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Tuesday, 27 June
00:53
Breaking: The FDA Creates a Path for Psychedelic Drug Trials Healthy Holistic Living
The Food and Drug Administration (FDA) recently released first-ever draft guidance, making way for psychedelic drug trials. This ground-breaking move may facilitate the mainstream acceptance of substances such as magic mushrooms and LSD as potential treatments for behavioral health conditions.
The Significance of the FDAs New Move
The ramifications of this development are far-reaching. Psychedelics are now on the cusp of becoming a multi-billion-dollar industry and gaining widespread acceptance after years of apprehension due to recreational use of these substances, coupled with their high risk of misuse.
Yet, the bulk of research conducted to date has been primarily backed by private sponsors. This scenario may change with the FDAs novel initiative, bringing the promising potential of these substances into the limelight.
The FDAs Decision in Detail
The FDAs decision, outlined in a 14-page document, proposes guidelines on conducting trials, collecting data, and ensuring subject safety for researchers exploring psychedelic treatments for various conditions. These range from PTSD, depression, and anxiety, to a variety of other mental health disorders.
This guidance came hot on the heels of the introduction of new legislation by a bipartisan coalition in Congress, led by Rep. Dan Crenshaw (R-Texas), which directed the issuance of clinical trial guidelines. The legislation, House Bill 4242, represents an important step in establishing regulatory frameworks for psychedelic research.
The Largest Psychedelic Conference in History
Interestingly, the FDAs announcement coincided with the largest psychedelic conference in history held in Denver. This conference saw participation from a wide spectrum of attendees, from New York Jets quarterback Aaron Rodgers to National Institute of Mental Health director Joshua Gordon, indicating the growing interest in this field.
A Deeper Look at the Psychedelic Substances
...
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Monday, 26 June
23:47
Major Breakthrough: How Botox enters brain cells, a discovery that could save lives Healthy Holistic Living
A groundbreaking study led by distinguished researchers from the University of Queensland has unveiled new insights about the complex mechanism through which Botox infiltrates brain cells. The profound findings, published in The EMBO Journal, are set to have a substantial impact on the medical and cosmetic industries and potentially pioneer new treatments for botulism.
Botox: A Multifaceted Tool from Bacterial Origins to Beauty Regimes
The team spearheaded by Professor Frederic Meunier and Dr. Merja Joensuu from the Queensland Brain Institute at the University of Queensland, successfully pinpointed the specific molecular pathway through which the botulinum neurotoxin type-A, popularly known as Botox, infiltrates neurons.
A compound released by the bacterium Clostridium botulinum, Botox has a long and intriguing history. Its initial medical application was in the treatment of strabismus, a condition characterized by misalignment of the eyes. Over time, its therapeutic applications expanded to include treatments for spasms, migraines, and even excessive sweating as documented by the Mayo Clinic and Hopkins Medicine.
Interestingly, Botoxs most widely recognized use today is in the cosmetic industry, where its employed to smooth wrinkles and rejuvenate the skin. However, the benefits of Botox go beyond the aesthetic realm. When deployed medically, Botox injections can provide various health benefits, such as:
- Alleviating chronic migraines: Regular Botox treatments can decrease the frequency of migraine attacks.
- Reducing hyperhidrosis: Botox can be used to manage excessive sweating.
- Treating muscle spasticity: Botox injections can relax muscles and improve mobility.
- Managing eye conditions: Early use of Botox was to address strabismus and blepharospasm (abnormal contraction of the eyelid muscles).
- Reducing overactive bladder symptoms: Botox has shown positive results in controlling urinary incontinence.
However, despite its numerous benefits, its critical to note that when botulinum toxin is released in large quantities by the bacterium Clostridium botulinum, it can cause the potentially lethal disease botulism.
Unraveling the Complex Mechanism of Botox
23:20
Community Shares | June 26th 2023 SafeMinds
- The first person to be diagnosed with autism has died at age 89. Donald Triplett, passed away from cancer in his hometown of Forest, Mississippi. Leo Kanner published his seminal paper Autistic Disturbances of Affective Contact in 1943, which outlined data on eleven children with similar behaviors. Donald was part of Kanners original cohort and considered case number one. Kanner used the term early infantile autism when diagnosing Triplett that same year.
- According to a new brief report, the majority of school-age children with autism living in an urban and ethnically diverse population presented with one or more comorbid diagnoses. Specifically, elementary school-age children were more likely to have an additional diagnosis of language disorder and attention-deficit hyperactivity disorder (ADHD). At the same time, adolescents were more likely to be diagnosed with depression.
- New research shows that health changes or illnesses can cause challenging behaviors in people with autism. Specifically, the authors found that appetite or dietary preferences, irritability and low mood, and loss of previously acquired skills were associated with changes in health. Based on these findings, the researchers suggest that caregivers should look for distress behaviors to better manage healthcare for those on the spectrum.
- The North Syracuse Central School District has settled a lawsuit for $1.55 million that alleged a student with autism did not receive the proper resources and care. The family sued in 2018 when their son was five, claiming that the district refused to provide Applied Behavior Analysis (ABA) therapy and...
23:10
Sweden Examines Health Outcomes for Older Adults with Autism SafeMinds
Study Shows Group Is at Higher Risk of Bodily Injuries, Heart Failure, Cystitis, Glucose Dysregulation, Iron Deficiency, Poisoning, and Self-Harm
The health outcomes of older adults with autism (45 years) have been sparsely studied over the years, leading to a lack of knowledge about the impact of intellectual disability and gender on the overall health patterns of this vulnerable population. However, recent research conducted in Sweden sought to fill this gap in knowledge. A research team conducted a longitudinal, retrospective, population-based cohort study of the Swedish population born between Jan 1, 1932, and Dec 31, 1967, to investigate the association between autism and physical health conditions in older adults. Using linked data from the nationwide Total Population Register and the National Patient Register, the authors investigated the association between autism and various physical health conditions in older adults, considering intellectual disability and gender. They discovered that older adults with autism had higher cumulative incidence and hazard ratios of physical conditions and injuries than their non-autistic counterparts. Specifically, they were at an increased risk of bodily injuries, heart failure, cystitis, glucose dysregulation or dysglycemia, iron deficiency or anemia, poisoning, and self-harm. These risks were observed regardless of intellectual disability or gender. The authors conclude that their findings highlight the importance of collaborative efforts from researchers and health service policymakers to provide older individuals with autism the necessary support to attain healthy longevity and high quality of life.
The post Sweden Examines Health Outcomes for Older Adults with Autism appeared first on SafeMinds.
23:08
Blood Sugar Spikes: Unraveling the Mystery and Understanding Its Effects Healthy Holistic Living
Sweet food and beverages are undeniably attractive, thanks to our brains inbuilt mechanisms that respond to their palatability with a surge of dopamine, a neurotransmitter that signals pleasure. This neural response, however, can lead to consequences beyond temporary bliss, particularly in the form of blood sugar spikes that come with a plethora of negative effects.
Alarmingly, such phenomena are not as uncommon as one might presume; research shows that a whopping 88% of people experience high blood sugar spikes, according to American Diabetes Association. A single spike in blood sugar post a meal can exacerbate oxidative stress and trigger inflammation. Over time, the incessant cycle of glucose peaks and troughs could pave the way for conditions like insulin resistance, stubborn weight gain, and even chronic illnesses like diabetes and heart disease.
While the ill-effects of sugar spikes are well-known, recognizing its signs might be tricky. Here, we will delve into seven common indicators of dysregulated glucose levels and provide comprehensive solutions to mitigate them.
Recognizing Blood Sugar Spikes: Seven Telltale Signs
- Feeling Hungry Soon After Eating: If hunger pangs strike within 90 minutes to two hours post your meal, its likely you experienced a blood sugar spike. The rapid plunge in glucose levels after a steep rise triggers the release of the hunger hormone, ghrelin, signaling the need to eat again.
- Cravings for Sweet Foods: A...
23:00
This Week with Sheila Holm Dr. Tenpenny
06-26-2023 Audio Version here: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/06-26-23-TW-SheilaHolm.mp4 About my guest: Sheila Holm is an internationally recognized speaker and []
23:00
Vitamin D Supplementation During the First 2 Years of Life Decreased the Risk of Psychiatric Problems in Later Childhood SafeMinds
High-Dose (1200 IU) vs. Standard-Dose (400 IU) until Age 2 Showed Less Internalizing Behaviors at Ages 6 to 8
A recent international investigation has examined the potential effects of high-dose vitamin D3 supplementation on psychiatric symptoms in healthy infants up to the age of 2 years. The study found that children who received a daily 1200-IU oral vitamin D3 supplement had a lower prevalence of clinically significant internalizing behaviors (e.g., symptoms of depression, loneliness, and anxiety) than those who received the standard recommended dose of 400 IU. Interestingly, the authors did not find any differences in externalizing behaviors (e.g., oppositional defiance disorder, conduct disorder, and antisocial personality disorder) between the two groups. The study also found that children from the 400-IU group with maternal 25(OH)D levels less than 30 ng/mL during pregnancy had significantly higher internalizing problem scores than children from the 1200-IU group, regardless of maternal 25(OH)D status. While previous studies have suggested that higher 25(OH)D levels during fetal life and early childhood may lower the risk of childhood psychopathology, this is the first randomized controlled trial to assess the potential impact of high-dose vitamin D3 supplementation in healthy infants and up to the age of 2 years on psychiatric symptoms during late preschool and early school age. The authors recommend that their findings be interpreted in context with outcomes related to childrens health related to growth patterns and allergies since lower doses of vitamin D3 were found to be more beneficial during infancy for those conditions.
The post Vitamin D Supplementation During the First 2 Years of Life Decreased the Risk of Psychiatric Problems in Later Childhood appeared first on SafeMinds.
20:00
Editor wont investigate data concerns about paper linking anti-prostitution laws to increased rape Retraction Watch
After reading an economics paper that claimed to document an increase in the rate of rape in European countries following the passage of prostitution bans, a data scientist had questions.
The scientist, who wishes to remain anonymous, sent a detailed email to an editor of the Journal of Law and Economics, which had published the paper last November, outlining concerns about the data and methods the authors used.
Among them: the historical rates of rape recorded in the paper did not match the values in the official sources the authors said they used. In other cases, data that were available from the official sources were missing in the paper, the researchers didnt incorporate all the data they had collected into their model, and a variable was coded inconsistently, the data scientist wrote. (Weve made the full critique available here.)
Given the consequences the conclusions of the article could have for people in the sex industry, the data scientist wrote, I hope that someone takes this very seriously and looks into it the [sic] validity of the analysis and the data they used.
In response, Sam Peltzman, an editor of the journal and a professor emeritus of economics at the University of Chicagos Booth School of Business, instructed the data scientist to contact the authors of the article:
The email raises serious questions but without any specific request. Your questions can better be answered by the authors than editors who, as you must know, cannot give each submission the kind of careful attention reflected in your email. Accordingly, we ask that you contact the authors directly if you have not already done so.
If you mean the email as a prologue to a critique, I am happy to discuss our relevant policies or any other question about our editorial process.
The data scientist wrote back with a specific request:
I have just informed you, the editor, that it appears that the authors made an error in at least one of their models that resulted in a substantive difference in the con...
14:05
RFK Jr. and Joe Rogan: Putting the old denialist technique of bad faith Debate me, bro! challenges on steroids Science-Based Medicine
Joe Rogan conveyed a challenge by antivax crank turned Presidential candidate RFK Jr. to vaccine scientist Dr. Peter Hotez to "debate me, bro!" In the week since, wealthy right wingers have added money to the inducement, and through an awful op-ed by Ross Douthat this weekend, even the New York Times has amped up the pressure for a "debate" about vaccines with RFK Jr. It looks like it's time to revisit the topic of why it's a bad idea to debate science deniers like RFK Jr. sooner than I had anticipated or wanted.
The post RFK Jr. and Joe Rogan: Putting the old denialist technique of bad faith Debate me, bro! challenges on steroids first appeared on Science-Based Medicine.10:00
Factory Farmed Salmon Full of Disease and Hazardous Chemicals Articles
Editor's Note: This article is a reprint. It was originally published December 11, 2018.
Salmon is the second most popular type of seafood in the U.S. (shrimp is the first), with just over 2 pounds consumed annually, per person.1 While many love its flavor, a key reason behind its popularity has to do with its perceived health benefits. As a rich source of beneficial animal-based omega-3 fats, salmon can, indeed, be a very healthy food choice.
However, it can also be among the worst food choices, and the difference lies in the details. While wild-caught Alaskan salmon is an example of good-for-you salmon, rich in healthy fats and low in pollutants, farm-raised salmon is not. Unfortunately, farm-raised makes up 75% of the salmon consumed worldwide, and its volume has increased nearly 1,000% from 1990 to 2015.2
Two Dumpsters of Rotting Salmon Discovered at Fish Farm
The video above, captured by Don Staniford of Scottish Salmon Watch, shows dead salmon rotting in dumpsters at two Scottish salmon farms, one owned by Marine Harvest and the other by Scottish Salmon Company.
This is symptomatic of factory farming its the underbelly of battery factory salmon farming. Infectious diseases are rife in the industry and about a fifth of farmed salmon stock is dying. The fish in these tanks are not going to shops but they have been swimming alongside ones that are, Staniford said in a news release.3 These fish are dying of horrible infections and diseases.
Its unclear how the fish in the video died, but salmon farms are required to store dead fish in a safe manner prior to disposal.4 How many farmed salmon are dying every year in Scotland?
According to Scottish Salmon Watch in a submission to the Scottish Parliament in March 2018...
How Colostrum Can Benefit Your Immune Health Articles
For the first three to four days after giving birth, all mammals, including humans, produce colostrum, also known as initial milk or first milk.1 Rich in enzymes, hormones, growth factors, cytokines and immune cells, this thick, yellow substance is produced only in small quantities, but is packed with so much nutrition that it easily meets the needs of the growing newborn during the first days of life.
About 250 active compounds have been identified in colostrum, but there are likely many others.2 Colostrum contains beneficial bacteria, as well, and acts directly on the babys tissues, ensuring optimal growth and development of the nervous, digestive and immune systems. As explained by researchers with Hirszfeld Institute of Immunology and Experimental Therapy in Wroclaw, Poland:3
"The nutrients and regulatory substances ensure normal growth, differentiation, maturation and function of the digestive system, protect against damage and allow it to heal, control the development of a normal intestinal microbiota and shape the local (gut-related) and systemic immune response."
Given the immense benefits of colostrum to newborns, its also been harnessed for its disease prevention, wellness and antiaging potential, particularly as it relates to immune system function.
Colostrum for Immune System health
Bovine colostrum contains similar bioactive components as human colostrum, albeit in different concentrations.4 Given its widespread availability, its been used for health purposes for thousands of years, including to heal wounds and protect against infection.5
Its believed that cytokines, immunoglobulins, growth factors, antimicrobial compounds and maternal immune cells are also transferred when colostrum is fed, supporting immunity.6 In fact, colostrum is so beneficial its often referred to as "liquid gold" or "immune milk."7 "Naturally produced bioactive components, immunoglobulins lay the foundation of life-long immunity," researchers explained in Food Bioscience.8
Immunoglobulin G (IgG) is the most common antibody in bovine colostrum (BC), making up 80% to 85% of the immunoglobulin present. The Food Bioscience team noted:9
...Contaminated COVID Products and Green Monkey Virus Articles
In the video above, Jessica Rose, Ph.D., interviews microbiologist Kevin McKernan on Good Morning CHD. McKernans team recently discovered1,2,3,4 simian virus 40 (SV40) promoters in Pfizers and Modernas bivalent mRNA COVID shots, which, for decades, have been suspected of causing cancer in humans.5 As explained in the abstract, posted on OSF Preprints in April 2023:6
Several methods were deployed to assess the nucleic acid composition of four expired vials of the Moderna and Pfizer bivalent mRNA vaccines. Two vials from each vendor were evaluated ... Multiple assays support DNA contamination that exceeds the European Medicines Agency (EMA) 330ng/mg requirement and the FDAs 10ng/dose requirements ...
Equally, if not more, troubling, these DNA contaminants also can alter the human genome. As explained by McKernan, genomic sequencing involves reading the letters of the genome, A, T, C and G, which make up the DNA code. Both DNA and RNA can be sequenced in this manner.
DNA can be likened to a copy of the hard drive of your cell, while RNA is like your task manager, dictating the software program being run in a given moment. When you sequence RNA, you get a sense of what the cell is being instructed to do, while sequencing DNA tells you everything the cell could possibly do if the proper instructions are present.
COVID Shots Contain Both RNA and DNA
Its been assumed that the COVID shots contained only RNA, but using genomic sequencing, McKernan discovered they contain DNA fragments as well, and there really should not be any. The RNA is basically copied, or Xeroxed off the DNA, and only the RNA should be in the final product.
As noted by McKernan, the DNA used is proprietary. They dont want people to know all the tricks they put in the DNA to drive maximum amount of Xeroxing, if you will. But what popped out during sequencing was the entire sequencing vector, which shows us everything theyre doing to drive the expression of this RNA, McKernan says.
So, we now know theyre using a T7 promoter, an SV40 promoter, an antibiotic-resistance gene, that the replication is bacterial in origin and more. As explained by McKernan, to get the amount of RNA required for these shots, you need very large amounts of DNA. To get the DNA required, a piece of DNA that codes for RNA in a circle, called a plasmid, was created and then reproduced inside E. coli in a...
08:35
There Are None So Double Blind As Those Who Will Not... Age of Autism The Rebel Alliance!
Last week, our Anne Dachel prepared a
list of questions to pose to VIDS - Vaccine Injury Deniers
- as a follow up to Robert Kennedy's podcast with Joe Rogan.
You can read it along with a
transcript here.
###
By Anne Dachel
When Robert Kennedy, Jr. was interviewed by Joe Rogan on June 15, 2023, he pointed out glaring malfeasance on the part of U.S. health officials.
WHERE ARE THE VACCINE SAFETY STUDIES?
Kennedy said:
And thats the problem with not doing real placebo controlled trials.
None of the vaccines are subjected to true placebo controlled trials. It is the only medical product that is exempt prior to licensure.
I said this for many, many years: Not one of these 72 vaccines has ever been tested pre-licensing in a placebo controlled trial where youre looking at vaccinated vs unvaccinated kids, looking for health outcomes. Never been done.
Tony Fauci was saying, [Kennedys]
lying. Hes not telling the truth. This is vaccine
misinformation.
I said to him, Tony, youve been telling people Im a liar when I say no vaccine has ever been, none of the mandated vaccinesnone of them have ever been tested in a placebo-controlled trial safety test prior to licensing.
And I said, Can you show me one vaccine that has been subject to a safety test. Show me one study that shows that.
He made this show of looking through They had brought in from NIH, this big tray full of file folders, and he made a show of looking through that at the time. H...
08:32
Examining the D in CPTSD | Terry Baranski Mad In America
From CPTSD Foundation: One of the banes of our cultures psychiatric ideology is its tendency to pathologize mental health difficulties as disorders and diseases, both of which imply that theres something wrong with a person that needs to be fixed. This often leads someone diagnosed with a disorder to self-shame, self-blame, and try to fight against their symptoms. In this article, Ill investigate the notion of disorders and argue that they are actually processes that, as trauma expert Gabor Mat eloquently states, are normal responses to abnormal circumstances.
. . . So what exactly are these dynamic processes? To shed some light, we must trace them back to their causes. With CPTSD (along with virtually any other mental health condition), the symptoms that manifest are, in my view, actually a collection of coping strategies that kicked in during childhood due to trauma. These adaptations are highly intelligent when they first come online they prevent our traumatic experiences from becoming even worse, and in many cases actually save our lives. Once the trauma is over, however, they often become maladaptive and outlive their usefulness.
. . . The notion of a disorder tends to create an attitude that symptoms are something to be gotten rid of to battle against using any means necessary. Far from being compassionate, this approach essentially puts the internal system at war with itself. The process perspective, on the other hand, opens the door to treatment modalities such as Internal Family Systems (IFS), which work with our coping strategies rather than against them, using self-compassion and understanding. IFS respects that coping strategies came about for good reasons, and therefore doesnt attempt to change behaviors directly. Instead, a bottom-up approach is used to heal and release a persons trauma, at which point behavioral change comes about as a natural outcome.
***
Back to Around the Web
The post...
06:38
Long COVID symptoms include hair loss and sexual dysfunction Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
Long COVID has a lot of health consequences, but it appears to be linked to hair loss and sexual dysfunction in men.
05:29
CDC recommends new RSV vaccines for older adults Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
A CDC advisory committee voted to recommend two new RSV vaccines specifically for adults 60 years and older.
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Sunday, 25 June
23:59
Why a Germ Expert Is Begging You To Remove the Foil or Plastic Seal Under the Lid of Your Containers After Opening Healthy Holistic Living
If you frequent Reddit or engage in household debates on food storage, youve likely encountered the controversy surrounding foil or plastic seals on food products like yogurt and sour cream. Should these seals be removed or retained for additional coverage after opening? One couple debated this question for an impressive ten years before a directive from the very product in question solved their quandary. The husband found the unexpected resolution under the contentious disposable seal, which was imprinted with a manufacturers instruction: To prolong freshness, completely remove and discard this foil seal.
This straightforward message from the product manufacturer may solve the debate, but it still leaves us wondering about the original purpose of the seals. Moreover, how can leaving these seals on an opened container compromise the freshness of its contents? In pursuit of these answers, we consulted two renowned germ experts.
Understanding the Purpose of Foil or Plastic Seals on Food Containers
According to Jason Tetro, a respected microbiologist and author of the book The Germ Files, there are two primary reasons for the existence of these seals. Firstly, it helps to increase shelf lifethe container is usually flushed with nitrogen before sealing, which reduces the amount of oxygen inside, he explains. Nitrogen flushing is a common technique used by food manufacturers to prolong the shelf-life of their products. The reduction of oxygen inside the container is intended to suppress the growth of aerobic bacteria and fungi, which can cause food to spoil.
Secondly, these seals serve as a protective barrier for the containers contents. It helps to prevent the introduction of chemicals and microbes that could spoil the products and/or cause illnesses, states Tetro.
Adding further clarity to this matter, microbial ecologist Jack A. Gilbert, Ph.D., a professor at the University of California San Diego, elaborates on the importance of the seal. He describes it as a safety and quality mechanism. It works by creating a barrier between the product and the external environment while also providing assurance to consumers that the product has not been tampered with prior to purchase.
Removing the Seal Post-Opening: A Crucial Practice for Food Safety
In casual parlance, breaking the seal refers to the first bathroom visit while c...
23:02
McDonalds Fry Scandal Unveiled: The Not-So-Vegetarian Secret Behind the Worlds Most Iconic Fries Healthy Holistic Living
This might leave you in a bit of a conundrum.
Popular TikToker, Jordan Howlett, famous for his intriguing fast food secrets, has dropped a bombshell revelation on his 9 million followers: McDonalds world-renowned fries might not be as vegetarian-friendly as we thought. This potentially game-changing information, targeting one of the key aspects of McDonalds global allure, has shaken the fast-food world to its core.
The Controversial Ingredient: Natural Beef Flavor
Howlett, 26, points out an ingredient named natural beef flavor thats found on the companys US online menu. He asserts that this is the reason why McDonalds fries taste different from everybody elses fries.
McDonalds cooks their fries with beef flavoring mixed within their vegetable oil, the San Diego-based TikToker explained in a recent TikTok video that has amassed over 9.6 million views. He suggests that this ingredient is what makes McDonalds fries irresistibly tasty but may pose a significant problem for vegetarians and those with specific dietary restrictions.
@jordan_the_stallion8 #stitch with @youraveragetechbro #fyp original sound Jordan_The_Stallion8
Howlett, upon discovering the use of beef flavoring in the fries,
was rather intrigued. I thought it was incredibly interesting, he
shared. He thought that the public, particularly those with dietary
restrictions, should be aware of this information. Whether it
contains meat or not doesnt really change my view on the McDonalds
fries. I still enjoy them, he added.
McDonalds Response: Beef Flavorings Recipe
McDonalds, on its website, confirms the use of beef flavoring in their fry prep...
22:17
This Widely Used Herb in Ayurveda Has Multiple Health Benefits Including Cancer Prevention, Inflammation Reduction, and Blood Purification Healthy Holistic Living
Rooted deep within the traditional medicinal practices of India lies an extraordinary herb, extensively used and profoundly respected for millennia: the Neem, scientifically known as Azadirachta indica. From disease prevention and longevity to overall bodily wellness, neem has repeatedly proven its extraordinary efficacy. Its numerous, scientifically backed health benefits span from potent anti-cancer and anti-inflammatory effects to blood purification, liver health, and beyond. This comprehensive guide will delve into the fascinating world of neem, offering an enriching insight into its myriad health benefits, as well as sharing useful tips on its usage.
The Neem Herb: A Potent Life Enhancer
Boasting a long history of therapeutic use, Neem has continued to pique the interest of both traditional herbal enthusiasts and modern scientists alike. The ancient Ayurvedic medicinal system recognized its versatile healing capabilities, which modern research has continued to corroborate and elaborate upon. Below, we will embark on an exploration of the numerous health benefits of neem.
1. Anti-Cancer Properties
Neems prowess as a potential natural anti-cancer agent has received significant attention within the scientific community. Various studies, such as this one, have underscored its potent anticancer properties. Neem extracts have demonstrated the capacity to inhibit the growth and spread of cancer cells, notably by inducing apoptosis the process of programmed cell death that prevents their uncontrolled proliferation. Beyond this, neem also enhances the immune systems ability to target and destroy cancer cells, making it an invaluable adjunctive therapy alongside conventional cancer treatments.
2. Anti-Inflammatory Properties
Chronic inflammation is a common denominator underlying numerous
health conditions, from cardiovascular diseases and arthritis to
diabetes. Neem exhibits remarkable
anti-inflammatory properties that can alleviate symptoms and
promote overall wellness. Active compounds in neem, like nimbin and
nimbidin, inhibit pro-inflammatory enzymes and cytokines, thereby
reducing inflammation and relieving discomfort. Integrating neem
into your daily routine can offer a natural, effective way to
manage inflammatory conditions.
...
21:37
N-Acetyl Cysteine: NAC Supplement Powerful Antioxidant Healthy Holistic Living
Research suggests that N-acetyl cysteine (NAC) the supplement form of the semi-essential amino acid L-cysteine is an effective, safe and low-cost treatment option for a range of conditions, including those that are both acute and chronic.
What are the benefits of taking NAC? Not only has been it been used for three decades as an effective mucolytic agent (mucous-thinner), but it also has uses including reducing inflammation, protecting the liver, and preventing/treating drug toxicity, insulin resistance, infertility due to PCOS and more.
What Is NAC?
N-acetyl cysteine, the supplement form of cysteine, is an amino acid that helps the body create and use protective antioxidants.
While cysteine is found in many high-protein foods, NAC is only obtained from taking supplements or prescription drugs.
Because the human body can create some NAC from other amino acids, particularly l-methionine and l-serine, it is considered to be a semi-essential amino acid. That means there isnt a daily requirement of NAC that you must get from your diet, but getting higher amounts can benefit some people.
Benefits
1. Has Antioxidant Effects and Helps Form Glutathione
NAC is involved in the regulation of the glutamatergic system. In other words,...
10:00
The Importance of Omega-3 for Cell Membrane Functionality Articles
In this interview, Nils Hoem, Ph.D., a research scientist with Aker Biomarine, the largest krill oil company in the world takes a deep dive into omega-3s and the crucial role they play in the health and functionality of your cell membranes.
In my academic life, I spent the first 20 years as a researcher at the University of Oslo. I got my master's and doctorate from the University of Oslo in pharmacology, and was an associate professor there ... Fifteen years ago, I came ... to work for Aker Biomarine ... as the chief scientist, but I'm, by heart and mind, really, a pharmacologist, Hoem says.
The Importance of Membranes
As explained by Hoem, the cellular membrane is the universal surface onto which, and into which, the cellular machinery is assembled. Very little in the cell just floats around. It's a very complex structure and the integrity of membranes is absolutely vital for the function of the cell, he says.
The cell membrane also hosts response elements and almost all signaling, except for hormones. Almost all short path signaling begins in the membrane. Your mitochondria also have an inner and outer membrane, and the function of these are also crucial for health.
Membranes are lipid structures made of phospholipids and other constituents. Inside we find phosphatidylcholine and phosphatidylethanolamine, two ampholytic phospholipids, meaning they have a polar end and nonpolar end.
The food you eat provides the raw material substrate that is then assembled into the mitochondrial and cellular membranes, which is why the type of fats you consume is so important.
Omega-6 Competes Against Omega-3
As explained by Hoem, there are two polyunsaturated fats (PUFAs) that are considered to be essential in conventional medicine. One of them is the omega-6 linoleic acid (LA), which is an 18-carbon molecule. Although the level of LA needed is likely significantly lower than suggested, it is a moot point as virtually consuming 10 times the suggestion. The other is omega-3 alpha-linolenic acid (ALA), which also has 18 carbons.
Your body cannot make these fats, so you must get them from your diet. That said, since LA is found in nearly every food, and you need very small amounts, its virtually impossible to become deficient in LA.
Others, such as the omega-3 EPA and DHA, which have 20 and 22 carbons respectively, can be synthesized in your body, provided you have enough available delta-6-desaturase, an enzyme responsible for their conversion.
The problem is that there's competitive inhibition for that enzyme, so when you have 10-fold (1,000%) more omega-6 in your system, then th...
Hallmarks of Alzheimer's Are Stimulated by This Substance Articles
Editor's Note: This article is a reprint. It was originally published March 10, 2019.
Boyd Haley, Ph.D., is a chemist specializing in the development of chemicals to chelate toxic metals, both from the environment and the human body. I had the opportunity to interview Haley (above) at the 2018 Academy of Comprehensive Integrative Medicine (ACIM) conference in Orlando.
Haleys Ph.D. is in chemistry and biochemistry. He conducted research funded by the National Institutes of Health (NIH) for 25 years at the University of Wyoming and at the University of Kentucky. Early in his career, he developed a biochemical detection system called nucleotide photoaffinity labeling and has published studies on its usage.1 Haley explains:
"I took ATP and made it radioactive, which isn't a big feat. But then I attached to that a molecule that would explode when it hit a photon of light. When it exploded, it made a very reactive intermediate that had a half-life of something like 10-12 or 10-13 seconds.
If ATP was bound to a protein, such as sodium potassium ATP [and] you hit it with light, it would form a covalent bond at the binding site of ATP on the enzyme it was interacting with
You could use these kinds of probes to see the difference between the ATP, guanosine diphosphate (GDP), cyclic adenosine monophosphate (AMP) and nicotinamide adenine dinucleotide (NADH) all these binding proteins, to see how the energetics of the cell was changing."
Haley's Alzheimer's Research
He later took a position with the Alzheimer's Center, a research center for Alzheimer's disease, where he collaborated with a former graduate student of his. The NIH funded their research for five years, which used Haley's technology to assess the differences of ATP, GDP and cyclic AMP binding proteins in normal brains versus those with Alzheimer's disease.
"There were dramatic differences," he says. For example, the enzyme creatine kinase, which is a fundamental enzyme, is 98% inhibited in Alzheimer's patients. They also discovered that tubulin a major brain protein that holds an axon in its extended form and controls the growth direction of axons and dendrites is inhibited by more than 80%.
In 1989, he published the paper2 "Aberrant Guanosine Triphosphate-Beta-Tubulin interaction in Alzheimer's disease" in the Annals of Neurology, stating that "These results support the hypothesis that microtubule formation is abnormal in brains affected by Alzheimer's disease."
...How the Censorship Industry Works, and How We Can Stop It Articles
In this video, I interview Mike Benz, executive director for the Foundation for Freedom Online. Benz started off as a corporate lawyer representing tech and media companies before joining the Trump administration, where he worked as a speech writer for Dr. Ben Carson, the former U.S. Secretary of Housing and Urban Development (HUD) and President Trump.
He also advised on economic development policy. He then joined the State Department as Deputy Assistant Secretary for International Communications and Information Technology. There, he ran the cyber desks at state, meaning all things having to do with the internet and foreign policy.
This is toward the end of 2020, which was a really fascinating time to witness the merger, in many respects, of big government and big tech companies themselves, he says. I had grown up, I think, like many Americans, with a belief that the First Amendment protected you against government censorship.
The terms of engagement that we had enjoyed from 1991, when the worldwide web rolled out, until 2016, the election in the U.S. and Brexit in the U.K., which is, really, the first political event where the election was determined, in many respects, by momentum on the internet.
There was that 25-year golden period where the idea of being censored by a private sector company, let alone the government, was considered something, to me, very deeply anathema to the American experience.
What I witnessed at the State Department because I was at the desk, basically, that Google and Facebook would call when they wanted favors abroad, when they wanted American protection or American policies to preserve their dominance in Europe, or in Asia or in Latin America.
And the U.S. government was doing favors for these tech companies while the tech companies were censoring the people who voted for the government. It was a complete betrayal of whatever social contract typically underlies the public-private partnership.
The Internet Was Founded by the National Security State
Ostensibly, the rapid expansion of censorship started post-2016, but you can make a strong argument that the internet was never intended to remain free forever. Rather, the intention for it to be used as a totalitarian tool was likely baked in from the start when the national security state founded it in 1968.
The worldwide web, which is the user interface, was launched in 1991, and my suspicion is that the public internet was seeded and allowed to grow in order to capture and make the most of the population dependent upon it, knowing that it would be...
08:45
Geoengineering Watch Global Alert News, June 24, 2023, #411 Geoengineering Watch
Dane Wigington GeoengineeringWatch.org Extreme
hail events have just hammered Colorado, Texas, Kansas and parts of
the Northeastern US, climate engineering and chemical ice
nucleation cloud seeding operations are core to the equation.
Temporary toxic surface cooldowns are a constant objective of the
geoengineers, the resulting consequences aren't a consideration for
them. Snow fell this week in
08:01
Survey Says Age of Autism The Rebel Alliance!
By Cathy Jameson
I love our quieter summer schedule. The alarm clock isnt screaming at us to wake up early. The kids arent rushing here and there. And Im able to sit still a bit longer to catch up on some things Ive had to put on hold. With the extra quiet time, Ive started to sift through my email to get rid of old messages. Every few days, I get rid of promotions that have expired and also delete school notices that are now irrelevant. In sitting down late last week to get sort through a handful of older messages, I saw that I had a new one. I made sure not to delete it:
Dear Cathy,
Over the course of the COVID-19 pandemic, Childrens Health Defense (CHD) experienced considerable growth in its membership, as people sought information about vaccine efficacy and safety, and community support in the face of restrictive government and workplace policies such as vaccine mandates. To our knowledge, little research has been done on the experiences and consequences of these policies for overall wellbeing, especially for people who declined vaccination.
If you subscribe to CHD, you probably saw that announcement, too. Coupled with it is the chance to take a survey to better understand our subscribers experiences with vaccine mandates since the beginning of the pandemic. The survey will take about 510 minutes to complete.
I have friends who knew to be skeptical of what our government was saying and doing early on during the pandemic. Some had never been vocal about vaccines. Now, they are being more than vocal. Theyre saying never again.
Never again will they be duped or talked into taking something so risky.
Never will they risk their job, their health, or their freedom.
Never.
Early on, when people would ask me where they could look for information about what was going on, I made sure to share the CHD webpage. Look here for some helpful resources. Check out what this group is working on. Read up on who the talking...
Go Back:30 Days | 7 Days | 2 Days | 1 Day
Saturday, 24 June
21:00
Weekend reads: A fraudster is sentenced to prison; how another reinvented himself; RFK Jr.s retraction, redux Retraction Watch
Would you consider a donation to support Weekend Reads, and our daily work?
The week at Retraction Watch featured:
- Plagiarism scandal engulfs high-profile academic in Latvia
- Journalism with impact: The work of Retraction Watch
- Financial advisor failed to disclose he had sued the organization his paper criticized
- In a Tipsters Note, a View of Science Publishings Achilles Heel
- Deplorable: Imaging journal to retract nearly 80 papers for compromised peer review
- Paper retracted more than eight months after author admitted to plagiarism
Our list of retracted or withdrawn COVID-19 papers is up to more than 300. There are now 41,000 retractions in our database which power...
20:00
Psychiatrys Denial of the Horrors of Tardive Dyskinesia Mad In America
Even though tardive dyskinesiaand also akathisia, which it resemblesare serious and horrible harms of psychiatric drugs, they are often overlooked or deliberately ignored by psychiatrists.
It took psychiatry 20 years to recognise tardive dyskinesia as an iatrogenic illness, even though it affects about 4-5% of the patients receiving neuroleptics per year. Poul Leber from the FDA concluded in 1984 that, over a lifetime, all patients might develop tardive dyskinesia. Three years later, the president of the American Psychiatric Association said on an Oprah Winfrey show that tardive dyskinesia was not a serious or frequent problem.
Neurologists are much better at spotting tardive
dyskinesia than psychiatrists and the same applies to researchers.
Researchers found tardive dyskinesia in 10 of 48 patients
consecutively admitted with acute psychosis and treated for at
least a week with neuroleptics, while the psychiatrists only made
this diagnosis in one of them.
Akathisia is also common but is also often missed, ignored or misinterpreted. In the same study, the researchers diagnosed akathisia in 27 patients, the clinicians only in 7. In a community sample of patients with schizophrenia, the prevalence was 19%.
Tardive dyskinesia is an involuntary drug-induced movement disorder characterised by repetitive purposeless movements. It can have many manifestations...
17:37
Steve Kirsch and Brandolinis law Science-Based Medicine
The amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it.
The post Steve Kirsch and Brandolinis law first appeared on Science-Based Medicine.11:19
13 Chemical Threats to Remove from Your Home GreenMedInfo
Visit our Re-post guidelines
While people are aware of the health risk caused by outdoor air pollution, few may consider that indoor air quality can also have a negative impact on their health. While many of these products are commonly used in the home there are healthier options available.
10:00
Throughout the pandemic and beyond, youve likely heard top political figures and Big Tech leaders talking about the opportunity to reset and build back better. Founder and executive chairman of the World Economic Forum (WEF) Klaus Schwab is often said to be the mastermind behind this and is credited with circulating the idea of The Great Reset, of which build back better is an integral part.
However, there are other nefarious players who may have even more power, namely the newly crowned King Charles III.
When The Great Reset was officially launched in 2020, it was not done so by Klaus Schwab or Bill Gates, but by Charles, Prince of Wales, then heir-apparent to the British throne, according to Winter Oak, an independent not-for-profit organization development agenda and a commitment to truth, freedom and social justice.1
Theyve outlined key details on why King Charles should be on your radar when it comes to the implantation of The Great Reset and Agenda 21 (Agenda for the 21st Century) the inventory and control plan for all land, water, minerals, plants, animals, construction, means of production, food, energy, information, education and all human beings in the world.
Is King Charles The Great Resetter?
In June 2020, King Charles, then The Prince of Wales, announced he was launching a new global initiative, The Great Reset, along with WEFs and His Royal Highness Sustainable Markets Initiative.2 A tweet from Clarence House stated:3
#TheGreatReset initiative is designed to ensure businesses and communities build back better by putting sustainable business practices at the heart of their operations as they begin to recover from the coronavirus pandemic.
Winter Oak explained:4
This may come as a bit of a surprise to those who see Charles as a bumbling but affable figure, who talks to his plants, loves traditional architecture, protects nature and tries to help young people get along in life. But the reality is that he is the head (or the very willing figurehead) of a vast empire of nefarious financial interests hiding hypocritically behind a facade of charitable philanthropy.
King Charles charitable enterprise spans a ...
Oral Myofacial Therapy Articles
Editor's Note: This article is a reprint. It was originally published April 7, 2013.
Orofacial myofunctional therapy is a profoundly useful treatment that may help treat the symptoms of a wide variety of health issues, from opening airways to headaches, temporomandibular joint disorders (TMJ), to poor digestion, just to name a few. It may be the most profound therapy available for the treatment of mild to moderate sleep apnea, which is a pervasive problem that affects many.
Myofunctional therapy is the "neuromuscular re-education or repatterning of the oral and facial muscles."1
The therapy includes facial and tongue exercises and behavior modification techniques to promote proper tongue position, improved breathing, chewing, and swallowing. Proper head and neck postures are also addressed. There are good studies to substantiate that it may resolve jaw problems and orthodontic relapse working in a multidisciplinary team.
It may also be an alternative or adjunctive treatment to facial plastic surgery, to help get rid of lines and saggy facial muscles, which is exciting. In fact, in Brazil, some myofunctional therapists work with plastic surgeons.
Joy Moeller, whom I had the good fortune of meeting as a result of an earlier interview with Carol Vander-Stoep (author of the book "Mouth Matters; How Your Mouth Ages Your Body and What YOU Can Do About It"), is a leading expert in this form of therapy in the U.S.
At the end of that interview with Vander-Stoep, we discussed the issue of being "tongue tied," and she happened to look into my mouth. A large population of Americans are estimated to have health problems related to poor orofacial function, and the vast majority have no idea their problems stem from the dysfunction of their mouth (primarily the tongue), breathing habits, and forward head and neck muscle function. It turns out I was one of them.
As a result, I got on a treatment plan with Moeller, who is a premier expert on myofunctional therapy in the U.S. We did regular Skype sessions for several months, and not only did I make great progress in resolving my tongue tie, but it had a profoundly beneficial effect on my posture and amount of deep sleep as well.
Of course, adult problems associated with tongue-tie are best prevented in infancy beginning with ensuring the normal duration of breastfeeding. However, tongue-tie often goes undetected by OBGYNs and pediatricians who, having been educated in a bottle-feeding culture, fail to connect the related breastfeeding issues.
When feeding issues are present, such as recurring maternal pain, thrush or mastitis, poor latch, inefficient emptying of the breast,...
Why Are Planes Using Pork Byproducts for Fuel? Articles
Rendered animal fats, a byproduct of raising animals on concentrated animal feeding operations (CAFOs), are commonly added to pet food and personal care products like soap and cosmetics. However, theyre also a growing part of "sustainable aviation fuels" (SAF), to the extent that theres not enough to go around.
A study conducted by Cerulogy for Transport & Environment (T&E) revealed increasing pressure on animal fat supplies as its use in biodiesel has skyrocketed 40-fold since 2006.1
8,800 Dead Pigs to Fuel One Transatlantic Flight
Animal fats are being touted as the latest sustainable biofuel, but as usage grows its already appearing to be an unsustainable fuel source. According to the T&E report, demand for animal fats for biofuel may triple from 2021 to 2030.2 However, in Europe, 46% of animal fat feedstocks are already used as biodiesel, suggesting supply wont keep up with demand.
The study calculated that to fuel one transatlantic flight from Paris to New York, 8,800 dead pigs are needed for one way. In the European Union, animal fats are categorized into three groups depending on their risk levels for disease transmission. While categories 1 and 2 can only be used for heating, category 3 can be used in a wider range of applications, including pet food, oleochemical industries and biofuel.
With biofuel creating more demand for those category 3 fats, other industries may be pushed out of the market or find products being made with animal-fat substitutes, which are usually cheaper available oils.3 Nicole Paley, deputy chief executive of UK Pet Food, told BBC:4
"These [animal fats] are really valuable ingredients for us and they are hard to replace, and they're put to good use already in a very sustainable way So actually diverting these ingredients to biofuels is actually creating another problem. It would put us in competition with the aviation industry. And when it comes to the purse strings of the aviation sector, the pet food industry would find it really difficult to compete."
Dickon Posnett from Argent Energy, which produces biodiesel from wastes, added, "If you make a big incentive for use of these lipids, animal fats, and used cooking oils, in aviation, it will inevitably take it away from other things. So if you want to increase aviation sustainability, at the expense of truck sustainability, then crack on. But that's a decision for the government to make."5
UK Considers Ban on Animal Fats in Aviatio...
06:31
Low risk of Guillain-Barr syndrome after COVID mRNA vaccines Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
New research shows that the risk of Guillain-Barr syndrome after receiving COVID-19 mRNA vaccines is the same as unvaccinated individuals.
05:44
Protective mechanism of salvianolic acid B on blood vessels. GreenMedInfo
PMID: Zhongguo Zhong Yao Za Zhi. 2023 Mar ;48(5):1176-1185. PMID: 37005801 Abstract Title: [Protective mechanism of salvianolic acid B on blood vessels]. Abstract: Salvianolic acid B(Sal B) is the main water-soluble component of Salvia miltiorrhiza Bunge. Studies have found that Sal B has a good protective effect on blood vessels. Sal B can protect endothelial cells by anti-oxidative stress, inducing autophagy, inhibiting endoplasmic reticulum stress(ERS), inhibiting endothelial inflammation and adhesion molecule expression, inhibiting endothelial cell permeability, anti-thrombosis, and other ways. In addition, Sal B can alleviate endothelial cell damage caused by high glucose(HG). For vascular smooth muscle cell(VSMC), Sal B can reduce the synthesis and secretion of inflammatory factors by inhibiting cyclooxygenase. It can also play a vasodilatory role by inhibiting Ca~(2+) influx. In addition, Sal B can inhibit VSMC proliferation and migration, thereby alleviating vascular stenosis. Sal B also inhibits lipid deposition in the subendothelium, macrophage apoptosis, thereby reducing the volume of subendothelial lipid plaques. For some atherosclerosis(AS) complications, such as peripheral artery disease(PAD), Sal B can promote angiogenesis, thereby improving ischemia. It should be pointed out that the conclusions obtained from different experiments are not completely consistent, which needs further research. In addition, previous pharmacokinetics showed that Sal B was poorly absorbed by oral administration, and it was unstable in the stomach, with a large first-pass effect in the liver. Sal B had fast distribution and metabolism in vivo and short drug action time. These affect the bioavailability and biological effects of Sal B, and the development of clinically valuable Sal B non-injectable delivery systems remains a great challenge.
05:42
Chlorogenic acid protective effects on paraquat-induced pulmonary oxidative damage and fibrosis. GreenMedInfo
PMID: J Biochem Mol Toxicol. 2023 Apr 3:e23352. Epub 2023 Apr 3. PMID: 37010041 Abstract Title: Chlorogenic acid protective effects on paraquat-induced pulmonary oxidative damage and fibrosis in rats. Abstract: Paraquat (PQ) is a widely used herbicide that can cause severe oxidative and fibrotic injuries in lung tissue. Due to the antioxidant and anti-inflammatory properties of chlorogenic acid (CGA), the present study investigated its effects on PQ-induced pulmonary toxicity. To this end, 30 male rats were randomly categorized into five groups of six. Initially, the first and third groups were treated intraperitoneally (IP) with normal saline and CGA (80mg/kg) for 28 consecutive days, respectively. The second, fourth, and fifth groups were treated with normal saline and 20 and 80mg/kg of CGA for 28 consecutive days, respectively, and received a single dose of PQ (IP, 20mg/kg) on Day 7. Then, the animals were anesthetized with ketamine and xylazine, and lung tissue samples were collected for biochemical and histological examinations. The results showed that PQ significantly increased hydroxyproline (HP) and lipid peroxidation (LPO) and decreased the lung tissue antioxidant capacity. In addition, myeloperoxidase (MPO) activity increased significantly, while glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activity declined substantially. The administration of therapeutic doses of CGA could prevent the oxidative, fibrotic, and inflammatory effects of PQ-induced lung toxicity, and these changes were consistent with histological observations. In conclusion, CGA may improve the antioxidant defense of lung tissue and prevent the spread of inflammation and the development of PQ-induced fibrotic injuries by enhancing antioxidant enzymes and preventing inflammatory cell infiltration.
05:40
Chlorogenic acid attenuates liver apoptosis and inflammation in endoplasmic reticulum stress-induced mice. GreenMedInfo
PMID: Iran J Basic Med Sci. 2023 Apr ;26(4):478-485. PMID: 37009010 Abstract Title: Chlorogenic acid attenuates liver apoptosis and inflammation in endoplasmic reticulum stress-induced mice. Abstract: OBJECTIVES: The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER)results in a state known as "ER stress". It can affect the fate of proteins and play a crucial role in the pathogenesis of several diseases. In this study, we investigated the protective effect of chlorogenic acid (CA) on the inflammation and apoptosis of tunicamycin-induced ER stress in mice.MATERIALS AND METHODS: We categorized mice into six groups: Saline, Vehicle, CA, TM, CA 20-TM, and CA 50-TM. The mice received CA (20 or 50 mg/kg) before intraperitoneal tunicamycin injection. After 72 hr of treatment, serum biochemical analysis, histopathological alterations, protein and/or mRNA levels of steatosis, and inflammatory and apoptotic markers were investigated by ELISA and/or RT-PCR.RESULTS: We found that 20 mg/kg CA decreased mRNA levels of, and. Moreover, CA supplementation prevented TM-induced liver injury through changes in lipid accumulation and lipogenesis markers of steatosis (), and exerted an inhibitory effect on inflammatory (and) and apoptotic markers (caspase 3,,, and), of liver tissue in ER stress mice.CONCLUSION: These data suggest that CA ameliorates hepatic apoptosis and inflammation by reducing NF-B and Caspase 3 as related key factors between inflammation and apoptosis.
05:37
N-acetyl cysteine and chlorogenic acid protection against cisplatin-induced nephrotoxicity. GreenMedInfo
PMID: Pharmaceuticals (Basel). 2023 Feb 22 ;16(3). Epub 2023 Feb 22. PMID: 36986437 Abstract Title: TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity. Abstract: BACKGROUND: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation, and apoptosis. Toll-4 receptors (TLR4) and NLPR3 inflammasome are pattern-recognition receptors responsible for activating inflammatory responses and are assigned to play a significant role with gasdermin (GSDMD) in acute kidney injuries. N-acetylcysteine (NAC) and chlorogenic acid (CGA) have documented nephroprotective effects by suppressing oxidative and inflammatory pathways. Therefore, the current study aimed to investigate the contribution of the upregulation of TLR4/inflammasomes/gasdermin signaling to Cp-induced nephrotoxicity and their modulation by NAC or CGA.METHODS: A single injection of Cp (7 mg/kg, i.p.) was given to Wistar rats. Rats received either NAC (250 mg/kg, p.o.) and/or CGA (20 mg/kg, p.o.) one week before and after the Cp injection.RESULTS: Cp-induced acute nephrotoxicity was evident by the increased blood urea nitrogen and serum creatinine and histopathological insults. Additionally, nephrotoxicity was associated with increased lipid peroxidation, reduced antioxidants, and elevated levels of inflammatory markers (NF-B and TNF-) in the kidney tissues. Moreover, Cp upregulated both TLR4/NLPR3/interleukin-1beta (IL-1) and caspase-1/GSDMD-signaling pathways, accompanied by an increased Bax/BCL-2 ratio, indicating an inflammatory-mediated apoptosis. Both NAC and/or CGA significantly corrected these changes.CONCLUSIONS: This study emphasizes that inhibition of TLR4/NLPR3/IL-1/GSDMD might be a novel mechanism of the nephroprotective effects of NAC or CGA against Cp-induced nephrotoxicity in rats.
05:33
Chlorogenic acid restores ovarian functions in mice with letrozole-induced polycystic ovarian syndrome. GreenMedInfo
PMID: Biomedicines. 2023 Mar 14 ;11(3). Epub 2023 Mar 14. PMID: 36979879 Abstract Title: Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor. Abstract: Around the world, polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic condition that typically affects 6-20% of females. Our study's major goal was to examine how chlorogenic acid (CGA) affected mice with endocrine and metabolic problems brought on by letrozole-induced PCOS. Group I served as the control for 81 days; Group II was given Letrozole (LETZ) orally at a dose of 6 mg/kg bw for 21 days to induce PCOS; Group III was given LETZ (6 mg/kg) for 21 days, followed by treatment with CGA (50 mg/kg bw daily) for 60 days. The study indicated that LETZ-treated mice displayed symptoms of PCOS, such as dyslipidemia, hyperinsulinemia, elevated testosterone, increases in inflammatory markers and malonaldehyde, and a decline in antioxidants (Ar, lhr, fshr, and esr2) in the ovaries. These alterations were affected when the mice were given CGA and were associated with reduced levels of adiponectin. Adiponectin showed interactions with hub genes, namely MLX interacting protein like (MLXIPL), peroxisome proliferator-activated receptor gamma Coactivator 1- alpha (PPARGC1), peroxisome proliferator-activated receptor gamma (Pparg), and adiponectin receptor 1 (Adipor1). Lastly, the gene ontology of adiponectin revealed that adiponectin was highly involved in biological processes. The findings from our research suggest that adiponectin has direct impacts on metabolic and endocrine facets of PCOS.
05:31
Effects of dietary chlorogenic acid on intestinal barrier function and the inflammatory response in broilers during lipopolysaccharide-induced immune stress. GreenMedInfo
PMID: Poult Sci. 2023 May ;102(5):102623. Epub 2023 Mar 4. PMID: 36972676 Abstract Title: Effects of dietary chlorogenic acid on intestinal barrier function and the inflammatory response in broilers during lipopolysaccharide-induced immune stress. Abstract: Immune stress exerts detrimental effects on growth performance and intestinal barrier function during intensive animal production with ensuing serious economic consequences. Chlorogenic acid (CGA) is used widely as a feed additive to improve the growth performance and intestinal health of poultry. However, the effects of dietary CGA supplementation on amelioration of the intestinal barrier impairment caused by immune stress in broilers are unknown. This study investigated the effects of CGA on growth performance, intestinal barrier function, and the inflammatory response in lipopolysaccharide (LPS) mediated immune-stressed broilers. Three hundred and twelve 1-day-old male Arbor Acres broilers were divided randomly into 4 groups with 6 replicates of thirteen broilers. The treatments included: i) saline group: broilers injected with saline and fed with basal diet; ii) LPS group: broilers injected with LPS and fed with basal diet; iii) CGA group: broilers injected with saline and feed supplemented with CGA; and iv) LPS+CGA group: broilers injected with LPS and feed supplemented with CGA. Animals in the LPS and LPS+CGA groups were injected intraperitoneally with an LPS solution prepared with saline from 14 d of age for 7 consecutive days, whereas broilers in the other groups were injected only with saline. LPS induced a decrease in feed intake of broilers during the stress period, but CGA effectively alleviated this decrease. Moreover, CGA inhibited the reduction of villus height and improved the ratio of villus height to crypt depth in the duodenum of broilers 24 and 72 h after LPS injection. In addition, dietary CGA supplementation significantly restored the expression of cation-selective and channel-forming Claudin2 protein 2 h after LPS injection in the ileum. LPS enhanced the expression of tumor necrosis factor-(TNF-) and interleukin-1(IL-1) in the small intestine, but this enhancement was blocked by CGA supplementation. The expression of interleukin-10 (IL-10) increased with LPS injection and CGA promoted the production of IL-10. CGA addition downregulated the expression of intestinal interleukin-6 (IL-6) of broilers under normal rearing conditions. However, CGA supplementation upregulated the expression of IL-6 of broilers 72 h after LPS injection. The data demonstrate that dietary supplementation with CGA alleviates intestinal barrier damage and intestinal inflammation induced by LPS injection during immune stress thereby improving growth performance of broilers.
...
05:28
Chlorogenic acid ameliorated non-alcoholic steatohepatitis. GreenMedInfo
PMID: Chem Biol Interact. 2023 May 1 ;376:110461. Epub 2023 Mar 23. PMID: 36965689 Abstract Title: Chlorogenic acid ameliorated non-alcoholic steatohepatitis via alleviating hepatic inflammation initiated by LPS/TLR4/MyD88 signaling pathway. Abstract: Non-alcoholic steatohepatitis (NASH) is a severe pathological stage in non-alcoholic fatty liver disease (NAFLD) and is generally recognized to be induced by chronic inflammation. Natural compound chlorogenic acid (CGA) is well-known for its anti-inflammatory capacity. This study aimed at evaluating the alleviation of CGA on NASH and further exploring its engaged mechanism via focusing on abrogating hepatic inflammation. Our results showed that CGA had a good amelioration on NASH in vivo. CGA alleviated liver oxidative injury by inducing nuclear factor erythroid 2-related factor 2 (Nrf2) activation and reduced liver steatosis via up-regulating peroxisome proliferator-activated receptor-alpha (PPAR). CGA attenuated hepatic inflammation in vivo, but didn't decrease the elevated lipopolysaccharide (LPS) content. CGA blocked the activation of nuclear factor kappa-B (NFB) or inflammasome both in MCDD-fed mice and in LPS-stimulated macrophages. CGA was found to directly bind to myeloid differentiation primary response 88 (MyD88), and thus competitively blocked the interaction between toll-like receptor 4 (TLR4) and MyD88, thereby abrogating hepatic inflammation initiated by LPS-TLR4-MyD88. Moreover, the CGA-provided anti-inflammatory effect was obviously disappeared in macrophages overexpressed MyD88. Hence, CGA has an excellent efficacy in improving NASH. CGA alleviated liver inflammation during NASH progression through blocking LPS-TLR4-MyD88 signaling pathway via directly binding to MyD88.
05:27
Chlorogenic acid may be a viable therapeutic option for bacterial and viral-induced acute respiratory distress syndrome-like pathology. GreenMedInfo
PMID: Clin Sci (Lond). 2023 May 31 ;137(10):785-805. PMID: 36951146 Abstract Title: Targeting TLR4/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-B axis. Abstract: Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a life-threatening condition caused due to significant pulmonary and systemic inflammation. Chlorogenic acid (CGA) has been shown to possess potent antioxidant, anti-inflammatory, and immunoprotective properties. However, the protective effect of CGA on viral and bacterial-induced ALI/ARDS is not yet explored. Hence, the current study is aimed to evaluate the preclinical efficacy of CGA in lipopolysaccharide (LPS) and polyinosinic:polycytidylic acid (POLY I:C)-induced ALI/ARDS models in vitro and in vivo. Human airway epithelial (BEAS-2B) cells exposed to LPS+POLY I:C significantly elevated oxidative stress and inflammatory signaling. Co-treatment with CGA (10 and 50M) prevented inflammation and oxidative stress mediated by TLR4/TLR3 and NLRP3 inflammasome axis. BALB/c mice, when chronically challenged with LPS+POLY I:C showed a significant influx of immune cells, up-regulation of pro-inflammatory cytokines, namely: IL-6, IL-1, and TNF-, and treatment with intranasal CGA (1 and 5 mg/kg) normalized the elevated levels of immune cell infiltration as well as pro-inflammatory cytokines. D-Dimer, the serum marker for intravascular coagulation, was significantly increased in LPS+ POLY I:C challenged animals which was reduced with CGA treatment. Further, CGA treatment also has a beneficial effect on the lung and heart, as shown by improving lung physiological and cardiac functional parameters accompanied by the elevated antioxidant response and simultaneous reduction in tissue damage caused by LPS+POLY I:C co-infection. In summary, these comprehensive, in vitro and in vivo studies suggest that CGA may be a viable therapeutic option for bacterial and viral-induced ALI-ARDS-like pathology.
05:24
A chlorogenic acid functional strategy of anti-inflammation, anti-coagulation and promoted endothelial proliferation for bioprosthetic artificial heart valves. GreenMedInfo
PMID: J Mater Chem B. 2023 Mar 22 ;11(12):2663-2673. Epub 2023 Mar 22. PMID: 36883900 Abstract Title: A chlorogenic acid functional strategy of anti-inflammation, anti-coagulation and promoted endothelial proliferation for bioprosthetic artificial heart valves. Abstract: Heart valve replacement has become an optimal choice for the treatment of severe heart valve disease. At present, most commercial bioprosthetic heart valves (BHVs) are made from porcine pericardium or bovine pericardium treated with glutaraldehyde. Nevertheless, due to the toxicity of residual aldehyde groups left after glutaraldehyde cross-linking, these commercial BHVs exhibit poor biocompatibility, calcification, risk of coagulation and endothelialization difficulty, which greatly affects the durability of the BHVs and shortens their service life. In this work, based on a chlorogenic acid functional anti-inflammation, anti-coagulation and endothelialization strategy and dual-functional non-glutaraldehyde cross-linking reagent OX-CO, a kind of functional BHV material OX-CA-PP has been developed from OX-CO cross-linked porcine pericardium (OX-CO-PP) followed by the convenient modification of chlorogenic acid through a reactive oxygen species (ROS) sensitive borate ester bond. The functionalization of chlorogenic acid can reduce the risk of valve leaf thrombosis and promote endothelial cell proliferation, which is beneficial to the formation of a long-term interface with good blood compatibility. Meanwhile, such a ROS responsive behavior can trigger intelligent release of chlorogenic acid on-demand to achieve the inhibition of acute inflammation at the early stage of implantation. Theandexperimental results show that the functional BHV material OX-CA-PP exhibits superior anti-inflammation, improved anti-coagulation, minimal calcification and promoted proliferation of endothelial cells, showing that this non-glutaraldehyde functional strategy has great potential for the application of BHVs and providing a promising reference for other implanted biomaterials.
05:22
Chlorogenic acid rich in coffee pulp extract suppresses inflammatory status. GreenMedInfo
PMID: Heliyon. 2023 Mar ;9(3):e13917. Epub 2023 Feb 18. PMID: 36873494 Abstract Title: Chlorogenic acid rich in coffee pulp extract suppresses inflammatory status by inhibiting the p38, MAPK, and NF-B pathways. Abstract: Coffee pulp (CP) is a coffee byproduct that contains various active ingredients, namely, chlorogenic acid (CGA) and caffeine. These active compounds show several benefits, including antihyperlipidemia, antioxidants, and anti-inflammation. However, the anti-inflammatory properties of Coffea pulp extract (CPE) are unknown. This work determined the impact of CPE on lipopolysaccharide (LPS)-activated murine macrophage cells and the molecular mechanism behind this action. RAW 264.7 cells were exposed to varying doses of CPE with or without LPS. Inflammatory markers and their mechanism were studied. CPE therapy has been shown to suppress the synthesis of inflammatory cytokines and mediators, namely, tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), IL-1, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and nitric oxide (NO), as well as prostaglandin E2 (PGE). Finally, CPE inactivated the nuclear factor-kappa B (NF-B) and MAPK signaling pathways. Consequently, CPE might be used as a nutraceutical to treat inflammation and its related disorders.
05:19
E-cigarette liquids and aldehyde flavoring agents inhibit CYP2A6 activity in lung epithelial cells. GreenMedInfo
PMID: ACS Omega. 2023 Mar 28 ;8(12):11261-11266. Epub 2023 Mar 13. PMID: 37008141 Abstract Title: E-Cigarette Liquids and Aldehyde Flavoring Agents Inhibit CYP2A6 Activity in Lung Epithelial Cells. Abstract: Certain e-liquids and aromatic aldehyde flavoring agents were previously identified as inhibitors of microsomal recombinant CYP2A6, the primary nicotine-metabolizing enzyme. However, due to their reactive nature, aldehydes may react with cellular components before reaching CYP2A6 in the endoplasmic reticulum. To determine whether e-liquid flavoring agents inhibited CYP2A6 in a cellular system, we investigated their effects on CYP2A6 using BEAS-2B cells transduced to overexpress CYP2A6. We demonstrated that two e-liquids and three aldehyde flavoring agents (cinnamaldehyde, benzaldehyde, and ethyl vanillin) exhibited dose-dependent inhibition of cellular CYP2A6.
05:17
Spokane debates $11 million, 5-year water fluoridation project Fluoride Action Network
Spokane is looking into fluoridating its water, and the expenditures may be more than the city can currently afford.
Coming in at $11 million up front and between $1.8 and $2.3 million in recurring yearly operating costs, implementation would take five or more years.
The Spokane City Councils study session on Thursday touched on the issue.
The purpose of this study was to assess the feasibility of putting fluoride into Spokanes water system, identifying how that would be done, what chemicals we would use, and the costs that go along with that, said Lee ODell, lead consulting engineer on the 502-page study.
Odell gave an overview of Spokanes water system.
With 250,000 people and 80,000 service connections across 1,100 miles of water main, the system pumps 24 billion gallons annually. The system currently has eight well stations, with 14 wells, 12 well pumps, 34 storage reservoirs, and 25 booster stations with 72 pumps.
A big part of the study was looking at how much equipment were going to have to put in and where its going to fit, said Odell.
He went on to address one of the primary cost drivers of the project.
At all of your well stations, it became evident that we were going to need new buildings at each facility, said Odell. We couldnt incorporate it into any of the existing facilities.
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Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection. GreenMedInfo
PMID: Front Immunol. 2023 ;14:1076772. Epub 2023 Mar 14. PMID: 36999019 Abstract Title: Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection. Abstract: E-cigarette use has rapidly increased as an alternative means of nicotine delivery by heated aerosolization. Recent studies demonstrate nicotine-containing e-cigarette aerosols can have immunosuppressive and pro-inflammatory effects, but it remains unclear how e-cigarettes and the constituents of e-liquids may impact acute lung injury and the development of acute respiratory distress syndrome caused by viral pneumonia. Therefore, in these studies, mice were exposed one hour per day over nine consecutive days to aerosol generated by the clinically-relevant tank-style Aspire Nautilus aerosolizing e-liquid containing a mixture of vegetable glycerin and propylene glycol (VG/PG) with or without nicotine. Exposure to the nicotine-containing aerosol resulted in clinically-relevant levels of plasma cotinine, a nicotine-derived metabolite, and an increase in the pro-inflammatory cytokines IL-17A, CXCL1, and MCP-1 in the distal airspaces. Following the e-cigarette exposure, mice were intranasally inoculated with influenza A virus (H1N1 PR8 strain). Exposure to aerosols generated from VG/PG with and without nicotine caused greater influenza-induced production in the distal airspaces of the pro-inflammatory cytokines IFN-, TNF, IL-1, IL-6, IL-17A, and MCP-1 at 7 days post inoculation (dpi). Compared to the aerosolized carrier VG/PG, in mice exposed to aerosolized nicotine there was a significantly lower amount of Mucin 5 subtype AC (MUC5AC) in the distal airspaces and significantly higher lung permeability to protein and viral load in lungs at 7 dpi with influenza. Additionally, nicotine caused relative downregulation of genes associated with ciliary function and fluid clearance and an increased expression of pro-inflammatory pathways at 7 dpi. These results show that (1) the e-liquid carrier VG/PG increases the pro-inflammatory immune responses to viral pneumonia and that (2) nicotine in an e-cigarette aerosol alters the transcriptomic response to pathogens, blunts host defense mechanisms, increases lung barrier permeability, and reduces viral clearance during influenza infection. In conclusion, acute exposure to aerosolized nicotine can impair clearance of viral infection and exacerbate lung injury, findings that have implications for the regulation of e-cigarette products.
05:16
Vaping should be stopped in the perioperative period to decrease the incidence of wound healing complications. GreenMedInfo
PMID: Surgery. 2023 Jun ;173(6):1452-1462. Epub 2023 Mar 29. PMID: 36997424 Abstract Title: The implications of vaping on surgical wound healing: A systematic review. Abstract: BACKGROUND: E-cigarette use is rapidly growing, and little is known about the postoperative complications. Cigarette smoking has been well-established to be associated with delayed wound healing and increased complications in surgical patients. Due to the intricate and harmonious nature of the wound-healing process, vaping may impair tissue regeneration, posing a risk for patients undergoing surgery. This systematic review aimed to review the evidence on the implications of vaping on wound healing.METHODS: A systematic search of PubMed and Scopus databases was conducted on October 2022 per Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The following keywords were used to conduct the search: vaping, vape, e-cigarettes, electronic cigarettes, wound healing, tissue regeneration, postoperative complications, wound infection, and blood flow.RESULTS: Of 5,265 screened articles, only 37 were eligible for qualitative synthesis. A total of 18 articles studied the effect of e-cigarettes on human volunteers, 14 investigated e-cigarette extract on human cell lines, and 5 used animal rat models.CONCLUSION: Despite limited objective data, the recommendation is that e-cigarettes be treated as tobacco cigarettes; hence, vaping should be stopped in the perioperative period to decrease the incidence of wound healing complications. Clinical trials are required to understand the health hazards of e-cigarettes further and maximize patient safety and clinical outcomes.
05:13
Flavored E-cigarette product aerosols induce transformation of human bronchial epithelial cells. GreenMedInfo
PMID: Lung Cancer. 2023 May ;179:107180. Epub 2023 Mar 22. PMID: 36989612 Abstract Title: Flavored E-cigarette product aerosols induce transformation of human bronchial epithelial cells. Abstract: OBJECTIVES: E-cigarettes are the most commonly used nicotine containing products among youth. In vitro studies support the potential for e-cigarettes to cause cellular stress in vivo; however, there have been no studies to address whether exposure to e-liquid aerosols can induce cell transformation, a process strongly associated with pre-malignancy. We examined whether weekly exposure of human bronchial epithelial cell (HBEC) lines to e-cigarette aerosols would induce transformation and concomitant changes in gene expression and promoter hypermethylation.MATERIALS AND METHODS: An aerosol delivery system exposed three HBEC lines to unflavored e-liquid with 1.2% nicotine, 3 flavored products with nicotine, or the Kentucky reference cigarette once a week for 12 weeks. Colony formation in soft agar, RNA-sequencing, and the EPIC Beadchip were used to evaluate transformation, genome-wide expression and methylation changes.RESULTS: Jamestown e-liquid aerosol induced transformation of HBEC2 and HBEC26, while unflavored and Blue Pucker transformed HBEC26. Cigarette smoke aerosol transformed HBEC4 and HBEC26 at efficiencies up to 3-fold greater than e-liquids. Transformed clones exhibited extensive reprogramming of the transcriptome with common and distinct gene expression changes observed between the cigarette and e-liquids. Transformation by e-liquids induced alterations in canonical pathways implicated in lung cancer that included axonal guidance and NRF2. Gene methylation, while prominent in cigarette-induced transformed clones, also affected hundreds of genes in HBEC2 transformed by Jamestown. Many genes with altered expression or epigenetic-mediated silencing were also affected in lung tumors from smokers.CONCLUSIONS: These studies show that exposure to e-liquid aerosols can induce a pre-malignant phenotype in lung epithelial cells. While the Food and Drug Administration banned the sale of flavored cartridge-based electric cigarettes, consumers switched to using flavored products through other devices. Our findings clearly support expanding studies to evaluate transformation potency for the major categories of e-liquid flavors to better inform risk from these complex mixtures.
05:12
Electronic cigarette exposure increases the severity of influenza a virus infection. GreenMedInfo
PMID: Int J Mol Sci. 2023 Feb 21 ;24(5). Epub 2023 Feb 21. PMID: 36901724 Abstract Title: Electronic Cigarette Exposure Increases the Severity of Influenza a Virus Infection via TRAIL Dysregulation in Human Precision-Cut Lung Slices. Abstract: The use of electronic nicotine dispensing systems (ENDS), also known as electronic cigarettes (ECs), is common among adolescents and young adults with limited knowledge about the detrimental effects on lung health such as respiratory viral infections and underlying mechanisms. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a protein of the TNF family involved in cell apoptosis, is upregulated in COPD patients and during influenza A virus (IAV) infections, but its role in viral infection during EC exposures remains unclear. This study was aimed to investigate the effect of ECs on viral infection and TRAIL release in a human lung precision-cut lung slices (PCLS) model, and the role of TRAIL in regulating IAV infection. PCLS prepared from lungs of nonsmoker healthy human donors were exposed to EC juice (E-juice) and IAV for up to 3 days during which viral load, TRAIL, lactate dehydrogenase (LDH), and TNF-in the tissue and supernatants were determined. TRAIL neutralizing antibody and recombinant TRAIL were utilized to determine the contribution of TRAIL to viral infection during EC exposures. E-juice increased viral load, TRAIL, TNF-release and cytotoxicity in IAV-infected PCLS. TRAIL neutralizing antibody increased tissue viral load but reduced viral release into supernatants. Conversely, recombinant TRAIL decreased tissue viral load but increased viral release into supernatants. Further, recombinant TRAIL enhanced the expression of interferon-and interferon-induced by E-juice exposure in IAV-infected PCLS. Our results suggest that EC exposure in human distal lungs amplifies viral infection and TRAIL release, and that TRAIL may serve as a mechanism to regulate viral infection. Appropriate levels of TRAIL may be important to control IAV infection in EC users.
05:11
Collingwood doc calls for fluoridated drinking water Fluoride Action Network
Given we are currently updating our drinking water systems, perhaps this would be a good time to re-explore this option, says Dr. Wade Mitchell in letter to council.
Collingwood physician Dr. Wade Mitchell has called on the town to reconsider its stance on water fluoridation.
A letter from Mitchell that was part of the June 19 council agenda cited a recent Canadian Family Physician journal article touting the benefits of water fluoridation and asked the town to consider adding flouride to the municipal water supply.
In the letter, Mitchell called on his experience as a family physician with experience in the emergency department at Collingwood General and Marine Hospital, noting the strong benefits and low, if any, risks of community fluoridation.
Given we are currently updating our drinking water systems, perhaps this would be a good time to re-explore this option, wrote Mitchell.
Chief executive officer Sonya Skinner confirmed to councillors that currently, Collingwood does not add fluoride to the drinking water supply.
There is a small amount of fluoride thats present naturally in the water when its pulled into the plant which I understand is in the range of 20 per cent of the minimum amount that would be recommended for teeth health, however there are quite strong views on both sides of this, said Skinner.
In Collingwood, were a bit of a special case in that were supplying several other communities with water. It does make it a bit more of a complex question, she said.
Fluoride is a mineral that helps prevent cavities by making the outer layer of teeth (enamel) harder. It can also help reverse early-stage tooth decay.
The amount of fluoride added to municipal water supplies to prevent cavities is based on provincial standards and federal guidelines and is closely monitored.
Scientists or doctors who oppose water...
05:10
Effect of supplemental antioxidant-based therapy on the oxidative stress level in COVID-19 patients. GreenMedInfo
PMID: Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Mar 1 ;44(1):7-16. Epub 2023 Mar 29. PMID: 36987766 Abstract Title: Effect of Supplemental Antioxidant-Based Therapy on the Oxidative Stress Level in COVID-19 Patients. Abstract: : COVID-19 is a disease in several stages starting with virus replication to dysregulation in immune system response, organ failure and recovery/death. Our aim was to determine the effect of Ganoderma lucidum, lycopene, sulforaphane, royal jelly and resveratrol extract on markers of oxidative stress, inflammation, routine laboratory analyses and duration of symptoms in COVID-19 patients.: The oxidative stress parameters and interleukines 6 and 8 (IL-6, IL-8), tumor necrosis factor alpha (TNF-) were determined in order to estimate the antioxidant and the anti-inflammatory effect of the product using a spectrophotometric and a magnetic bead-based multiplex assay in serum of 30 patients with mild form of COVID-19.: Statistically significant differences were obtained for all investigated parameters between the treated patients and the control group. Moreover, significant differences were observed for leukocytes, neutrophil to leukocyte ratio and iron. The average duration of the symptoms was 9.40.487 days versus 13.10.483 days in the treatment and the control group, respectively (p=0.0003).: Our results demonstrated the promising effect of Ge132+Naturalon reducing the oxidative stress and the IL-6, IL-8 and TNF-levels, and symptoms duration in COVID-19 patients. The evidence presented herein suggest that the combination of Ganoderma lucidum extract, lycopene, sulforaphane, royal jelly and resveratrol could be used as a potent an adjuvant therapy in diseases accompanied by increased oxidative stress and inflammation.
05:08
Public Health considers impact of putting fluoride in Manx water Fluoride Action Network
Research will be carried out on the impact of water fluoridation on reducing tooth decay in children.
Tynwald members supported the move by public health at the June sitting in a combined vote after the issue split the court the previous month.
It was put forward in an amendment by Health Minister Lawrie Hooper as a potentially more cost-effective alternative to fluoride varnish.
That had been suggested by a committee exploring childrens oral health.
The public health directorate will now prepare a research paper, which will be considered by the Council of Ministers by December 2023.
The amendment tasked the body with exploring fluoridation of water, the effects this may have on the population.
It also included looking at to what extent it would reduce levels of tooth decay and whether it would be a more efficient and effective way of preventing tooth decay in children than targeted fluoride varnish application.
The report and any conclusions and recommendations is due to be placed on the Tynwald regist...
05:07
Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy. GreenMedInfo
PMID: Front Pharmacol. 2023 ;14:1127123. Epub 2023 Mar 23. PMID: 37033616 Abstract Title: polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy. Abstract: Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. However, drug therapies that can reverse the maladaptive process and restore heart function are limited.polysaccharides (GLPs) are one of the main active components of(), and they have various pharmacological effects. GLPs have been used as Chinese medicine prescriptions for clinical treatment. In this study, cardiac hypertrophy was induced by transverse aortic constriction (TAC) in mice. We found that GLPs ameliorate Ang II-induced cardiomyocyte hypertrophyand attenuate pressure overload-induced cardiac hypertrophy. Further research indicated that GLPs attenuated the mRNA levels of hypertrophic and fibrotic markers to inhibit cardiac hypertrophy through the PPAR/PGC-1pathway. Overall, these results indicate that GLPs inhibit cardiac hypertrophy through downregulating key genes for hypertrophy and fibrosis and attenuate pressure overload-induced pathological cardiac hypertrophy by activating PPAR. This study provides important theoretical support for the potential of using GLPs to treat pathological myocardial hypertrophy and heart failure.
05:05
Potential anti-rheumatoid arthritis activities and mechanisms of Ganoderma lucidum polysaccharides. GreenMedInfo
PMID: Molecules. 2023 Mar 8 ;28(6). Epub 2023 Mar 8. PMID: 36985456 Abstract Title: Potential Anti-Rheumatoid Arthritis Activities and Mechanisms ofPolysaccharides. Abstract: Rheumatoid arthritis (RA) is a chronic and autoimmune disease characterized by inflammation, autoimmune dysfunction, and cartilage and bone destruction. In this review, we summarized the available reports on the protective effects ofpolysaccharides (GLP) on RA in terms of anti-inflammatory, immunomodulatory, anti-angiogenic and osteoprotective effects. Firstly, GLP inhibits RA synovial fibroblast (RASF) proliferation and migration, modulates pro- and anti-inflammatory cytokines and reduces synovial inflammation. Secondly, GLP regulates the proliferation and differentiation of antigen-presenting cells such as dendritic cells, inhibits phagocytosis by mononuclear macrophages and nature killer (NK) cells and regulates the ratio of M1, M2 and related inflammatory cytokines. In addition, GLP produced activities in balancing humoral and cellular immunity, such as regulating immunoglobulin production, modulating T and B lymphocyte proliferative responses and cytokine release, exhibiting immunomodulatory effects. Thirdly, GLP inhibits angiogenesis through the direct inhibition of vascular endothelial cell proliferation and induction of cell death and the indirect inhibition of vascular endothelial growth factor (VEGF) production in the cells. Finally, GLP can inhibit the production of matrix metalloproteinases and promote osteoblast formation, exerting protective effects on bone and articular cartilage. It is suggested that GLP may be a promising agent for the treatment of RA.
05:03
Reishi and Lion's Mane mushroom powder can be used for the fortification of semolina pasta. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Mar 17 ;12(3). Epub 2023 Mar 17. PMID: 36978986 Abstract Title: The Addition of Reishi and Lion's Mane Mushroom Powder to Pasta Influences the Content of Bioactive Compounds and the Antioxidant, Potential Anti-Inflammatory, and Anticancer Properties of Pasta. Abstract: The influence of a 2.5% and 5% addition of dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro-health properties of pasta was studied. In samples subjected to gastrointestinal digestion, the content of phenolic compounds and the antioxidant, potential anti-inflammatory, and antiproliferative properties were significantly higher. The qualitative-quantitative analysis of phenolic compounds performed using the LC-MS/MS technique indicated that the Reishi-enriched pasta was characterized by a higher content of syringic (R2.5 sample), while pasta supplemented with Lion' Mane had a higher content of vanillin in relation to the control pasta. In the case of ethanolic extracts, samples supplemented with the Reishi mushrooms (R5 sample) were characterized by higher ABTS antiradical properties and a reducing power while the sample supplemented with Lion's Mane (L5 sample) had a higher ability to inhibit lipoxygenase in relation to the control sample. In conclusion, the results suggest that Reishi and Lion's Mane mushroom powder can be used for the fortification of semolina pasta, conferring slightly healthier characteristics of the product.
05:01
Neuroprotective effects of erinacine A on an experimental model of traumatic optic neuropathy. GreenMedInfo
PMID: Int J Mol Sci. 2023 Jan 12 ;24(2). Epub 2023 Jan 12. PMID: 36675019 Abstract Title: Neuroprotective Effects of Erinacine A on an Experimental Model of Traumatic Optic Neuropathy. Abstract: Erinacine A (EA), a natural neuroprotectant, is isolated from a Chinese herbal medicine, Hericium erinaceus. The aim of this study was to investigate the neuroprotective effects of EA in a rat model of traumatic optic neuropathy. The optic nerves (ONs) of adult male Wistar rats were crushed using a standardized method and divided into three experimental groups: phosphate-buffered saline (PBS control)-treated group, standard EA dose-treated group (2.64 mg/kg in 0.5 mL of PBS), and double EA dose-treated group (5.28 mg/kg in 0.5 mL of PBS). After ON crush, each group was fed orally every day for 14 days before being euthanized. The visual function, retinal ganglion cell (RGC) density, and RGC apoptosis were determined using flash visual-evoked potentials (fVEP) analysis, retrograde Fluoro-Gold labelling, and TdT-dUTP nick end-labelling (TUNEL) assay, respectively. Macrophage infiltration of ON was detected by immunostaining (immunohistochemistry) for ED1. The protein levels of phosphor-receptor-interacting serine/threonine-protein kinase1 (pRIP1), caspase 8 (Cas8), cleaved caspase 3 (cCas3), tumour necrosis factor (TNF)-, tumour necrosis factor receptor1 (TNFR1), interleukin (IL)-1, inducible nitric oxide synthase (iNOS), nuclear factor erythroid 2-related factor 2 (Nrf2), haem oxygenase-1 (HO-1), and superoxide dismutase 1 (SOD1) were evaluated by Western blotting. When comparing the standard EA dose-treated group and the double EA dose-treated group with the PBS-treated group, fVEP analysis showed that the amplitudes of P1N2 in the standard EA dose group and the double EA dose-treated group were 1.8 and 2.4-fold, respectively, higher than that in the PBS-treated group (p
04:57
Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex. GreenMedInfo
PMID: Front Nutr. 2022 ;9:977287. Epub 2022 Sep 2. PMID: 36118772 Abstract Title: Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice. Abstract: Since the 1990s, the prevalence of mental illnesses, such as depression, has been increasing annually and has become a major burden on society. Due to the many side effects of antidepressant drugs, the development of a complementary therapy from natural materials is an urgent need. Therefore, this study used a complex extract of chlorella and lion's mane mushroom and evaluated its antidepressant effects. Six-month-old male senescence-accelerated mice prone-8 (SAMP8) were divided into positive control; negative control; and low, medium, and high-dose groups. All groups were treated with corticosterone (CORT) at 40 mg/Kg/day for 21- days to induce depression in the animals, and the effects of different test substances on animal behavior was observed. The positive control group was intraperitoneally injected with a tricyclic antidepressant (Fluoxetine, as tricyclic antidepressant), the control group was given ddHO, and the test substance groups were administered test samples once daily for 21 days. The open field test (OFT) and forced swimming test (FST) were applied for behavior analyses of depression animal models. The OFT results showed that the mice in the positive control and the medium-, and high-dose groups demonstrated a significantly prolonged duration in the central area and a significantly increased travel distance. In the FST, the positive control and the medium, and high-dose groups displayed significantly reduced immobility times relative to the control group. The blood analysis results showed significant decreases in triglyceride and blood urea nitrogen levels relative to the positive control and the medium- and high-dose groups. Notably, in the positive control and the medium- and high-dose groups, brain-derived neurotrophic factor (BDNF) increase by more than in the control group. In summary, medium and high dose of extract of chlorella and lion's mane mushroom could improve depression behavior in animals and have the potential to be antidepressant health care products.
04:54
The effects of Chlorella vulgaris on cardiovascular risk factors. GreenMedInfo
PMID: Biomed Pharmacother. 2023 Jun ;162:114624. Epub 2023 Apr 3. PMID: 37018990 Abstract Title: The effects of Chlorella vulgaris on cardiovascular risk factors: A comprehensive review on putative molecular mechanisms. Abstract: High incidence rate of cardiovascular disease (CVD) make this condition as an important public health concern. The use of natural products in treating this chronic condition has increased in recent years one of which is the single-celled green alga Chlorella. Chlorella vulgaris (CV) has been studied for its potential benefits to human health due to its biological and pharmacological features. CV contains a variety of macro and micronutrients, including proteins, omega-3, polysaccharides, vitamins, and minerals. Some studies have indicated that taking CV as a dietary supplement can help reduce inflammation and oxidative stress. In some studies, cardiovascular risk factors that are based on hematological indices did not show these benefits, and no molecular mechanisms have been identified. This comprehensive review summarized the research on the cardio-protective benefits of chlorella supplementation and the underlying molecular processes.
04:52
Royal jelly and Chlorella vulgaris mitigate gibberellic acid-induced cytogenotoxicity and hepatotoxicity. GreenMedInfo
PMID: Foods. 2023 Mar 13 ;12(6). Epub 2023 Mar 13. PMID: 36981150 Abstract Title: Royal Jelly andMitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPAR/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation. Abstract: Gibberellic acid (GA3) is a well-known plant growth regulator used in several countries, but its widespread use has negative effects on both animal and human health. The current study assesses the protective effect of royal jelly (RJ) and(CV) on the genotoxicity and hepatic injury induced by GA3 in rats. Daily oral administration of 55 mg/kg GA3 to rats for 6 constitutive weeks induced biochemical and histopathological changes in the liver via oxidative stress and inflammation. Co-administration of 300 mg/kg RJ or 500 mg/kg CV with GA3 considerably ameliorated the serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase),GT (gamma-glutamyl transferase), total bilirubin, and albumin. Lowered malondialdehyde, tumor necrosis factor(TNF-), and nuclear factorB (NF-B) levels along with elevated SOD (superoxide dismutase), CAT (catalase), and GPx (glutathione peroxidase) enzyme activities indicated the antioxidant and anti-inflammatory properties of both RJ and CV. Also, they improved the histological structure and reduced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions along with up-regulating peroxisome proliferator activated receptor(PPAR) and down-regulating activator protein 1 (AP-1) gene expression. Additionally, chromosomal abnormalities and mitotic index were nearly normalized after treatment with RJ and CV. In conclusion, RJ and CV can protect against GA3-induced genotoxicity and liver toxicity by diminishing oxidative stress and inflammation, and modulating the PPAR/AP-1 signaling pathway.
04:49
Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing. GreenMedInfo
PMID: Acta Pharm Sin B. 2023 Jan ;13(1):410-424. Epub 2022 Jun 23. PMID: 36815029 Abstract Title: sp.-ameliorated undesirable microenvironment promotes diabetic wound healing. Abstract: Chronic diabetic wound remains a critical challenge suffering from the complicated negative microenvironments, such as high-glucose, excessive reactive oxygen species (ROS), hypoxia and malnutrition. Unfortunately, few strategies have been developed to ameliorate the multiple microenvironments simultaneously. In this study,sp. (Chlorella) hydrogels were prepared against diabetic wounds.experiments demonstrated that living Chlorella could produce dissolved oxygen by photosynthesis, actively consume glucose and deplete ROS with the inherent antioxidants, during the daytime. At night, Chlorella was inactivatedby chlorine dioxide with human-body harmless concentration to utilize its abundant contents. It was verifiedthat the inactivated-Chlorella could supply nutrition, relieve inflammation and terminate the oxygen-consumption of Chlorella-respiration. The advantages of living Chlorella and its contents were integrated ingeniously. The abovementioned functions were proven to accelerate cell proliferation, migration and angiogenesis. Then, streptozotocin-induced diabetic mice were employed for further validation. Theoutcomes confirmed that Chlorella could ameliorate the undesirable microenvironments, including hypoxia, high-glucose, excessive-ROS and chronic inflammation, thereby synergistically promoting tissue regeneration. Given the results above, Chlorella is considered as a tailor-made therapeutic strategy for diabetic wound healing.
04:47
Identification of berberine as a potential therapeutic strategy for kidney clear cell carcinoma and COVID-19 based on analysis of large-scale datasets. GreenMedInfo
PMID: Front Immunol. 2023 ;14:1038651. Epub 2023 Mar 23. PMID: 37033923 Abstract Title: Identification of berberine as a potential therapeutic strategy for kidney clear cell carcinoma and COVID-19 based on analysis of large-scale datasets. Abstract: BACKGROUND: Regarding the global coronavirus disease 2019 (COVID)-19 pandemic, kidney clear cell carcinoma (KIRC) has acquired a higher infection probability and may induce fatal complications and death following COVID-19 infection. However, effective treatment strategies remain unavailable. Berberine exhibits significant antiviral and antitumour effects. Thus, this study aimed to provide a promising and reliable therapeutic strategy for clinical decision-making by exploring the therapeutic mechanism of berberine against KIRC/COVID-19.METHODS: Based on large-scale data analysis, the target genes, clinical risk, and immune and pharmacological mechanisms of berberine against KIRC/COVID-19 were systematically investigated.RESULTS: In total, 1,038 and 12,992 differentially expressed genes (DEGs) of COVID-19 and KIRC, respectively, were verified from Gene Expression Omnibus and The Cancer Genome Atlas databases, respectively, and 489 berberine target genes were obtained from official websites. After intersecting, 26 genes were considered potential berberine therapeutic targets for KIRC/COVID-19. Berberine mechanism of action against KIRC/COVID-19 was revealed by protein-protein interaction, gene ontology, and Kyoto Encyclopedia of Genes and Genomes with terms including protein interaction, cell proliferation, viral carcinogenesis, and the PI3K/Akt signalling pathway. In COVID-19 patients, ACOX1, LRRK2, MMP8, SLC1A3, CPT1A, H2AC11, H4C8, and SLC1A3 were closely related to disease severity, and the general survival of KIRC patients was closely related to ACOX1, APP, CPT1A, PLK1, and TYMS. Additionally, the risk signature accurately and sensitively depicted the overall survival and patient survival status for KIRC. Numerous neutrophils were enriched in the immune system of COVID-19 patients, and the lives of KIRC patients were endangered due to significant immune cell infiltration. Molecular docking studies indicated that berberine binds strongly to target proteins.CONCLUSION: This study demonstrated berberine as a potential treatment option in pharmacological, immunological, and clinical practice. Moreover, its therapeutic effects may provide potential and reliable treatment options for patients with KIRC/COVID-19.
04:47
The subterranean chemistry that explains Indias groundwater contamination Fluoride Action Network
As Vajinder Kumar saw more and more cases of cancer in young and old as he travelled through village after village in the Malwa region in northern India he became increasingly concerned. In one village I saw 30 cases of cancer, in another 25, and many people living with brain and nerve disorders, says Kumar, a chemist at Akal University, who has visited more than 100 villages over the past six years, mainly in south-west Malwa. In one centre for children, I saw 500 cases of children severely affected with developmental problems. The grandparents and parents of the affected children say there is no family history of such developmental disorders.
A study by a team of scientists from universities in Punjab, Sikkim and West Bengal, including Kumar, describes how uranium, arsenic and other toxic elements are mobilised in aquifers and surface waters, contaminating drinking water and irrigation in Punjab. It is but the latest in a series of reports on how uranium, arsenic and other contaminants plague a number of regions in the country.
The latest exhaustive review of over 200 reports and analysis of the physical and chemical parameters of the entire Malwa region shows that its groundwater is unfit to drink. Uranium and arsenic in groundwater pose a significant threat to human health, leading to a high prevalence of cancer. Malwa has a relatively high cancer incidence compared with, for example, Aurangabad district in Maharashtra state in central India, which has low uranium levels and a relatively low cancer incidence (exact figures are difficult to come by for the Malwa region).
[Malwa] is also known as the cancer belt of Punjab, Kumar tells Chemistry World. Many residents also suffer from other conditions linked to water contaminated with excess fluoride and arsenic. Fluorosis is characterised by dental and crippling bone problems, while arsenicosis or arsenic poisoning is characterised by cancers and skin lesions, as well as heart disorders and diabetes. Malwa region needs special and serious attention, says Kumar.
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04:45
Berberine attenuates epithelial mesenchymal transition in bleomycin-induced pulmonary fibrosis. GreenMedInfo
PMID: Life Sci. 2023 Jun 1 ;322:121665. Epub 2023 Apr 5. PMID: 37028546 Abstract Title: Berberine attenuates epithelial mesenchymal transition in bleomycin-induced pulmonary fibrosis in mice via activating AR and mitigating the SDF-1/CXCR4 signaling. Abstract: AIMS: Berberine is endowed with anti-oxidant, anti-inflammatory and anti-fibrotic effects. This study explored the role of adenosine Areceptor (AR) activation and SDF-1/CXCR4 signaling suppression in the protective effects of berberine in bleomycin-induced pulmonary fibrosis in mice.MAIN METHODS: Pulmonary fibrosis was generated in mice by injecting bleomycin (40 U/kg, i.p.) on days 0, 3, 7, 10 and 14. Mice were treated with berberine (5 mg/kg, i.p.) from day 15 to day 28.KEY FINDINGS: Severe lung fibrosis and increased collagen content were observed in the bleomycin-challenged mice. Pulmonary AR downregulation was documented in bleomycin-induced pulmonary fibrosis animals and was accompanied by enhanced expression of SDF-1/CXCR4. Moreover, TGF-1elevation and pSmad2/3 overexpression were reported in parallel with enhanced epithelial mesenchymal transition (EMT) markers expression, vimentin and-SMA. Besides, bleomycin significantly elevated the inflammatory and pro-fibrogenic mediator NF-B p65, TNF-and IL-6. Furthermore, bleomycin administration induced oxidative stress as depicted by decreased Nrf2, SOD, GSH and catalase levels. Interestingly, berberine administration markedly ameliorated the fibrotic changes in lungs by modulating the purinergic system through the inhibition of AR downregulation, mitigating EMT and effectively suppressing inflammation and oxidative stress. Strikingly, AR blockade by SCH 58261, impeded the pulmonary protective effect of berberine.SIGNIFICANCE: These findings indicated that berberine could attenuate the pathological processes of bleomycin-induced pulmonary fibrosis at least partially via upregulating AR and mitigating the SDF-1/CXCR4 related pathway, suggesting AR as a potential therapeutic target for the management of pulmonary fibrosis.
04:43
Berberine is a suppressor of hedgehog signaling cascade in colorectal cancer. GreenMedInfo
PMID: Phytomedicine. 2023 Jun ;114:154792. Epub 2023 Mar 30. PMID: 37028248 Abstract Title: Berberine is a suppressor of Hedgehog signaling cascade in colorectal cancer. Abstract: BACKGROUND: Colorectal cancer (CRC) is a malignant affliction that burdens people globally. Overactivated Hedgehog signal is highly implicated in CRC pathogenesis. Phytochemical berberine exerts strong potency on CRC, with molecular mechanism elusive.PURPOSE: We sought to study berberine's anti-CRC action and explore its underlying mechanism based on Hedgehog signaling cascade.METHODS: In CRC HCT116 cells and SW480 cells treated with berberine, the proliferation, migration, invasion, clonogenesis, apoptosis and cell cycle were measured, with determination of Hedgehog signaling pathway activity. Following establishment of mouse model of HCT116 xenograft tumor, the efficacies of berberine on carcinogenesis, pathological manifestation and malignant phenotypes of CRC were examined, with analysis of Hedgehog signaling axis in HCT116 xenograft tumor tissues. Additionally, toxicological study of berberine was conducted on zebrafish.RESULTS: Berberine was discovered to suppress the proliferation, migration, invasion and clonogenesis of HCT116 cells and SW480 cells. Furthermore, berberine caused cell apoptosis and blockaded cell cycle at phase G/Gin CRC cells, with dampened Hedgehog signaling cascade. In HCT116 xenograft tumor of nude mice, berberine inhibited tumor growth, alleviated pathological score, and promoted apoptosis and cell cycle arrest in tumor tissues, through constraining Hedgehog signaling. The toxicological study of berberine on zebrafish indicated that berberine incurred damage to the liver and heart of zebrafish at high dosage and prolonged administration.CONCLUSIONS: Taken together, berberine may inhibit the malignant phenotypes of CRC through diminishing Hedgehog signaling cascade. However, the potential adverse reactions should be taken into account upon abuse of berberine.
04:37
Berberine ameliorates the neurological dysfunction of the gastric fundus. GreenMedInfo
PMID: Saudi Pharm J. 2023 Mar ;31(3):433-443. Epub 2023 Feb 2. PMID: 37026044 Abstract Title: Berberine ameliorates the neurological dysfunction of the gastric fundus by promoting calcium channels dependent release of ACh in STZ-induced diabetic rats. Abstract: BACKGROUND: It has been reported diabetic gastroparesis is related to diabetic autonomic neuropathy of the gastrointestinal tract, and berberine (BBR) could ameliorate diabetic central and peripheral neuropathy. However, the influence of BBR on the function and motility of the gastric fundus nerve is unclear.METHODS: A diabetic rat model was constructed, and HE staining was used to observe the morphological changes in the gastric fundus. The changes in cholinergic and nitrogen-related neurochemical indexes and the effects of BBR on them were measured using Elisa. The effects of BBR on the neural function and motility of gastric fundus were investigated by electric field stimulation (EFS) induced neurogenic response in vitro.RESULTS: In the early stage of STZ-induced diabetic rats, the contractile response of gastric fundus induced by EFS was disorder, disturbance of contraction amplitude, and the cell bodies of neurons in the myenteric plexus of gastric fundus presented vacuolar lesions. Administration with BBR could improve the above symptoms. BBR further enhanced the contraction response in the presence of a NOS inhibitor or the case of inhibitory neurotransmitters removal. Interestingly, the activity of ACh could affect NO release directly and the enhancement of BBR on contractile response was canceled by calcium channel blockers completely.CONCLUSIONS: In the early stage of STZ-induced diabetic rats, the neurogenic contractile response disorder of the gastric fundus is mainly related to cholinergic and nitrergic nerve dysfunction. BBR promotes the release of ACh mainly by affecting the calcium channel to improve the neurological dysfunction of the gastric fundus.
04:34
Berberine rescues D-ribose-induced Alzheimer's pathology. GreenMedInfo
PMID: Int J Mol Sci. 2023 Mar 20 ;24(6). Epub 2023 Mar 20. PMID: 36982968 Abstract Title: Berberine Rescues D-Ribose-Induced Alzheimer's Pathology via Promoting Mitophagy. Abstract: Mitochondrial dysfunction is considered an early event of Alzheimer disease (AD). D-ribose is a natural monosaccharide that exists in cells, especially in mitochondria, and can lead to cognitive dysfunction. However, the reason for this is unclear. Berberine (BBR) is an isoquinoline alkaloid that can target mitochondria and has great prospect in the treatment of AD. The methylation of PINK1 reinforces the burden of Alzheimer's pathology. This study explores the role of BBR and D-ribose in the mitophagy and cognitive function of AD related to DNA methylation.mice andcells were treated with D-ribose, BBR, and mitophagy inhibitor Mdivi-1 to observe their effects on mitochondrial morphology, mitophagy, neuron histology, AD pathology, animal behavior, and PINK1 methylation. The results showed that D-ribose induced mitochondrial dysfunction, mitophagy damage, and cognitive impairment. However, BBR inhibition of PINK1 promoter methylation can reverse the above effects caused by D-ribose, improve mitochondrial function, and restore mitophagy through the PINK1-Parkin pathway, thus reducing cognitive deficits and the burden of AD pathology. This experiment puts a new light on the mechanism of action of D-ribose in cognitive impairment and reveals new insights in the use of BBR for AD treatment.
04:14
The Government Has a Moral Duty to Help Those Harmed by Prescription Drugs Mad In America
From The BMJ: This week, BBC1s Panorama drew sharp attention to the problem of prescribed drug dependence and withdrawal in the United Kingdom, providing insight into an iatrogenic problem affecting large numbers of people internationally. While this has been a problem for decades, the Panorama programme shows that there are still almost no NHS services to support patients who have been harmed by taking medicines as prescribed by their doctor, such as antidepressants and benzodiazepines. In the absence of these services, the programme detailed how patients experiencing severe and prolonged withdrawal symptoms have resorted to online peer groups for validation, support, and safe drug tapering advice. The patient community, it seems, has been forced to develop its own withdrawal protocols (e.g. for antidepressants) in the absence of sufficient tapering guidance being advanced by NICE (The National Institute for Health and Care Excellence) or any other national clinical guidelines internationally.
. . . We believe that the NHS has a clinical and moral obligation to help those who have been harmed by taking their medication as prescribed. Panorama has revealed the scale of the problem and the horrendous impact it has had on so many peoples lives. To help mitigate these impacts, we therefore urgently call upon the UK government to fund and implement withdrawal support services, including a national helpline.
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The post The Government Has a Moral Duty to Help Those Harmed by Prescription Drugs appeared first on Mad In America.
04:10
The Invisible Cage Called Freedom: My Work, My Kids, My Mental Health Mad In America
I
see my 3-year-olds innocent smile as she plays and rides her tricycle, and I cant help but feel sad and worried about my daughters future. I dont want them to hurt and be disappointed in a world that can nbe so cruel and heartless.
I observe little Pheanix, whos over-the-moon as she does her exciting little dancebecause, after so many frustrating trial-and-error attempts, she finally can peddle forward smoothly and continuously. She searches for me and yells, I did it, Mama! Her voice strikes my soul, as instantaneously and simultaneously I felt warmhearted, proud, and also nostalgic because I know time will go by so quickly.
When did she get so big, so smart, so kind? What did I do to deserve her? I dont want her world to shatter, and her dreams to evaporate. I know it is my responsibility as a mother to prepare her for the disappointment of what life can be. She and her baby sister Zaphyre deserve better than what I haveand had.
I must admit something: The reason I had Pheanix was to hel...
03:29
Race and Abuse in Inpatient Settings: What Happens Behind Locked Doors Mad In America
Irvo Noel Otieno was a 28-year-old Black man who died of asphyxia due to being smothered by seven deputies in a Virginia mental hospital in March of 2023. This didnt get as much publicity as the George Floyd case and Im not even sure if it inspired any protests.
A very similar thing happened to me on multiple occasions. As a petite Mexican-American woman Ive been physically assaulted by nurses and security guards so many times that I lost count. One incident in particular that I remember happened at Oregon Health and Science University in Portland, OR, I believe in 2011 or 2012, when I refused my medication because the doctor changed the dosage without consulting me. The male nurse called in a big burly male security guard to pin me down so that the nurse could forcibly inject me with medication. I remember the doctor actually being apologetic the next day saying they should have told me about changing my medication. When I asked another security guard about it, he angrily told me that they were there to protect staff not patients.
I had forgotten this incident and thought I had left it behind in the past. But an offhand remark from my psychiatrist su...
02:58
How Do Dental Implants Work? A Guide About Dental Implants Waking Science
In spite of remarkable advances in dental care, many people still suffer from a myriad of dental conditions. These problems range from decay, periodontal diseases, and injuries, that can cost them their smiles.
The good news is dental implants can restore your dental health and get you smiling confidently once again. Dental implants look just like your natural teeth, and sometimes they look even better! You can usually get dental implants with your regular dentist.
Dental implants are made from titanium. They look like hollow screws. The second part of the implant connects the screw to the crown. This part is known as the abutment, which is also made from titanium material. The third and most visible part of the implant is the tooth itself. Although dental implants are artificial, they require as much care and attention as you give your natural teeth.
But how do dental implants work exactly? Here is a guide about the dental implants procedure:
1. Titanium Post Is Inserted Into the Jawbone
Dental implants rely on a vital component like titanium
post. It would be impossible to have a dental implant without this
component. This is because the post secures the implant in
place.
However, before affixing the titanium post, your dentist should first assess the jawbone to determine its density and quality. The jawbone should be healthy and strong enough to support and fuse the post. This forms a strong bond that cannot be broken, securing the implants.
2. Using Titanium Post, Which Is Bio-Compatible
This is the primary reason why a titanium post is
preferred when it comes to securing dental implants. The body
doesnt see titanium as a foreign object, so it doesnt reject it.
Among surgically implanted devices, dental implants are the most
compatible with the human body. They have the highest chances of
success among surgically implanted devices.
3. Implanting the Titanium Post
...
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Friday, 23 June
23:38
4 Best Low Oxalate Alternatives to Almond Flour The Healthy Home Economist
Low oxalate alternatives to almond flour and other types of nut meal for keto or grain-free baking and cooking needs. My grain-free blueberry pecan cobbler food feature in the weekly newsletter elicited a number of questions for a low oxalate alternative to the nut flour portion of the recipe. Why Do Some People Avoid High
The post 4 Best Low Oxalate Alternatives to Almond Flour appeared first on The Healthy Home Economist.
09:00
Critically Thinking Jun 22 2023 Dr. Tenpenny
06-22-2023 Audio Track: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/Critically-Thinking-Shows/CriticallyThinking-with-DrT-and-DrP-Episode-149-5DOCS-June-22-2023.mp4 Join Critically Thinking with these 2 doctors for an informal conversation among peers. []
Tuesday, 20 June
05:05
Letter to the editor: Tynwald members should not back fluoride in tap water Fluoride Action Network
Tynwald will vote on mass medication via fluoridation of the public water supply when it next meets on June 20. Hopefully it will again reject the proposal.
The NHS asserts that fluoridation is safe and effective, the only potential side-effect being tooth discolouration called dental fluorosis. Scientists associated with the Fluoride Action Network (FAN) would disagree.
The FAN website provides links to a lot of independent research and highlights certain facts.
Thankfully, most fresh water supplies contain very low levels of fluoride.