreenMedInfo

PMID: Molecules. 2023 Feb 16 ;28(4). Epub 2023 Feb 16. PMID: 36838850 Abstract Title: Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review. Abstract: Pharmacologists have been emphasizing and applying plant and herbal-based treatments in vascular diseases for decades now. Olives, for example, are a traditional symbol of the Mediterranean diet. Hydroxytyrosol is an olive-derived compound known for its antioxidant and cardioprotective effects. Acknowledging the merit of antioxidants in maintaining endothelial function warrants the application of hydroxytyrosol in endothelial dysfunction salvage and recovery. Endothelial dysfunction (ED) is an impairment of endothelial cells that adversely affects vascular homeostasis. Disturbance in endothelial functioning is a known precursor for atherosclerosis and, subsequently, coronary and peripheral artery disease. However, the effects of hydroxytyrosol on endothelial functioning were not extensively studied, limiting its value either as a nutraceutical supplement or in clinical trials. The action of hydroxytyrosol in endothelial functioning at a cellular and molecular level is gathered and summarized in this review. The favorable effects of hydroxytyrosol in the improvement of endothelial functioning from in vitro and in vivo studies were scrutinized. We conclude that hydroxytyrosol is capable to counteract oxidative stress, inflammation, vascular aging, and arterial stiffness; thus, it is beneficial to preserve endothelial function both in vitro and in vivo. Although not specifically for endothelial dysfunction, hydroxytyrosol safety and efficacy had been demonstrated via in vivo and clinical trials for cardiovascular-related studies.

09:12

Hydroxytyrosol and its potential uses on intestinal and gastrointestinal disease. GreenMedInfo

PMID: Int J Mol Sci. 2023 Feb 4 ;24(4). Epub 2023 Feb 4. PMID: 36834520 Abstract Title: Hydroxytyrosol and Its Potential Uses on Intestinal and Gastrointestinal Disease. Abstract: In recent years, the phytoconstituents of foods in the Mediterranean diet (MD) have been the subject of several studies for their beneficial effects on human health. The traditional MD is described as a diet heavy in vegetable oils, fruits, nuts, and fish. The most studied element of MD is undoubtedly olive oil due precisely to its beneficial properties that make it an object of interest. Several studies have attributed these protective effects to hydroxytyrosol (HT), the main polyphenol contained in olive oil and leaves. HT has been shown to be able to modulate the oxidative and inflammatory process in numerous chronic disorders, including intestinal and gastrointestinal pathologies. To date, there is no paper that summarizes the role of HT in these disorders. This review provides an overview of the anti-inflammatory and antioxidant proprieties of HT against intestinal and gastrointestinal diseases.

09:10

Hydroxytyrosol reduces foam cell formation and endothelial inflammation. GreenMedInfo

PMID: Int J Mol Sci. 2023 Jan 20 ;24(3). Epub 2023 Jan 20. PMID: 36768382 Abstract Title: Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPAR/LXR/ABCA1 Pathway. Abstract: Cholesterol accumulation in macrophages leads to the formation of foam cells and increases the risk of developing atherosclerosis. We have verified whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory and antioxidant properties, can reduce the cholesterol build up in THP-1 macrophage-derived foam cells. We have also investigated the potential mechanisms. Oil Red O staining and high-performance liquid chromatography (HPLC) assays were utilized to detect cellular lipid accumulation and cholesterol content, respectively, in THP-1 macrophages foam cells treated with HT. The impact of HT on cholesterol metabolism-related molecules (SR-A1, CD36, LOX-1, ABCA1, ABCG1, PPARand LRX-) in foam cells was assessed using real-time PCR (RT-qPCR) and Western blot analyses. Finally, the effect of HT on the adhesion of THP-1 monocytes to human vascular endothelial cells (HUVEC) was analyzed to study endothelial activation. We found that HT activates the PPAR/LXRpathway to upregulate ABCA1 expression, reducing cholesterol accumulation in foam cells. Moreover, HT significantly inhibited monocyte adhesion and reduced the levels of adhesion factors (ICAM-1 and VCAM-1) and pro-inflammatory factors (IL-6 and TNF-) in LPS-induced endothelial cells. Taken together, our findings suggest that HT, with its ability to interfere with the import and export of cholesterol, could represent a new therapeutic strategy for the treatment of atherosclerotic disease.

09:06

Hydroxytyrosol: Its role in the prevention of cardiovascular diseases GreenMedInfo

PMID: Heliyon. 2023 Jan ;9(1):e12963. Epub 2023 Jan 13. PMID: 36704293 Abstract Title: Hydroxytyrosol: Its role in the prevention of cardiovascular diseases. Abstract: In recent years, non-pharmacology treatments and their effectiveness have gained popularity due to their beneficial properties in the prevention of cardiovascular diseases. Phenolic compounds intake provides a natural means of improvingantioxidant status. Thus, the purpose of this review is to discuss the potential benefits of hydroxytyrosol (HT), a phenolic compound with powerful antioxidant and anti-inflammatory properties, in preventing and reducing cardiovascular risk factors, concretely atherosclerosis. Closer inspection of the studies showed a significant improvement of lipid profile, antioxidant capacity and inflammatory state. A note of caution is due instudies because the lack of validated approaches difficult the goodness of fit with theand clinical research. However, animal and clinical studies were very encouraging, determining HT supplementation useful on inflammation, oxidative stress, endothelial function and cardiovascular diseases in general.

09:02

Young Mother Sues Corrupt Baltimore County Social Services Who Kidnapped Her Daughter, but She Needs Your Help Medical Kidnap

Iris is back with her family now, and her mother, Jennifer Guskin, has sued the government agents responsible for illegally kidnapping her daughter when she was a baby. Photo supplied by family.

by Brian Shilhavy
Editor, Health Impact News

Last month we introduced our readers to Jennifer Guskin who was sexually trafficked as a child, suffering evils more horrible than anything else we had ever published before, with a video I put together of Jennifer sharing her story.

See:

Child Sex Trafficking with the Rich and Powerful: The Jennifer Guskin Story

WARNING: GRAPHIC CONTENT ABOUT TOPICS SUCH AS CANNIBALISM, CHILD SEX, TORTURE, MURDER, ETC. NOT SUITABLE FOR CHILDREN VIEWER DISCRETION ADVISED!

This is on our Bitchute channel, and will also be on our Telegram channel.

When Jennifer first went public about her life and the horrors she suffered as a child back in 2018, the Baltimore County Department of Social Services Child Advocacy Center, working together with Howard County General Hospital, took custody of her newborn daughter on false charges of drug abuse.

After an investigation cleared her of any drug abuse, they allegedly continued to hold her baby and stipulated that to get her baby back she had to stop talking on Social Media.

Jennifer writes:

As an infant, I was adopted by a family in NY who subsequently sold me to various individuals and entities throughout my childhood.

Ive been to Epstein Island and on multiple Lolita Express types of flights.

Ive witnessed high-profile individuals forced to rape children while being filmed under threat of death for themselves and their loved ones.

Shortly after going public with my story, Child Protective Services opened a Substance Exposed Newborn case, even though all dru...

09:02

Young Mother Sues Corrupt Baltimore County Social Services Who Kidnapped Her Daughter, but She Needs Your Help Vaccine Impact

Iris is back with her family now, and her mother, Jennifer Guskin, has sued the government agents responsible for illegally kidnapping her daughter when she was a baby. Photo supplied by family.

by Brian Shilhavy
Editor, Health Impact News

See:

Child Sex Trafficking with the Rich and Powerful: The Jennifer Guskin Story

WARNING: GRAPHIC CONTENT ABOUT TOPICS SUCH AS CANNIBALISM, CHILD SEX, TORTURE, MURDER, ETC. NOT SUITABLE FOR CHILDREN VIEWER DISCRETION ADVISED!

This is on our Bitchute channel, and will also be on our Telegram channel.

After an investigation cleared her of any drug abuse, they allegedly continued to hold her baby and stipulated that to get her baby back she had to stop talking on Social Media.

Jennifer writes:

As an infant, I was adopted by a family in NY who subsequently sold me to various individuals and entities throughout my childhood.

Ive been to Epstein Island and on multiple Lolita Express types of flights.

Ive witnessed high-profile individuals forced to rape children while being filmed under threat of death for themselves and their loved ones.

Shortly after going public with my story, Child Protective Services opened a Substance Exposed Newborn case, even though all dru...

09:00

Effects of oleuropein and hydroxytyrosol on inflammatory mediators. GreenMedInfo

PMID: Int J Mol Sci. 2022 Dec 26 ;24(1). Epub 2022 Dec 26. PMID: 36613822 Abstract Title: Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging. Abstract: Aging is associated with a low-grade, systemic inflammatory state defined as "inflammaging", ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.

08:56

Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease. GreenMedInfo

PMID: Sci Rep. 2023 Feb 11 ;13(1):2452. Epub 2023 Feb 11. PMID: 36774383 Abstract Title: Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway. Abstract: Major pathological features of Parkinson's disease (PD) include increase in oxidative stress leading to the aggregation of-synuclein, mitochondrial dysfunction and apoptosis of dopaminergic neurons. In addition, downregulation of the expression of neurotrophic factors like-Brain Derived Neurotrophic Factor (BDNF) is also involved in PD progression. There has been a lot of interest in trophic factor-based neuroprotective medicines over the past few decades to treat PD symptoms. Rotenone, an insecticide, inhibits the mitochondrial complex I causing overproduction of ROS, oxidative stress, and aggregation of-synuclein. It has been shown that BDNF and Tropomyosin receptor kinase B (TrkB) interaction initiates the regulation of neuronal cell development and differentiation by the serine/threonine protein kinases like Akt and GSK-3. Additionally, Transcription factor CREB (cAMP Response Element-binding protein) also determines the gene expression of BDNF. The homeostasis of these signalling cascades is compromised with the progression of PD. Therefore, maintaining the equilibrium of these signalling cascades will delay the onset of PD. Oleuropein (OLE), a polyphenolic compound present in olive leaves has been documented to cross blood brain barrier and shows potent antioxidative property. In the present study, the dose of 8, 16 and 32 mg/kg body weight (bwt) OLE was taken for dose standardisation. The optimised doses of 16 and 32 mg/kg bwt was found to be neuroprotective in Rotenone induced PD mouse model. OLE improves motor impairment and upregulate CREB regulation along with phosphorylation of Akt and GSK-3in PD mouse. In addition, OLE also reduces the mitochondrial dysfunction by activation of enzyme complexes and downregulates the proapoptotic markers in Rotenone intoxicated mouse model. Overall, our study suggests that OLE may be used as a therapeutic agent for treatment of PD by regulating BDNF/CREB/Akt signalling pathway.

08:51

Eriodictyol suppresses gastric cancer cells. GreenMedInfo

PMID: Pharmaceuticals (Basel). 2022 Nov 27 ;15(12). Epub 2022 Nov 27. PMID: 36558929 Abstract Title: Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway. Abstract: Gastric cancer (GC) is among the five most common malignancies worldwide. Traditional chemotherapy cannot efficiently treat the disease and faces the problems of side effects and chemoresistance.Fructus (POF), with flavonoids as the main bioactive compounds, exerts anti-cancer potential. In this study, we compared the anti-GC effects of the main flavonoids from POF and investigated the anti-cancer effects of eriodictyol towards GC both in vitro and in vivo. CCK-8 assays were performed to examine the inhibitory effects of common flavonoids from POF on GC cell viability. Colony formation assays were used to determine cell proliferation after eriodictyol treatment. Cell cycle distribution was analyzed using flow cytometry. Induction of apoptosis was assessed with Annexin V/PI staining and measurement of related proteins. Anti-cancer effects in vivo were investigated using a xenograft mouse model. Potential targets of eriodictyol were clarified by network pharmacological analysis, evaluated by molecular docking, and validated with Western blotting. We found that eriodictyol exhibited the most effective inhibitory effect on cell viability of GC cells among the common flavonoids from POF including quercetin, taxifolin, and kaempferol. Eriodictyol suppressed colony formation of GC cells and induced cell apoptosis. The inhibitory effects of eriodictyol on tumor growth were also validated using a xenograft mouse model. Moreover, no obvious toxicity was identified with eriodictyol treatment. Network pharmacology analysis revealed that PI3K/AKT signaling ranked first among the anti-GC targets. The molecular docking model of eriodictyol and PI3K was constructed, and the binding energy was evaluated. Furthermore, efficient inhibition of phosphorylation and activation of PI3K/AKT by eriodictyol was validated in GC cells. Taken together, our results identify eriodictyol as the most effective anti-GC flavonoids from POF and the potential targets of eriodictyol in GC. These findings suggest that eriodictyol has the potential to be a natural source of anti-GC agents.

08:49

Eriodictyol attenuates cholangiocarcinoma malignancy. GreenMedInfo

PMID: Anticancer Res. 2022 Aug ;42(8):3789-3798. PMID: 35896263 Abstract Title: Eriodictyol Attenuates Cholangiocarcinoma Malignancy by Regulating HMOX1 Expression: AnStudy. Abstract: BACKGROUND/AIM: Cholangiocarcinoma remains one of the most dangerous types of cancer. Eriodictyol is a well-known flavonoid having effective bioactivity against various malignant tumor types. However, the anticancer effect of eriodictyol against cholangiocarcinoma remains ambiguous. Thus, the aim of the present study was to investigate the effects of eriodictyol on human cholangiocarcinoma.MATERIALS AND METHODS: The biological effects of eriodictyol were validated by viability assay, colony formation and western blot analysis. The significance of heme oxygenase 1 (HMOX1) expression in cholangio-carcinoma was demonstrated using bioinformatics analysis and knockdown of HMOX1 by transfection with short interfering (si)-RNA.RESULTS: Eriodictyol highly reduced the in vitro viability of SNU-308, SNU-478, SNU-1079, and SNU-1196 cholangiocarcinoma cells compared with that of 293T cells, in a dose-dependent manner. The anticancer effect of eriodictyol was achieved by caspase-3-mediated apoptosis. In particular, eriodictyol increased HMOX1 expression, which resulted in attenuation of cholangiocarcinoma cell proliferation. In contrast, ablating HMOX1 expression by si-RNA transfection against HMOX1 made cholangiocarcinoma cells insensitive to the antiproliferative effect of eriodictyol treatment.CONCLUSION: These results collectively indicate that eriodictyol acts as an anticancer agent via regulation of HMOX1 expression against human cholangiocarcinoma.

08:17

Young Mother Sues Corrupt Baltimore County Social Services Who Kidnapped Her Daughter, but She Needs Your Help Health Impact News

Iris is back with her family now, and her mother, Jennifer Guskin, has sued the government agents responsible for illegally kidnapping her daughter when she was a baby. Photo supplied by family.

by Brian Shilhavy
Editor, Health Impact News

See:

Child Sex Trafficking with the Rich and Powerful: The Jennifer Guskin Story

WARNING: GRAPHIC CONTENT ABOUT TOPICS SUCH AS CANNIBALISM, CHILD SEX, TORTURE, MURDER, ETC. NOT SUITABLE FOR CHILDREN VIEWER DISCRETION ADVISED!

This is on our Bitchute channel, and will also be on our Telegram channel.

After an investigation cleared her of any drug abuse, they allegedly continued to hold her baby and stipulated that to get her baby back she had to stop talking on Social Media.

Jennifer writes:

As an infant, I was adopted by a family in NY who subsequently sold me to various individuals and entities throughout my childhood.

Ive been to Epstein Island and on multiple Lolita Express types of flights.

Ive witnessed high-p...

08:10

Cause of death released for 1 of 2 pest control workers who died after Pompano Beach job Fluoride Action Network

Leon Johnson, 64, was one of three pest control workers who became sick after fumigating the Baers Furniture warehouse on April 22

The Broward County Medical Examiner has released its report on the death of a man who fell ill after fumigating a furniture warehouse in Pompano Beach back in April.

Leon Johnson, 64, was one of three pest control workers who became sick after fumigating the Baers Furniture warehouse on April 22.

Police found Johnson dead inside his car that night outside his Hollywood home on Taft Street, after a concerned neighbor called police.

A second worker was found dead in Boynton Beach, while a third worker identified as Cris Anderson, the owner of the pest control company had to be hospitalized in Palm Beach County but survived.

According to the medical examiners report obtained by NBC6 on Wednesday, the official cause of death for Johnson was acute toxic effects of fluoride. The manner of death was ruled an accident.

The medical examiner wrote that Johnson used sulfuryl fluoride on the job and was accidentally poisoned by it.

Johnson and the two other men, who worked for Anderson Pest Control of West Palm Beach, were fumigating the warehouse when two of them felt sick and started vomiting, the report said. They had already been working 32-36 hours straight, the report said.

Its a mystery that three lifetime professionals would end up being in this situation where three of them suffered severe injury and two deaths in a process they have done day after day, said Joseph Madalon, the Johnson familys attorney. So something clearly is wrong and trying to figure out what that is, is where we are right now.

Johnson had worked at Anderson Pest Control for more than a decade and spent the bulk of his career...

08:05

Podcast: The Rise in Forced Treatment and Abusive Guardianships Mad In America

From PsychCentral: Theres a common misconception that, due to asylum closures, only dangerous people get committed to psychiatric wards and hospitals. We also believe that forcing someone with mental illness into treatment is rare. However, millions of Americans are subjected to psychiatric detention or forced treatment every year.

Often well-meaning family members are trying to help, but end up traumatizing and permanently damaging their loved ones. Join us as investigative journalist Rob Wipond explains how most states have broadened their criteria for psychiatrically detaining someone far beyond imminent harm and that as a practical matter, this could happen to almost anyone. Join us for a special two-part episode of Inside Mental Health.

Gabe Howard: What about the parents, the majority of people pushing for these kinds of laws and this kind of intervention are parents of adult children with mental illness, and they claim that they have insight into their kids best interests, they know their children and they know that this will be helpful. Now, youve been talking about problems with doctors or hospitals, but family members are often the ones pushing for this, not the medical establishment.

Rob Wipond: Yeah. So, I have a couple concerns about that that are really deep. And one of the biggest ones is this is of course a very important group. This is the strongest lobby group in America and Canada that have been reshaping these laws. Family members are very vocal and very passionate about trying to forcibly drug their own loved ones. And they have influenced legislation around the country. So, this is the dominant voice on these issues. And one of my biggest concerns is that almost never when these families are talking do they seem to have any awareness that some families are abusive . . . you have to look at America and what we know about family abuse and know that it is very common. Child sexual abuse, physical abuse, parents themselves who have emotional difficulties of different kinds. And so, you need to account for that if youre going to lobby legislators to expand the powers of families, to make sure that someone else in the family gets forcibly medicated, heavily tranquilized against their will. You need some sort of level of accountability and oversight to ensure that this is not nefariously and abusively used by a family member who doesnt have the best of intentions in mind. And this is really common and this is what I found, is that its doctors just dont have the time or resources to do, you know, an extensive investigation into a family and really figure out whats truly going on here. So, they often just take the testimony at face value, go, oh, thats how Person X was behaving? Okay. You know, and this testimony is enormously powerful.

. . . The other piece I want to highligh...

07:51

Potential cancer treatment effects of brusatol or eriodictyol combined with 5-fluorouracil (5-FU) in colorectal cancer cell. GreenMedInfo

PMID: Naunyn Schmiedebergs Arch Pharmacol. 2022 Sep ;395(9):1109-1123. Epub 2022 Jul 20. PMID: 35857038 Abstract Title: Potential cancer treatment effects of brusatol or eriodictyol combined with 5-fluorouracil (5-FU) in colorectal cancer cell. Abstract: Colorectal cancer is among the most frequently diagnosed cancers in patients today. In the treatment of this disease, combination or multicomponent therapy has been identified as a potential method to improve patient response and delay side effects. The aim of this study was to determine the effects on cell viability of commercial Bru and Erio used together with the anticancer drug 5-FU in the human colorectal cancer (CRC) cell line (HT-29 cell line) for the first time, as far as can be determined from available literature at this time. Additionally, the research seeks to study any potential effects on apoptosis. For this purpose, the effects of independent and combined treatments of the aforementioned agents on cell viability were investigated through the MTT experiment. Apoptotic effects were determined by Annexin V/PI and real-time PCR methods. In addition, a cell cycle analysis was used to determine the distribution of cells in the cycle. Data from experiments for 48 h showed that Bru, alone or in combination with 5-FU, is capable of causing an increase in the percentage of apoptotic cells in HT-29 cells compared to those of Erio alone or in combination with 5-FU. A significant increase in the level of bax and caspase-3 apoptotic genes was also detected in combinations of ICconcentrations of Bru and 5-FU. These findings suggest that unlike Erio, Bru alone or in combination with 5-FU may be useful for increasing the effects of 5-FU used in the treatment of CRC and to provide data on alternative treatment approaches.

07:44

Eriodictyol attenuates H2O2-induced oxidative damage in human dermal fibroblasts. GreenMedInfo

PMID: Nutrients. 2022 Jun 20 ;14(12). Epub 2022 Jun 20. PMID: 35745283 Abstract Title: Eriodictyol Attenuates HO-Induced Oxidative Damage in Human Dermal Fibroblasts through Enhanced Capacity of Antioxidant Machinery. Abstract: Oxidative stress in dermal fibroblasts is strongly correlated with the aging process of the skin. The application of natural compounds that can increase the ability of dermal fibroblasts to counteract oxidative stress is a promising approach to promote skin health and beauty. Eriodictyol is a flavonoid that exerts several pharmacological actions through its antioxidant properties. However, its protective effects on dermal fibroblasts have not yet been investigated. In this study, we investigated whether eriodictyol protects human dermal fibroblasts (BJ fibroblasts) from the harmful effects of hydrogen peroxide (HO). Eriodictyol pretreatment significantly prevented necrotic cell death caused by HOexposure. In addition, the level of 2',7'-dichloro-dihydro-fluorescein oxidation was decreased, and that of glutathione was maintained, indicating that the beneficial effects of eriodictyol against HOwere closely associated with oxidative-stress attenuation. Eriodictyol mediates its antioxidant effects on dermal fibroblasts against HOthrough (i) the direct neutralization of reactive oxygen species; (ii) the enhancement of the activities of HO-detoxifying enzymes, including catalase and glutathione peroxidase; and (iii) the induction of the expressions of catalase and glutathione peroxidase 1 via the activation of the Nrf2 signaling system. These results support the potential application of eriodictyol as an ingredient in skincare products for cosmeceutical and pharmaceutical purposes.

07:42

Eriodictyol inhibits breast carcinogenesis. GreenMedInfo

n/a PMID: Phytomedicine. 2022 Jul 20 ;102:154159. Epub 2022 May 7. PMID: 35580441 Abstract Title: Eriodictyol inhibits breast carcinogenesis by targeting circ_0007503 and repressing PI3K/Akt pathway. Abstract: BACKGROUND: Eriodictyol in citrus fruits, Eriodictyon californicum and several Chinese herbal medicines shows great promise for chronic disease prevention, including cancers. However, its role in chemopreventive activities against breast carcinogenesis is unknown. PURPOSE: In the present study, we investigated the chemopreventive effect and the underlying mechanism of eriodictyol on carcinogens-induced breast carcinogenesis in vivo and in vitro. METHODS: The carcinogenic transformation in MCF10A cells was induced by the environmental carcinogens in vitro. The chemopreventive effect in vivo was evaluated by using the experimental model of 1-methyl-1-nitrosourea (MNU)-induced mammary tumorigenesis in rats. The activation of the PI3K/Akt pathway was detected by western blot assay; the levels of circular RNAs (circRNAs) were measured by qRT-PCR. RESULTS: First, eriodictyol significantly reduces cells viability and induces apoptosis in breast cancer cells in a dose-dependent manner in vitro (P < 0.05). Next, eriodictyol could effectively suppress environmental carcinogens-induced acquisition of carcinogenic properties in human breast epithelial cell MCF10A (P < 0.05). In vivo, eriodictyol administration reduces the incidence of mammary tumor by 50% in carcinogen-treated female rats (P < 0.05). Further study revealed that eriodictyol represses the PI3K/Akt signaling pathway and down-regulates the level of circ_0007503 in breast cancer cells and in breast carcinogenesis (P < 0.01). When the effect of eriodictyol on circ_0007503 was blocked by transfection of a circ_0007503 over-expression plasmid, the cytotoxic effects and the suppression of the PI3K/Akt pathway of eriodictyol in breast cancer cells were significantly reduced (P < 0.05). CONCLUSION: Our data indicated that eriodictyol could effectively suppress breast carcinogenesis in vitro and in vivoThe mechanism may be attributed to targeting circ_0007503 and inhibiting PI3K/Akt pathway.

07:40

Eriodictyol and homoeriodictyol improve memory impairment. GreenMedInfo

PMID: Molecules. 2022 Apr 12 ;27(8). Epub 2022 Apr 12. PMID: 35458684 Abstract Title: Eriodictyol and Homoeriodictyol Improve Memory Impairment in A-Induced Mice by Inhibiting the NLRP3 Inflammasome. Abstract: (1) Alzheimer's disease (AD) is a neurodegenerative disorder, and it is now widely accepted that neuroinflammation plays a key role in its pathogenesis. Eriodictyol (Eri) and homoeriodictyol (Hom), dihydroflavonoids extracted from a variety of plants, have been confirmed to display a relationship with neuroprotection. (2) Methods: An AD mouse model was constructed by intracerebroventricular (ICV) injection of the Apeptide, and Eri and Hom were administered orally for 4 weeks. UPLC-MS/MS was used to determine whether Eri and Hom cross the blood-brain barrier to exert their therapeutic effects. Histological changes in the brain and levels of Awere evaluated, and Y-maze and new object recognition experiments were conducted to assess the effects of Eri and Hom on A-induced memory impairment in mice. The levels of oxidative stress and apoptosis in peripheral immune cells and progenitor cells in the hippocampal region were analyzed by flow cytometry and in vitro assays. Western blotting and enzyme-linked immunosorbent assays (ELISA) were used to measure the expression levels of NLRP3 inflammasome-related proteins and inflammatory factors in the brain. The effect of nigericin (an agonist of the NLRP3 inflammasome) on Eri and Hom intervention in LPS-induced N9 microglia was examined using a High Content Screening System. (3) Results: Eri and Hom reduced neuronal damage in mouse brain tissue, decreased Alevels in the brain, downregulated oxidative stress and apoptosis levels, and improved learning and memory capacity by crossing the blood-brain barrier to exert its effects. Moreover, Eri and Hom inhibited NLRP3 inflammasome activation and ameliorated immune cell disorder. Furthermore, the effect of Eri and Hom on LPS-induced N9 microglia disappeared after the addition of nigericin to agonize NLRP3 receptors. (4) Conclusions: Eri and Hom improved A-induced memory impairment in mice by inhibiting the NLRP3 inflammasome.

07:35

Proteomic analysis of the protective effect of eriodictyol on benzo(a)pyrene-induced caco-2 cytotoxicity. GreenMedInfo

PMID: Front Nutr. 2022 ;9:839364. Epub 2022 Mar 3. PMID: 35308267 Abstract Title: Proteomic Analysis of the Protective Effect of Eriodictyol on Benzo(a)pyrene-Induced Caco-2 Cytotoxicity. Abstract: We evaluated the possible protective effects of six polyphenols on benzo(a)pyrene (BaP)-induced cytotoxicity in Caco-2 cells. We show that treatment with quinic acid, ferulic acid, homovanillic acid, trolox and BaP decreased cell viability, whereas naringenin and eriodictyol affected viability in a bi-phasic manner with low concentrations decreasing viability whereas higher concentrations increase viability. Co-treatment with 20M eriodictyol or naringenin reduced BaP-induced cytotoxicity, including cell apoptosis, cell cycle progression, and oxidative stress. Our results show that the protective effect of eriodictyol was superior to that of naringenin. The potential protective mechanisms of eriodictyol on BaP-induced toxicity were investigated by proteomics. We identified 80 differentially expressed proteins (DEPs) with proteins associated with genetic information processing pathway representing the highest proportion and number of proteins responding to eriodictyol treatment, including key proteins such as RPA2, SNRPA, RAD23B, NUP155 and AARS. Our results provide new knowledge on how polyphenols may prevent BaP-induced carcinogenesis.

07:30

Macluraxanthone B inhibits LPS-induced inflammatory responses in RAW264.7 and BV2 cells. GreenMedInfo

PMID: Immunopharmacol Immunotoxicol. 2022 Feb ;44(1):67-75. Epub 2021 Nov 25. PMID: 34821534 Abstract Title: Macluraxanthone B inhibits LPS-induced inflammatory responses in RAW264.7 and BV2 cells by regulating the NF-B and MAPK signaling pathways. Abstract: OBJECTIVE: The prenylated xanthones compounds, macluraxanthone B (MCXB) was isolated from the MeOH extracts of. In this study, we investigated the effect of MCXB on inflammatory response.MATERIALS AND METHODS: Anti-inflammatory effects of MCXB were examined in lipopolysaccharide (LPS)-stimulated RAW264.7 and BV2 cells. We observed their anti-inflammatory effects by ELISA, western blot analysis, and immunofluorescence.RESULTS: MCXB significantly inhibited the LPS-stimulated production of nitric oxide (NO), prostaglandin E2 (PGE), interleukin-6 (IL-6), and tumor necrosis factor (TNF)-in RAW264.7 and BV2 cells. MCXB also reduced the LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 proteins. Incubating cells with MCXB prevented subsequent activation of the nuclear factor kappa B (NF-B) signaling pathway by inhibiting the nuclear localization and DNA-binding activity of the p65 subunit induced by LPS. MCXB inhibited the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 mitogen-activated protein kinases (MAPKs) in RAW264.7 and BV2 cells. MCXB induced the expression of heme oxygenase (HO)-1 protein, and the inhibitory effect of MCXB on nitric oxide production was partially reversed by a selective HO-1 inhibitor.DISCUSSION AND CONCLUSIONS: Our results suggested that the anti-inflammatory effect of MCXB is partly regulated by HO-1 induction. In conclusion, MCXB could be a useful candidate for the development of therapeutic and preventive agents to treat inflammatory diseases.

07:27

Immuno-modulatory effects of macluraxanthone on macrophage phenotype and function. GreenMedInfo

PMID: Nat Prod Res. 2021 Dec ;35(23):5409-5414. Epub 2020 Jun 8. PMID: 32508145 Abstract Title: Immuno-modulatory effects of macluraxanthone on macrophage phenotype and function. Abstract: Macluraxanthone was previously reported to have many biological activities, including anti-cholinesterase, anti-oxidant, anti-cancer, anti-malarial and anti-inflammatory effects. The aim of the current study was to further characterise the effect of macluraxanthone on human macrophage, a type of immune cell that has been implicated in the development of various inflammatory diseases. The expression of surface markers and cytokine production by THP-1 human macrophages following treatment with macluraxanthone were investigated. Macluraxanthone was shown to promote polarisation of M1-like pro-inflammatory macrophages by increasing the percentage of macrophages expressing CD86, while decreasing their CD14, CD11b and CD80 expression. However, in the presence of the pro-inflammatory stimulus lipopolysaccharide, macluraxanthone significantly decreased TNF-and IL-10 cytokine production.

07:24

Gerontoxanthone I and macluraxanthone induce mitophagy and attenuate ischemia/reperfusion injury. GreenMedInfo

PMID: Front Pharmacol. 2020 ;11:452. Epub 2020 Apr 15. PMID: 32351391 Abstract Title: Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury. Abstract: Mitophagy is a crucial process in controlling mitochondrial biogenesis. Balancing mitophagy and mitochondrial functions is required for maintaining cellular homeostasis. In this study, we found that Gerontoxanthone I (GeX1) and Macluraxanthone (McX), xanthone derivatives isolated fromC. Y. Wu ex Y. H. Li, induced Parkin puncta accumulation and promoted mitophagy. GeX1 and McX treatment induced the degradation of mitophagy-related proteins such as Tom20 and Tim23. GeX1 and McX directly stabilized PTEN-induced putative kinase 1 (PINK1) on the outer membrane of the mitochondria, and then recruited Parkin to mitochondria. This significantly induced phosphorylation and ubiquitination of Parkin, suggesting that GeX1 and McX mediate mitophagy through the PINK1-Parkin pathway. Transfecting ParkinS65A or pretreated MG132 abolished the induction effects of GeX1 and McX on mitophagy. Furthermore, GeX1 and McX treatment decreased cell death and the level of ROS in an ischemia/reperfusion (IR) injury model in H9c2 cells compared to a control group. Taken together, our data suggested that GeX1 and McX induce PINK1-Parkin-mediated mitophagy and attenuate myocardial IR injury.

07:06

Bellidifolin protects H9c2 cells from hydrogen peroxide-induced injury. GreenMedInfo

PMID: Toxicol Rep. 2022 ;9:1655-1665. Epub 2022 Aug 17. PMID: 36518482 Abstract Title: Bellidifolin from(Michx.) Hulten protects H9c2 cells from hydrogen peroxide-induced injury via the PI3K-Akt signal pathway. Abstract: Cardiovascular disease is the most common disease in the world and the first among the causes of human death. Its morbidity and mortality increase annually, but no effective treatment is available. Therefore, new drugs should be developed to treat cardiovascular disease.(Michx.) Hulten () is an important Mongolian medicine in China and elicits protective effects on cardiovascular health. In this study, liquid chromatography-mass spectrometry (LC-MS) combined with network pharmacology was used to screen the main active ingredients and confirm that bellidifolin was one of the main components for the treatment of ischemic heart disease. Then, rat myocardial (H9c2) cells injury model induced by hydrogen peroxide (HO)was established to verify the effect of bellidifolin on oxidative stress stimulation, including determination of antioxidant enzyme activity and apoptosis. Transcriptome sequencing, qRT-PCR, and western blot were performed to further verify the antioxidant stress mechanism of bellidifolin. Results showed that bellidifolin pretreatment decreased the rate of apoptosis and the levels of lactate dehydrogenase (LDH), creatine kinase (CK), and alanine aminotransferase (ALT). Conversely, it increased the contents of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in a dose-dependent manner, indicating that bellidifolin caused a protective effect on cardiomyocyte injury. Bellidifolin minimized the HO-induced cell injury by activating the PI3K-Akt signal pathway and downregulating glycogen synthase kinase-3(GSK-3) and p-Akt1/Akt1. Therefore, this work revealed thathas a good development prospect as an edible medicinal plant in cardiovascular disease. Its bellidifolin component is a potential therapeutic agent for cardiovascular disease induced by oxidative stress damage.

06:47

Shingles vaccine may be linked to lower dementia risk Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

A new study suggests that individuals who have received the shingles (herpes zoster) vaccine have a significantly lower risk of dementia.

Skeptical Raptor

06:30

Bellidifolin ameliorates myocardial fibrosis. GreenMedInfo

PMID: Evid Based Complement Alternat Med. 2022 ;2022:6841276. Epub 2022 May 9. PMID: 35586685 Abstract Title: Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-Signalling Activation to Ameliorate Myocardial Fibrosis. Abstract: Myocardial fibrosis is the main morphological change of ventricular remodelling caused by cardiovascular diseases, mainly manifested due to the excessive production of collagen proteins. SRY-related high mobility group-box gene 9 (SOX9) is a new target regulating myocardial fibrosis. Bellidifolin (BEL), the active component of, can prevent heart damage. However, it is unclear whether BEL can regulate SOX9 to alleviate myocardial fibrosis. The mice were subjected to isoproterenol (ISO) to establish myocardial fibrosis, and human myocardial fibroblasts (HCFs) were activated by TGF-1 in the present study. The pathological changes of cardiac tissue were observed by HE staining. Masson staining was applied to reveal the collagen deposition in the heart. The measurement for expression of fibrosis-related proteins, SOX9, and TGF-1 signalling molecules adopted Western blot and immunohistochemistry. The effects of BEL on HCFs, activity were detected by CCK-8. The result showed that BEL did not affect cell viability. And, the data indicated that BEL inhibited the elevations in-SMA, Collagen I, and Collagen III by decreasing SOX9 expression. Additionally, SOX9 suppression by siRNA downregulated the TGF-1 expression and prevented Smad3 phosphorylation, as supported by reducing the expression of-SMA, Collagen I, and Collagen III. In vivo study verified that BEL ameliorated myocardial fibrosis by inhibiting SOX9. Therefore, BEL inhibited SOX9 to block TGF-1 signalling activation to ameliorate myocardial fibrosis.

06:24

Mangiferin relieves carbon tetrachloride-induced liver fibrosis. GreenMedInfo

PMID: Sci Rep. 2023 Mar 13 ;13(1):4172. Epub 2023 Mar 13. PMID: 36914687 Abstract Title: Mangiferin relieves CCl4-induced liver fibrosis in mice. Abstract: Hepatic fibrosis is a late stage process of many chronic liver diseases. Blocking the fibrosis process will be beneficial to the treatment and recovery of the diseases. Mangiferin has many pharmacological activities. Recently, it has been reported that mangiferin may relieve tissue fibrosis, including renal, myocardial, pulmonary fibrosis via anti-inflammatory and anti-oxidative effects in animal models. Here, we investigate the effects of mangiferin on CCl4-induced liver fibrosis and the underlying mechanism in mice. Thirty-two male C57BL/6 mice were randomly divided into 4 groups (n=8 in each group), injected with carbon tetrachloride (10% CCl4) for 8 weeks, and oral administrated with mangiferin (50 mg/kg or 100 mg/kg) from the fifth week. The serum levels of ALT, AST were analyzed to evaluate liver function. H&E, Masson's trichrome and Sirius red staining were used to assess liver morphology and the degree of liver fibrosis. Quantitative RT-PCR and Western blot were used to assay the gene expression and protein levels. The results showed that mangiferin alleviated the serum levels of AST, ALT, ALP, TBA and TBIL, reduced liver lesions, prevented hepatic parenchymal necrosis, and ameliorated collagen accumulation in the liver of CCl4-treated mice. Meanwhile, mangiferin inhibited the expression of inflammatory genes IL-6 and IL-1, fibrogenic genes-SMA, TGF-and MMP-2 and bile acid metabolism genes ABCB4, ABCB11, SULT2A1 in the liver of CCl4-treated mice. Furthermore, mangiferin reduced collagen accumulation and HSCs activation, inhibited the p-IB and p-p65 protein levels. Our results suggest that mangiferin could alleviate liver fibrosis in CCl4-treated mice through inhibiting NF-B signaling, and mango consuming may have beneficial effects to hepatic fibrosis.

06:18

Mangiferin can alleviate chronic unpredictable mild stress induced tumor growth and the treatment of colorectal liver metastases patients. GreenMedInfo

PMID: Heliyon. 2023 Mar ;9(3):e13753. Epub 2023 Feb 15. PMID: 36873506 Abstract Title: Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway. Abstract: BACKGROUND: Evidence indicates that chronic stress promotes progression of colorectal liver metastases (CLM). Mangiferin is the active chemical constituent of the rhizomes of. Mangiferin (MGF) exerts anti-inflammatory, anti-proliferative, anti-angiogenic, anti-fibrotic and antioxidant effects in a variety of cancers. Its mechanism in chronic stress and tumor growth is still poorly understood.METHODS: To investigate the effects of MGF on the CLM and tumor-associated depression, activated hepatic stellate cells (a-HSCs), HT-29 CRC cells, were used in chronic unpredictable mild stress (CUMS) of tumor-bearing models. Potential antidepressant activity was determined by FST, TST, SIT and serum cytokine (IL-6, IL-18 and TNF-) examination. Downstream signaling molecules were detected by Western blot, immunohistochemistry and fluorescence microscopy.RESULTS: CUMS induced depression behavior and depression-related cytokines and promoted tumor growth in CLM. MGF-treated mice significantly improved chronic stress behaviors by reducing depression-related cytokines. In addition, MGF treatment inhibits WAVE2 signaling pathway, leading to TGF-1 induced HSC inhibition, thereby reducing depressive behavior and tumor growth in CLM.CONCLUSION: MGF can alleviate CUMS induced tumor growth and the treatment of CLM patients with MGF may be beneficial.

06:07

Induction of apoptosis and decrease of autophagy in colon cancer cells by an extract of lyophilized mango pulp. GreenMedInfo

PMID: Int J Environ Res Public Health. 2023 Feb 25 ;20(5). Epub 2023 Feb 25. PMID: 36901174 Abstract Title: Induction of Apoptosis and Decrease of Autophagy in Colon Cancer Cells by an Extract of Lyophilized Mango Pulp. Abstract: Previous studies have indicated that mango fruit has a chemopreventive capacity against colorectal cancer cells. The objective of this research was to evaluate the effect of an aqueous extract of lyophilized mango pulp (LMPE) on colon adenocarcinoma cells (SW480) and their metastatic derivatives (SW620) death and cellular invasion. DNA fragmentation was assessed by TUNEL assay; autophagy and expression of DR4 and Bcl-2 by flow cytometry; the expression of 35 apoptosis-related proteins and of matrix metalloproteinases 7 and 9 by immunodetection; and the invasive capacity of the cells by Boyden chamber. The results showed that LMPE at 30 mg/mL and 48 h of exposure results in DNA fragmentation and apoptosis in SW480 (

06:03

Antidiabetic properties of mango in animal models and humans. GreenMedInfo

PMID: Nutr Res. 2023 Mar ;111:73-89. Epub 2023 Jan 28. PMID: 36841190 Abstract Title: Antidiabetic properties of mango in animal models and humans: A systematic review. Abstract: Mango has long been an attractive source of nutrition and pharmacological therapeutics. The mango plant (Mangifera indica L.) contains bioactive compounds that may have antidiabetic properties. This systematic review investigated the evidence for antidiabetic properties of the different parts of the mango plant in managing type 2 diabetes mellitus in animal models and humans. The electronic databases PubMed, FSTA, Web of Science, CINAHL, MEDLINE, and Cochrane Library were systematically searched to identify articles with clear objectives and methodologies available in the English language with publication date limits up to December 2020. Twenty-eight of 1001 animal and human studies met the inclusion criteria that investigated antidiabetic properties of mango from leaf (31%), flesh (38%), seed-kernel (7%), peel (14%), stem-bark (7%), and by-product (3%). Results support the glucose-lowering properties of mango in both animals and human. Proposed antidiabetic mechanisms of action include inhibition of-amylase and-glucosidase, improved antioxidant status, improved insulin sensitivity, facilitated glucose uptake, and gene regulation of glucose transporter type 4, insulin receptor substrate 1, and phosphoinositide 3-kinase. The animal and randomized control trial findings suggest that mango may be beneficial as an antidiabetic agent. Although these studies hold promise, additional observational studies and randomized control trials are required because human studies are significantly fewer in number, use mango flesh almost exclusively, and had modest blood glucose effects. Additional research gaps include identifying the mechanisms of action for the different components of the mango plant.

06:00

Inhibition of cell proliferation and induction of cell cycle arrest in colon cancer cells. GreenMedInfo

PMID: Prev Nutr Food Sci. 2022 Dec 31 ;27(4):436-447. PMID: 36721744 Abstract Title: Inhibition of Cell Proliferation and Induction of Cell Cycle Arrest in Colon Cancer Cells by Lyophilized Mango (L.) Pulp Extract. Abstract: The present study evaluated the antiproliferative capacity and possible cell death mechanisms of lyophilized mango pulp extract (LMPE), applied to human colon cancer cells (SW480) and their metastasis-derived counterparts (SW620). The total phenolic content of LMPE was estimated by the Folin-Ciocalteu method. Three assays were employed to determine its antioxidant capacity: ferric-reducing antioxidant power, oxygen radical absorbance capacity, and 2,2-diphenyl-1-picrylhydrazyl. Furthermore, the antiproliferative activity of LMPE was assessed by sulforhodamine B, clonogenic, and Ki-67 assays. Flow cytometry was employed to examine the cell cycle, production of intracellular reactive oxygen species (ROS), cell-surface phosphatidylserine, and change in mitochondrial membrane potential. LMPE exhibited a high level of total phenolic content and antioxidant activity. The mean maximal inhibitory concentration values of LMPE at 48 h of exposure were 43 and 29 mg/mL for SW480 and SW620, respectively. In the SW480 and SW620 cell lines, LMPE at 50 mg/mL and 48 h of exposure induced an increase in intracellular ROS, cell cycle arrest in the G2/M phase, and probably, apoptotic processes without mitochondrial depolarization. LMPE had an antiproliferative capacity against the human colorectal cancer cell lines SW480 and SW620. These results highlight the chemopreventive potential of LMPE in colorectal cancer treatments.

05:58

Alpha-mangostin Inhibited M1 polarization of macrophages/monocytes in antigen-induced arthritis. GreenMedInfo

PMID: Drug Des Devel Ther. 2023 ;17:563-577. Epub 2023 Feb 23. PMID: 36860800 Abstract Title: -Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated ReceptorSimultaneously. Abstract: BACKGROUND: -Mangostin (MG) showed the potentials in alleviating experimental arthritis, inhibiting inflammatory polarization of macrophages/monocytes, and regulating peroxisome proliferators-activated receptor(PPAR-) and silent information regulator 1 (SIRT1) signals. The aim of this study was to analyze the correlations among the above-mentioned properties.METHODS: Antigen-induced arthritis (AIA) was established in mouse, which was treated with MG in combination with SIRT1/PPAR-inhibitors to clarify the role of the two signals in the anti-arthritic actions. Pathological changes were systematically investigated. Phenotypes of cells were investigated by flow cytometry. Expression and co-localization of SIRT1 and PPAR-proteins in joint tissues were observed by the immunofluorescence method. Finally, clinical implications from the synchronous up-regulation of SIRT1 and PPAR-were validated by experiments in vitro.RESULTS: SIRT1 and PPAR-inhibitors (nicotinamide and T0070097) reduced the therapeutic effects of MG on AIA mice, and abrogated MG-induced up-regulation of SIRT1/PPAR-and inhibition of M1 polarization in macrophages/monocytes. MG has a good binding affinity to PPAR-, and MG promoted the co-expression of SIRT1 and PPAR-in joints. Synchronously activating SIRT1 and PPAR-was revealed to be necessary by MG to repress inflammatory responses in THP-1 monocytes.CONCLUSION: MG binds PPAR-and excites this signaling to initiate ligand-dependent anti-inflammatory activity. Due to certain unspecified signal transduction crosstalk mechanism, it then promoted SIRT1 expression and further limited inflammatory polarization of macrophages/monocytes in AIA mice.

05:38

Professor Mottron Disputes Northern Ireland Autism Rate Age of Autism The Rebel Alliance!

By Anne Dachel

A recent article from Northern Ireland got my attention.

The title was, Idea that 5% of all Northern Ireland's children are autistic is 'a fantasy' claims international expert.

Reporter Adam Kula focused on Professor Laurent Mottron from Montreal as an international expert who disputes the current autism rate in Northern Ireland: one in every 20 students.

Mottron dismissed the rate as fantasy and called it the result of over-diagnosis, and he said, The definition of autism may get too vague to be meaningful, trivializing the condition.

This of course is surprising since weve all been forced-fed the claim that all ever-increasing autism is always the result of BETTER DIAGNOSING/GREATER AWARENESS. It seems the experts are still getting it wrong.

HOLD ON. There are those who dispute the idea that were watering down the definition of autism.

The piece cited Jill Escher, the president of the National Council on Severe Autism, who challenged Mottron on the validity of the one in 20 rate for autism. She said, It boggles my mind that it is not the subject of the highest possible alarm and inquiry.

Reporter Kula raised the question of the disparity between the rate in Northern Ireland and the rest of the U.K.

This story first reared its head on May 24, when by Mark Baker, head of the Controlled Schools Support Council (CSSC), gave evidence to the House of Commons' Northern Ireland Affairs Committee.

"One in 20 children in Northern Ireland of school age has a diagnosis of autism," he told MPs.

"[It is] one in 57 in the rest of the UK. The need in Northern Ireland is significantly different."

To put that in perspective, that would mean 5% of Northern Irish children are diagnosed with autism, compared with 1.8% in the rest of the UK.

I immediately thought of all the articles Ive posted on Loss of Brain Trust that clearly show a massive f...

02:12

Video: Mental Health In Survival, Pt. 2: Depression

Depression is more common during and after a major life event, and I think youll agree the end of the world as we know it would qualify. Traumatic experiences can cause depression and even PTSD, which Dr. Joe Alton discusses in the next video in this series. If the grid goes down long enough, many[Read More]

The post Video: Mental Health In Survival, Pt. 2: Depression first appeared on .

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Wednesday, 14 June

23:50

Why Is PFAS in My Kale? Alliance for Natural Health USA Protecting Natural Health

After years of covering our exposure to toxic PFAS chemicals, the Alliance for Natural Health USA is fed up with the government cronyism that permits chemical companies to continue poisoning our bodies, our children, and our environment with PFAS. We need action TODAY!

The FDA and EPA the very agencies that are charged with protecting our health and our environment have largely turned a blind eye to the chemical companies that have spent decades hiding the horrific truth about the dangers PFAS as they continued to contaminate our water, soil, and food.

As a result of this decades long coverup, we still dont know the full extent of how bad PFAS are for us, but from the little we do know, it is clear that PFAS are killing Americans. PFAS are known as forever chemicals because they dont easily break down in our bodies and the environment. Studies show that PFAS exposure is linked to an enormous number of frightening health effects, including:

Infertility, birth defects, gestational diabetes, pre-eclampsia (pregnancy-induced high blood pressure), and low birth weight
Developmental delays in children, including accelerated puberty, bone variations, behavioral changes, and allergies, asthma, and childhood obesity
Cancer (non-Hodgkins lymphoma, breast, testicular, prostate, liver and kidney cancers)
Ulcerative colitis
Decreased immune system response to infections
Hormone interference and thyroid disease
Obesity and increased cholesterol

Up until the last few years, we thought PFAS was a contained problem you could protect yourself from by avoiding things like nonstick pans, fast food packaging, and microwaved popcorn. But finally, in 2019, the FDA began very limited testing of PFAS in common U.S. food items and found what we believe is alarming levels of PFAS contamination in certain seafood.

This led our staff at ANH to wonder: Are Americans really being told the truth about our levels of PFAS exposure in food?

We decided to test this question with a pilot study that found shocking results. ANH staff purchased organic and conventional kale from our local grocery stores in New York (Stop & Shop), Pennsylvania (Weis), Georgia (Publix), and Arizona (Whole Foods). If PFAS were found in kale, one of the healthiest options available at the store, we would have a clear indication of the extent of PFAS contamination of our food supply.

We sent our local grocery store kale to be tested for PFAS, hoping to confirm what the FDA stat...

22:13

Dubious Autonomic Nervous System Claims Science-Based Medicine

Beware overblown claims that autonomic testing can help almost anything.

The post Dubious Autonomic Nervous System Claims first appeared on Science-Based Medicine.

20:01

Embodying Emotional Taboos: Musicians and Mental Health Mad In America

Mia Berrin is a songwriter, producer, and recording artist based out of Brooklyn, whose project, Pom Pom Squad, has garnered attention over the last few years for its grunge-pop sound and introspective lyrics. Her debut album, Death of a Cheerleader, was released in 2020 via Berlin-based label City Slang and has since been featured in Rolling Stone, Pitchfork, Billboard, and more. Mia has been open about the impact of her queer, POC, and bipolar identities on her career in music, and speaks with Karin Jervert and Amy Biancolli at Mad in America more about patriarchy, the music industry, and mental health.

The transcript below has been edited for length and clarity. Listen to the audio of the interview here.

Karin Jervert: Im here today with Mia Berrin, the front woman of the American indie rock/grunge band from Brooklyn, Pom Pom Squad. The group, with Shelby Keller drums and Alex Mercuri guitar, cut their teeth playing packed Brooklyn apartments, but they quickly graduated to packed Brooklyn venues, alongside artists like Soccer Mommy, Adult Mom, and Pronoun. The bands latest album is Death of a Cheerleader. Were really happy to have her on and talk to her today. Also, Mia, so welcome. So glad to have you here.

Mia Berrin: Thank you so much. Im glad to be here.

Amy Biancolli: Mia, Im just curious to hear how you would describe the stressors of the music industry. Could you speak to that a little bit?

Berrin: I can absolutely relate to that. Ive been a full-time musician for the past two and a half years, which has been a huge lifestyle change. Before that I was a student and I was doing day jobs. Working retail requires different skill sets than working in the music industry. In terms of the music industry, I quit my day job to go on tour, and most of my job since then has been touring. Im back home right now for the first time. Its the longest consecutive amount of time Ive been home in two years, which has been three months.

For me, being bipolar, something like getting sleep is really important, taking my medication at the same time, making sure Im eating properly, making sure that Im drinking enough water, just doing all of the things that your bodys baseline needs in general, but also that your body needs as a baseline to maintain your mental stability and keep you seeing clearly. The way that the touring industry works, its just not conducive to anyones...

13:58

COVID Shots Associated With Increased Risk of Blindness Health Nut News

While U.S. health agencies have admitted that myocarditis (heart inflammation), and a related condition called pericarditis (inflammation of the heart sack), are potential side effects of the COVID jab,1 the U.S. Centers for Disease Control and Prevention has ignored hundreds of other safety signals that have shown up during their Proportional Reporting Ratio (PRR) data mining of the []

The post COVID Shots Associated With Increased Risk of Blindness appeared first on Health Nut News.

11:13

Amazon and Starbucks Sued for Collecting, Retaining, Storing, Converting, Using, Sharing, and Profiting from Palm Scans Medical Kidnap

Comments by Brian Shilhavy
Editor, Health Impact News

Several consumers in New York have sued Amazon.com and Starbucks for unauthorized use of their palm scans.

Plaintiffs bring this action for damages and other legal and equitable remedies resulting from the illegal actions of Amazon and Starbucks in collecting, retaining, storing, converting, using, sharing, and profiting from Plaintiffsand other similarly situated individuals biometric identifier information (referred to at times as biometrics)their hand geometry (hand geometry or palm scans or palm prints) and/or body geometry (physiological characteristics concern[ing] the shape or composition of the body)in direct violation of the New York City Biometric Identifier Information Law.

On January 11, 2021, the City of New York enacted a new law that requires retailers and other commercial establishments that collect, retain, convert, store, or share customers biometric identifier information to notify their customers of these practices before customers enter those establishments. SeeN.Y.C. Admin. Code 22-1201 et seq.

The type of information the law applies to includes any physiological or biological characteristic that is used to identify (or assist in identifying) a person, such asfacial recognition, retina scans, fingerprints, handprints, or any other identifying characteristic like the shape or size of a persons body. (Source.)

BiometricUpdate.com reported on this.

Amazon and coffee retailer Starbucks are being sued in U.S. federal district court for misusing customers biometric identifiers.

The proposed class action (2:23-cv-00852) has been filed in the Western District Court of Washington. The named plaintiffs, Suzanne Mallouk, Alfredo Rodriguez Perez and Arjun Dhawan, claim their privacy rights were violated when visiting New York City stores that used Amazons One palm biometric scanners.

(The trio had filed separate cases...

11:13

Amazon and Starbucks Sued for Collecting, Retaining, Storing, Converting, Using, Sharing, and Profiting from Palm Scans Vaccine Impact

Comments by Brian Shilhavy
Editor, Health Impact News

Several consumers in New York have sued Amazon.com and Starbucks for unauthorized use of their palm scans.

Plaintiffs bring this action for damages and other legal and equitable remedies resulting from the illegal actions of Amazon and Starbucks in collecting, retaining, storing, converting, using, sharing, and profiting from Plaintiffsand other similarly situated individuals biometric identifier information (referred to at times as biometrics)their hand geometry (hand geometry or palm scans or palm prints) and/or body geometry (physiological characteristics concern[ing] the shape or composition of the body)in direct violation of the New York City Biometric Identifier Information Law.

On January 11, 2021, the City of New York enacted a new law that requires retailers and other commercial establishments that collect, retain, convert, store, or share customers biometric identifier information to notify their customers of these practices before customers enter those establishments. SeeN.Y.C. Admin. Code 22-1201 et seq.

The type of information the law applies to includes any physiological or biological characteristic that is used to identify (or assist in identifying) a person, such asfacial recognition, retina scans, fingerprints, handprints, or any other identifying characteristic like the shape or size of a persons body. (Source.)

BiometricUpdate.com reported on this.

Amazon and coffee retailer Starbucks are being sued in U.S. federal district court for misusing customers biometric identifiers.

The proposed class action (2:23-cv-00852) has been filed in the Western District Court of Washington. The named plaintiffs, Suzanne Mallouk, Alfredo Rodriguez Perez and Arjun Dhawan, claim their privacy rights were violated when visiting New York City stores that used Amazons One palm biometric scanners.

(The trio had filed separate cases...

10:43

Immunopotentiation effects of apigenin on NK cell proliferation and killing pancreatic cancer cells. GreenMedInfo

PMID: Int J Immunopathol Pharmacol. 2023 ;37:3946320231161174. PMID: 36848930 Abstract Title: Immunopotentiation effects of apigenin on NK cell proliferation and killing pancreatic cancer cells. Abstract: Apigenin is a kind of flavonoid with many beneficial biological effects. It not only has direct cytotoxicity to tumor cells, but also can boost the antitumor effect of immune cells by modulating immune system. The purpose of this study was to investigate the proliferation of NK cells treated with apigenin and its cytotoxicity to pancreatic cancer cells in vitro, and explore its potential molecular mechanism. In this study, the effect of apigenin on NK cell proliferation and killing pancreatic cancer cells were measured by CCK-8 assay. Perforin, granzyme B (Gran B), CD107a, and NKG2D expressions of NK cells induced with apigenin were detected by flow cytometry (FCM). The mRNA expression of Bcl-2, Bax and protein expression of Bcl-2, Bax, p-ERK, and p-JNK in NK cells were evaluated by qRT-PCR and western blotting analysis, respectively. The results showed that appropriate concentration of apigenin could significantly promote the proliferation of NK cells in vitro and enhance the killing activity of NK cells against pancreatic cancer cells. The expressions of surface antigen NKG2D and intracellular antigen perforin and Gran B of NK cells were upregulated after treating with apigenin. Bcl-2 mRNA expression was increased, while Bax mRNA expression was decreased. Similarly, the expression of Bcl-2, p-JNK, and p-ERK protein was upregulated, and the expression of Bax protein was downregulated. The molecular mechanism of the immunopotentiation effects of apigenin may be that it up-regulates Bcl-2 and down-regulates Bax expression at the gene and protein levels to facilitate NK cell proliferation, and up-regulates the expression of perforin, Gran B, and NKG2D through the activation of JNK and ERK pathways to enhance NK cell cytotoxicity.

10:24

The aqueous extracts of Ageratum conyzoides inhibit inflammation by suppressing NLRP3 inflammasome activation. GreenMedInfo

PMID: J Ethnopharmacol. 2023 Jun 12 ;309:116353. Epub 2023 Mar 10. PMID: 36907476 Abstract Title: The aqueous extracts of Ageratum conyzoides inhibit inflammation by suppressing NLRP3 inflammasome activation. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Ageratum conyzoides L. (Asteraceae), a well-known and widely distributed traditional tropical medicinal herb, has been used to treat diverse diseases. Our preliminary research has shown that aqueous extracts of A. conyzoides leaf (EAC) have anti-inflammatory activity. However, the detailed underlying anti-inflammatory mechanism of EAC is still unclear.AIM OF THE STUDY: To determine the anti-inflammatory mechanism of action of EAC.MATERIALS AND METHODS: The major constituents of EAC were identified by ultra-performance liquid chromatography (UPLC) combined with quadrupole-time-of-flight mass/mass spectrometry (UPLC-Q-TOF-MS/MS). LPS and ATP were used to activate the NLRP3 inflammasome in two types of macrophages (RAW 264.7 and THP-1 cells). The cytotoxicity of EAC was measured by the CCK8 assay. The levels of inflammatory cytokines and NLRP3 inflammasome-related proteins were detected by ELISA and western blotting (WB), respectively. The oligomerization of NLRP3 and ASC and the resulting inflammasome complex formation were observed by immunofluorescence. The intracellular reactive oxygen species (ROS) level was measured by flow cytometry. Finally, an MSU-induced peritonitis model was established to evaluate the anti-inflammatory effects of EAC in vivo.RESULTS: Twenty constituents were identified in the EAC. Kaempferol 3,7-diglucoside, 1,3,5-tricaffeoylquinic acid, and kaempferol 3,7,4'-triglucoside were found to be the most potent ingredients. EAC significantly reduced the levels of IL-1, IL-18, TNF-, and caspase-1 in the two types of activated macrophages, implying that EAC can inhibit the activation of the NLRP3 inflammasome. A mechanistic study revealed that EAC inhibited NLRP3 inflammasome activation by blocking NF-B signalling pathway activation and scavenging the level of intracellular ROS to prevent NLRP3 inflammasome assembly in macrophages. Furthermore, EAC attenuated the in vivo expression of inflammatory cytokines by suppressing NLRP3 inflammasome activation in a peritonitis mouse model.CONCLUSION: Our results demonstrated that EAC inhibited inflammation by suppressing NLRP3 inflammasome activation, highlighting that this traditional herbal medicine might be used to treat NLRP3 inflammasome-driven inflammatory diseases.

10:22

Computational screening for new neuroprotective ingredients against Alzheimer's disease from bilberry by cheminformatics approaches. GreenMedInfo

PMID: Front Nutr. 2022 ;9:1061552. Epub 2022 Dec 9. PMID: 36570129 Abstract Title: Computational screening for new neuroprotective ingredients against Alzheimer's disease from bilberry by cheminformatics approaches. Abstract: Bioactive ingredients from natural products have always been an important resource for the discovery of drugs for Alzheimer's disease (AD). Senile plaques, which are formed with amyloid-beta (A) peptides and excess metal ions, are found in AD brains and have been suggested to play an important role in AD pathogenesis. Here, we attempted to design an effective and smart screening method based on cheminformatics approaches to find new ingredients against AD from(bilberry) and verified the bioactivity of expected ingredients through experiments. This method integrated advanced artificial intelligence models and target prediction methods to realize the stepwise analysis and filtering of all ingredients. Finally, we obtained the expected new compound malvidin-3-O-galactoside (Ma-3-gal-Cl). Theexperiments showed that Ma-3-gal-Cl could reduce the OHgeneration and intracellular ROS from the A/Cu/AA mixture and maintain the mitochondrial membrane potential of SH-SY5Y cells. Molecular docking and Western blot results indicated that Ma-3-gal-Cl could reduce the amount of activated caspase-3binding with unactivated caspase-3 and reduce the expression of phosphorylated p38binding with mitogen-activated protein kinase kinases-6 (MKK6). Moreover, Ma-3-gal-Cl could inhibit the Aaggregationbinding with Amonomer and fibers. Thus, Ma-3-gal-Cl showed significant effects on protecting SH-SY5Y cells from A/Cu/AA induced damageantioxidation effect and inhibition effect to the Aaggregation.

10:14

Neuroprotective and antioxidant potential of Vaccinium myrtillus and Vaccinium arctostaphylos leaves. GreenMedInfo

PMID: Life (Basel). 2022 Dec 11 ;12(12). Epub 2022 Dec 11. PMID: 36556444 Abstract Title: Caucasian Blueberry: Comparative Study of Phenolic Compounds and Neuroprotective and Antioxidant Potential of Vaccinium myrtillus and Vaccinium arctostaphylos Leaves. Abstract: (1) Background: Two Caucasian blueberriesL. andL. are famous berry bushes growing in the Caucasus region and used to treat neurological diseases, but the chemistry and bioactivity of leaf extracts are still poorly studied. (2) Methods: Phenolic compounds ofandleaf extracts were profiled and quantified by HPLC-PDA-ESI-tQ-MS. The neurotropic potential ofextracts was studied using the model of middle cerebral artery permanent occlusion to determine cerebral blood flow, the area of the brain tissue necrosis, and antioxidant enzyme activity (including superoxide dismutase, succinate dehydrogenase, and cytochrome C oxidase), as well as the concentration of TBARS. (3) Results: Hydroxycinnamates and flavonoids were identified in the leaves ofand, and the dominant metabolite of both extracts was 5--caffeoylquinic acid in the amount of 105-226 mg/g. The studied extracts enhanced the cerebral hemodynamics and decreased the frequency of necrotic and lipooxidative processes in the brain tissue, accompanied by an increase in the activity of antioxidant enzymes. The positive effect ofwas stronger and exceeded the effectiveness ofstandardized extract. (4) Conclusion: The leaf extracts of Caucasian blueberriesandas a new source of hydroxycinnamates demonstrated a protective effect of the brain ischemia pathology and can be used as therapeutic agents to treat neurological diseases.

10:00

Secret Push to Bury Paraquats Link to Parkinsons Disease Articles

Paraquat is an herbicide and registered desiccant that has been used on American farms since 1964. A desiccant is a chemical that speeds up the ripening of the crop and dries it out, which facilitates harvesting and allows it to be harvested sooner than were the crop left to dry naturally.

Desiccation is also used to improve profits, as farmers are penalized when the grain contains moisture. The greater the moisture content of the grain at sale, the lower the price they get.

While 50 countries have banned paraquat due to its extreme toxicity and adverse effects on health (a single sip is lethal to a human¹), the chemical remains legal in the U.S., provided farmers receive training on its application. Proper application doesnt ensure its safety, however, as recent lawsuits by thousands of farmers make clear.

Paraquat Linked to Parkinsons Disease

A considerable body of evidence² links paraquat to Parkinsons disease and, as of mid-March 2023, 2,998 lawsuits filed by farmers with Parkinsons disease had been consolidated in Illinois federal court. The first bellwether trial is scheduled to begin in October 2023.³

The farmers are suing Syngenta, the lead manufacturer, and Chevron, a key distributor, arguing the herbicide caused their disease, and that the manufacturer was aware of this risk and concealed it from the public.

The discovery process has unearthed a trove of documents⁴ showing Syngenta has indeed known that paraquat poses neurological risks and feared the possibility of lawsuits for decades.

Most of the paraquat lawsuits are taking place in Illinois federal court, but class actions have also been filed with state courts in California, Florida, Pennsylvania, and Washington. The first state court trial is scheduled to begin in September 2023 in California.⁵ As reported by the Miller & Zois law firm, which is handling paraquat cases in all 50 U.S. states:⁶

Parkinsons disease is a progressive neurodegenerative disorder of the brain that affects primarily the motor system, the part of the central nervous system that controls movement.

The characteristic symptoms of Parkinsons disease are its primary motor symptoms: resting tremor; bradykinesia (slowness in voluntary movement and reflexes); rigidity; and postural instability. There...

Kidney and Gastro Issues Linked to Popular Pill to Get Thin Articles

The latest weight loss craze to hit Hollywood and beyond is semaglutide, more popularly known as Ozempic, the brand name of the drug marketed to improve blood sugar in people with Type 2 diabetes.

Semaglutide is also known as Wegovy, which is prescribed to adults interested in weight loss. The weekly injectable drug is available only by prescription and costs $1,349 a month¹ but its in high demand among those looking to shed a few pounds.

New York dermatologist Dr. Paul Jarrod Frank told People, "It's the drug of choice these days for the 1%."² He says he can always spot users due to "Ozempic face," a gaunt appearance that can occur due to fat loss, which may make you appear older, particularly in the face.

But this undesirable side effect is the least of your worries if you choose to use semaglutide. The blockbuster drug, slated to bring in more than $10 billion in annual sales,³ has also been linked to a growing number of serious health disorders.

How Does Semaglutide Work?

Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1RAs). As a peptide hormone, GLP-1 is, among other things, part of a group of incretin hormones, which are released when you eat to regulate insulin, along with many other functions.⁴

Along with affecting insulin, GLP-1 may influence the nervous system, leading to an appetite-reducing response. Many taking semaglutide report that the drug makes them feel full, faster, so theyre satisfied eating smaller amounts.

"[Semaglutide] is a hormone that is produced while we eat; it tells the brain that we are full," Dr. Katherine H. Saunders, cofounder of Intellihealth, told the New York Post. "It helps people to feel less hungry, to feel full faster and to stay full longer. But it does so when we actually are less full."⁵

A 2021 study funded by Novo Nordisk, the drugs maker, found using semaglutide once a week led to a 14.9% reduction in body weight among adults with obesity.⁶ A cohort study of overweight or obese adults also found total body weight loss of 5.9% after three months of using semaglutide and 10.9% after six months.⁷

Now the drug isnt only being pawned off as a weight loss panacea but also an "anti-addiction drug." "People taking Ozempic for weight loss say they have also stopped drinking, smoking, shopping and even nail biting," The Atlantic reported in Ma...

This Thyroid Condition Is a Top Public Health Issue Articles

Editor's Note: This article is a reprint. It was originally published July 23, 2018.

Iodine deficiency and the thyroid conditions related to it are a serious public health concern. Several studies published earlier this year suggest iodine deficiency is re-emerging. While about 40% of the world's population is thought to be at risk of iodine deficiency,¹ residents of developed countries are increasingly found to be lacking this essential nutrient.

Your body cannot produce iodine so you must get if from your diet. Iodine is necessary to make thyroid hormones, which control your metabolism and other vital functions. Because your thyroid hormones also support proper bone and brain development in utero and during infancy, the proper intake of iodine is critically important for pregnant women, nursing mothers and their babies.

What Is Iodine and Why Is It Important?

As mentioned, iodine is an essential element needed for the production of thyroid hormone. Because your body does not make iodine, you need to be intentional to ensure you obtain sufficient amounts of this nutrient on a daily basis. Although iodine can be sourced from the foods you eat or through a supplement, many people eating a standard American diet generally get enough iodine simply by using table salt. I'll say more about salt later in the article.

When your body lacks sufficient iodine, it cannot make enough thyroid hormone. If your deficiency is severe, your thyroid may become enlarged, a condition also known as a goiter. Iodine deficiency can also cause hypothyroidism (low thyroid function). In some cases, lack of sufficient iodine can trigger intellectual disabilities and developmental problems in infants and children whose mothers were iodine deficient during pregnancy.²

According to the American Thyroid Association, iodine deficiency has also been linked to "increased difficulty with information processing, diminished fine motor skills, extreme fatigue, depression, weight gain and low basal body temperatures, among other things."³

Studies Highlight Iodine Deficiency as an Emerging Problem

A 2018 study published in the journal Nutrients⁴ involving 1,007 mothers who gave birth to 1,017 children (including 10 twin pairs; multiple births other than twins were excluded), suggests iodine deficiency is a significant public health issue in Norway. After collecting data multiple times...

09:56

Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury. GreenMedInfo

PMID: J Chem Neuroanat. 2023 Jan ;127:102193. Epub 2022 Nov 19. PMID: 36414183 Abstract Title: Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury. Abstract: Traumatic brain injury may trigger the secondary brain injury, which has the potential to be reversible and thus preventable. Anthocyanins are phylotherapeutic plants, which are reported to exhibit anti-inflammatory properties. This study aimed to evaluate the therapeutic efficiency of an anthocyanin, namely Vaccinium myrtillus, to alleviate secondary brain injury and identify possible mechanism of actions. It is hypothesized that lipid peroxidation and Na+ -K+ -ATPase activity may be involved in neuronal ischemia. Thus, brain tissue Malondialdehyde content, Na+ -K+ -ATPase content, and cleaved caspase-3 content was investigated following moderate head trauma in a rat model. Twenty-four Sprague-Dawley male rats were allocated into four groups: Control, Trauma, Solvent-Control, and Treatment. Trauma and Solvent-Control groups showed more prominent brain edema, neuronal ischemia, vascular congestion, increase in brain tissue Malondialdehyde and cleaved caspase-3 levels, and decreased Na+-K+-ATPase activity compared to the Control group. Although the Treatment group had comparable histological signs to the Trauma and Solvent-Control groups, Malondialdehyde level and Na+-K+-ATPase activity was similar to Control group, and cleaved caspase-3 levels were lower compared to Trauma and Solvent-Control groups. We conclude that anthocyanin extracts may alleviate secondary brain injury via anti-oxidative and anti-apoptotic mechanisms.

09:50

Anti-inflammatory activity of bilberry. GreenMedInfo

PMID: Curr Issues Mol Biol. 2022 Sep 30 ;44(10):4570-4583. Epub 2022 Sep 30. PMID: 36286028 Abstract Title: Anti-Inflammatory Activity of Bilberry (L.). Abstract: Inflammation is important in the pathogenesis of several chronic diseases. The anti-inflammatory properties of berries have been investigated but the anti-inflammatory activity of bilberry has received little attention and a detailed review is yet to be published. Therefore, we compiled information on the phytochemicals of bilberry and preclinical and clinical studies of its anti-inflammatory properties. The review was based on studies from 2007 to date. Phytoconstituents of bilberries were phenolic acids, organic acids, anthocyanins, coumarins, flavonols, flavanols, tannins, terpenoids, and volatile chemicals. Data from cell and animal model studies show that bilberry has an anti-inflammatory effect by lowering tumor necrosis factor-, interleukin (IL)-6, and IL-1expression, inducing nitric oxide synthases and cyclooxygenases, and altering the nuclear factor kappa B and Janus kinase-signal transducer and activator of transcription signaling pathways. Bilberry supplementation as fruits (frozen, processed, and whole), juices, and anthocyanins reduced levels of inflammatory markers in most clinical studies of metabolic disorders. Therefore, bilberry may be useful for the prevention and treatment of chronic inflammatory disorders.

09:45

Dried bilberry alleviates the inflammation and adverse metabolic effects caused by a high-fat diet. GreenMedInfo

PMID: Int J Mol Sci. 2022 Sep 20 ;23(19). Epub 2022 Sep 20. PMID: 36232316 Abstract Title: Dried Bilberry (L.) Alleviates the Inflammation and Adverse Metabolic Effects Caused by a High-Fat Diet in a Mouse Model of Obesity. Abstract: Obesity is an increasing problem worldwide. It is often associated with co-morbidities such as type II diabetes, atherosclerotic diseases, and non-alcoholic fatty liver disease. The risk of these diseases can be lowered by relieving the systemic low-grade inflammation associated with obesity, even without noticeable weight loss. Bilberry is an anthocyanin-rich wild berry with known antioxidant and anti-inflammatory properties. In the present study, a high-fat-diet-induced mouse model of obesity was used to investigate the effects of air-dried bilberry powder on weight gain, systemic inflammation, lipid and glucose metabolism, and changes in the gene expression in adipose and hepatic tissues. The bilberry supplementation was unable to modify the weight gain, but it prevented the increase in the hepatic injury marker ALT and many inflammatory factors like SAA, MCP1, and CXCL14 induced by the high-fat diet. The bilberry supplementation also partially prevented the increase in serum cholesterol, glucose, and insulin levels. In conclusion, the bilberry supplementation alleviated the systemic and hepatic inflammation and retarded the development of unwanted changes in the lipid and glucose metabolism induced by the high-fat diet. Thus, the bilberry supplementation seemed to support to retain a healthier metabolic phenotype during developing obesity, and that effect might have been contributed to by bilberry anthocyanins.

09:42

Centella asiatica, hyaluronic acid and prebiotic-based gel is effective for preventing recurrent vulvovaginal candidiasis relapse in women of reproductive age. GreenMedInfo

PMID: Clin Med Insights Case Rep. 2023 ;16:11795476231161170. Epub 2023 Mar 16. PMID: 36950702 Abstract Title: Experience With a Non-Hormonal Centella Asiatica, Hyaluronic Acid and Prebiotic-Based Vaginal Gel in Women With Recurrent Vulvovaginal Candidiasis: Case Studies. Abstract: Recurrent vulvovaginal candidiasis (RVVC) affects millions of women worldwide, severely impairing their quality of life. Despite the existence of multiple induction and maintenance therapeutic strategies, mainly based on antifungals, relapse rates are still high. Palomacareis a vaginal gel containing, among others, hyaluronic acid and, with repairing and moisturizing properties. A series of 5 clinical cases showed that symptoms improved and even disappeared in women with RVVC receiving Palomacare. None of the patients experienced recurrence after the treatment, having their vaginal health restored, suggesting that the non-hormonal, hyaluronic acid and prebiotic-based gel is effective for preventing RVVC relapse in women of reproductive age.

09:14

Amazon and Starbucks Sued for Collecting, Retaining, Storing, Converting, Using, Sharing, and Profiting from Palm Scans Health Impact News

Comments by Brian Shilhavy
Editor, Health Impact News

Several consumers in New York have sued Amazon.com and Starbucks for unauthorized use of their palm scans.

Plaintiffs bring this action for damages and other legal and equitable remedies resulting from the illegal actions of Amazon and Starbucks in collecting, retaining, storing, converting, using, sharing, and profiting from Plaintiffsand other similarly situated individuals biometric identifier information (referred to at times as biometrics)their hand geometry (hand geometry or palm scans or palm prints) and/or body geometry (physiological characteristics concern[ing] the shape or composition of the body)in direct violation of the New York City Biometric Identifier Information Law.

On January 11, 2021, the City of New York enacted a new law that requires retailers and other commercial establishments that collect, retain, convert, store, or share customers biometric identifier information to notify their customers of these practices before customers enter those establishments. SeeN.Y.C. Admin. Code 22-1201 et seq.

The type of information the law applies to includes any physiological or biological characteristic that is used to identify (or assist in identifying) a person, such asfacial recognition, retina scans, fingerprints, handprints, or any other identifying characteristic like the shape or size of a persons body. (Source.)

BiometricUpdate.com reported on this.

Amazon and coffee retailer Starbucks are being sued in U.S. federal district court for misusing customers biometric identifiers.

The proposed class action (2:23-cv-00852) has been filed in the Western District Court of Washington. The named plaintiffs, Suzanne Mallouk, Alfredo Rod...

08:01

A defined anthocyanin mixture sourced from bilberry and black currant inhibits Measles virus and various herpesviruses. GreenMedInfo

PMID: BMC Complement Med Ther. 2022 Jul 8 ;22(1):181. Epub 2022 Jul 8. PMID: 35804339 Abstract Title: A defined anthocyanin mixture sourced from bilberry and black currant inhibits Measles virus and various herpesviruses. Abstract: BACKGROUND: Anthocyanin-containing plant extracts and carotenoids, such as astaxanthin, have been well-known for their antiviral and anti-inflammatory activity, respectively. We hypothesised that a mixture of Ribes nigrum L. (Grossulariaceae) (common name black currant (BC)) and Vaccinium myrtillus L. (Ericaceae) (common name bilberry (BL)) extracts (BC/BL) with standardised anthocyanin content as well as single plant extracts interfered with the replication of Measles virus and Herpesviruses in vitro.METHODS: We treated cell cultures with BC/BL or defined single plant extracts, purified anthocyanins and astaxanthin in different concentrations and subsequently infected the cultures with the Measles virus (wild-type or vaccine strain Edmonston), Herpesvirus 1 or 8, or murine Cytomegalovirus. Then, we analysed the number of infected cells and viral infectivity and compared the data to non-treated controls.RESULTS: The BC/BL extract inhibited wild-type Measles virus replication, syncytia formation and cell-to-cell spread. This suppression was dependent on the wild-type virus-receptor-interaction since the Measles vaccine strain was unaffected by BC/BL treatment. Furthermore, the evidence was provided that the delphinidin-3-rutinoside chloride, a component of BC/BL, and purified astaxanthin, were effective anti-Measles virus compounds. Human Herpesvirus 1 and murine Cytomegalovirus replication was inhibited by BC/BL, single bilberry or black currant extracts, and the BC/BL component delphinidin-3-glucoside chloride. Additionally, we observed that BC/BL seemed to act synergistically with aciclovir. Moreover, BC/BL, the single bilberry and black currant extracts, and the BC/BL components delphinidin-3-glucoside chloride, cyanidin-3-glucoside, delphinidin-3-rutinoside chloride, and petunidin-3-galactoside inhibited human Herpesvirus 8 replication.CONCLUSIONS: Our data indicate that Measles viruses and Herpesviruses are differentially susceptible to a specific BC/BL mixture, single plant extracts, purified anthocyanins and astaxanthin. These compounds might be used in the prevention of viral diseases and in addition to direct-acting antivirals, such as aciclovir.

08:00

Happy Hour with Alex Newman Dr. Tenpenny

06-13-2023 Listen to audio here. If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/06-13-23-HHr-AlexNewman.mp4 About my guest: Alex Newman is an award-winning international journalist, []

07:53

Xanthohumol improves cognitive impairment. GreenMedInfo

PMID: Psychopharmacology (Berl). 2023 May ;240(5):1169-1178. Epub 2023 Mar 20. PMID: 36939856 Abstract Title: Xanthohumol improves cognitive impairment by regulating miRNA-532-3p/Mpped1 in ovariectomized mice. Abstract: RATIONALE: Studies have shown the potential neuroprotective effect of xanthohumol, while whether xanthohumol has the ability of repairing cognitive impairment and its underlying mechanism still remains obscure.OBJECTIVES: To unravel the mechanism of xanthohumol repairing cognitive impairment caused by estrogen deprivation.METHODS: C57BL/6 J female mice that underwent bilateral ovariectomy to establish cognitive decline model were randomly divided into three xanthohumol-treated groups and a saline-treated model group. For identifying the neuroprotective function of xanthohumol, Morris water maze (MWM) test and open field test (OFT) were conducted. After extracting total RNA of mouse hippocampus of different groups, mRNA-seq and microRNA (miRNA)-seq analysis were performed, and the differentially expressed miRNAs (DEMIs) and their target genes were further validated by qPCR. MiR-532-3p and its downstream gene Mpped1 were screened as targets of xanthohumol. Influence of miR-532-3p/Mpped1 to cognitive ability was examined via MWM test and OFT after stereotactic brain injection of Mpped1 overexpressed adeno-associated virus. The regulation of miR-532-3p on Mpped1 was confirmed in hippocampal neuronal cell line HT22 by luciferase reporter gene assay.RESULTS: Xanthohumol treatment reversed the cognitive decline of OVX mice according to behavioral tests. By comparing miRNA levels of xanthohumol-treated groups with saline-treated group, we found that the main changed miRNAs were miR-122-5p, miR-532-3p, and miR-539-3p. Increased miR-532-3p in OVX mice was suppressed by xanthohumol treatment. Furthermore, the downstream gene of miR-532-3p, Mpped1, was also increased by xanthohumol and showed the capability of relieving cognitive impairment of OVX mice after overexpressed in hippocampus. The 3' untranslated region of Mpped1 was identified as the target region of miR-532-3p, and agomiR-532-3p remarkably reduced the expression of Mpped1 mRNA.CONCLUSIONS: Xanthohumol has the ability of repairing cognitive impairment through removing the inhibition of miR-532-3p on Mpped1 in mouse hippocampus. This finding not only advances the understanding of neuroprotective mechanism of xanthohumol, but also provides novel treatment targets for dementia of postmenopausal women.

07:46

Mistreated Mental Health Patients Should Be Given Compensation, Public Apology, Report Finds Mad In America

From Australian Broadcasting Corporation: The Victorian government has been accused of trying to force changes to an independent report into the trauma caused by compulsory mental health treatment, with the author claiming he was threatened by department officials.

Last year mental health consultant Simon Katterl, who has lived experience, was contracted by the Department of Health to provide advice to the mental health minister about the impact of compulsory mental health treatments on patients.

The report found that Victorians who had suffered gross human rights violations during mental health treatment against their will should be offered financial redress by the state with a full public apology from the government.

Some people who had a mental illness were subjected to compulsory treatment that included seclusion, restraint and coercive treatment including the use of induced comas.

Author of report claims government demanded changes, made threats

The special report, commissioned by the department to provide advice to the mental health minister, has also called for Victoria to set up a restorative justice process. This would allow consumers people who were patients in the mental health system and carers the chance to publicly detail the trauma they suffered as a result of treatment.

[Katterl has] accused the department of pressuring him to change the recommendations of his report, which he refused to do. A whole series of personal threats were made against me, to prevent me from releasing the report or to change the report, Mr Katterl said.

He said he was told he would not be considered for future work if he did not make changes to the recommendations. He said the department was particularly concerned about the restorative justice process. The state government has distanced itself from the report.

Article

...

07:45

Xanthohumol inhibits non-small cell lung cancer. GreenMedInfo

PMID: Phytother Res. 2023 Mar 7. Epub 2023 Mar 7. PMID: 36882184 Abstract Title: Xanthohumol inhibits non-small cell lung cancer via directly targeting T-lymphokine-activated killer cell-originated protein kinase. Abstract: Xanthohumol is a principal prenylated chalcone isolated from hops. Previous studies have shown that xanthohumol was effective against various types of cancer, but the mechanisms, especially the direct targets for xanthohumol to exert an anticancer effect, remain elusive. Overexpression of T-lymphokine-activated killer cell-originated protein kinase (TOPK) promotes tumorigenesis, invasion and metastasis, implying the likely potential for targeting TOPK in cancer prevention and treatment. In the present study, we found that xanthohumol significantly inhibited the cell proliferation, migration and invasion of non-small cell lung cancer (NSCLC) in vitro and suppressed tumor growth in vivo, which is well correlated with inactivating TOPK, evidenced by reduced phosphorylation of TOPK and its downstream signaling histone H3 and Akt, and decreased its kinase activity. Moreover, molecular docking and biomolecular interaction analysis showed that xanthohumol was able to directly bind to the TOPK protein, suggesting that TOPK inactivation by xanthohumol is attributed to its ability to directly interact with TOPK. The findings of the present study identified TOPK as a direct target for xanthohumol to exert its anticancer activity, revealing novel insight into the mechanisms underlying the anticancer activity of xanthohumol.

07:32

Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis. GreenMedInfo

PMID: Front Pharmacol. 2023 ;14:1105726. Epub 2023 Jan 18. PMID: 36744265 Abstract Title: Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR. Abstract: Severe acute pancreatitis (SAP) is a lethal gastrointestinal disorder, yet no specific and effective treatment is available. Its pathogenesis involves inflammatory cascade, oxidative stress, and autophagy dysfunction. Xanthohumol (Xn) displays various medicinal properties, including anti-inflammation, antioxidative, and enhancing autophagic flux. However, it is unclear whether Xn inhibits SAP. This study investigated the efficacy of Xn on sodium taurocholate (NaT)-induced SAP (NaT-SAP)and. First, Xn attenuated biochemical and histopathological responses in NaT-SAP mice. And Xn reduced NaT-induced necrosis, inflammation, oxidative stress, and autophagy impairment. The mTOR activator MHY1485 and the AKT activator SC79 partly reversed the treatment effect of Xn. Overall, this is an innovative study to identify that Xn improved pancreatic injury by enhancing autophagic fluxinhibition of AKT/mTOR. Xn is expected to become a novel SAP therapeutic agent.

06:32

Mexicos Proposed Ban on GM Corn Angers the U.S. and Canada Medical Kidnap

Mexican Heirloom Corn varieties are in danger from GM corn imports from the U.S. and Canada. Image source.

by Brian Shilhavy
Editor, Health Impact News

Certain states in Mexico have banned the planting and cultivation of genetically modified corn from the U.S. in recent years, in order to preserve heirloom varieties of corn (maize) that have existed in Mexico for thousands of years.

In 2022, Mexico proposed a ban on imports of GM corn as a country, and now the U.S. and Canada are teaming up to protest and to try and force Mexico to keep importing GM corn.

The AP reported last week:

Canada joins US in trade dispute hearings against Mexicos proposed ban on GM corn

MEXICO CITY (AP) Canada said Friday it will join a trade dispute panel that the United States requested over Mexicos proposed limits on imports of genetically modified corn.

The U.S. government asked that the dispute process be formally opened on June 2, after talks with the Mexican government failed to yield results.

The panel of experts would have about half a year to study the complaint and release its findings. Trade sanctions could follow if Mexico is found to have violated the U.S.-Mexico Canada free trade agreement.

Mexico wants to ban GM corn for human consumption, and perhaps eventually ban it for animal feed as well, something that both its northern partners say would damage trade and violate USMCA requirements that any health or safety standards be based on scientific evidence.

Canada shares the concerns of the U.S. that Mexicos measures are not scientifically supported and have the potential to unnecessarily disrupt trade in the North American market, Canadas Ministry of Agriculture and Agri-Food said in a statement.

Mexico is the leading importer of U.S. yellow corn, most of which is genetically modified. Almost all is fed to cattle, pigs and chickens in Mexico, which doesnt grow enough feed corn. Corn for human consumption in Mexico is almost entirely domestically-grown white corn, though corn-meal chips or other processed products could p...

06:32

Mexicos Proposed Ban on GM Corn Angers the U.S. and Canada Vaccine Impact

Mexican Heirloom Corn varieties are in danger from GM corn imports from the U.S. and Canada. Image source.

by Brian Shilhavy
Editor, Health Impact News

In 2022, Mexico proposed a ban on imports of GM corn as a country, and now the U.S. and Canada are teaming up to protest and to try and force Mexico to keep importing GM corn.

The AP reported last week:

Canada joins US in trade dispute hearings against Mexicos proposed ban on GM corn

MEXICO CITY (AP) Canada said Friday it will join a trade dispute panel that the United States requested over Mexicos proposed limits on imports of genetically modified corn.

The U.S. government asked that the dispute process be formally opened on June 2, after talks with the Mexican government failed to yield results.

The panel of experts would have about half a year to study the complaint and release its findings. Trade sanctions could follow if Mexico is found to have violated the U.S.-Mexico Canada free trade agreement.

Mexico wants to ban GM corn for human consumption, and perhaps eventually ban it for animal feed as well, something that both its northern partners say would damage trade and violate USMCA requirements that any health or safety standards be based on scientific evidence.

Canada shares the concerns of the U.S. that Mexicos measures are not scientifically supported and have the potential to unnecessarily disrupt trade in the North American market, Canadas Ministry of Agriculture and Agri-Food said in a statement.

Mexico is the leading importer of U.S. yellow corn, most of which is genetically modified. Almost all is fed to cattle, pigs and chickens in Mexico, which doesnt grow enough feed corn. Corn for human consumption in Mexico is almost entirely domestically-grown white corn, though corn-meal chips or other processed products could p...

06:25

Highly cited Lancet long COVID study retracted and republished Retraction Watch

One of the first studies of long COVID has been retracted and replaced seven months after editors marked it with an expression of concern citing data errors.

The original paper, 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study, was published in The Lancet in January 2021. It was the first large cohort study with 6-months follow-up of people hospitalized with COVID-19, according to an editorial published simultaneously, and has been cited more than 2,000 times, according to Clarivates Web of Science. The World Health Organization, for example, cited it in several documents.

Last November, the article received an expression of concern stating that a researcher had contacted the journal about inconsistencies between that study and a paper published in August 2021, also in The Lancet, describing the same cohort of patients after one year of follow up.

In view of the extent of these data errors, the notice stated, the journal editors issued the expression of concern while they conducted a review of corrected data the papers authors had submitted.

Following the expression of concern, the work was cited by some 400 other papers.

After their investigation, the editors decided to retract the article and replace it with a corrected version, according to a...

06:13

Polio vaccine does not cause cancer another anti-vax myth debunked Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

There is anti-vax claim that the polio vaccine causes cancer. There is no evidence supporting the claim, it's another myth debunked.

Skeptical Raptor

06:02

Mexicos Proposed Ban on GM Corn Angers the U.S. and Canada Health Impact News

Mexican Heirloom Corn varieties are in danger from GM corn imports from the U.S. and Canada. Image source.

by Brian Shilhavy
Editor, Health Impact News

In 2022, Mexico proposed a ban on imports of GM corn as a country, and now the U.S. and Canada are teaming up to protest and to try and force Mexico to keep importing GM corn.

The AP reported last week:

Canada joins US in trade dispute hearings against Mexicos proposed ban on GM corn

MEXICO CITY (AP) Canada said Friday it will join a trade dispute panel that the United States requested over Mexicos proposed limits on imports of genetically modified corn.

The U.S. government asked that the dispute process be formally opened on June 2, after talks with the Mexican government failed to yield results.

The panel of experts would have about half a year to study the complaint and release its findings. Trade sanctions could follow if Mexico is found to have violated the U.S.-Mexico Canada free trade agreement.

Mexico wants to ban GM corn for human consumption, and perhaps eventually ban it for animal feed as well, something that both its northern partners say would damage trade and violate USMCA requirements that any health or safety standards be based on scientific evidence.

Canada shares the concerns of the U.S. that Mexicos measures are not scientifically supported and have the potential to unnecessarily disrupt trade in the North American market, Canadas Ministry of Agri...

06:00

Ep 488 Health span vs. Age span The future is now Dr Ron Unfiltered Uncensored

With the future of medicine now using frequency healing, we also have some bio hacks to help us live young to an old age. Today is part 5 of antiaging.

04:48

From Ryan White to the Biden White House Age of Autism The Rebel Alliance!

Who remembers Ryan White, a boy with HIV who had to fight to attend school? Ryan's law was passed in 1990, to prevent discrimination against people with HIV. We call them Human Beings. I saw a Tweet yesterday, Princess Diana shaking the hand and hugging a man with advanced AIDS at a time when people with AIDS were considered the lepers (more on leprosy in a moment) in the 1980s. The photo was scandalous.

One of the lighter moments a President gets to preside over is inviting winning athletes to celebrate their prowess. I think President Trump made the news for serving Big Macs instead of fancy food, didn't he? He sure knew his audience. The 2023 Biden White House discriminated against the College Athlete Day participants who were not vaccinated for Covid. They had to socially distance and wear a mask. That makes for a nice photo op, doesn't it? Photographer says, "Hey you in the mask, can you scoot over a bit to fit in the shot," and a White House staffer screams, "Stay away!!!" ( I made that up.)

Unvaccinated, healthy, vigorous, successful college athletes were made to drink from a separate water fountain. And I do not bring up Jim Crow law horrors glibly. That WAS America. Blacks lived in a parallel America. Separate and unequal. Whites praised the vile treatment. People with HIV AIDS lived in a shameful America. Isolated. Feared. And people without a Covid vaccine are still being subjected to a discrimination condoned and encouraged by the Medical Community, Public Health and those at the highest levels of government. The President of the United States.

Oh, the Leprosy mention? The CDC has worked hard to end the stigma of this biblical scourge. People with leprosy who are being treated with antibiotics can live a normal life among their family and friends and can continue to attend work or school. But your healthy, under or unvaccinated students can NOT. Remember this. Forever.

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04:00

Dehydration

The most important substance a person needs to survive (after air) is water. Up to 60 percent of the human body is comprised of it. Indeed, youd be lucky to survive more than three days without some good old H2O. In the coming dog days of summer, maintaining water status (hydration) will be imperative if[Read More]

The post Dehydration first appeared on .

02:52

7 Ways on How to Get Moisture Out of Headlights Waking Science

Not only does it make them appear unsightly, having moisture in your headlights can have a significant impact on nighttime vision and therefore has real consequences for your safety. This could happen due to a minor flaw during installation or perhaps the moisture has seeped in over time. Either way, this is typically a fairly easy problem to fix. You can restore the original condition of your headlights if you act quickly.

If you happen to notice that there is moisture in your headlights or that you arent getting the quality of night vision that youre used to, follow these different ways on how to get moisture out of headlights:

1. Understanding the impact moisture has on your headlights

Before we get into the details of how to remove it, lets take a look at why it is important to eliminate headlight moisture in the first place. When it comes to driving at night in particular, moisture can dim headlights and potentially even produce blind spots if left unattended for too long.

As this clearly has an impact on the cars ability to function safely, it could also mean that the vehicle wont be able to pass a basic safety inspection and that you could even be pulled over for not meeting the safety standards of a road-worthy car.

2. Avoid breaking the seal

As you work to get moisture out of the headlights, be careful about breaking the seal. Until you understand the extent of the problem, it is best not to immediately go ahead and break the seal around the headlight when trying to determine the cause of the moisture. Keep in mind that it will be fairly easy to break the seal between the headlight lens and the housing but fixing it and getting the seal secured again is a more complicated matter.

If youre not able to create a firm seal, youll simply end up with the same problem (if not worse down the road. If youre comfortable working with sealant, it can still be an at-home repair job but read on to ensure you check out all your options before making things more complicated tha...

02:35

NIMHs It-girls: The Genain Quadruplets and the Whiteness of Psychiatry Mad In America

Their picture graces countless textbooks, a haunting image of madness multiplied. Writing for Mad in America in 2019, Patrick Hahn called their case a sad and sordid tale, but also the most celebrated one in psychiatric genetics.

The Genain quadruplets were a set of identical sisters diagnosed with schizophrenia in their twenties in the 1950s, catching the attention of researchers at the newly formed National Institute of Mental Health (NIMH). The institutes scientific director, Seymour Kety, was then studying the role of genetics in the development of schizophrenia. A neuroscientist by training, Kety believed that the brain held clues to geneticsand that examining twins in which one or more had a schizophrenia diagnosis could prove fruitful.

When the researchers first learned of the foursome from Lansing, Michigan whod all been found to have the mental illness, they could hardly help but wonder what further proof of a genetic etiology of schizophrenia anyone would want to have, in the words of NIMH psychologist David Rosenthal. After three years of psychiatric evaluations, doll play, handwriting analyses, Rorschach tests, electroencephalography, galvanic skin response tests, and more, they adopted a more measured theory, which Rosenthal outlined in his 1963 edited book, The Genain Quadruplets: A Case Study and Theoretical Analysis of Heredity and Environment in Schizophrenia: The sisters suffered from an unhappy collusion of nature and nurture. Theyd inherited some predisposition to illness, then been subjected to a thoroughly pathogenic home. Both of their parents practiced irrationality and wielded control over every aspect of their lives. There were also vertical and horizontal identification patterns within the family, meaning that the quadruplets over-identified with their parents and one another.

As Hahn notes, the fact that all four were reportedly sexually assaulted did seem to not strike the books contributors as consequential, and the pseudonym assigned to themmeaning dire birthprioritized genetics. Over the decades, as tragedy forced Rosenthal into retirement and NIMHs psychology laboratory capitulated to the brain sciences, researchers became more decided that biology was primarily to blame, fashioning the sisters into the poster children of psychiatric genetics. Their case is now invoked to illustrate the primacy of heredity, though, as Hahn writes, it reveals much more about its chroniclers than about its intended subjects.

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23:31

he effect of metformin on some cardiovascular outcomes was not significantly better than the non-metformin therapy or DPP-4i in T2DM patients based on observational studie GreenMedInfo

PMID: Front Cardiovasc Med. 2022 ;9:944902. Epub 2022 Sep 23. PMID: 36211585 Abstract Title: Effect of metformin on adverse outcomes in T2DM patients: Systemic review and meta-analysis of observational studies. Abstract: BACKGROUND: The cardiovascular protection effect of metformin on patients with type 2 diabetes mellitus (T2DM) remains inconclusive. This systemic review and meta-analysis were to estimate the effect of metformin on mortality and cardiovascular events among patients with T2DM.METHODS: A search of the Pubmed and EMBASE databases up to December 2021 was performed. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled by a random-effects model with an inverse variance method.RESULTS: A total of 39 studies involving 2473009 T2DM patients were adopted. Compared to non-metformin therapy, the use of metformin was not significantly associated with a reduced risk of major adverse cardiovascular event (MACE) (HR = 1.06, 95%CI 0.91-1.22;= 82%), hospitalization (HR = 0.85, 95%CI 0.64-1.13;= 98%), heart failure (HR = 0.86, 95%CI 0.60-1.25;= 99%), stroke (HR = 1.16, 95%CI 0.88-1.53;= 84%), and risk of AMI (HR = 0.88, 95%CI 0.69-1.14;= 88%) in T2DM patients. Metformin was also not associated with significantly lowered risk of MACE compared to dipeptidyl peptidase-4 inhibitor (DPP-4i) in T2DM patients (HR = 0.95, 95%CI 0.73-1.23;= 84%).CONCLUSIONS: The effect of metformin on some cardiovascular outcomes was not significantly better than the non-metformin therapy or DPP-4i in T2DM patients based on observational studies.

23:00

Morning Coffee Jun 13, 2023 Dr. Tenpenny

06-13-2023 Audio Track: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/6-13-2023-Morn-coffee-5docs.mp4 In this episode of Morning Coffee, I talk a bit about detoxification []

21:30

How To Use Limes Or Lemons and Cloves To Repel Mosquitoes All Summer Long (Without The Harmful Cancerous Chemicals in Off Spray) Healthy Holistic Living

Every summer, across the globe, humans brace for the arrival of one of their tiniest, yet most troublesome enemies mosquitoes. According to the World Health Organization, mosquitoes are the deadliest creatures on the planet, responsible for millions of deaths annually, mostly due to malaria. In addition to this, they transmit several diseases such as Zika virus, dengue, and yellow fever. Their peak seasonality varies by region but usually aligns with warmer weather and rainy seasons, which provide ideal conditions for breeding.

Commercial repellents are the standard go-to solution, but many of these, such as those containing DEET, present a number of health concerns. Studies have linked DEET to potential risks, including skin irritation, neurotoxicity, and even cancer. These findings have prompted many individuals to seek safer, natural alternatives to ward off these pesky insects.

Environmental Working Group identifies DEET (in concentrations less than 30 percent) as one of its top picks to reduce the risk of life-altering disease from tick and mosquito bites with low toxicity concerns. But the organization stresses that precaution and proper application is essential. It also IDs science-backed DEET-free options.

Although studies indicate mixed results, there is some evidence that DEET contains carcinogenic properties that can produce dangerous effects when inhaled or applied to the skin. Scientists in Germany investigated the genotoxic effects of three widely used pesticides, including DEET. When cells from tissue biopsies were exposure to DEET for 60 minutes, the pesticide displayed potential carcinogenic effects in human nasal mucosal cells. (...

21:05

An Epic Biography Filled with Drama, Conflict, and Surmounted Challenges. Age of Autism The Rebel Alliance!

The Real RFK Jr biography written by Dick Russell from Skyhorse Publishing debuts on June 20th. This book would be important even if Robert Kennedy Jr was not running for the Democratic nomination for the office of President of the United States. Pre-sales MATTER in publishing. Click and buy your copies today. Share with friends, family, Little Free Libraries.

Kennedy has been a stalwart champion for the underdog for decades. And Lord knows, we're included in the underdog category. The description sounds a lot like our lives, "An epic biography filled with drama, conflict, and surmounted challenges."

From the publisher:

The Real RFK Jr. is an intimate biographical portrait examining the controversial activist's journey from anguish and addiction to becoming the country's leading environmental champion fighting government corruption, corporate greed, and a captured media. Written by his longtime colleague Dick Russell, the biography also exposes the misconceptions and explains the rationale behind Kennedy's campaign to protect public health.

Provided exclusive source material, including access to Kennedys unpublished writings and personal journals, the author conducted dozens of interviews with him as well as numerous friends and associates. Russell delves into everything from Kennedys sometimes death-defying river rafting adventures to his pioneering legal cases against polluters such as Smithfield Foods and Monsanto, while founding the worlds largest water protection group. The Real RFK Jr. also examines Kennedys pursuit of the truth about the assassinations of his father and uncle, the wrongful murder conviction of his cousin, and the false narratives around the COVID-19 pandemic.
...

12:06

Apocynin abrogates methotrexate-induced nephrotoxicity. GreenMedInfo

PMID: Arch Pharm Res. 2023 Apr ;46(4):339-359. Epub 2023 Mar 13. PMID: 36913116 Abstract Title: Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-B-p65/p38-MAPK, IL-6/STAT-3, PPAR-, and SIRT1/FOXO3 signaling pathways. Abstract: The present study was designed to evaluate the potential renoprotective impacts of apocynin (APC) against nephrotoxicity induced by methotrexate (MTX) administration. To fulfill this aim, rats were allocated into four groups: control; APC (100 mg/kg/day; orally); MTX (20 mg/kg; single intraperitoneal dose at the end of the 5th day of the experiment); and APC+MTX (APC was given orally for 5 days before and 5 days after induction of renal toxicity by MTX). On the 11th day, samples were collected to estimate kidney function biomarkers, oxidative stress, pro-inflammatory cytokines, and other molecular targets. Compared to the MTX control group, treatment with APC significantly decreased urea, creatinine, and KIM-1 levels and improved kidney histological alterations. Furthermore, APC restored oxidant/antioxidant balance, as evidenced by a remarkable alleviation of MDA, GSH, SOD, and MPO levels. Additionally, the iNOS, NO, p-NF-B-p65, Ace-NF-B-p65, TLR4, p-p38-MAPK, p-JAK1, and p-STAT-3 expressions were reduced, while the IB, PPAR-, SIRT1, and FOXO3 expressions were significantly increased. In NRK-52E cells, MTX-induced cytotoxicity was protected by APC in a concentration-dependent manner. In addition, increased expression of p-STAT-3 and p-JAK1/2 levels were reduced in MTX-treated NRK-52E cells by APC. The in vitro experiments revealed that APC-protected MTX-mediated renal tubular epithelial cells were damaged by inhibiting the JAK/STAT3 pathway. Besides, our in vivo and in vitro results were confirmed by predicting computational pharmacology results using molecular docking and network pharmacology analysis. In conclusion, our findings proved that APC could be a good candidate for MTX-induced renal damage due to its strong antioxidative and anti-inflammatory bioactivities.

11:12

Restless legs syndrome: What you need to know | 2 Chipur

You were pretty sure you had it. Still, it was good to get the diagnosis. Are you looking for more restless legs syndrome info? Maybe cause, treatment? Heres what you need to know

The post Restless legs syndrome: What you need to know | 2 first appeared on Chipur.

11:04

Inhibition of oxidative stress by apocynin attenuated chronic obstructive pulmonary disease progression. GreenMedInfo

PMID: Br J Pharmacol. 2023 Mar 12. Epub 2023 Mar 12. PMID: 36908040 Abstract Title: Inhibition of oxidative stress by apocynin attenuated chronic obstructive pulmonary disease progression and vascular injury by cigarette smoke exposure. Abstract: BACKGROUND AND PURPOSE: Cardiovascular disease affects up to half of the patients with chronic obstructive pulmonary disease (COPD), exerting deleterious impact on health outcomes and survivability. Vascular endothelial dysfunction marks the onset of cardiovascular disease. The present study examined the effect of a potent NADPH Oxidase (NOX) inhibitor and free-radical scavenger, apocynin, on COPD-related cardiovascular disease.EXPERIMENTAL APPROACH: Male BALB/c mice were exposed to either room air (Sham) or cigarette smoke (CS) generated from 9 cigarettesday, 5 days a week for up to 24weeks with or without apocynin treatment (5 mgkgday, intraperitoneal injection).KEY RESULTS: Eight-weeks of apocynin treatment reduced airway neutrophil infiltration (by 42%) and completely preserved endothelial function and endothelial nitric oxide synthase (eNOS) availability against the oxidative insults of cigarette smoke exposure. These preservative effects were maintained up until the 24-week time point. 24-week of apocynin treatment markedly reduced airway inflammation (reduced infiltration of macrophage, neutrophil and lymphocyte), lung function decline (hyperinflation) and prevented airway collagen deposition by cigarette smoke exposure.CONCLUSION AND IMPLICATIONS: Limiting NOX activity may slow COPD progression and lower cardiovascular disease risk, particularly when signs of oxidative stress become evident.

10:50

Combination therapy of niacin and apocynin attenuates lung injury during sepsis. GreenMedInfo

PMID: J Surg Res. 2023 May ;285:51-58. Epub 2023 Jan 12. PMID: 36640610 Abstract Title: Combination Therapy of Niacin and Apocynin Attenuates Lung Injury During Sepsis in Rats. Abstract: INTRODUCTION: Oxidative stress contributes to tissue injury through reactive oxygen species-dependent signaling pathways during sepsis. We studied therapeutic benefits of the combination therapy of niacin, which increased reduced glutathione levels, and apocynin, which suppressed reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) activity, in septic rats.MATERIALS AND METHODS: Polymicrobial sepsis was induced through cecal ligation and puncture (CLP) with antibiotics in male Sprague-Dawley rats (n = 189). The rats were randomly divided into sham, CLP, CLP + niacin, CLP + apocynin, and CLP + niacin + apocynin groups. Six hours after CLP, vehicle, niacin (360 mg/kg through the orogastric tube), and/or apocynin (20 mg/kg through intraperitoneal injection) were administered. The occurrence of mortality for 72 h after CLP was observed. Next, a separate set of animals was euthanized at 24 h post-CLP for lung tissue analyses.RESULTS: Combination therapy with niacin and apocynin significantly improved survival in rats with sepsis (75.0% versus 28.8%, P = 0.006) but monotherapy with niacin or apocynin did not. Monotherapy with niacin and apocynin appeared to increase NADPH levels and decrease Nox levels and activity, respectively, but failed to show statistical significances. However, combination therapy significantly decreased Nox levels and activity, increased NADPH and glutathione levels, decreased intranuclear nuclear factor-B (NF-B) p65 levels, reduced inflammatory cytokine expression and malondialdehyde levels, and attenuated histological lung injuries.CONCLUSIONS: Combination therapy with niacin and apocynin synergistically attenuated lung injuries and improved survival in rats with sepsis through niacin-induced glutathione redox cycle activation and apocynin-induced Nox suppression.

10:47

Apocynin-loaded PLGA nanomedicine tailored with galactosylated chitosan intrigue asialoglycoprotein receptor in hepatic carcinoma. GreenMedInfo

PMID: Int J Pharm. 2023 Jan 25 ;631:122536. Epub 2022 Dec 23. PMID: 36572262 Abstract Title: Apocynin-loaded PLGA nanomedicine tailored with galactosylated chitosan intrigue asialoglycoprotein receptor in hepatic carcinoma: Prospective targeted therapy. Abstract: Nature serves as a priceless source for phytomedicines to treat different types of cancer, including hepatocellular carcinoma (HCC). Apocynin (APO), an anti-cancer phytomedicine, is a particular nicotinamide adenine dinucleotide phosphate-oxidase (NADPH-oxidase) inhibitor, which has recently dawned for its multilateral pharmacological activities. As far as we are aware, no investigation has been carried out yet to develop a targeted-nanostructured delivery system of APO to HCC. Consequently, chitosan derivative with galactose groups namely; galactosylated chitosan (GC), particularly recognized by the asialoglycoprotein receptor (ASGR), was synthesized and its chemical structure was thoroughly characterized by substantial techniques. Afterwards, GC-coated nanoplatform for hepatocyte attachment "APO-loaded galactosylated chitosan-coated poly(d,l-lactide-co-glycolide) nanoparticles (APO-loaded GC-coated PLGA NPs)" was developed. The prosperous APO-loaded GC-coated PLGA NPs would be comprehensively appraised through extensive investigations. Their solid state characterization using Fourier transform-infrared spectroscopy, powder X-ray diffraction, and differential scanning calorimetry proved APO's encapsulation in the polymeric matrix. Transmission electron microscopy imaging of the investigated NPs highlighted their spherical architecture with a nanosized range and a characteristic halo-like appearance traceable to the GC coating of the NPs' surface. Saliently, the results of in vitro cytotoxicity screening revealed the spectacular anti-cancer efficacy of APO-loaded GC-coated PLGA NPs formula against the HepG2 cell line. Moreover, the fluorescence microscope disclosed the distinguished cellular uptake of such formula via ASGPR mediated endocytosis. Inclusively, a multifunctional nano-phytomedicine delivery system with a promising active hepatocyte-targeting, effective uptake into HepG2 cells, and sustained drug release pattern was successfully developed.

10:42

Apocynin and its chitosan nanoparticles attenuated cisplatin-induced multiorgan failure. GreenMedInfo

PMID: Life Sci. 2023 Feb 1 ;314:121313. Epub 2022 Dec 22. PMID: 36565813 Abstract Title: Apocynin and its chitosan nanoparticles attenuated cisplatin-induced multiorgan failure: Synthesis, characterization, and biological evaluation. Abstract: Cisplatin (CDDP) is an effective chemotherapeutic drug that has been used successfully in treating various tumors. Although its higher antineoplastic agent activity, CDDP exhibited severe side effects that limit its use. CDDP-induced toxicity is attributed to oxidative stress and inflammation. Apocynin (APO) is a bioactive phytochemical with potent antioxidant and anti-inflammatory properties. However, pharmaceutical experts face significant hurdles due to the limited bioavailability and quick elimination of APO. Therefore, we synthesized a chitosan (CTS)-based nano delivery system using the ionic gelation method to enhance APO bioactivity. CTS-APO-NPs were characterized using different physical and chemical approaches, including FTIR, XRD, TGA, Zeta-sizer, SEM, and TEM. In addition, the protective effect of CTS-APO-NPs against CDDP-induced nephrotoxicity, hepatotoxicity, and cardiotoxicity in rats was evaluated. CTS-APO-NPs restored serum biomarkers and antioxidants to their normal levels. Also, histopathological examination was used to assess the recovery of heart, kidney, and liver tissues. CTS-APO-NPs attenuated the oxidative stress mediated by Nrf2 activation while it dampened inflammation mediated by NF-B suppression. CTS-APO-NPs is a potentially attractive target for more therapeutic trials.

10:38

Effects of apocynin on sciatic nerve injury. GreenMedInfo

PMID: Biotech Histochem. 2023 Apr ;98(3):172-178. Epub 2022 Nov 28. PMID: 36440649 Abstract Title: Effects of apocynin on sciatic nerve injury in rabbits. Abstract: We investigated the effects of apocynin (APO) on experimental sciatic nerve compression injury in rabbits. We used 21 male rabbits divided randomly into three groups of seven. The control group was subjected to sciatic nerve compression with no further intervention. The APO treated group was subjected to compression injury and 20mg/kg APO was administered daily for 21days by intraperitoneal injection beginning the day after the injury. The sham group was treated with APO without injury. The control group exhibited shrinkage of axons, disruption of myelin sheaths and loss of nerve fibers. The damage for the control group was significantly greater than for the sham group. The severity of histopathology was decreased in the APO treated group compared to the control group, as was the oxidative stress index. Our findings suggest that APO treatment may contribute to healing of sciatic nerve damage.

10:16

Apocynin prevents medullary respiratory neurodegeneration and respiratory pattern dysfunction. GreenMedInfo

PMID: Neuroscience. 2022 Oct 15 ;502:91-106. Epub 2022 Aug 4. PMID: 35934251 Abstract Title: Oxidative Stress Inhibition Via Apocynin Prevents Medullary Respiratory Neurodegeneration and Respiratory Pattern Dysfunction in a 6-Hydroxydopamine Animal Model of Parkinson's Disease. Abstract: Parkinson's Disease (PD) is a neurogenerative disorder characterized by the death of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc), leading to motor, cognitive, learning, and respiratory dysfunctions. New evidence revealed that breathing impairment in PD mainly results from oxidative stress (OS) that initiates apoptotic signaling in respiratory neurons. Here, we investigated the role of OS inhibition using apocynin (non-specific NADPH oxidase inhibitor) in a 6-OHDA PD animal model in the neural control of breathing. The PD model was confirmed with a 70% reduction in TH-expressing neurons within the SNpc. After 20 and 40days of PD induction, no differences were observed in superoxide anion levels in any respiratory nuclei. At 30days after PD induction, 6-OHDA animals presented OS that was prevented in all respiratory nuclei by adding apocynin to the drinking water for 10days. Forty days after PD animal model induction, impaired motor and breathing function, reduced Phox2b and NK1 receptors-expressing neurons in the medullary respiratory areas; decreased latency to fall in the rotarod motor test; and attenuated respiratory frequency and minute ventilation parameters at rest and under hypercapnia conditions were observed. After 20days of apocynin treatment, neurodegeneration of respiratory nuclei and breathing dysfunction in 6-OHDA animals were prevented. Thus, OS contributes to respiratory neuron death, consequently leading to breathing dysfunction in the 6-OHDA PD animal model. Furthermore, these results present a new perspective for preventing the onset and progression of PD-related respiratory impairments.

10:02

Apocynin reduces cytotoxic effects of monosodium glutamate in the brain. GreenMedInfo

PMID: Spectrochim Acta A Mol Biomol Spectrosc. 2022 Oct 15 ;279:121495. Epub 2022 Jun 9. PMID: 35700610 Abstract Title: Apocynin reduces cytotoxic effects of monosodium glutamate in the brain: A spectroscopic, oxidative load, and machine learning study. Abstract: Herein, we examined the modulatory effects ofApocynum (APO) on Monosodium Glutamate (MSG)-induced oxidative damage on the brain tissue of rats after long-term consumption of blood serum components by biochemical assays, Fourier transform infrared spectroscopy(FTIR), and machine learning methods. Sprague-Dawley male rats were randomly divided into the Control, Control + APO, MSG, and MSG + APO groups (n = 8 per group). All administrations were made by oral gavage saline, MSG, or APO and they were repeated for 28 days of the experiments. Brain tissue and blood serum samples were collected and analyzed for measurement levels ofmalondialdehyde (MDA),glutathione (GSH),myeloperoxidase (MPO), superoxide dismutase (SOD) activity, and Spectroscopic analysis. After 29 days, the results were evaluated using machine learning (ML). The levels of MDA and MPO showed changes in the MSG and MSG + APO groups, respectively. Changes in the proteins and lipids were observed in the FTIR spectra of the MSG groups. Additionally, APO in these animals improved the FTIR spectra to be similar to those in the Control group. The accuracy of the FTIR results calculated by ML was 100%. The findings of this study demonstrate that Apocynin treatment protectsagainst MSG-induced oxidative damage by inhibitingreactive oxygen speciesand upregulatingantioxidant capacity, indicating its potential in alleviatingthe toxic effects of MSG.

10:00

COVID Shots Associated With Increased Risk of Blindness Articles

While U.S. health agencies have admitted that myocarditis (heart inflammation), and a related condition called pericarditis (inflammation of the heart sack), are potential side effects of the COVID jab,¹ the U.S. Centers for Disease Control and Prevention has ignored hundreds of other safety signals that have shown up during their Proportional Reporting Ratio (PRR) data mining of the Vaccine Adverse Event Reporting System (VAERS).

For example, in individuals aged 18 and older, there are 770 safety signals for different adverse events, and more than 500 of them have a stronger safety signal than myocarditis and pericarditis.²

Range of Eye Problems Reported Post-Jab

The broad range of reported side effects is also astounding. They involve just about every part, organ and system of the body, including a range of eye problems. For example, looking at the list of reported side effects in 18-and-over age group in the CDCs PRR document,³ we find:

Ocular discomfort

Eye contusions (bruising)

Eye color change

Eyelid sensory disorder

Hypoesthesia eye (numbness of the eye, typically resulting from nerve damage and/or blood clots that result in tissue damage)

Retinal vein occlusion (blood clot in the vein that carries deoxygenated blood from your retina back to your heart)

Retinal artery occlusion (blood clot in the artery that feeds blood to your retina)

Eye hemorrhage

Retinal migraine (a retinal disease accompanied by migraine caused by ischemia or vascular spasm in or behind the affected eye; bouts can cause diminished vision or temporary blindness)

Ophthalmic migraine (a nervous system problem typically involving the third, fourth or sixth cranial nerves that allow for various eye movements; the condition is associated with severe headache and pain around the eyes; double vision is common during bouts)

Ophthalmic Vascular Events Linked to COVID Jab

Two recent papers specifically highlight the risk of ophthalmic vascular events, which can lead to blindness, following the COVID jab. Basically, what were talking about are acute ischem...

How to Support Long-Term Fertility of Your Soil Articles

Fertile soil is a key to life on Earth. While industrial agriculture has decimated soil fertility via the use of destructive plowing, overgrazing and the use of carbon-depleting chemical fertilizers and pesticides, for decades researchers have been inspired by terra preta de Indio, or dark earth of the Indians.¹

This soil, found in the Amazon basin, is thought to be hundreds or thousands of years old and its among the most fertile soil in the world. This is despite the fact that its in a tropical location, where large amounts of rainfall can cause nutrient runoff that leaves soil depleted.

Theres much debate and research over what makes terra preta so fertile, but one theory has to do with biochar, a soil amendment similar to charcoal that can boost the carbon content of your soil while enhancing nutrient availability and retention.² Carbon sequestration can reduce the carbon dioxide load in the atmosphere, and once sequestered in the soil, the carbon actively nourishes soil health and improves water retention.

The Mechanisms Behind Long-Term Soil Fertility

Writing in Medium, Austin Liu, principal biochar investigator at the Local Carbon Network, delves into how water-soluble nutrients are retained and exchanged in soil and why this is so important for the health of your soil. The reason why tropical soils tend to be poor for agriculture is because plants use water to absorb and transport nutrients water-soluble nutrients.

These water-soluble nutrients are prone to leaching whenever soil is saturated with water, by rain or irrigation. Applying chemical fertilizers isnt any help, as they, too, are water-soluble. Liu explains:³

What then is the difference between a soil that can retain water soluble plant nutrients and one which cannot? The difference is each soils ion exchange capacity cation exchange capacity for positive ions and anion exchange capacity for negative ions. Since the major water soluble plant nutrients are all ionic, the ability to capture and exchange ions results in the ability to capture and release water soluble nutrients.

High cation exchange capacity, or CEC, and anion exchange capacity, or AEC, are metrics of fertile soil. Cations have a positive charge while anions have a negative charge. Liu listed several examples of cation plant nutrients, which include potassium, magnesium, calcium, ammonium, iron, selenium and zinc.

Major anion nutrients include nitrate, phosphate, sulfate and chloride. Liu explains what this means in terms of keeping nutrients in your soil, rather than having them run off:^...

Benefits of Going Organic Articles

Editor's Note: This article is a reprint. It was originally published January 9, 2018.

Many people want to lead a healthier lifestyle but aren't sure where to start. In the realm of diet, in fact, most Americans (52%) believe it's easier to calculate their income taxes than figure out what to eat to stay healthy.¹ It shouldn't feel this hard, which is why I want to give you one tangible step you can take to overhaul your diet, and lifestyle, for the better: Go organic.

A survey by the Organic Trade Association revealed that, in 2017, Americans bought more organic foods and household products than ever, with sales reaching $47 billion in 2016 an 8% increase from 2015.² Katherine Paul, associate director of the Organic Consumers Association (OCA), said in a news release, " I think you are looking at a better-educated population that is connecting the dots between what they eat and their health."³

This is true, indeed, and organic products are now available in close to 20,000 natural food stores and 3 out of 4 conventional grocery stores in the U.S.

Even the U.S. Department of Agriculture acknowledges their staying power in the marketplace, noting "Organic products have shifted from being a lifestyle choice for a small share of consumers to being consumed at least occasionally by a majority of Americans."⁴ But despite the gains in popularity, organic sales account for only about 6% of total U.S. food sales in 2023.⁵

Avoiding Pesticides Is the No. 1 Reason People Buy Organic

"Polling shows the No. 1 reason people go organic is to avoid pesticides, chemicals and all of those things that are not allowed in organics," Paul said,⁶ and this is a primary reason why going organic is so important for your health and the environment. Not only do these chemicals threaten the Earth as we know it, but they pose a direct risk to human health, including to developing babies.

In research presented at a 2017 Children's Environmental Health Network (CEHN) conference in Washington, D.C., it was demonstrated that women exposed to higher glyphosate levels during pregnancy had babies born earlier and with lower adjusted birth weights.⁷ What's more, the chemical was detected in more than 90% of the mothers in the study.

Glyphosate, the active ingredient in Monsanto's Roundup herbicide, has made headlines b...

09:58

Apocynin attenuates diabetes-induced skeletal muscle dysfunction. GreenMedInfo

PMID: Life (Basel). 2022 May 1 ;12(5). Epub 2022 May 1. PMID: 35629342 Abstract Title: Apocynin Attenuates Diabetes-Induced Skeletal Muscle Dysfunction by Mitigating ROS Generation and Boosting Antioxidant Defenses in Fast-Twitch and Slow-Twitch Muscles. Abstract: In response to diabetes mellitus, skeletal muscle is negatively affected, as is evident by reduced contractile force production, increased muscle fatigability, and increased levels of oxidative stress biomarkers. Apocynin is a widely used NADPH oxidase inhibitor, with antioxidant and anti-inflammatory potential. It has been effective for amelioration of a variety of disorders, including diabetic complications. Therefore, the present study was conducted to evaluate the effects and action mechanisms of apocynin in slow- and fast-twitch diabetic rat muscles. Male Wistar rats were rendered diabetic by applying intraperitoneally a single dose of streptozotocin (45 mg/kg). Apocynin treatment (3 mg/kg/day) was administered over 8 weeks. Fasting blood glucose (FBG), insulin tolerance and body weight gain were measured. Both slow (soleus) and fast (extensor digitorum longus, EDL) skeletal muscles were used for muscle function evaluation, oxidative stress markers, and evaluating gene expression using qRT-PCR. Treatment with apocynin significantly reduced FBG levels and enhanced insulin tolerance. Apocynin also prevented muscle contractile dysfunction in EDL muscle but had no significant effect on this parameter in soleus muscles. However, in both types of muscles, apocynin mitigated the oxidative stress by decreasing ROS levels and increasing total glutathione levels and redox state. Concomitantly, apocynin also statistically enhanced Nrf-2 and GLU4 mRNA expression and downregulated NOX2, NOX4, and NF-B mRNA. Collectively, apocynin exhibits properties myoprotective in diabetic animals. These findings indicate that apocynin predominantly acts as an antioxidant in fast-twitch and slow-twitch muscles but has differential impact on contractile function.

09:30

Effects of Myrtus communis extract and apocynin on lens oxidative damage and boron levels. GreenMedInfo

PMID: Turk J Ophthalmol. 2021 Dec 28 ;51(6):344-350. PMID: 34963261 Abstract Title: Effects ofL. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats with a High Fat-Diet. Abstract: OBJECTIVES: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD).MATERIALS AND METHODS: Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined.RESULTS: The HFD increased serum triglyceride (p

09:25

Higher levels of niacin intake were associated with decreased odds of glaucoma. GreenMedInfo

PMID: J Glaucoma. 2023 Jun 1 ;32(6):443-450. Epub 2023 Mar 20. PMID: 36946914 Abstract Title: Associations Between Niacin Intake and Glaucoma in the National Health and Nutrition Examination Survey. Abstract: PRCIS: This study examined the association between dietary niacin intake and glaucoma in the 2005-2008 National Health and Nutrition Examination Survey (NHANES). Increased niacin intake was associated with lower odds of glaucoma overall and among women.PURPOSE: To examine the association between dietary niacin intake and glaucoma in the 2005-2008 NHANES.MATERIALS AND METHODS: This cross-sectional study included adult participants of the 2005-2008 NHANES. The exposure was dietary niacin intake, which was examined as a continuous and categorical variable. The outcome was glaucoma as defined by regraded disc images. Covariates included age, sex, race/ethnicity, education level, income, body mass index, smoking status, alcohol use, cardiovascular disease, diabetes mellitus, daily energy intake, vitamin B2 and B6 consumption, and macular degeneration. Adjusting for all covariates, logistic regression was performed to examine the association between niacin intake and glaucoma in the overall population and stratified by sex.RESULTS: The weighted population included 5371 individuals (109,734,124 weighted), of whom 55 (1.0%) had glaucoma. Each 1 mg increase in niacin intake was associated with a 6% decreased odds of glaucoma odds [adjusted odds ratio (aOR) = 0.94, 95% CI = 0.90, 0.98]. Among women, increased niacin intake was associated with decreased odds of glaucoma both with niacin as a continuous (aOR = 0.89, 95% CI = 0.80, 0.99 per 1 mg increase in niacin intake) and binary variable (aOR = 0.35, 95% CI = 0.14, 0.90 for higher vs lower niacin intake).CONCLUSIONS: In the 2005-2008 NHANES population, higher levels of niacin intake were associated with decreased odds of glaucoma overall and in women. Further studies are needed to examine the potential protective effects of niacin on glaucoma risk.

09:22

The consumption of adequate amounts of niacin can reduce the risk of diabetes. GreenMedInfo

PMID: Exp Clin Endocrinol Diabetes. 2023 May 22. Epub 2023 May 22. PMID: 36805533 Abstract Title: Association of Dietary Niacin Intake with Diabetes in Adults in the United States. Abstract: OBJECTIVE: Previous studies have shown inconsistent associations between niacin supplementation and diabetes, and little is known about the relationship between dietary niacin intake and the risk of diabetes in the general population. Our study aimed to explore the association between dietary niacin intake and the risk of diabetes in the adult population in the United States.METHODS: Data from the 2005-2016 National Health and Nutrition Examination Surveys were analyzed. Diabetes was diagnosed according to the American Diabetes Association criteria. Multivariate logistic regression models were used to estimate the association between dietary niacin intake and diabetes. Covariates included age, sex, race, family income, educational level, drinking status, smoking status, marital status, and physical activity.RESULTS: This study included 24494 participants, of which 13.63% had diabetes. In the fully adjusted model, a high niacin intake was significantly associated with a reduced risk of diabetes in a dose-dependent manner. When extreme quintiles of niacin intake were compared, the multivariable-adjusted odds ratio was 0.66 (95% confidence interval: 0.49, 0.88) for diabetes, and per ten-unit increment in dietary niacin intake was associated with a 14% lower risk of diabetes. When niacin intake was less than 15.01mg/d, a ten-unit increment in niacin intake was associated with a 24% higher risk of diabetes. However, the effect was not statistically significant.CONCLUSIONS: Our results suggest that the consumption of adequate amounts of niacin can reduce the risk of diabetes. Furthermore, this protective effect disappeared when the niacin intake was insufficient (less than 15.01mg/d).

09:03

Neuroprotective effects of carnosic acid: insight into its mechanisms of action. GreenMedInfo

PMID: Molecules. 2023 Mar 2 ;28(5). Epub 2023 Mar 2. PMID: 36903551 Abstract Title: Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action. Abstract: Carnosic acid is a diterpenoid abundantly present in plants belonging to the genusandof the familyaccounting for their application in traditional medicine. The diverse biological properties of carnosic acid that include antioxidant, anti-inflammatory, and anticarcinogenic activities have instigated studies on its mechanistic role, providing further insights into its potential as a therapeutic agent. Accumulating evidence has established the relevance of carnosic acid as a neuroprotective agent exhibiting therapeutic efficacy in combatting neuronal-injury-induced disorders. The physiological importance of carnosic acid in the mitigation of neurodegenerative disorders is just beginning to be understood. This review summarizes the current data on the mode of action through which carnosic acid exerts its neuroprotective role that may serve to strategize novel therapeutic approaches for these debilitating neurodegenerative disorders.

09:00

Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP. GreenMedInfo

PMID: Behav Brain Res. 2023 Feb 25 ;440:114257. Epub 2022 Dec 13. PMID: 36526017 Abstract Title: Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP. Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. The main therapeutic approach available nowadays relieves motor symptoms but does not prevent or stop neurodegeneration. Rosmarinic acid (RA), an ester of caffeic and 3,4-dihydroxyphenylacetic acids, is obtained from numerous plant species such as Salvia officinalis L. (sage) and Rosmarinus officinalis (rosemary). This compound has a wide spectrum of biological activities, such as antioxidant and anti-inflammatory, and could be an additional therapy for neurodegenerative disorders. Here we evaluated the potential neuroprotective effects of RA treatment in a murine model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mice were separated into four groups: CN, Control/saline; RA, Rosmarinic acid/vehicle; MPTP, MPTP/saline; MPTP+RA, MPTP/RA. RA (20 mg/kg, or vehicle) was administered orally by intra-gastric gavage for 14 days, one hour before MPTP or saline injection. MPTP groups received the drug (30 mg/kg, intraperitoneally) once a day for five days (fourth to the eighth day of the experiment). MPTP-treated animals displayed hyperlocomotion behavior, which was significantly prevented by RA treatment. In addition, RA treatment increased dopaminergic signaling in the parkinsonian mice and improved the monoaminergic system in healthy animals. Analysis of alterations in the striatal mRNA expression of dopaminergic system components showed that MAO-A expression was increased in the MPTP+AR group. Overall, this study brings new evidence of the potential neuroprotective properties of RA not only in preventing behavioral features observed in PD, but also by improving neurotransmission in the healthy brain.

09:00

On Your Health-Jun 12 2023 Dr. Mark Sherwood Dr. Tenpenny

06-12-2023 Listen to audio of interview here. Click on the video below to watch this episode: https://drtenpenny.b-cdn.net/2023/06-12-23-OYH.mp4 About my guest: Dr. Sherwood is a co-author of 3 []

08:56

Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis. GreenMedInfo

PMID: Int Immunopharmacol. 2023 Apr ;117:110003. Epub 2023 Mar 15. PMID: 36931000 Abstract Title: Rosmarinic acid ameliorates skin inflammation and pruritus in allergic contact dermatitis by inhibiting mast cell-mediated MRGPRX2/PLC1 signaling pathway. Abstract: BACKGROUND: Allergic contact dermatitis (ACD) is one of the most common dermatoses, which has high disease burden and quality of life impairment. Anti-histamine is not effective in a part of the ACD patients. Thus, the discovery of novel antipruritic therapy is of highly demand.OBJECTIVE: In this study, we investigated the anti-pruritic effects of rosmarinic acid (RA) and explored the underlying mechanism.METHOD: SPF Balb/c mice were randomly divided into control group, ACD model group, RA group (1.0 mg/kg) and loratadine (LORA) group (1.5 mg/kg). Back epidermal thickness was recorded. H&E staining was used for pathological observation. Mast cell degranulation was assessed by toluidine blue staining. ELISA assay was employed to detect cytokines levels. Cortistatin-14 (CST-14) and Mas-related G protein-coupled receptor X2 (MRGPRX2) expression was detetcted by RT-PCR and western blot. Molecular docking assay was used to predict the affinity of RA and MRGPRX2. Surface plasmon resonance (SPR) assay was used to verify structure affinity of RA and MRGPRX2.RESULTS: RA treatment significantly decreased epidermal keratinization and inflammatory cell infiltration in ACD mouse model. Administration of RA significantly reduced secretion of histamine, IL-13, and mRNA expression of CST-14. Furthermore, RA treatment increased mRNA expression of MRGPRX2. In addition, Molecular docking results predict that RA has a good affinity with MRGPRX2. RA displayed a structure affinity (K = 8.89 10) with MRGPRX2 by SPR. RA inhibited CST-14 and Compound 48/80 (C48/80)-induced mast cell activation via MRGPRX2-PLC1-PKC-NF-B signaling pathway.CONCLUSION: RA exhibits anti-pruritic and anti-inflammatory effects in ACD mice by inhibiting MRGPRX2-PLC1-PKC-NF-B signaling pathway. RA might emerge as a potential drug for the treatment of pruritus and skin inflammation in the setting of ACD.

08:53

Myrtus communis and celastrol enriched plant cell culture extracts control together the pivotal role of cutibacterium acnes and inflammatory pathways in acne. GreenMedInfo

PMID: J Eur Acad Dermatol Venereol. 2023 Mar ;37 Suppl 2:12-19. PMID: 36729401 Abstract Title: Myrtus communis and Celastrol enriched plant cell culture extracts control together the pivotal role of Cutibacterium acnes and inflammatory pathways in acne. Abstract: INTRODUCTION: Acne is a multifactorial inflammatory disease of the pilosebaceous unit in which Cutibacterium acnes is one of the main triggers. A strong predominance of C. acnes phylotype IA1 is present in acne skin with higher biofilm organization and virulence, promoting local immuno-inflammation, especially the Th17 pathway.OBJECTIVES: We evaluated the single and combined pharmacological properties of the plant extracts, Myrtus communis (Myrtacine) and Celastrol enriched plant cell culture (CEE) extracts on the C. acnes/Th17 pathway.METHODS: The effect of Myrtacineon the virulence of C. acnes phylotype IA1 was quantified according to the expression of several related genes. The activity of Myrtacineand CEE on the inflammatory cascade was assessed using monocytes-derived dendritic cells (Mo-DC) stimulated with membranes or biofilms of the C. acnes phylotype IA1. Finally, the effect of CEE on the Th17 pathway was studied using C. acnes stimulated sebocyte 2D cultures and 3D skin tissue models containing preactivated Th17 cells.RESULTS: Myrtacinehad an anti-virulence effect, evident as a significant and strong inhibition of the expression of several virulence factor genes by 60%-95% compared to untreated controls. Myrtacineand CEE significantly inhibited proinflammatory cytokine (IL-6, IL-8, IL-12p40 and TNF-) production by Mo-DC in response to C. acnes phylotype IA1. Interestingly, these two ingredients resulted in synergistic inhibition of most cytokines when used in combination. Finally, we demonstrated an inhibitory effect of CEE, in solution or formulated at 0.3%, specifically on IL-17 release by Th17 lymphocytes in a C. acnes-stimulated sebocyte 2D cultures and by Th17-lymphocytes integrated in a 3D skin models.CONCLUSIONS: 2D and 3D models were developed to represent relevant and specific pathways involved in acne. Myrtacineand CEE were shown to alter one or more of these pathways, indicating their potential beneficial effects on this disease.

08:31

Antileukemic, antioxidant, anti-inflammatory and healing activities induced by a polyphenol-enriched fraction extracted from leaves of myrtus. GreenMedInfo

PMID: Nutrients. 2022 Nov 27 ;14(23). Epub 2022 Nov 27. PMID: 36501085 Abstract Title: Antileukemic, Antioxidant, Anti-Inflammatory and Healing Activities Induced by a Polyphenol-Enriched Fraction Extracted from Leaves ofL. Abstract: Natural products have offered a number of exciting approaches in cancer treatment over the years. In this study, we investigated the prophylactic and therapeutic effects of the polyphenol-enriched fraction extracted from(PEMC) on acute and chronic leukemia. According to the UHPLC-MS, the fraction is rich in flavonoids. Protective activity of the PEMC was assessed by evaluating the antioxidant, anti-inflammatory, wound healing, and hemolysis potential in a series of in vivo and in vitro assays, while the therapeutic approach consisted of the evaluation of cytotoxic activity of the PEMC against HL60 and K562 leukemia cell lines. Safety of the fraction was also evaluated on a non-cancerous Vero cell line and by an acute toxicity test performed in mice. The PEMC demonstrated a significant anti-inflammatory and healing potential. The activities found at the dose of 100 mg/kg were better than those observed using a reference drug. The PEMC demonstrated a significant antioxidant effect and a specific cytotoxicity towards HL60 (IC= 19.87M) and K562 (IC= 29.64M) cell lines being non-toxic to the Vero cell line. No hemolytic activity was observed in vitro and no toxicity effect was found in mice. Thus, the PEMC has a pharmacological potential as both preventive and therapeutic agent. However, further research is necessary to propose its mechanism of action.

08:26

Treatment with apocynin selectively restores hippocampal arteriole function and seizure-induced hyperemia in a model of preeclampsia. GreenMedInfo

PMID: J Cereb Blood Flow Metab. 2022 Aug ;42(8):1425-1436. Epub 2022 Feb 9. PMID: 35137612 Abstract Title: Treatment with apocynin selectively restores hippocampal arteriole function and seizure-induced hyperemia in a model of preeclampsia. Abstract: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with neurovascular dysfunction, cognitive impairment and increased seizure susceptibility. Here, we sought to determine if treatment of experimental PE (ePE) rats with apocynin could prevent hippocampal arteriolar (HA) dysfunction and impaired seizure-induced hyperemia within the hippocampus, a brain region central to cognition and seizure generation. Isolated and pressurized HAs from Sprague Dawley rats that were normal pregnant (Preg; n=8), ePE (n=8) or ePE treated with apocynin for 2weeks of gestation (ePE+apo; n=8) were compared. Hippocampal blood flow (n=6/group) was measured using hydrogen clearance before and during seizure. Aorta elastin was quantified using histochemistry. ePE was associated with HA dysfunction including reduced contraction to endothelin-1 and diminished dilation to the endothelium-dependent vasodilator NS309 that was prevented by apocynin. However, apocynin had no effect on ePE-induced impairment of dilation to the nitric oxide donor sodium nitroprusside, but increased myogenic tone and substantially increased HA distensibility. Seizure-induced hyperemia was impaired in ePE rats that was restored by apocynin. Aorta from ePE rats had reduced elastin content, suggesting large artery stiffness, that was unaffected by apocynin. Thus, while apocynin partially prevented HA dysfunction, its restoration of functional hyperemia may be protective of seizure-induced injury during eclampsia.

08:17

Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2 and XBP-1 pathways after stroke. GreenMedInfo

PMID: Brain Res Bull. 2022 May ;182:1-11. Epub 2022 Feb 7. PMID: 35143926 Abstract Title: Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2and XBP-1 pathways after stroke. Abstract: Stroke leads to disturbance in the physiology of the ER (Endoplasmic Reticulum) that triggers UPR (Unfolded Protein Response) pathways aimed to compensate neuronal cell damage. However, sustained UPR causes stressful conditions in the ER lumen forming abnormal protein aggregates. Stroke-induced oxidative stress also amalgamates with UPR to safeguard and ensure the proper functioning of brain cells. Thus we tested the effect of apocynin (a potent antioxidant) post-treatment in experimental stroke on the outcome of ER stress and UPR branch pathways. We administered a low dose of apocynin at 1 mg/kg (intraperitoneal) to adult Sprague-Dawley rats subjected to Middle Cerebral Artery Occlusion (MCAO) for two-time points. The first dose immediately after re-establishing the blood flow and another at 6 h of reperfusion. Apocynin post-treatment significantly reduced ROS (Reactive Oxygen Species) generation at an early reperfusion time point of 4 h. It preserved neuronal morphology, dendritic spine density, reduced protein aggregation, and brain damage after 24 h of reperfusion. Apocynin post-treatment regulates the two UPR branch pathways in our experimental paradigm. 1) Down-regulation of eIF2(Eukaryotic Initiation Factor 2) phosphorylation, and CHOP (C/EBP homologous protein) 2) by reducing the XBP-1 (X-Box binding Protein-1) mRNA splicing downstream to PERK (Protein Kinase RNA-Like ER Kinase) and IRE1(Inositol Requiring Enzyme 1alpha) UPR pathways, respectively. Bioinformatics prediction showed that apocynin has binding sites for PERK (Protein Kinase RNA-Like ER Kinase) and IRE1proteins. The amino acid residues interacting with apocynin were Cys891 and Gln889 (for PERK), and the amino acids Ser726, Arg722, and Ala719 (for IRE1) lying within their activation loop. Overall, these studies indicate that apocynin post-treatment might regulate ER stress/UPR pathways and minimize stroke brain damage, thus having implications for developing newer strategies for stroke treatment.

08:14

Neuroprotective role of apocynin against pentylenetetrazole kindling epilepsy and associated comorbidities. GreenMedInfo

PMID: Behav Brain Res. 2022 Feb 15 ;419:113699. Epub 2021 Nov 29. PMID: 34856299 Abstract Title: Neuroprotective role of apocynin against pentylenetetrazole kindling epilepsy and associated comorbidities in mice by suppression of ROS/RNS. Abstract: Epilepsy is a neurological disease that transpires due to the unusual synchronized neuronal discharge within the central nervous system, which drives repetitious unprovoked seizures. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is a complex enzyme accountable for reactive oxygen species (ROS) production, neurodegeneration, neurotoxicity, memory impairment, vitiates normal cellular processes, long term potentiation, and thus, implicated in the pathogenesis of epilepsy. Therefore, the present study was sketched to examine the neuroprotective effect of apocynin, NADPH oxidase inhibitor in pentylenetetrazole kindling epilepsy, and induced comorbidities in mice. Mice (either sex) were given pentylenetetrazole (35 mg/kg, i.p.) every other day up to 29 days, and a challenge test was executed on the 33day. Pretreatment with apocynin (25, 50, and 100 mg/kg, i.p.) was carried out from 1to 33day. Rotarod and open field test were performed on the 1, 10, 20, and 30days of the study. Animals were tutored on the morris water maze from 30to 33day, and the retention was registered on the 34day. Tail suspension test and elevated plus maze were sequentially performed on the 32and 33day of the study. On the 34day, animals were sacrificed, and their brains were isolated to conduct biochemical estimation. NADPH oxidase activation due to chronic pentylenetetrazole treatment resulted in generalized tonic-clonic seizures, enhanced oxidative stress, remodeled neurotransmitters' level, and resulted in comorbidities (anxiety, depression, and memory impairment). Pretreatment with apocynin significantly restricted the pentylenetetrazole induced seizure severity, ROS production, neurotransmitter alteration, and comorbid conditions by inhibiting the NADPH oxidase enzyme.

07:54

Why Are So Many Girls on SSRIs? Mad In America

From Girls/Freya India: I believe that girls are genuinely suffering in the modern world and also that a major part of it is the marketisation and medicalisation of their normal distress . . . I think we are kidding ourselves if we pretend that condensing every emotion into something diagnosable and solvable with consumption isnt doing profound psychological damage to Gen Z.

We shouldnt stigmatise those who are suffering. But we should think carefully about our compassion, where we direct it, and how it can be co-opted. Because I dont believe for a second that compassion is making serious medication as accessible and convenient as possible to the point it resembles Deliveroo. I dont believe compassion is expanding the pharmaceutical market to include any girl who experiences negative emotions. And nor is it normalising and normalising and normalising diagnoses and drugs until we start to stigmatise how it feels to be human.

The truth is that we are a generation of girls and young women with more drugs available to us than ever before. For every surge of anxiety, sadness, panic, period pain or social awkwardness, theres Prozac, Paxil, Celexa, Effexor, Zoloft. Diagnosed in five minutes. Prescribed in ten. Its futuristic. Its revolutionary. It doesnt really work. Because the easier they make it to sign prescriptions and swallow pills, and the more Mental Health Awareness months and weeks and campaigns flood our inboxes and app stores and algorithms, the worse we seem to feel.

So thats my fear. My fear is that in those millions of girls taking SSRIs and other serious medications, many arent doing so because of a very successful mental health awareness campaign, but a very successful marketing campaign. And that isnt something we should ignore. In fact, that is something we really should be raising awareness of.

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07:27

Wildfires that are Not Natural Product of the Geoengineering Agenda Medical Kidnap

Unnatural wildfires in California. Images from YouTube Video here.

Comments by Brian Shilhavy
Editor, Health Impact News

The evidence is mounting that the wildfires in Canada are not natural, but part of the geoengineering agenda.

Here are two videos that will help the public understand how these wildfires in Canada are not natural, similar to previous wildfires in California, and are part of the geoengineering agenda.

First, the Geoengineering Watch Global Alert News from June 10, 2023, by Dane Wigington, is here. Dane deals extensively with the Canadian wildfires in this episode.

He references a report he published back in 2019 that explains how the geoengineering terrorists are able to cause these unnatural wildfires.

Engineering Catastrophic Wildfires To Temporarily Cool Arctic With Smoke (Updated)

Are covert climate engineering operations connected to the exponentially increasing wildfires all over the world? June, 2019, was the hottest month ever recorded on our planet.

July, 2019, is expected to break the all time heat record that was just set the month before. Scientists are frantically sounding the alarm about accelerating and immense Arctic heat and crashing polar ice.

Unprecedented nor...

07:27

Wildfires that are Not Natural Product of the Geoengineering Agenda Vaccine Impact

Unnatural wildfires in California. Images from YouTube Video here.

Comments by Brian Shilhavy
Editor, Health Impact News

The evidence is mounting that the wildfires in Canada are not natural, but part of the geoengineering agenda.

Here are two videos that will help the public understand how these wildfires in Canada are not natural, similar to previous wildfires in California, and are part of the geoengineering agenda.

First, the Geoengineering Watch Global Alert News from June 10, 2023, by Dane Wigington, is here. Dane deals extensively with the Canadian wildfires in this episode.

He references a report he published back in 2019 that explains how the geoengineering terrorists are able to cause these unnatural wildfires.

Engineering Catastrophic Wildfires To Temporarily Cool Arctic With Smoke (Updated)

Are covert climate engineering operations connected to the exponentially increasing wildfires all over the world? June, 2019, was the hottest month ever recorded on our planet.

July, 2019, is expected to break the all time heat record that was just set the month before. Scientists are frantically sounding the alarm about accelerating and immense Arctic heat and crashing polar ice.

Unprecedented nor...

07:25

Apocynin attenuates diabetic cardiomyopathy by suppressing ASK1-p38/JNK signaling. GreenMedInfo

PMID: Eur J Pharmacol. 2021 Oct 15 ;909:174402. Epub 2021 Aug 1. PMID: 34348125 Abstract Title: Apocynin attenuates diabetic cardiomyopathy by suppressing ASK1-p38/JNK signaling. Abstract: Diabetic cardiomyopathy (DCM) significantly increased the morbidity of heart failure in diabetic patients. Long-time oxidative stress is an indisputable contributor for DCM development. Apocynin (APO) has been suggested to be a potential drug against oxidative stress. The study aims to find out the effects of APO on DCM and the related mechanisms. Mice were randomly divided into four groups: control (CON), APO, DCM and DCM + APO. Echocardiography analyses, histological analyses, Western blot and RT-PCR were used to explore the roles and mechanisms of APO in DCM. Isolated neonatal rat cardiomyocytes (NRCMs) and cardiac fibroblasts (CFs) were used for further confirming the APO treatment effects in vitro. Deteriorated cardiac function, enlarged cardiomyocytes, excess cardiac fibrosis and significant cardiac oxidative stress were observed in DCM group. However, APO treatment successfully improved cardiac function, decreased cardiac hypertrophy and fibrosis, and depressed oxidative stress. Mechanistically, APO treatment markedly suppressed apoptosis signal regulating kinase 1(ASK1)-p38/c-jun N-terminal kinase (JNK) signaling and reduced apoptosis. It also inhibited NRCM apoptosis and CF activation via depressing ASK1-p38/JNK signaling in vitro. Moreover, adenovirus-mediated ASK1 overexpression completely removed the protection of APO in vitro. In conclusion, APO treatment could effectively attenuate DCM-associated injuries in vivo and protect against high glucose-induced NRCM and CF injuries in vitro via suppressing ASK1-p38/JNK signaling. APO might be a potential ASK1 inhibitor for treating DCM.

07:15

Judge orders cancer researchers art collection seized to pay fees from failed libel suit Retraction Watch

The sheriff of Franklin County, Ohio, has received an order to seize and sell property of Carlo Croce, a cancer researcher at The Ohio State University in Columbus, to pay his nearly $1.1 million debt to lawyers who represented him in failed libel and defamation suits.

Last December, a judge ordered Croce to pay $1,098,642.80, plus interest, to Kegler Brown Hill & Ritter, which was one of the firms that represented him in his libel lawsuit against the New York Times and his defamation case against David Sanders, a researcher at Purdue University in West Lafayette, Ind.

He lost both cases, and the firm sued him for $900,000 in unpaid fees. Croce also lost a suit against Ohio State in which he sought to regain his post as chair of his department after the university removed him.

Croces appeal of the December judgment is still in process, but in January the court denied his request for a temporary stay of execution, meaning garnishment and other enforcement of the judgment can continue unless Croce can provide a surety bond or letter of credit for the full amount of the judgment, plus 18 months worth of interest.

Croce and his current lawyer, Andrew Mills Holford of Johrendt & Holford, and Maria M. Guthrie of Kegler Brown, who was r...

07:15

Apocynin prevents anxiety-like behavior and histone deacetylases overexpression induced by sub-chronic stress. GreenMedInfo

PMID: Biomolecules. 2021 Jun 15 ;11(6). Epub 2021 Jun 15. PMID: 34203655 Abstract Title: Apocynin Prevents Anxiety-Like Behavior and Histone Deacetylases Overexpression Induced by Sub-Chronic Stress in Mice. Abstract: Anxiety disorders are common mental health diseases affecting up to 7% of people around the world. Stress is considered one of the major environmental risk factors to promote anxiety disorders through mechanisms involving epigenetic changes. Moreover, alteration in redox balance and increased reactive oxygen species (ROS) production have been detected in anxiety patients and in stressed-animal models of anxiety. Here we tested if the administration of apocynin, a natural origin antioxidant, may prevent the anxiety-like phenotype and reduction of histone acetylation induced by a subchronic forced swimming stress (FSS) paradigm. We found that apocynin prevented the enhanced latency time in the novelty-suppressed feeding test, and the production of malondialdehyde induced by FSS. Moreover, apocynin was able to block the upregulation of p47phox, a key subunit of the NADPH oxidase complex. Finally, apocynin prevented the rise of hippocampal,and, and the reduction of histone-3 acetylation levels promoted by FSS exposure. In conclusion, our results provide evidence that apocynin reduces the deleterious effect of stress and suggests that oxidative stress may regulate epigenetic mechanisms.

07:12

Protective effects of apocynin against ionizing radiation-induced hepatotoxicity. GreenMedInfo

PMID: Biotech Histochem. 2022 Apr ;97(3):228-235. Epub 2021 Jun 14. PMID: 34120545 Abstract Title: Protective effects of apocynin against ionizing radiation-induced hepatotoxicity in rats. Abstract: Radiation hepatotoxicity is thought to be due to free oxygen radicals. We investigated the protective effects of apocynin (APO) against ionizing radiation induced oxidative stress in liver tissue following whole body ionizing radiation. We divided rats into four groups. The control group was injected intraperitoneally (i.p.) with saline for five consecutive days. A second group was injected i.p. with saline for 5 days and after 24 h, a single-dose of radiation (800 cGy) was administered to the whole abdomen. A third group was injected i.p. with 20 mg/kg APO for 5 days. A fourth group was injected i.p. with APO for 5 days and after 24 h, the rats were exposed to radiation. Ionizing radiation induced hepatotoxicity was demonstrated biochemically by significant changes in oxidative and antioxidant parameters. Our findings suggest that APO treatment may be protective against radiation induced hepatic injury by decreasing oxidative stress and increasing antioxidant activity.

07:04

Gun control laws and firearm mortality a public health imperative Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

It is a public health imperative that researchers continue to show that gun control laws save numerous lives.

Skeptical Raptor

07:04

Wildfires that are Not Natural Product of the Geoengineering Agenda Health Impact News

Unnatural wildfires in California. Images from YouTube Video here.

Comments by Brian Shilhavy
Editor, Health Impact News

The evidence is mounting that the wildfires in Canada are not natural, but part of the geoengineering agenda.

Here are two videos that will help the public understand how these wildfires in Canada are not natural, similar to previous wildfires in California, and are part of the geoengineering agenda.

First, the Geoengineering Watch Global Alert News from June 10, 2023, by Dane Wigington, is here. Dane deals extensively with the Canadian wildfires in this episode.

He references a report he published back in 2019 that explains how the geoengineering terrorists are able to cause these unnatural wildfires.

Engineering Catastrophic Wildfires To Temporarily Cool Arctic With Smoke (Updated)

Are covert climate engineering operations connected to the exponentially increasing wildfires all over the world? June, 2019, was the hottest month ever recorded on our planet.

July, 2019, is...

06:59

Apocynin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. GreenMedInfo

PMID: Bratisl Lek Listy. 2021 ;122(1):78-84. PMID: 33393325 Abstract Title: Apocynin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Abstract: AIMS: The aim was to investigate the improvement properties of apocynin and its potential mechanism on diabetes-associated cognitive decline.METHODS: In this study, the model of diabetic rat was established by STZ (50 mg/kg) and treated with apocynin (16 mg/kg/d for 12 weeks). The cognitive ability was evaluated by Morris water maze test. The indicators of oxidative stress (SOD and MDA) were analyzed by spectrophotometer. The inflammatory cytokines were measured by real time-PCR and ELISA. The protein expressions of Nrf-2, HO-1, Bcl-2 and Bax were determined by Western blot.RESULTS: Treatment with apocynin ameliorated diabetes-related learning and memory injury, as represented by decreasing escape latency and enhancement of the number of times of crossing platform, in the Morris water maze test. In hippocampus, apocynin markedly augmented SOD activity and inhibited MDA level to alleviate oxidative stress. Moreover, apocynin obviously relieved inflammatory reaction by suppressing TNF-, IL-1and IL-6 concentrations. Concomitantly, apocynin also statistically enhanced Nrf-2 and HO-1 protein expression to improve DACD. Lastly, apocynin notably ameliorated Bax/Bcl-2 ratio by regulating Bax and Bcl-2 protein expression to mitigate apoptosis.CONCLUSION: Our results have shown that apocynin may be a valid therapeutic agent against DACD via modulation of antioxidant, anti-inflammatory, and anti-apoptosis (Tab. 1, Fig. 18, Ref. 35).

06:35

Apocynin inhibits placental TLR4/NF-B signaling pathway and ameliorates preeclampsia-like symptoms. GreenMedInfo

PMID: Pregnancy Hypertens. 2020 Oct ;22:210-215. Epub 2020 Oct 14. PMID: 33099123 Abstract Title: Apocynin inhibits placental TLR4/NF-B signaling pathway and ameliorates preeclampsia-like symptoms in rats. Abstract: OBJECTIVE: We aimed to investigate the potency of apocynin in ameliorating preeclampsia and explore the underlying mechanisms.METHODS: Preeclampsia model was constructed in rats by administering 200 mg/kg/day L-NAME. Apocynin was given orally in drinking water. Systolic blood pressure and proteinuria were monitored during treatment. Survival rate rate of the pups and placental weight were assessed. Serum sFlt-1, PIGF, IL-6 and placental TLR4 levels were measured using ELISA or qRT-PCR.RESULTS: Apocynin dose-dependently decreased systolic blood pressure and proteinuria during gestation. Survival rate of the pups and placental weight were improved by apocynin treatment. Apocynin ameliorated the imbalance of sFlt-1 and PIGF in serum and placenta of rats with preeclampsia. Apocynin attenuated serum inflammatory cytokine expression and placental inflammation most likely due to downregulation of the placental TLR4/NF-kB pathway in L-NAME treated rats.CONCLUSIONS: Apocynin potently ameliorates the L-NAME-induced preeclampsia, which is achieved by re-balancing the sFlt-1 and PIGF levels, attenuating inflammation, and inhibiting TLR4/NF-B p65 signaling.

06:28

Evaluation of apocynin in vitro on high glucose-induced oxidative stress on tenocytes. GreenMedInfo

PMID: Bone Joint Res. 2020 Jan ;9(1):23-28. Epub 2020 May 16. PMID: 32435452 Abstract Title: Evaluation of apocynin in vitro on high glucose-induced oxidative stress on tenocytes. Abstract: AIMS: The purpose of this study was to evaluate the in vitro effects of apocynin, an inhibitor of nicotinamide adenine dinucleotide phosphate oxidase (NOX) and a downregulator of intracellular reactive oxygen species (ROS), on high glucose-induced oxidative stress on tenocytes.METHODS: Tenocytes from normal Sprague-Dawley rats were cultured in both control and high-glucose conditions. Apocynin was added at cell seeding, dividing the tenocytes into four groups: the control group; regular glucose with apocynin (RG apo+); high glucose with apocynin (HG apo+); and high glucose without apocynin (HG apo-). Reactive oxygen species production, cell proliferation, apoptosis and messenger RNA (mRNA) expression of NOX1 and 4, and interleukin-6 (IL-6) were determined in vitro.RESULTS: Expression of NOX1, NOX4, and IL-6 mRNA in the HG groups was significantly higher compared with that in the RG groups, and NOX1, NOX4, and IL-6 mRNA expression in the HG apo+ group was significantly lower compared with that in the HG apo- group. Cell proliferation in the RG apo+ group was significantly higher than in the control group and was also significantly higher in the HG apo+ group than in the HG apo- group. Both the ROS accumulation and the amounts of apoptotic cells in the HG groups were greater than those in the RG groups and were significantly less in the HG apo+ group than in the HG apo- group.CONCLUSION: Apocynin reduced ROS production and cell death via NOX inhibition in high-glucose conditions. Apocynin is therefore a potential prodrug in the treatment of diabetic tendinopathy.2020;9(1):23-28.

06:23

Apocynin is an antidepressant agent. GreenMedInfo

PMID: Behav Brain Res. 2020 Jun 18 ;388:112643. Epub 2020 Apr 24. PMID: 32339552 Abstract Title: Apocynin as an antidepressant agent: in vivo behavior and oxidative parameters modulation. Abstract: Depression is one of the most common mood disorders, which affects one in six people at some point in life. However, the treatment of this disease is still a challenge. Chronic corticosterone administration (CCA) is a widely used animal model to study the mechanisms involved, as well as possible therapeutic strategies for the treatment of depression. Moreover, elevated oxidative stress has been observed in psychiatric disorders, including major depression and, in this context, antioxidant therapy may be a potential therapeutic alternative. In this study, we investigated the effect of seven days of treatment with apocynin, an antioxidant of natural origin, on depressive-like behavior and oxidative parameters in mice submitted to CCA. After 21 days of corticosterone administration (20 mg/Kg/day, subcutaneously, s.c.), we observed the development of depressive-like behavior with an increase in immobility time on tail suspension test and forced swimming test and reduction in total grooming time on splash test. Also, we found high superoxide dismutase activity and hydrogen peroxide levels whereas catalase activity was reduced in the prefrontal cortex, hippocampus and striatum. Seven days of treatment with apocynin (100 mg/Kg/day orally, p.o), performed immediately after corticosterone administration in the last week of protocol, was able to reverse the most of these changes, revealing its antidepressant-like effect. In conclusion, our results suggest apocynin as an antidepressant-like agent with a mechanism of action based on the attenuation of oxidative changes induced by CCA.

06:20

Protective effects of apocynin on damaged testes of rats exposed to methotrexate. GreenMedInfo

PMID: Turk J Med Sci. 2020 Aug 26 ;50(5):1409-1420. Epub 2020 Aug 26. PMID: 32394677 Abstract Title: Protective effects of apocynin on damaged testes of rats exposed to methotrexate. Abstract: BACKGROUND/AIM: Methotrexate (MTX), widely used as a drug in cancer, has many adverse effects on tissues. Apocynin (APO) is a NADPH oxidase inhibitor and is known with many antioxidant properties. In this study, we aimed to evaluate the adverse effects of MTX on testicular tissue and the protective effects of APO at two different doses (20 mg/kg and 50 mg/kg) on MTX-induced testicular damage.MATERIALS AND METHODS: Fifty adult male Wistar albino rats (8 weeks old and weighing 200250 g) were divided into five groups of 10 rats each: 1. saline control, 2. dimethyl sulfoxide (DMSO) control, 3. MTX, 4. APO-20 + MTX, and 5. APO-50 + MTX. All injections were performed intraperitoneally. At the end of day 28, all rats were sacrificed under anesthesia. The testes were evaluated histologically and the blood samples were analyzed biochemically.RESULTS: According to histological and biochemical analyses, there was no significant difference between the DMSO and control groups. In terms of the histological findings, MTX group was significantly the worst affected group compared to the others, and in this group, apoptotic cell number (P = 0.011) was significantly increased in comparison with the control group. Except MTX, there was no significant difference in apoptotic cell number of the other groups compared to the control group. In the MTX group, malondialdehyde (MDA, P = 0.017) and myeloperoxidase (MPO, P

06:16

Apocynin suppressed oxidative stress and inflammation in gestational diabetes. GreenMedInfo

PMID: Reprod Sci. 2020 Feb ;27(2):722-730. Epub 2020 Jan 1. PMID: 32046403 Abstract Title: TLR4/NF-B Signaling Pathway Participates in the Protective Effects of Apocynin on Gestational Diabetes Mellitus Induced Placental Oxidative Stress and Inflammation. Abstract: Gestational diabetes mellitus (GDM) is a temporary form of diabetes during pregnancy which influences the health of both mother and child. Both inflammation and oxidative stress have been implicated in the pathophysiology of GDM. Apocynin, acetophenone with anti-oxidative and anti-inflammation activities, has been shown to protect against insulin resistance. In the current study, the effects of apocynin on GDM symptoms, productive outcomes, oxidative stress, and inflammation were evaluated and the underlying mechanisms were explored. We administrated apocynin to GDM mice and monitored the GDM symptoms including body weight, serum levels of glucose, insulin, lipid profile, and the fetal outcomes in GDM mice. We also evaluated the effects of apocynin on placental oxidative stress, inflammation, and activation of TLR4/NF-B signaling pathway in GDM mice. Here, we reported that apocynin treatment significantly reduced serum levels of glucose, cholesterol, triglyceride, and low-density lipoprotein in GDM mice, while significantly increased serum level of insulin and high-density lipoprotein. Apocynin improved fetal outcomes in GDM mice. Apocynin ameliorated placental oxidative stress and inflammation and inhibited TLR4/NF-B signaling pathway activation in GDM mice. We concluded that apocynin suppressed oxidative stress and inflammation in GDM by inhibiting the TLR4/NF-B signaling pathway.

06:15

Increased risk of shingles after COVID-19 time to get both vaccines Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Research has provided evidence that there is an increased risk of shingles, or herpes zoster, after a COVID-19 infection.

Skeptical Raptor

05:57

New vaccines wishlist I am looking beyond COVID-19 Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

There are several new vaccines in various stages of development that will soon be available to prevent some serious infectious diseases.

Skeptical Raptor

05:53

Intercessory prayer in medicine systematic reviews say it does not work Skeptical Raptor

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Intercessory prayer, where people pray for the health of someone in a hospital, has been studied for a while to determine whether it is effective. I keep reading that people believe it has been proven to work, but I have always been skeptical. I didnt realize that there are published studies about intercessory prayer, but Read More Intercessory prayer in medicine systematic reviews say it does not work

Skeptical Raptor

05:42

Targeting cellular microtubule by phytochemical apocynin exhibits autophagy-mediated apoptosis to inhibit lung carcinoma progression. GreenMedInfo

PMID: Phytomedicine. 2020 Feb ;67:153152. Epub 2019 Dec 19. PMID: 31887479 Abstract Title: Targeting cellular microtubule by phytochemical apocynin exhibits autophagy-mediated apoptosis to inhibit lung carcinoma progression and tumorigenesis. Abstract: BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide. Several targets have been identified for lung cancer therapy, amongst which 'Microtubule' and its dynamics are the most widely studied and used in therapy. Tubulin-microtubule polymer dynamics are highly sought after targets in the field of anti-cancer drug designing. Natural compounds are important sources for developing anticancer therapeutics owing to their efficacy and lower cytotoxicity. Evidence suggested that therapeutic targeting of microtubule by natural compounds is amongst the most widely used interventions in numerous cancer therapies including lung cancer.PURPOSE: To determine the efficacy of apocynin (a natural compound) in suppressing the progression of lung carcinoma both in vitro and in vivo, along with the identification of targets and the underlying mechanism for developing a novel therapeutic approach.METHODS: We have demonstrated themicrotubule depolymerizing role of apocynin by established protocols in cellular and cell-free system. The efficacy of apocynin to inhibit lung carcinoma progression was studied on A549 cells.The tumoricidal ability of apocynin was studied in BALB/c mice model as well.Mice were classified into 4 groups namely-group II mice as tumor control; group III-IV mice asalso tumor-induced but treated with differential apocynin doses whereas group I mice were kept as normal.RESULTS: Apocynin, showed selective cytotoxicity towards lung cancer cells rather than normal lung fibroblast cells. Apocynin inhibited oncogenic properties including growth, proliferation (p

05:40

Massena to continue to add fluoride to water supply Fluoride Action Network

MASSENA The Village of Massena will continue to add fluoride to the village water supply following a special board meeting on June 6.

The Village Board of Trustees approved the continuation of fluoridation for the 2023-24 fiscal year by a 5-1 vote.

A need for the special meeting presented itself after hydrofluosilicic acid (HFS) was removed during a previous vote on water treatment supplies when Trustee Ken McGowan said using HFS was an outdated practice and questioned the need. McGowan was the only no vote during the special meeting.

Over a dozen village residents were also in attendance at the meeting, with many speaking in favor of continuing the use of fluoride in the village water supply.

Speaking in favor of fluoridation

Multiple speakers came forward to support the continuation of fluoridation, including two doctors with a wealth of knowledge on the subject.

Dr. Charles Negus, who practiced in dentistry for 43 years, said the discussion is one that was undertaken long ago.

We had this discussion 58 years ago. It has been in the water 57 years, he said.

Negus told board members and attendees that fluoridation of water is a recommended treatment by the American Medical Association, American Dental Association and the World Health Organization.

The World Health Organization said fluoridation of the water supply was the most important health gain in 50 years and thats because dental decay attacks not just your teeth but the whole body because of its start in the whole digestive system, he said.

Negus also commented that there have been no adverse effects reported by any reputable researcher.

And I want to stress the word reputable, he said.

Negus also spoke to the nature of individuals failing to following through taking prescribed medication, saying that compliance among those to take prescribed medication or written prescriptions is at best 60%.

If youre going to rely on people to take a non-prescribed medication, I think you will find it will be even less and that will affect our poorest people, he said.

Resident Margaret Demo also spoke in favor of continued fluoridation, saying it was a matter of protecting children moving forward.

Demo said she was very disturbed to think it was possible they may remove fluoride from the water supply.

I have three sons that are in their 40s, 50s age range and they have benefited greatly from having the fluoride in the water. One of my sons never had a cavity. The other two have had one, two tops and theyve been fortunate that they were able to have the fluoride and good dental care, she said.

Demo said she was concerned for all children, especially those that do not have the benefit of quality dental care.

I dont know the whole thing about why its even being raised and who it will benefit to take this away from the...

05:19

New details emerge after 152 koalas killed on private property: Unacceptable Fluoride Action Network

Embarrassing is how the Victorian governments approach to koala management has been described after a population living across a contaminated plantation became so sick over 150 animals were euthanised. Others determined to be in acceptable health were released back into the same forest.

Concerns about the governments handling of the situation at an industrial site in Portland were raised in parliament by Animal Justice Party MP Georgie Purcell. Since then her team have been inundated with questions about the koalas welfare from Australia and overseas.

Killing over 150 koalas cannot be considered appropriate management as they say it is. The Victorian public simply wont accept it, Ms Purcell told Yahoo News Australia. That is why they are so desperate to cover up what is going on and why it has been so difficult to get any answers or outcomes about the koalas.

The severity of the problem was revealed in May, when US industrial-giant Alcoa confirmed it euthanised 152 of 348 koalas health-checked between 2019 and 2023. The animals had been living in eucalyptus trees next to its aluminium smelter and many were suffering from a bone disease called fluorosis.

The assessments continue to show the health status of the population is poor. About 60 per cent of koalas assessed over the last two years have had to be euthanised due to health impacts associated with both overpopulation and exposure to fluoride emissions, Alcoa told Yahoo at the time.

Fluorosis is a disease that causes bone deformities and malnutrition. It has been linked to fluoride emissions created during the production of aluminium. The Environment Protection Authority (EPA)...

04:56

19 Supplements that Can Cause Liver Injury Healthy Holistic Living

This my friends, is why I postulate that people taking little to no supplements are often better off health-wise than those choosing to take many.

The LiverTox database ranks supplements and drugs on a 5-point scale [A to E] to estimate whether a substance is known to cause liver injury. The scale is defined below:

A=Well known cause
B=Highly likely cause
C=Probable cause
D=Possible cause
E=Unlikely cause
E*=Suspected but unproven cause
X=Unknown

Signs of Liver Injury

A liver injury is at the core of so many health issues I see in clients. When the liver is impaired by not being able to do its job properly, all the body systems take a hit.

While below you can find the most severe indications of a liver injury, its important to know that theres a large spectrum of ways your liver can be impacted that arent always so obvious. Sometimes it takes days, weeks, or months to see a noticeable impact, and at that rate, its hard to correlate it with a supplement or drug because the change happened so slowly over time.

N...

03:00

Critical Psychiatry Textbook, Chapter 8: Depression and Mania (Affective Disorders) (Part Seven) Mad In America

Editors Note: Over the next several months, Mad in Gtzsches book, Critical Psychiatry Textbook. In this blog, he continues to detail the way the pharmaceutical industry and the drug regulators hide the increase in suicide attempts and deaths on depression pills. Each Monday, a new section of the book is published, and all chapters are archived here.

In 2014, ten years after the FDA had issued a black-box warning on depression pills because the rate of suicidal thinking or behaviour was twice as high among young patients on a depression pill as on placebo,^303,337 a psychiatrist argued in New England Journal of Medicine that the FDA should consider removing the warning entirely.³³⁷

His arguments were untenable. He found it disturbing that the warning had decreased the use of depression pills also in adults, for whom there is solid evidence of a positive effect of anti-depressant medication on suicide risk. As we shall see, the truth is the opposite.

He opined that the risk posed by untreated depressionin terms of morbidity and mortalityhas always been far greater than the very small risk associated with antidepressant treatment. We need to better educate physicians, to help them understand that although they cannot ignore that small risk, they can safely manage it by carefully monitoring their patients, particularly children and adolescents, during pharmacotherapy....

01:47

ANH Counterpunches FTC in Free Speech Fight Alliance for Natural Health USA Protecting Natural Health

ANH-USA has submitted a Freedom of Information Act (FOIA) request to learn the real motivations for the FTCs attack on free speech in the natural products sector. Action Alert!

Our FOIA request stems from concerns that the Federal Trade Commissions (FTC) recent guidance will have the effect of limiting consumer access to vital scientific information about the benefits of dietary supplements and other natural products. We believe the agency is poised to start cracking down on health claims related to nutrients, and we want to learn how the new FTC policy was generated, which could potentially serve as the basis for a legal challenge to the agencys overreach.

As we said in our previous coverage of this topic, were facing a government-led campaign to conceal the remarkable truth about the healing and disease-preventing powers of foods and nutrients, ultimately misleading the public so that they spend their money on drugs rather than natural supplements. This new policy is the culmination of many years of work on the part of federal agencies to block Americans from learning about how to manage their health with natural products rather than FDA-approved drugs.

Heres how we got to this point. In a revision to its Health ProductsCompliance Guidance issued in December 2022, the FTC aims to impose drug standards on supplements, requiring expensive randomized controlled human clinical testing for supplement companies to make most health claims. The agency then sent out a barrage of 670 letters to companies, including those selling dietary supplements, homeopathic products, and functional foods, warning them that if they make claims without scientific substantiation to the level required by the FTCs new guidance, they will face large civil penaltiesup to $50,120 per violation.

This is an absurd overreach that is a backhanded way of banning many health-related claims for supplements. As weve explained many times, clinical trials are incredibly expensive. Drug companies can afford them because drugs are patentable and the costs can be recouped when the drug is approved and sold for exorbitant prices. Nutrients generally cannot be strongly patented, so the costs of clinical trials cannot be recouped. The government knows this, so the attempt to req...

01:44

The PFAS-Tobacco Connection Alliance for Natural Health USA Protecting Natural Health

As the nation continues to focus attention on PFAS forever chemicals, the research is increasingly telling us that the problem is far, far worse than previously imagined. The time to act is now. Action Alert!

For some time now, weve been sounding the alarm about the extensive contamination of the environment with PFAS chemicals, and what that means for human health. PFAS, or polyfluoroalkyl substances, are a group of chemicals used in hundreds of consumer products. They are nicknamed forever chemicals because they do not break down in the environment and accumulate in blood and organs.

After decades of being relatively unknown, PFAS contamination as a public health issue arose in the early 2000s when residents of Parkersburg, WV sued DuPont for contaminating their town and wrecking their health. Since then, independent scientists and environmental health monitors have been taking a closer look at this issue. Unfortunately, it seems like the more we find out, the worse this problem gets.

ANH-USA will be shining a light on PFAS contamination in just a few weeks, when we will release our very own pilot studyso stay tuned, you wont want to miss this report.

In the meantime, here is a roundup of PFAS news stories from just the last few weeks.

Chemical industry using Big Tobaccos playbook

The chemical industry used the tactics of the tobacco industry to delay public awareness of the toxicity of PFAS and, in turn, delayed regulations governing their use. These are the conclusions of a study looking at decades of internal documents from the chemical industry proving that manufacturers of PFAS chemicals knew they were dangerous but concealed the information.

As they were hiding this information, companies lied to their own employees and the American public. A 1980 DuPont memo, for example, told employees that PFAS chemicals were about as toxic as table salt. Yet as early as 1961, DuPonts chief toxicologist found that very low doses of PFAS exposure enlarged rats livers, recommending that PFAS be handled with extreme care. In 1970, a DuPont-funded lab found PFAS to be highly toxic when inhaled and moderately toxic when ingested. In the early 1980s, a confidential internal report detailed birth defects among pregnant Teflon plant employees, but the company later said We know of no evidence of birth defects caused by [PFAS].

These actions to conceal the truth about PFAS toxicity have endangered countless American lives and poisoned the e...

01:44

How the Nobel Prize Summit Sold Out on Real Science Alliance for Natural Health USA Protecting Natural Health

From ANH-International

The Nobel Prize Summit held between 24^th and 26^th May 2023 in Washington DC showcased how the war against the viral infection of misinformation and disinformation is to be fought by academic institutions, the mainstream media, social media companies, and governments. The summits title, Truth, Trust and Hope is a reflection of a view held by the organisers and their backers. They uphold that unless this war is won, public trust in science is done for. You may not be surprised to learn that cancel culture and artificial intelligence (AI) are expected to play key roles in the battle strategy against scientific misinformation.

The great thing is not having a mind, writes Nobel Laureate Louise Glck, in her poem The Red Poppy. And what a great thing indeed, for having a mind is perhaps one of the biggest obstacles in the way of authoritarianism and the hunger of a few for extreme power. Peoples minds can be either a tool to further an agenda, or a hindrance to achieving it. It depends from what perspective you choose to look at it. Well explore the idea of perspectives throughout the article.

The Nobel Prize Summit began by putting the assembled in-person and virtual audience into an almost trance-like state with a performance piece about mis- and dis-information by film producer Smriti Keshari. Warning: dont be put off by the performers disembodied mouth, the words which emanate from it are too insightful to be ignored this is art, for corporate science protectionisms sake!

.Were their eyes or ears or nose or memory, playing tricks on them? [] Did they see something that wasnt there? What were they to believe? Disinformations web, tangled threads of falsehood spread, truth obscured, misled. Extracts of the monologue from Smriti Kesharis performance piece at the Nobel Prize Summit.

It turns out Kesharis piece was inspired by Samuel Becketts 1972 monologue Not I that is delivered in a similar way: via an illuminated, seemingly disembodied mouth. Keshari borrowed another idea from Becketts work in which the previously voiceless protagonist begins to doubt he...

Tuesday, 06 June

23:00

Morning Coffee Jun 06, 2023 Dr. Tenpenny

06-06-2023 Audio Track: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/6-6-2023-Morn-coffee-plandemic3.mp4 If you enjoyed this show, and want to join us live for []

09:00

On Your Health-Jun 05 2023 Dr. Shannon Kroner Dr. Tenpenny

06-05-2023 Listen to audio of interview here. Click on the video below to watch this episode: https://drtenpenny.b-cdn.net/2023/06-05-23-OYH.mp4 About my guest: Dr. Shannon Kroner has a Doctorate in []

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