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Thursday, 27 July
23:22
Exclusive: Public health journal says it will retract vaping paper for questions authors say were addressed in peer review Retraction Watch
The journal BMC Public Health plans to retract an article that found smoking rates fell faster than expected in the US as use of e-cigarettes increased, Retraction Watch has learned.
The authors contend that they addressed the issues cited in the retraction notice during the peer review process and say they addressed them even more extensively when the journal said they intended to retract.
The paper, Population-level counterfactual trend modelling to examine the relationship between smoking prevalence and e-cigarette use among US adults, was published last October. The authors are all employees of Pinney Associates, a consulting firm that they disclosed provide[s] consulting services on tobacco harm reduction on an exclusive basis to Juul Labs Inc. The article also disclosed that Juul Labs funded the research and reviewed and provided comments on a draft manuscript.
Some journals, including several in the BMJ family and the American Journal of Public Health, will not publish research funded by the tobacco industry, which has led to at least one retraction. But the planned BMC Public Hea...
11:42
Anti-inflammatory pathways of kefir in murine model: a systematic review. GreenMedInfo
PMID: Nutr Rev. 2023 May 18. Epub 2023 May 18. PMID: 37203423 Abstract Title: Anti-inflammatory pathways of kefir in murine model: a systematic review. Abstract: CONTEXT: Kefir consumption has been associated with immune response modulation, antioxidant, and anti-inflammatory effects.OBJECTIVE: The objective of this systematic review was to investigate the role of kefir against inflammation and the main response mechanisms involved in this process in a murine model.DATA SOURCES: The searches were searched in the PubMed, Science Direct, and LILACS databases. Only murine model studies, according to PRISMA guidelines, published in the past 10years were included.STUDY SELECTION: Only articles about original and placebo-controlled experiments in murine models used to investigate the anti-inflammatory mechanisms of kefir were considered. Of the articles found, 349 were excluded according to the following criteria: duplicate articles (n=99), off-topic title and abstract (n=157), reviews (n=47), studies in vitro (n=29), and studies with humans (n=17). In total, 23 studies were included in this review.DATA EXTRACTION: Two independently working authors assessed the risk of bias and extracted data from the included studies.RESULTS: Kefir consumption had positive effects on inflammation modulation. The main mechanisms involved were the reduction of pro-inflammatory and molecular markers; reduction in inflammatory infiltrate in tissues, serum biomarkers, risk factors for chronic diseases, and parasitic infection; composition and metabolic activity change of intestinal microbiota and mycobiota; activation of humoral and cellular immunity; and modulation of oxidative stress.CONCLUSIONS: Kefir modulates the immune system in different experimental models, among other secondary outcomes, to improve overall health. The beverage reduces inflammation through the alternation between innate, Th1, and Th2 responses, reducing levels of pro-inflammatory cytokines while increasing those of anti-inflammatory ones. In addition, it also mediates immunomodulatory and protective effects through the numerous molecular biomarkers and organic acids produced and secreted by kefir in the intestinal microbiota. The health-promoting effects attributed to kefir may help in the different treatments of inflammatory, chronic, and infectious diseases in the population.
10:51
Persisto Ergo Sum Age of Autism The Rebel Alliance!
Borrowed from
Facebook. Reminded of a Joni Mitchell song:
And the seasons, they go round and round. And the painted ponies go
up and down. Were captives on the carousel of time. We cant return.
We can only look behind from where we came. And go round and round
and round in the circle game.
Keep persisting friends.
###
Order today, from Skyhorse Publishing.
The Wuhan Cover Up How Health
Officials Conspired with the Chinese Military to Hide the Origins
of COVID-19 (Childrens Health Defense)
The Wuhan Cover-Up pulls back the curtain on how the US
government's increase in biosecurity spending after the 2001 terror
attacksfacilitated by Dr. Anthony Fauci, director of the National
Institute of Allergy and Infectious Diseases (NIAID)set in motion a
plan to transform the NIAID into a de facto Defense Department
agency.
While Dr. Fauci zealously funded and pursued gain-of-function
research, concern grew among some scientists and government
officials about the potential for accidental or deliberate release
of weaponized viruses from labs that might trigger worldwide
pandemics. A moratorium was placed on this research, but true to
form, Dr. Fauci found ways to continue unperturbedoutsourcing some
of the most controversial experiments offshore to China and
providing federal funding to Wuhan Institute of Virology's (WIV's)
leading researchers for gain-of-function studies in partnership
with the Chinese military and the Chinese Communist Party.
...
10:00
How to Deal With Grief: Yes, There Is Light Articles
Freedom Under Attack
One of the things that is driving a lot of people crazy right now is the ease with which our inalienable freedoms are being taken away.
It seems unfathomable and insane. Weve believed so naively in our hearts that due to our great luck of living in the West, we can move around as we please and say what we think. But now? Now, suddenly, we find ourselves in a place where we are just like the folks in other parts of the world where people have no meaningful rights. And our hearts scream, why is being done to us, why?!!
We are now being told to trust the Man over the evidence of our own eyes. We are told to "not do our own research" and keep our opinions to ourselves. We are told to take shorter showers and freak out about our gas stoves.
We are told to feel bad about ourselves in general unless we are willing to let go of whatever bodily and spiritual sovereignty weve enjoyed up until three years ago and replace our independent decision making with internalized enthusiasm and compliance with the barking orders of the day.
It is very hard for any human being to process the fact that our sovereign bodies are viewed by our elected and unelected rulers not as our sovereign bodies but as property of theirs. By the way, when we talk about bodily sovereignty, we often do so in the context of vaccine mandates but the mandates are merely "their" foot in the door. "They" want more!
For example, in 2019, in a curious article titled, "Privacy in 2034: A corporation owns your DNA (and maybe your body)," Fast Company asked: "Should you have a right to keep your emotions, mental state, and other biometric details private from persistent recognition?" Oh really, should I? You are asking me that with a straight face? Well, I happen to know the correct answer to that question, and the answer is, "Yes, I should, and I do, and by the way, its an abusive question to ask."
So indeed, it is very hard to process the fact that our sovereign bodies are treated by the "masters" as property of theirs. It was very hard for those who had faced such abuse in the past, and it is very hard for us.
It is hard to face the absurd "new normal" reality in which many joys of life that weve b...
Researchers Find Microplastics in Stool Samples Articles
Editor's Note: This article is a reprint. It was originally published November 7, 2018.
Tests reveal both tap water and bottled water1 contain microplastics, as does your many foods, especially seafood2,3 and sea salt,4 but also any food that has been stored in plastic packaging.
The suspicion that we're consuming our own plastic pollution was recently reconfirmed when researchers reported the discovery of microplastic particles in human stool samples. The consequences of ingesting microscopic plastic bits and pieces is still relatively unknown.
But considering the fact that plastic will not degrade within a human lifetime, and that many of the chemicals used in the production of plastic are known endocrine disruptors, chances are the impact on human health may be greater than suspected.
Animal research has also shown microplastics affect the gut barrier and the composition of gut microbiota in mice, and that they have toxic effects on the liver in fish.
Microplastic Debris Found in Human Stool Samples
The study5,6,7,8 in question was done by researchers from the Medical University of Vienna in collaboration with the Austrian Environment Agency. The findings of this pilot study were presented October 23, 2018, at the annual United European Gastroenterology conference in Vienna. As reported by Salon magazine:9
"Eight people from Finland, Italy, Japan, the Netherlands, Poland, Russia, the United Kingdom and Austria participated in the study. Each person kept a food diary the week before the stool sampling occurred which showed researchers that all participants were exposed to foods that were either wrapped in plastic, or they drank from plastic bottles. Six of the eight ate sea fish, too; none of them were vegetarians."
The stool samples were tested for the presence of 10 different types of plastics, of which nine were found in the samples. On average, participants had 20 microplastic particles per 10 grams of stool.
The most common types of plastic were polypropylene (found in bottle caps), polyethylene terephthalate or PET (found in water bottles, plastic bags and textile fibers)...
Chase Shuts Down Bank Accounts of Mercola and Key Employees Articles
July 13, 2023, JP Morgan Chase Bank suddenly informed me they are closing all of my business accounts, both banking and investment accounts, along with the personal accounts of my CEO, my CFO and their respective spouses and children.
No reason for the decision was given, other than there was "unexpected activity" on an unspecified account. The oldest of these accounts has been active for 18 years.
Politically-Motivated Harassment
This is what the new social credit system looks like, and what every soul on the planet can expect from the central bank digital currencies (CBDCs) that are being rolled out. Go against the prevailing narrative of the day, and your financial life will be deleted with the push of a button.
It's difficult enough trying to navigate this hurdle today. Once everything is digitized, cash eradicated and the social credit system completely integrated and automated, this kind of retaliatory action for wrongthink could be a death sentence for some people.
My CFO, Amalia Legaspi, whose Chase accounts including a joint account with her husband were closed along with mine, is now struggling to figure out how to pay for her husband's health care in the Philippines. He's bedridden with dementia and is wholly dependent on her financial support, and she's not allowed to open another bank account in his name.
"I have to provide all the legal documentations including notarized physicians' affidavit from the Philippines to prove that my husband is incapable of handling his finances and request the Federal to directly deposit the pension to my own personal account," Legaspi told Florida's Voice.1
Legaspi's son's account which he's using to pay for college expenses was also cancelled. My CEO, Steven Rye, believes his and his wife's accounts were shut down because of my opinions on COVID-19. He told Florida's Voice:2
"I believe they cancelled all of the accounts because of Dr. Mercola's (our employer) opinions. He has carried a contradictory view throughout the COVID narrative and co-authored the best-selling book 'The Truth About COVID-19,' which exposed the likelihood that this virus was engineered in a laboratory funded by the NIH."
In May 2023, Florida Gov. Ron DeSantis signed legislation specifically prohibiting financial institutions from denying or canceling services based on political or religious beliefs.3
Apparent...
09:29
Kefir has a beneficial effect in decreasing insulin resistance. GreenMedInfo
PMID: Curr Drug Targets. 2023 ;24(7):599-612. PMID: 37102491 Abstract Title: Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Abstract: BACKGROUND: Fermentation of lactose in milk by bacteria and yeasts naturally present in kefir grains produces a beverage that has been suggested to have cardiovascular benefits. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of this kefir beverage on cardiometabolic risk factors.METHODS: Literature search utilised PubMed, Scopus, ISI Web of Science, and Google Scholar for articles published from inception until June 2021. Cardiometabolic risk indices extracted included insulin and insulin resistance (HOMA_IR), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood sugar (FBS), haemoglobin A1c (HbA1c) and body weight (BW). In total, six RCTs (314 subjects) were selected for the meta-analysis. Inverse-variance weighted mean difference (WMD) with a 95% confidence interval (CI) was calculated for the mean changes in TC, TG, HDL-C, LDL-C, FBS, HbA1c and BW compared to baseline. A random effects model was used to estimate the pooled WMD.RESULTS: Kefir intake significantly reduced fasting insulin (WMD: -3.69 micro-IU/mL,95% CI: -6.30 to -1.07, p = 0.006, I= 0.0%) and HOMA-IR (WMD: -2.56, 95% CI: -3.82 to -1.30,
09:22
Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis. GreenMedInfo
PMID: Front Cell Dev Biol. 2023 ;11:1158812. Epub 2023 Apr 6. PMID: 37091976 Abstract Title: Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis in atherogenic diet-fedknockout mice. Abstract: Vascular calcification (VC) and osteoporosis were previously considered two distinct diseases. However, current understanding indicates that they share common pathogenetic mechanisms. The available medicines for treating VC and osteoporosis are limited. We previously demonstrated that kefir peptides (KPs) alleviated atherosclerosis in high-fat diet (HFD)-induced apolipoprotein E knockout () mice. The present study further addressed the preventive effects of KPs on VC and osteoporosis inmice fed a high-cholesterol atherogenic diet (AD).Seven-week-oldand wild-type C57BL/6 mice were randomly divided into five groups (= 6). The development of VC and osteoporosis was evaluated after AD feeding for 13 weeks in KP-treatedmice and compared to C57BL/6 andmice fed a standard chow diet (CD).The results indicated that KP-treatedmice exhibited lower serum total cholesterol, oxidized low-density lipoprotein (ox-LDL), malondialdehyde (MDA) levels, and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatine kinase (CK) activities, which suggested that KPs prevented hyperlipidemia and possible damages to the liver and muscle inmice. KPs reduced serum tumor necrosis factor-(TNF-) and the local expression of TNF-, IL-1, and macrophage-specific CD68 markers in aortic tissues, which suggested that KPs inhibited inflammatory responses in AD-fedmice. KPs reduced the deposition of lipid, collagen, and calcium minerals in the aortic roots of AD-fedmice, which suggested that KPs inhibited the calcific progression of atherosclerotic plaques. KPs exerted osteoprotective effects in AD-fedmice, which was evidenced by lower levels of the bone resorption marker CTX-1 and higher levels of the bone formation marker P1NP. KPs improved cortical bone mineral density and bone volume and reduced trabecular bone loss in femurs.The present data suggested that KPs attenuated VC and osteoporosis by reducing oxidative stress and inflammatory responses in AD-fedmice. Our findings contribute to the application of KPs as preventive medicines for the treatment of hyperlipidemia-induced vascular and bone degeneration.
09:03
Feelings: Dont be afraid of the dark Chipur
Feelings: when they turn the front porch lights on we sense warmth and safety. But they can just as easily provoke a cold and terrifying gloom. Weve heard it since we were kids, dont be afraid of the dark.
The post Feelings: Dont be afraid of the dark first appeared on Chipur.
08:35
Kombucha beverages produced from fruits, vegetables, and plants. GreenMedInfo
PMID: Foods. 2023 Apr 27 ;12(9). Epub 2023 Apr 27. PMID: 37174355 Abstract Title: Kombucha Beverages Produced from Fruits, Vegetables, and Plants: A Review on Their Pharmacological Activities and Health Benefits. Abstract: Kombucha is a traditional health beverage produced by fermenting sweetened tea with a symbiotic culture of bacteria and yeasts. Consumption of kombucha beverages has been growing and there is kombucha commercially available worldwide as one of the most famous low-alcohol beverages. Kombucha beverages have been claimed to have beneficial effects on human health because they contain a variety of bioactive compounds that possess various functional properties. At present, several kinds of raw material (e.g., milk, fruit, vegetables, and herbs) have been fermented with kombucha consortium and consumed as kombucha beverages. Although several studies have been written regarding the biological activities of kombucha and raw materials, there is however little information available on the characterization of their components as well as the biological activities of fermented kombucha from many raw material mixtures. Several pharmacological activities were reviewed in the scientific literature, describing their potential implications for human health. In addition, the adverse effects and toxicity of kombucha consumption were also reviewed. In this study, we focused on the main and latest studies of the pharmacological effects of kombucha beverages produced from various kinds of raw materials, including antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, anticancer, antidiabetic, antihypertensive, and antihyperlipidemic effects in in vitro and in vivo studies.
08:24
The True Cost of Julian Assanges Persecution: An Exclusive Interview with Stella Assange Medical Kidnap
The MintPress podcast, The Watchdog, hosted by British-Iraqi hip hop artist Lowkey, closely examines organizations about which it is in the public interest to know including intelligence, lobby and special interest groups influencing policies that infringe on free speech and target dissent. The Watchdog goes against the grain by casting a light on stories largely ignored by the mainstream, corporate media.
It is now four years since Julian Assange was imprisoned in Belmarshs high-security prison in London and eleven since he was forced into hiding in the Ecuadorean Embassy in the same city. But even before then, the Australian publisher and WikiLeaks co-founder has been under relentless attack from powerful bodies his organization exposed.
Today in The Watchdog studio, Lowkey is joined by Assanges wife Stella. Stella Assange is a South-African born lawyer and human rights defender. Her most famous case is undoubtedly that of her husband, whom she married in 2022. For years, Stella has tirelessly traveled the world raising awareness of Julians situation. Before marrying Julian, she attained degrees from the School of African and Oriental Studies (SOAS) in London and from the University of Oxford.
For Lowkey, Assanges brilliance was taking his anti-war passions and finding a way to directly work with units within the U.S. military to make the public aware of the illegal, immoral, and deeply unpopular decisions being taken in our name. As he said today:
Some of the most deeply heinous and hideous aspects of the Iraqi and Afghan occupations by the U.S., Britain and their allies, have been revealed within the WikiLeaks files. We are talking about millions of documents being made available to the public to understand truly what was happening.
Perhaps the most infamous leak was the Collateral Murder video, which showed footage of American helicopter pilots casually carrying out a massacre of Iraqi civilians in Baghdad in 2007, two of whom were Reuters-employed journalists.
Despite this, the media cheered Assanges arrest. The Washington Posts editorial board, for example, claimed Assange...
08:24
The True Cost of Julian Assanges Persecution: An Exclusive Interview with Stella Assange Vaccine Impact
The MintPress podcast, The Watchdog, hosted by British-Iraqi hip hop artist Lowkey, closely examines organizations about which it is in the public interest to know including intelligence, lobby and special interest groups influencing policies that infringe on free speech and target dissent. The Watchdog goes against the grain by casting a light on stories largely ignored by the mainstream, corporate media.
It is now four years since Julian Assange was imprisoned in Belmarshs high-security prison in London and eleven since he was forced into hiding in the Ecuadorean Embassy in the same city. But even before then, the Australian publisher and WikiLeaks co-founder has been under relentless attack from powerful bodies his organization exposed.
Today in The Watchdog studio, Lowkey is joined by Assanges wife Stella. Stella Assange is a South-African born lawyer and human rights defender. Her most famous case is undoubtedly that of her husband, whom she married in 2022. For years, Stella has tirelessly traveled the world raising awareness of Julians situation. Before marrying Julian, she attained degrees from the School of African and Oriental Studies (SOAS) in London and from the University of Oxford.
For Lowkey, Assanges brilliance was taking his anti-war passions and finding a way to directly work with units within the U.S. military to make the public aware of the illegal, immoral, and deeply unpopular decisions being taken in our name. As he said today:
Some of the most deeply heinous and hideous aspects of the Iraqi and Afghan occupations by the U.S., Britain and their allies, have been revealed within the WikiLeaks files. We are talking about millions of documents being made available to the public to understand truly what was happening.
Perhaps the most infamous leak was the Collateral Murder video, which showed footage of American helicopter pilots casually carrying out a massacre of Iraqi civilians in Baghdad in 2007, two of whom were Reuters-employed journalists.
Despite this, the media cheered Assanges arrest. The Washington Posts editorial board, for example, claimed Assange...
08:11
Freemason Elon Musk Rebrands Twitter to X New Everything App is the Goal Medical Kidnap
When an inverted image of the new Twitter logo is placed next to the new X logo it resembles the Masonic Logo.
by Brian Shilhavy
Editor, Health Impact News
Last year I published an article about Elon Musk purchasing Twitter, and his desire to turn it into an everything app similar to the Chinese WeChat app, which is the main app China uses to combine social media, digital identity, vaccination and medical status, criminal history, tracking and surveillance, digital currency, shopping, carbon footprint, and other digital information. See:
Freemason Technocrat Elon Musk Proudly Displays his Allegiance to Satan on Halloween Beware the Twitter Trap!
Elon Musks baphomet Satanic costume from last Halloween.
A video had surfaced at that time of Musk stating his intentions for purchasing Twitter.
We also reported that several large foreign Twitter investors had received access to confidential information about the social network, possibly including its users personal data and financial statistics as part of Elon Musks deal on his Twitter acquisition. (Source.)
Musks plans to turn Twitter into an everything app that would provide new levels of tracking individuals is apparently becoming a reality, as Musk changed the name of Twitter to X earlier this week.
Forbes reported:
El...
08:10
Freemason Elon Musk Rebrands Twitter to X New Everything App is the Goal Vaccine Impact
When an inverted image of the new Twitter logo is placed next to the new X logo it resembles the Masonic Logo.
by Brian Shilhavy
Editor, Health Impact News
Last year I published an article about Elon Musk purchasing Twitter, and his desire to turn it into an everything app similar to the Chinese WeChat app, which is the main app China uses to combine social media, digital identity, vaccination and medical status, criminal history, tracking and surveillance, digital currency, shopping, carbon footprint, and other digital information. See:
Freemason Technocrat Elon Musk Proudly Displays his Allegiance to Satan on Halloween Beware the Twitter Trap!
Elon Musks baphomet Satanic costume from last Halloween.
A video had surfaced at that time of Musk stating his intentions for purchasing Twitter.
We also reported that several large foreign Twitter investors had received access to confidential information about the social network, possibly including its users personal data and financial statistics as part of Elon Musks deal on his Twitter acquisition. (Source.)
Musks plans to turn Twitter into an everything app that would provide new levels of tracking individuals is apparently becoming a reality, as Musk changed the name of Twitter to X earlier this week.
Forbes reported:
El...
08:04
The True Cost of Julian Assanges Persecution: An Exclusive Interview with Stella Assange Health Impact News
The MintPress podcast, The Watchdog, hosted by British-Iraqi hip hop artist Lowkey, closely examines organizations about which it is in the public interest to know including intelligence, lobby and special interest groups influencing policies that infringe on free speech and target dissent. The Watchdog goes against the grain by casting a light on stories largely ignored by the mainstream, corporate media.
It is now four years since Julian Assange was imprisoned in Belmarshs high-security prison in London and eleven since he was forced into hiding in the Ecuadorean Embassy in the same city. But even before then, the Australian publisher and WikiLeaks co-founder has been under relentless attack from powerful bodies his organization exposed.
Today in The Watchdog studio, Lowkey is joined by Assanges wife Stella. Stella Assange is a South-African born lawyer and human rights defender. Her most famous case is undoubtedly that of her husband, whom she married in 2022. For years, Stella has tirelessly traveled the world raising awareness of Julians situation. Before marrying Julian, she attained degrees from the School of African and Oriental Studies (SOAS) in London and from the University of Oxford.
For Lowkey, Assanges brilliance was taking his anti-war passions and finding a way to directly work with units within the U.S. military to make the public aware of the illegal, immoral, and deeply unpopular decisions being taken in our name. As he said today:
Some of the most deeply heinous and hideous aspects of the Iraqi and Afghan occupations by the U.S., Britain and their allies, have been revealed within the WikiLeaks files. We are talking about millions of documents being made available to the public to understand truly what was happening.
Perhaps the most infamous leak was the Collateral Murder video, which showed footage of American helicopter pilots casually carrying out a massacre of Iraqi civilia...
07:37
Freemason Elon Musk Rebrands Twitter to X New Everything App is the Goal Health Impact News
When an inverted image of the new Twitter logo is placed next to the new X logo it resembles the Masonic Logo.
by Brian Shilhavy
Editor, Health Impact News
Last year I published an article about Elon Musk purchasing Twitter, and his desire to turn it into an everything app similar to the Chinese WeChat app, which is the main app China uses to combine social media, digital identity, vaccination and medical status, criminal history, tracking and surveillance, digital currency, shopping, carbon footprint, and other digital information. See:
Freemason Technocrat Elon Musk Proudly Displays his Allegiance to Satan on Halloween Beware the Twitter Trap!
Elon Musks baphomet Satanic costume from last Halloween.
A video had surfaced at that time of Musk stating his intentions for pur...
07:26
In Australian Mental Health Units, Women Are Drugged Up, Dehydrated and Retraumatised Mad In America
From Australian Broadcasting Corporation: Casey is one of too many women suffering serious trauma because of the treatment they are subjected to in public and private mental health units across Australia.
Some say theyre leaving facilities in a worse condition than when they arrived, having reported sexual assault or discrimination. Many report being administered high dosages of medication without any support on release, while some say they were even denied adequate water.
The problem, experts say, is that Australias mental health facilities are in too many cases exacerbating patients underlying trauma by placing them in mixed gender wards and taking a medical first approach based on using medication to treat symptoms. Health systems need to stop blaming patients for their illness, they say, and focus more on delivering trauma informed care.
. . . While youre at your worst, you are put on medication to stabilise you, and then youre just dumped back into the world, [said Maree*].
Everyone looks at the symptoms, not the cause, so its like, You need to change your behaviour this is happening because you are a flawed human being.'
***
Back to Around the Web
The post In Australian Mental Health Units, Women Are Drugged Up, Dehydrated and Retraumatised appeared first on Mad In America.
07:11
Cold and flu supplements do not work, do not boost the immune system Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
There are many cold and flu supplements that are pushed on us every winter. Is there any scientific evidence that they work?
06:08
Two servings of fatty fish every week does it help your heart? Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
There are a lot of claims that eating two servings of fatty fish every week can help your heart. But what does the science say?
05:44
High-dose ginseng berry kombucha significantly ameliorated ethanol-induced behavioral changes. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Mar 22 ;12(3). Epub 2023 Mar 22. PMID: 36979022 Abstract Title: Hangover-Relieving Effect of Ginseng Berry Kombucha Fermented byandin Ethanol-Treated Cells and Mice Model. Abstract: This study aimed to evaluate the hangover relieving effect of ginseng berry kombucha (GBK) fermented withandin in vitro and in vivo models. The antioxidant activity and oxidative stress inhibitory effect of GBK were evaluated in ethanol-treated human liver HepG2 cells. In addition, biochemical and behavioral analyses of ethanol treated male ICR mice were performed to confirm the anti-hangover effect of GBK. The radical scavenging activity of GBK was increased by fermentation, and the total ginsenoside content of GBK was 70.24g/mL. In HepG2 cells, in which oxidative stress was induced using ethanol, GBK significantly increased the expression of antioxidant enzymes by upregulating the Nrf2/Keap1 pathway. Moreover, GBK (15 and 30 mg/kg) significantly reduced blood ethanol and acetaldehyde concentrations in ethanol-treated mice. GBK significantly increased the levels of alcohol-metabolizing enzymes, including alcohol dehydrogenase and acetaldehyde dehydrogenase. The balance beam test and elevated plus maze test revealed that high-dose GBK significantly ameliorated ethanol-induced behavioral changes. Collectively, GBK exerted a protective effect against ethanol-induced liver damage by regulating the Nrf2/Keap1 pathway.
03:49
How Curcumin Targets Cancer GreenMedInfo
Though different tumors have diverse molecular pathologies and you wouldn't expect one herb would work for almost all of them, you'd be wrong. This one is amazingly versatile
03:48
How Curcumin Targets Cancer GreenMedInfo
Originally published on www.mercola.com
Though different tumors have diverse molecular pathologies and you wouldn't expect one herb would work for almost all of them, you'd be wrong. This one is amazingly versatile.
STORY AT-A-GLANCE
03:00
The Clinical Uses of Stoic Acceptance Mad In America
Stoic philosophy seems to be having a revival. Im guessing thats because many well-meaning people are looking for a life philosophy with which to approach the current deluge of seemingly insurmountable social problemsglobal warming, systemic racism, political tribalism, oppressive religiositywith a measure of realism and control that prevents them from becoming perpetually demoralized. The concept of stoic acceptance pivots on distinguishing between things that we have no control over whatsoever and things over which we have some, but not complete control, and marshalling our energies around the latter. In the political realm, this is akin to the 60s countercultural anthem, think globally, act locally. Or, centering your focus and remedial efforts on sources of injustice that are small, actionable, and achievable that present themselves in your everyday life.
These ideas can help in forming a therapeutic mindset,
which psychotherapists can pass along to their clients. As a
therapist myself, I have noticed that many clients frame their
treatment goals in ways that readily set them up for
disappointment: My goal is to save our marriage; turn my teenage
son into a successful student; get my wife to embrace and maintain
a sober lifestyle; make my emotionally constricted husband more
empathic; restore our sex life to what it was like before kids
entered the picture; change my emotionally reactive girlfriend into
a calm person. Stating goals predicated on a desperately needed
outcomerather than as responsible steps to take that may or may not
eventuate in that outcomecan be a recipe for disappointment.
The overly ambitious ways some clients define their treatment goals, mixed with the sense of urgency and demandingness in which their goals are asserted, can invite even the most well-intentioned therapist to collude with clients unrealistic aspirations. How do we reframe such clients treatment goals i...
02:35
Chase Bank Shuts Accounts of Natural Health Advocate Dr. Joesph Mercola, Refuses To Say Why GreenMedInfo
Including the accounts of staff and their family.
02:34
Chase Bank Shuts Accounts of Natural Health Advocate Dr. Joesph Mercola, Refuses To Say Why GreenMedInfo
Originally published on www.reclaimthenet.org by Cindy
Harper
Including the accounts of staff and their family.
Go Back:30 Days | 7 Days | 2 Days | 1 Day
Wednesday, 26 July
23:20
Speaking Naturally with Dr. Leo Pruimboom Alliance for Natural Health USA Protecting Natural Health
Dr. Leo Pruimboom is the latest guest on Speaking Naturally, a podcast in which Rob Verkerk, PhD, ANHs founder and Executive and Scientific Director, has uncensored conversations with some of the worlds leading researchers, scientists, and thinkers.
Dr. Pruimboom is the founder of clinical psychoneuroimmunology CPNI for short, or KPNI if youre in Europe and the Intermittent Living concept. Please note the distinction between psychoneuroimmunology (PNI), which was a concept advanced by Robert Ader and Nicholas Cohen back in 1975, and clinical psychoneuroimmunology, the practical and clinical application of PNI principles, Dr. Pruimbooms brainchild.
He describes clinical psychoneuroimmunology as an advanced and complete medicine that provides an integrative overview of patients health. It examines interconnected body systems and their relationship with psychological, social and ecological aspects of the patients life. Thus, it would be closer to the mark to say that CPNI is the application of clinical psycho-neurosocio-endo-metabolo-immunology in the pursuit of the multiple risk factors which activate disease mechanisms. Hard science, anchored by a core of epistemology, delivered with softer skills.
Dr. Pruimboom admits hes been criticized at times for being too hypothesis-led, but the world has been built on those willing to follow a hunch and take a risk. Undeterred by any detractors, Dr. Pruimboom has spent over 3 decades pioneering the field of clinical PNI and developing and directing educational programs. His masters courses have been hosted by four different universities and he regularly runs external CPNI courses and webinars for medical professionals.
This year sees CPNI celebrating 35 successful years as a translational medical discipline. In October 2024 the International CPNI Masters will be launched in the UK and we are also pleased to be able to announce that you will have a rare opportunity to spend a day with Dr. Pruimboom in November 2023 see below for more details!
Save the date: a day with Dr. Pruimboom
Email your interest to join Dr. Leo Pruimboom for a unique, one-off, CPNI Masterclass (prior knowledge of CPNI not required), hosted by Dr. Rob Verkerk and suppo...
23:16
Dentistry, Cavities, Kids, Autism Age of Autism The Rebel Alliance!
Note: Below is an article from Children's
Health Defense's The Defender. It's more than relevant to the
autism community. Dental work is often difficult for our
kids. And worse so for adults with autism. Did you know
that Medicaid only pays for 1 cleaning a year for adults?
Many of our adult children require hospital based general
anesthesia for a routine cleaning or filling and X-rays. I
recently saw a hospital bill for a hospital filling. $16,000.
Autism will bankrupt everyone everywhere. Few adult dentists will
even treat special needs adults. And most? They just YANK OUT
THE TEETH. Take a look at older individuals with ID - gaps,
toothless. It's a travesty. Yet another.
###
Study Sheds New Light on Kids, Tooth Decay and Bacteria Teamwork'
New research by University of Pennsylvania scientists shows how multiple oral bacteria interact in complex ways to form dental plaque, leading to cavities in children. The study found a little-known bacterium that teams up with a known decay-causing microbe to attack tooth enamel aggressively.
By
Angelo DePalma, Ph.D.
More than half of young children and adolescents in the U.S. have
at least one dental cavity, with
lower-income children more than twice as likely to be affected as
kids from well-to-do households.
Gum disease, an even more serious consequence of oral bacteria running amok, has been detected in up to 73% of children under age 11, with incidence climbing during adolescence.
Cavities may be filled, and gum disease successfully treated but not addressing the underlying causes of these conditions can lead to serious health problems later in life.
In fact, the Mayo Clinic describes oral health as the...
23:07
Exclusive: City of Hope cancer researcher goes to court to fight misconduct finding Retraction Watch
An alumna of the lab of Carlo Croce, a high-profile cancer researcher at The Ohio State University with 14 retractions, has sued the institution over the results of its investigation that found she committed research misconduct.
Flavia Pichiorri is now a principal investigator with her own lab researching potential therapies for multiple myeloma at City of Hope a cancer center that also owns Cancer Treatment Centers of America in Duarte, Calif.
She worked at Ohio State from 2004-16, first as a postdoctoral researcher in Croces lab, then as a research scientist, and finally as an assistant professor of hematology. She has been a PI on grants that garnered millions of dollars in funding from the National Institutes of Health since switching jobs.
After Pichiorri left Ohio State, the university received allegations that some of her work contained fake data in the form of manipulated and reused images. A subsequent investigation, finalized in 2020, found that Pichiorri was responsible for the faked data in four publications, one of which was a correction, spanning from her time in Croces lab through her establishing her own lab at Ohio State. Nature reported the universitys findings last year, calling them one of the first determinations of research misconduct relating to work done in Croces lab.
Now, Pichiorri is suing her former employer, alleging in her complaint that the investigation was flawed, the findings invalid, and the issues identified in her work the result of honest error. She further alleges that the uni...
22:57
FDA Misleads on CBD Safety Alliance for Natural Health USA Protecting Natural Health
providing further evidence that the agency is trying to engineer a ban on affordable CBD to protect drug industry profits. Action Alert!
As the evidence of CBDs myriad health benefits continues to pile up, it increasingly looks to us like the FDA is preparing to issue a ban on CBD supplements. We must support bills in Congress that take the issue out of the FDAs hands by allowing the sale of CBD in supplement form.
Lawmakers do appear to be taking this issue seriously. In addition to the bill introduced by Representative Morgan Griffith (R-VA), another similar bill has just been introduced by Senators Ron Wyden (D-OR), Rand Paul (R-KY), Jeff Merkley (D-OR), and Representative Earl Blumenauer (D-OR) to allow the sale of CBD in supplements. Additionally, Congress is holding a hearing on July 27 during which members will formally scrutinize the impact of the FDAs failure to develop a regulatory pathway for the sale of CBD in supplements and food. Lets show the FDA the scale of our opposition to its unjustified plan and demonstrate the huge level of grassroots support for CBD supplements ahead of the hearing.
We want to make it crystal clear what we face if we dont stop the FDA in its tracks. CBD, or cannabidiol, is one of over 100 natural compounds called cannabinoids found in a wide range of plants, most notably the hemp plant. The cells of our bodies are laced with cannabinoid receptors that form part of the endocannabinoid system that is essential to life and to robust health. We produce cannabinoids internally (endocannabinoids) and we also consume them in some foods (exocannabinoids). Most of these cannabinoids, including CBD, are not psychoactive THC being an exception but they all offer profound benefits. CBD is one of the most well researched non-psychoactive cannabinoids and it has an incredible array of health benefits, with evidence showing that has profound ...
22:50
Multivitamins Boost Memory Alliance for Natural Health USA Protecting Natural Health
A new study confirms the powerful effects that low-cost dietary supplements can have on our health. Lets support legislation to make supplements more affordable and more widely available to Americans. Action Alert!
A recent study found that those taking multivitamins were 3 years younger in terms of their memory function than those taking a placebo. This builds on evidence from last year finding that multivitamins slowed memory and cognitive decline. And heres the kicker: these benefits were found despite the fact that Centrum Silvera lower quality big seller in supermarket and pharmacy chains, widely viewed as having limited health value by integrative healthcare providerswas the multivitamin used in the study! This is a testament to the benefits that dietary supplements can provide us; lets support multiple bills in Congress that would make these products more available to Americans by allowing them to be covered expenses for Health Savings Accounts (HSAs) and Flexible Savings Accounts (FSAs).
Consider that almost 40 percent of those over age 65 experience some form of memory loss. More than 10 percent of people over 65 have Alzheimers. It is truly remarkable that a simple (low quality) multivitamin improved memory while weve heard about dozens and dozens of Alzheimers drugs failing. The benefits of multivi...
22:44
LAUNCH Ethics for Health Professionals Alliance for Natural Health USA Protecting Natural Health
From ANH-International
Medical ethics appears to have been put on the back burner in recent times and coercive medical procedures, lack of properly informed consent and breaches of respect for autonomy of individuals have become commonplace. These challenges triggered our interest in re-creating a framework for medical ethics, taking the best of modern ethical principles, as well as the the best from traditional, and even ancient systems. Last month, we released the first of eight pillars of our Health and Ethics Framework, dealing with the relationship between doctors and other health professionals and their patients or clients. It is one of the most important relationships in healthcare and because the relationship, not just the interventions that might be prescribed, has therapeutic value in itself, it is sometimes referred to as the therapeutic relationship.
Today, we release the second pillar, specifically dealing with ethics that relate to Health Professionals.
Eight ethical principles relevant to health professionals
The eight overarching principles weve developed for this second pillar, aim to ensure that health professionals themselves are cared for, and subscribe to principles that help build trust, and, in turn, ensure they are able to be of optimal service to others in ways that really meet their patients or clients needs.
The 8 headline principles are listed below; and youll find the full details about them in the Pillar 2 framework document (see below).
- Self-care
- Continuous education
- Collaboration with other health professionals
- Health creation and regeneration
- Avoiding over-diagnosis and over-treatment
- Sustainable practice
- Professionalism
- Reporting malpractice, injustice and corruption
At ANH, we know that the majority of our supporters and subscribers are either members of the public with a very keen interest in health, especially natural health while a significant number are also health professionals.
The post LAUNCH Ethics for Health Professionals first appeared on Alliance for Natural Health USA - Protecting Natural Health....
22:03
Washington Post Falls For Acupuncture Pseudoscience Science-Based Medicine
An opinion piece falls for all the usual acupuncture misdirection.
The post Washington Post Falls For Acupuncture Pseudoscience first appeared on Science-Based Medicine.22:02
Setting the Record Straight: CCDH Lied, People Died, and the Real Disinformation Agents Have Now Been Exposed GreenMedInfo
Visit our Re-post guidelines
Our 2020 warning to the public that the FDA was anticipating life-threatening adverse events, and even deaths, from the soon to be deployed mRNA jabs was falsely labeled as "disinformation" by the CCDH, the US government, and the global media, and yet, sadly, our warning turned out to be devastatingly true. When will the real disinformation agents be held accountable for their dishonesty, defamation, and for colluding to deprive many millions of Americans of informed consent?
12:59
Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms. GreenMedInfo
PMID: Food Funct. 2023 Jun 6 ;14(11):5205-5216. Epub 2023 Jun 6. PMID: 37191091 Abstract Title: Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice. Abstract: Aloe emodin is a natural anthraquinone derived from aloe or rhubarb, showing anti-renal fibrosis, anti-atherosclerosis and anti-cancer effects. Aloe emodin also shows neuroprotective effects in ischemic stroke rats. Naturally, anthraquinone derivatives generally have the effect of inhibiting the transforming growth factor-1 (TGF-1) pathway. There is an increase in the calcium/calmodulin-dependent protein kinase II (CaMKII) and TGF-1 levels in both Huntington's disease (HD) patients' brains and HD transgenic mice. Thus, we hypothesized that aloe emodin may inhibit the phosphorylation of CaMKII (p-CaMKII) and TGF-1/sma- and mad-related protein (Smad) signaling in the brain, further preventing motor and cognitive dysfunction. Aloe emodin was orally administered to 10- to 20-week-old HD R6/1 transgenic mice. Aloe emodin improved the motor coordination of R6/1 transgenic mice in the rotarod test and attenuated visual recognition impairment in the novel object recognition test. Aloe emodin downregulated levels of the mutant huntingtin protein, p-CaMKII and TGF-1, but not the TGF-2 or TGF-3 levels, in the brains of R6/1 mice. Aloe emodin could also inhibit neuronal apoptosis in the hippocampus of R6/1 mice. Altogether, these results indicated that aloe emodin prevents several HD-like symptoms through the inhibition of CaMKII/Smad and TGF-1/Smad signaling in mice.
10:00
What Can You Do to Help Prevent Cataracts? Articles
In the video above, Dr. Eric Berg, a chiropractor and health educator, reviews what he believes are some of the best natural alternatives to prevent and/or treat cataracts.
Cataracts1 is an eye condition that causes your vision to blur due to a buildup of proteins on the lens of your eye. Left untreated, cataracts can result in progressive loss of vision and, ultimately, blindness.
Risk factors for cataracts include heavy alcohol use, smoking, older age, diabetes, toxic substances, certain medications and trauma to the eye.2 Signs and symptoms that cataracts are forming include:3,4
|
Blurry, cloudy or foggy vision |
Changes in color perception |
|
Difficulty driving at night due to glare from lights |
Sensitivity to sunlight |
|
Nearsightedness |
Double vision |
|
Glasses and contacts no longer seem to improve your vision |
Cataract Surgery Is Not Risk-Free
The most common treatment for cataracts is surgery, but as noted by Berg, its not without risks. In 42% of cases, cataract surgery results in dry eyes, and in 20% of cases, it leaves the patient with a droopy eyelid. Other potential side effects include floaters, retinal detachment, eye infection, glaucoma, further vision loss and secondary cataracts.5
Like Berg, I would strongly encourage trying one or more natural remedies before resorting to surgery. He points out that scientific evidence showing the efficacy of natural remedies are typically scant, but that doesnt mean theyre useless. The reason for this lack of scientific evidence is because few are willing to invest the funds required to study a compound that will never turn a profit.
You cannot patent foods or natural nutrients, for example, and supplements dont hold a candle with respect to profitability compared to drugs. You cannot charge hundreds or thousands of dollars for a bottle of supplements. On the other hand, the risk you take by trying a natural remedy is near nonexistent.
...Stunning Results From Sunscreen Testing Articles
Editor's Note: This article is a reprint. It was originally published May 30, 2018.
While regular, consistent, sensible sun exposure is vital for optimal health and well-being having many benefits beyond vitamin D production overexposure can result in skin damage that could raise your risk of skin cancer.
This means if you're spending the day at the beach or engaging in outdoor activities for hours at a stretch, you likely need to bring some form of sun protection. While clothing is an ideal choice, most people opt for sunscreen, which can have a number of adverse ramifications.
Not only do many sunscreens contain toxic ingredients, many are also only half as effective as claimed. Consumer Reports recently issued its 2018 Sunscreen Buying Guide,1 which notes that testing reveals more than 70 sunscreen products do not provide the level of UVB protection stated on the label. As a result, you may end up getting sunburned anyway. The report also found that only a dozen or so products offered decent protection against both UVA and UVB rays.
Can You Trust the Sun Protection Factor?
Sun protection factor (SPF) is a measure of how long the product will prevent your skin from burning when exposed to UVB rays. "For example, assuming you apply and reapply the sunscreen correctly, if you'd normally burn after 20 minutes in the sun, an SPF 30 protects for about 10 hours," Consumer Reports explains. However, it's important to realize that the SPF applies to UVB rays only, and not UVA, which are actually responsible for most of the UV damage.
To protect against UVA, you need to look for a broad-spectrum product that specifies protecting against UVA. Unless specified, it's safe to assume it does not protect against UVA. It's also important to realize that no sunscreen is capable of blocking 100% of UVB or UVA. As a general guideline:
- SPF 30 blocks 97% of UVB
- SPF 50 blocks 98% of UVB
- SPF 100 blocks 99% of UVB
As in previous years, recent testing again reveals many products overstate their SPF. In this round of testing, 24 of the 73 products evaluated2 offered less than half of the protection promised by their stated SPF. What this means is if a product is labeled SPF 30, it may only offer SPF 15 protection or less, which could lead to overexposure and burning. This finding echoes the results of other investigators as well. For example:
- A JAMA Dermatology study published last year found nearly half of the top-rated sunscreen products tested failed to meet the standards set by the American Academy of Dermatology3
- An analysis by Consumer Report...
Diabetes Will Double by 2050 Articles
In 2021, 529 million people had diabetes worldwide, for a prevalence of 6.1%, making it among the top 10 leading causes of death and disability.1 However, this figure may roughly double by 2050, reaching more than 1.31 billion,2 according to a team of scientists with the Institute for Health Metrics and Evaluation (IHME) at the University of Washington's School of Medicine.3
The systematic analysis used data from the Global Burden of Diseases study, revealing that diabetes prevalence in regions such as North Africa and the Middle East may reach as high as 16.8% up from 9.3%4 in 2021. Further, close to half of the 204 countries and territories included in the study will have a diabetes prevalence rate over 10%.5
Type 2 Diabetes Accounts for 96% of Cases
The study revealed that nearly all global cases of diabetes 96% are Type 2, with high body mass index coming in as the primary risk factor, accounting for 52.2% of related disability and mortality. The next most common risk factors included:6
- Environmental/occupational risks
- Tobacco use
- Low physical activity
- Alcohol use
Those 65 and older were also more likely to be affected. This age group had a diabetes prevalence rate of more than 20% worldwide, which rose to 24.4% for those aged 75 to 79. Breaking it down by region, over-65s in North Africa and the Middle East had a diabetes prevalence rate of 39.4%, compared to 19.8% in Central Europe, Eastern Europe and Central Asia.7
The study, which was funded by the Bill & Melinda Gates Foundation, found diabetes rates are expected to increase in every country in the world. In Latin America and the Caribbean, for instance, diabetes is expected to affect 11.3% of the region's population by 2050.8 According to the study's lead author, IHME's Liane Ong:9
"The rapid rate at which diabetes is growing is not only alarming but also challenging for every health system in the world, especially given how the disease also increases the risk for ischemic heart disease and stroke.
While the general public might believe that T2D is simply associated with obesity, lack of ex...
09:34
Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis. GreenMedInfo
PMID: Int J Biol Macromol. 2023 Jul 1 ;242(Pt 1):124779. Epub 2023 May 11. PMID: 37172697 Abstract Title: Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis. Abstract: Psoriasis is a disease that causes keratinocytes to proliferate ten times faster than normal, resulting in chronic inflammation and immune cell infiltration in the skin. Aloe vera (A. vera) creams have been used topically for treating psoriasis because they contain several antioxidant species; however, they have several limitations. Natural rubber latex (NRL) has been used as occlusive dressings to promote wound healing by stimulating cell proliferation, neoangiogenesis, and extracellular matrix formation. In this work, we developed a new A. vera-releasing NRL dressing by a solvent casting method to load A. vera into NRL. FTIR and rheological analyzes revealed no covalent interactions between A. vera and NRL in the dressing. We observed that 58.8 % of the loaded A. vera, present on the surface and inside the dressing, was released after 4 days. Biocompatibility and hemocompatibility were validated in vitro using human dermal fibroblasts and sheep blood, respectively. We observed that ~70 % of the free antioxidant properties of A. vera were preserved, and the total phenolic content was 2.31-fold higher than NRL alone. In summary, we combined the antipsoriatic properties of A. vera with the healing activity of NRL to generate a novel occlusive dressing that may be indicated for the management and/or treatment of psoriasis symptoms simply and economically.
09:31
kombucha consumption may be beneficial to intestinal health. GreenMedInfo
PMID: Nutrients. 2022 Dec 8 ;14(24). Epub 2022 Dec 8. PMID: 36558393 Abstract Title: Kombuchas from Green and Black Tea Modulate the Gut Microbiota and Improve the Intestinal Health of Wistar Rats Fed a High-Fat High-Fructose Diet. Abstract: The Western diet can negatively affect the gut microbiota and is associated with metabolic disorders. Kombucha, a tea fermented by a symbiotic culture of bacteria and yeast (SCOBY), is known for its bioactive properties and has become popular in the last years. In this study, we evaluated the effects of regular kombucha consumption on the gut microbiota and on outcomes related to the intestinal health of Wistar rats fed a high-fat high-fructose diet. After eight weeks receiving a standard diet (AIN-93M) (n = 10) or a high-fat and high-fructose diet (HFHF) (n = 30) to induce metabolic disorders, the animals were subdivided into four groups: AIN-93M (n = 10); HFHF (n = 10); GTK (HFHF + green tea kombucha (n = 10); and BTK (HFHF + black tea kombucha; n = 10) for 10 weeks. Although body composition did not differ among the groups, the HFHF diet was associated with metabolic alterations, and stimulated the growth of gram-negative bacteria such asand. Kombucha ingestion could somewhat modulate the gut microbiota, attenuating the effects of a Western diet by increasing propionate production and favoring the growth of beneficial bacteria, such asin the GTK group. Our results suggest that regular kombucha consumption may be beneficial to intestinal health, which can be mostly attributed to its high content and diversity of phenolic compounds.
09:24
Emodin-induced necroptosis in prostate cancer cells. GreenMedInfo
PMID: Chem Biodivers. 2023 Jun ;20(6):e202201130. Epub 2023 Jun 6. PMID: 37062702 Abstract Title: Emodin-Induced Necroptosis in Prostate Cancer Cells via the Mitochondrial Fission HSP90/MLKL/PGAM Pathway. Abstract: Currently, prostate cancer is one of the major malignant tumors in males. Recurrence and metastasis are the main obstacles that prevent the effective treatment of prostate cancer. In the present study, we aimed to evaluate emodin (EG) against human prostate cancer PC3 and DU145cells. Our study showed that EG significantly decreased the cell viability of PC3 and DU145cells and strikingly induced non-apoptotic cell death via necroptosis that was visualized through colony formation assay, Hoechst 33258 staining, and TEM analysis. Furthermore, RNA-sequencing and KEGG functional enrichment analysis revealed that the necroptosis-related pathway was activated upon EG treatment in PC3cells. mRNA and protein expression of necroptosis markers were analyzed by qPCR and immunoblotting, which implied that EG-induced cell necroptosis via enhancing the expression of MLKL and HSP90AA1 activating PGAM pathway which is considered as a key mediator of mitochondrial fission and leading to ROS generation in PC3 and DU145cells. Thus, our findings suggested that EG is a new small molecule agonist that induced necroptosis in prostate cancer cells via the mitochondrial fission HSP90/MLKL/PGAM pathway.
09:22
Green tea and kombucha characterization: Phenolic composition, antioxidant capacity and enzymatic inhibition potential. GreenMedInfo
PMID: Food Chem. 2023 May 15 ;408:135206. Epub 2022 Dec 12. PMID: 36528993 Abstract Title: Green tea and kombucha characterization: Phenolic composition, antioxidant capacity and enzymatic inhibition potential. Abstract: The present study aimed to carry out the physical-chemical, antioxidant, and enzymatic characterization of green tea and kombucha. It was observed that kombucha had lower pH, higher acidity, and solids content compared to green tea. As for the concentration of total phenolic compounds by the Folin Ciocalteu method, there was no significant difference between the beverages. In the antioxidant analysis by the DPPH assay, it was observed that both green tea and kombucha presented significant antioxidant capacity. In the TBARS analysis with the pH of the beverages neutralized, both showed a significant reduction in lipid peroxidation; however, kombucha exhibited pro-oxidant activity when evaluated in its natural form by this method. The beverages also showed significant inhibitory activity of the-glucosidase enzyme, however, green tea presented superior inhibitory potential.
08:23
Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease. GreenMedInfo
PMID: Heliyon. 2023 May ;9(5):e15406. Epub 2023 Apr 11. PMID: 37144207 Abstract Title: Exploring the therapeutic efficacy ofpeptides in ameliorating Alzheimer's disease. Abstract: Alzheimer's disease (AD) is one of the neurodegenerative disorders, the hallmarks of which include deposits of extracellular beta-amyloid (A) as well as intracellular tau neurofibrillary tangles (NFTs) tangles. With disease progression, neuronal apoptosis combined with cerebral atrophy occurs, leading to cognitive impairment and long-term memory loss. Recently,species have been identified as a functional food and are being explored for the prevention of various diseases widely studied to prevent or treat many neurodegenerative diseases. Hence, we for the first time investigated the neuroprotective effects ofshort-chain peptides (CPPs) i.e.10 kDa on theandneuronal injury models. Ourresults showed that CPP with a molecular weight of 1-3 kDa and 3-10 kDa could elevate the survival rate of Aor l-Glutamic acid-injured N2A cells. These treatments also inhibited Aand tau NFTs in N2A cells and prevented progressive neuronal cellular damage by suppressing inflammatory cytokines such as PGE2, iNOS, IL-6, TNF-, COX-2, IL-1, TGF-1, and NF-B. Further, ourA-induced AD mice model demonstrated that 1-3 kDa or 3-10 kDa CPP could improve spatial cognition and learning memory. We also observed a decreased cell loss ratio in CA1-CA3 hippocampal regions. Taken together, our findings imply that CPPs may exert their anti-AD impact through anti-inflammatory, and anti-amyloid activities via reducing APP and tau NFT.
08:03
Coffee health benefits what does science say? Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
A newly published, peer-reviewed paper provides some evidence that moderate amounts of coffee have health benefits.
08:00
Happy Hour with Donica Hudson Dr. Tenpenny
07-25-2023 Listen to audio here: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-25-23-HHr-DonicaHudson.mp4 This interview we will discuss the following topics and []
07:45
Comparison of effects of low level laser therapy and local corticosteroid injection in the treatment of plantar fasciitis. GreenMedInfo
PMID: Turk J Phys Med Rehabil. 2023 Mar ;69(1):8-14. Epub 2022 Oct 27. PMID: 37201000 Abstract Title: Comparison of effects of low level laser therapy and local corticosteroid injection in the treatment of plantar fasciitis. Abstract: OBJECTIVES: The purpose of the study was to compare low-level laser therapy (LLLT) and local corticosteroid injection in the treatment of plantar fasciitis.PATIENTS AND METHODS: This retrospective study was performed with 56 patients (6 males, 50 females; mean age: 44.710.1 years; range, 18 to 65 years) between January 2015 and March 2016. The patients were equally divided into two groups: Group 1, comprising patients who underwent a one-time local corticosteroid injection into the heel by the same physician, and Group 2, including patients who had gallium arsenide laser therapy at a wavelength of 904 nm lasting 10 sessions. Evaluations were done at pre-treatment, post-treatment, and two weeks, one month, and three months after the post-treatment evaluation. The post-treatment evaluation was accepted as the 10day after the injection in Group 1 and as the time after the last session of the laser treatment in Group 2. Each visit was compared with the previous visit for within-group analysis. The Visual Analog Scale (VAS), Heel Tenderness Index (HTI), and Foot Function Index (FFI) were assessed.RESULTS: Pain scores in Group 1 and Group 2 were not associated with statistically significant differences (p>0.05). Within-groups analysis demonstrated statistically significant differences concerning VAS subgroups (p
07:35
Top Arkansas Psychiatrist Accused of Falsely Imprisoning Patients and Medicaid Fraud Mad In America
From NBC News: . . . Dr. Brian Hyatt, was one of the most prominent psychiatrists in Arkansas and the chairman of the board that disciplines physicians. But hes now under investigation by state and federal authorities who are probing allegations ranging from Medicaid fraud to false imprisonment.
. . . VanWhy and at least 25 other former patients
have sued Hyatt, alleging that they were held against their will in
his unit for days and sometimes weeks. And Arkansas Attorney
General Tim Griffins office has accused Hyatt of running an
insurance scam, claiming to treat patients he rarely saw and then
billing Medicaid at the highest severity code on every patient,
according to a search warrant affidavit.
As the lawsuits piled up, Hyatt remained chairman of the Arkansas State Medical Board. But he resigned from the board in late May after Drug Enforcement Administration agents executed a search warrant at his private practice.
I am not resigning because of any wrongdoing on my part but so that the Board may continue its important work without delay or distraction, he wrote in a letter.
***
Back to...
07:30
U.S. Government Wants Facial Scans of All Children: To Protect Children or to Traffick Them? Medical Kidnap
by Brian Shilhavy
Editor, Health Impact News
The FTC (Federal Trade Commission) of the federal U.S. Government is considering allowing businesses to use biometric facial scans of children under the age of 13 as a new mechanism for obtaining parental consent.
The Federal Trade Commission is seeking comment on an application from the Entertainment Software Rating Board (ESRB) and others for a new mechanism for obtaining parental consent under the Childrens Online Privacy Protection Act Rule.
ESRB, which currently operates a COPPA safe harbor program, was joined in its application by Yoti, a digital identity company, and SuperAwesome, which provides technology to help companies comply with parental verification requirements. The companies have requested approval for the use of Privacy-Protective Facial Age Estimation technology, which analyzes the geometry of a users face to confirm that they are an adult.
Under the COPPA Rule, online sites and services directed to children under 13 must obtain parental consent before collecting or using personal information from a child. The Rule lays out a number of acceptable methods for gaining parental consent but also includes a provision allowing interested parties to submit new verifiable parental consent methods to the Commission for approval.
In a Federal Register notice, the FTC is seeking comment on a number of questions related to the application including whether the proposed age verification method is covered by existing methods; whether the proposed method meets the requirements under the COPPA Rule; and whether the proposed method poses a privacy risk to consumers personal information, including their biometric information.
The public will have until August 21, 2023 to submit a comment. After they are submitted, comments will be posted to Regulations.gov.
NOTE: Publication of this Federal Register notice is required by the Rule and does not indicate Commission approval or endorsement of the program. The Commission has 120 days to review proposed verifiable parental consent methods and must set forth its conclusions in writing. (Emphasis mine. Full Press Release.)
As the FTC noted in this press release, Under the COPPA Rule, online sites and services directed to children under 13 must...
07:30
U.S. Government Wants Facial Scans of All Children: To Protect Children or to Traffick Them? Vaccine Impact
by Brian Shilhavy
Editor, Health Impact News
The FTC (Federal Trade Commission) of the federal U.S. Government is considering allowing businesses to use biometric facial scans of children under the age of 13 as a new mechanism for obtaining parental consent.
The Federal Trade Commission is seeking comment on an application from the Entertainment Software Rating Board (ESRB) and others for a new mechanism for obtaining parental consent under the Childrens Online Privacy Protection Act Rule.
ESRB, which currently operates a COPPA safe harbor program, was joined in its application by Yoti, a digital identity company, and SuperAwesome, which provides technology to help companies comply with parental verification requirements. The companies have requested approval for the use of Privacy-Protective Facial Age Estimation technology, which analyzes the geometry of a users face to confirm that they are an adult.
Under the COPPA Rule, online sites and services directed to children under 13 must obtain parental consent before collecting or using personal information from a child. The Rule lays out a number of acceptable methods for gaining parental consent but also includes a provision allowing interested parties to submit new verifiable parental consent methods to the Commission for approval.
In a Federal Register notice, the FTC is seeking comment on a number of questions related to the application including whether the proposed age verification method is covered by existing methods; whether the proposed method meets the requirements under the COPPA Rule; and whether the proposed method poses a privacy risk to consumers personal information, including their biometric information.
The public will have until August 21, 2023 to submit a comment. After they are submitted, comments will be posted to Regulations.gov.
NOTE: Publication of this Federal Register notice is required by the Rule and does not indicate Commission approval or endorsement of the program. The Commission has 120 days to review proposed verifiable parental consent methods and must set forth its conclusions in writing. (Emphasis mine. Full Press Release.)
As the FTC noted in this press release, Under the COPPA Rule, online sites and services directed to children under 13 must...
07:23
The role of low-level laser therapy in bone healing. GreenMedInfo
PMID: Int J Mol Sci. 2023 Apr 12 ;24(8). Epub 2023 Apr 12. PMID: 37108257 Abstract Title: The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review. Abstract: Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application.
07:15
Neuroprotective effects of photobiomodulation. GreenMedInfo
PMID: J Biophotonics. 2023 Apr 19:e202300012. Epub 2023 Apr 19. PMID: 37074708 Abstract Title: Neuroprotective effects of photobiomodulation by hormesis on scopolamine induced neurodegenerative diseases of memory disorders in rats a paradigm shift. Abstract: The loss and progressive dysfunction of neurons are hallmarks of neurodegenerative diseases. The aim of the current study is to explore the effects of photobiomodulation at 460-660nm (100-1000 lux units) on the progression of scopolamine-induced cognitive dysfunctions in Wistar male rats. Photobiomodulation (PBM) is defined as "the use of monochromatic or quasi-monochromatic light from a low-power laser or light-emitting diode (LED) source to modify or modulate biological functions." Neuroprotective activity was assessed by in vivo models such as the Morris water maze, the elevated plus maze (EPM), and the T-maze. After using scopolamine (1mg/kg/day) as a dementia induction model for 21days, the induction was primarily due to impairments in cholinergic transmission, oxidative stress, and inflammation. The in vitro determinations, including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-alpha (TNF-), Interleukin 1 beta (IL-1), and alkaline phosphatase (ALP), were assessed biochemicals and biomarkers. The structural and morphological integrity of the cortex and hippocampus was investigated through histopathology. In vivo studies of exteroceptive behavior models such as the Morris water maze, the EPM, and the T-maze revealed that administration of scopolamine resulted in enhanced escape latency time (ELT), transfer latency (TL), and decreased percentage alternation, respectively. The levels of AChE, BChE, reduced, GSH, SOD, TNF-, IL-1and ALP were increased, while MDA level was decreased. In contrast to normal and control groups with treatment groups, histopathology of the cortex and hippocampus examination revealed the maintenance of structural integrity and densities of CA1 and CA3 neuronal cells. However, network pharmacology predicted Camodulation of various pathways, among the treatments with red LED light showed highly significant amelioration compared with normal and control groups. Photobiomodulation by hormesis, chromophores in cells, and tissues excitation can influence neuroprotective effect mainly by scavenging of ROS, variation in the level of GSH MDA and SOD mitochondrial electron transfer, the improved abscopal effects on improved in gut microbiome by resembles the of fecal ALP level correlation of intestinal microbiome, cholinergic neurotransmissions, anti-inflammatory, and antioxidant activities.
...
07:11
Low-level laser selectively inhibiting colorectal cancer cell metabolic activity and inducing apoptosis. GreenMedInfo
PMID: Photochem Photobiol Sci. 2023 Jul ;22(7):1707-1720. Epub 2023 Apr 18. PMID: 37071386 Abstract Title: Low-level laser selectively inhibiting colorectal cancer cell metabolic activity and inducing apoptosis for delaying the development of intestinal cancer. Abstract: Low-level laser irradiation (LLLI) is a novel approach that shows promise for the treatment of colorectal cancer (CRC). However, the molecular mechanisms underlying its biochemical effects and gene expression remain unclear. Here, LLLI (632.8 nm) was used to treat CRC RKO cells and normal small intestinal NCM460 cells. LLLI showed a significant dose- and time-dependent effect on cell viability, in which a single dose of irradiation at 15 J/cmselectively inhibited the growth of RKO cells but largely unaffected the activity of NCM460 cells. And then, LLLI produced an internal response, effectively reducing the level of HOin tumor cells, downregulating the mitochondrial membrane potential, and improving the efficiency of apoptosis in CRC, but no internal response was observed in NCM460 cells under the same conditions. Furthermore, the expression of several important genes in the classical WNT pathway was significantly downregulated, and the pathway was inactivated after LLLI intervention, thereby inhibiting tumor cell growth. Simultaneously, TNF-was effectively activated to stimulate the caspase family members of the death effector to initiate apoptosis led by the extrinsic pathway. LLLI successfully achieves tumor cell normalization while delivering a potent anticancer effect, expected to be a novel therapeutic modality for CRC.
07:04
Low-level laser therapy for rheumatoid arthritis. GreenMedInfo
PMID: J Lasers Med Sci. 2022 ;13:e62. Epub 2022 Dec 10. PMID: 37041796 Abstract Title: Low-Level Laser Therapy for Rheumatoid Arthritis: A Review of Experimental Approaches. Abstract: Rheumatoid arthritis (RA) is an inflammatory and autoimmune disorder that is characterized by joint inflammation, pain, physical disability, and morning stiffness. In the present study, the effect of low-level laser therapy (LLLT) on RA was reviewed."Low-level laser therapy", "rheumatoid arthritis disease", and "photobiomodulation" keywords were searched in Google Scholar, PubMed, and Medline.A literature survey led to a discussion about the immunology of the RA, laser therapy, mechanism of LLLT action, and anti-inflammatory and immunomodulatory properties of LLLT.It was concluded that LLLT could improve RA patients' quality of life, reduce pain, and enhance physical movement.
06:56
Low-level laser therapy was effective in reducing chronic nonspecific neck pain. GreenMedInfo
PMID: J Lasers Med Sci. 2022 ;13:e74. Epub 2022 Dec 23. PMID: 37041770 Abstract Title: Efficacy of Low-Level Laser Therapy for the Treatment of Nonspecific Chronic Neck Pain: Low-Level Laser Therapy vs. Sham Laser. Abstract: The most common type of neck pain is chronic nonspecific pain. There are conflicting opinions about the beneficial effects of a low-level laser in reducing chronic nonspecific neck pain. The aim of this study was to evaluate the efficacy of low-level laser therapy (LLLT) for the treatment of non-specific chronic neck pain.This study was conducted as a prospective randomized clinical trial. Forty-four patients were randomly divided into two groups: (1) Intervention group (n=22): LLLT in the red spectra range with a wavelength of 980 (nm) and a power of 16 (J/cm) was irradiated in the affected areas of the neck, the muscles along the spine, and the upper trapezius; (2) sham group (n=22): A low-level laser was irradiated with a passive probe (non-laser red light) in the affected areas of the neck, the muscles along the spine, and the upper trapezius. The treatment protocol consisted of 12 sessions (15 minutes, three times a week, for four weeks). These patients were evaluated for pain using the visual analog scale (VAS) (0-10). The patients were followed up for four weeks.This study showed a statistically significant reduction in chronic nonspecific neck pain in the LLLT group (
06:46
U.S. Government Wants Facial Scans of All Children: To Protect Children or to Traffick Them? Health Impact News
by Brian Shilhavy
Editor, Health Impact News
The FTC (Federal Trade Commission) of the federal U.S. Government is considering allowing businesses to use biometric facial scans of children under the age of 13 as a new mechanism for obtaining parental consent.
The Federal Trade Commission is seeking comment on an application from the Entertainment Software Rating Board (ESRB) and others for a new mechanism for obtaining parental consent under the Childrens Online Privacy Protection Act Rule.
ESRB, which currently operates a COPPA safe harbor program, was joined in its application by Yoti, a digital identity company, and SuperAwesome, which provides technology to help companies comply with parental verification requirements. The companies have requested approval for the use of Privacy-Protective Facial Age Estimation technology, which analyzes the geometry of a users face to confirm that they are an adult.
Under the COPPA Rule, online sites and services directed to children under 13 must obtain parental consent before collecting or using personal information from a child. The Rule lays out a number of acceptable methods for gaining parental consent but also includes a provision allowing interested parties to submit new verifiable parental consent methods to the Commission for approval.
In a Federal Register notice, the FTC is seeking comment on a number of questions related to the application including whether the proposed age verification method is covered by existing methods; whether the proposed method meets the requirements under the COPPA Rule; and whether the proposed method poses a privacy risk to consumers personal information, including their biometric information.
The public will have until August 21, 2023 to submit a comment. After they are submitted, comments will be posted to Regulations.gov.
NOTE: Publication of this Federal Register notice is required by the Rule and does not indicate Commission approval or endorsement of the program. The Commission has 120 days to review proposed verifiable parental consent methods and must set forth its conclusions in writing...
06:40
Excess Republican deaths after COVID vaccines became available Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
Newly published research shows that Republican voters had higher excess deaths than Democrats once COVID-19 vaccines became available.
06:27
High-power laser photobiomodulation therapy for immediate pain relief of refractory oral mucositis. GreenMedInfo
PMID: Oral Dis. 2023 May 19. Epub 2023 May 19. PMID: 37203784 Abstract Title: High-power laser photobiomodulation therapy for immediate pain relief of refractory oral mucositis. Abstract: PURPOSE: We aimed to evaluate the efficacy of high-power (class IV) laser photobiomodulation (PBM) therapy for immediate pain relief due to oral mucositis (OM) refractory to recommended first-line therapy.METHODS: This retrospective study included 25 cancer patients with refractory chemotherapy- or radiotherapy-induced OM (16 and 9 patients, respectively) that were treated for pain relief with an intraoral InGaAsP diode laser (power density=1.4W/cm). Pain was self-assessed immediately before and after laser treatment using a 0-to-10 numeric rating scale ([NRS], "0"=no pain, "10"=intolerable pain).RESULTS: Patients reported an immediate decrease in pain following 94% (74 of 79) of the PBM sessions, in 61% (48 sessions) the pain reduction was over 50%, and in 35% (28 sessions) the initial pain was completely eliminated. There were no reports of increased pain post-PBM. For chemotherapy and radiotherapy-treated patients, mean reduction in pain NRS post-PBM was 4.82.5 (p
06:25
Repeated low-level red-light therapy was a novel and effective intervention for myopia prevention. GreenMedInfo
PMID: JAMA Netw Open. 2023 Apr 3 ;6(4):e239612. Epub 2023 Apr 3. PMID: 37099298 Abstract Title: Effect of Repeated Low-level Red Light on Myopia Prevention Among Children in China With Premyopia: A Randomized Clinical Trial. Abstract: IMPORTANCE: Myopia is a global concern, but effective prevention measures remain limited. Premyopia is a refractive state in which children are at higher risk of myopia, meriting preventive interventions.OBJECTIVE: To assess the efficacy and safety of a repeated low-level red-light (RLRL) intervention in preventing incident myopia among children with premyopia.DESIGN, SETTING, AND PARTICIPANTS: This was a 12-month, parallel-group, school-based randomized clinical trial conducted in 10 primary schools in Shanghai, China. A total of 139 children with premyopia (defined as cycloplegic spherical equivalence refraction [SER] of -0.50 to 0.50 diopter [D] in the more myopic eye and having at least 1 parent with SER-3.00 D) in grades 1 to 4 were enrolled between April 1, 2021, and June 30, 2021; the trial was completed August 31, 2022.INTERVENTIONS: Children were randomly assigned to 2 groups after grade stratification. Children in the intervention group received RLRL therapy twice per day, 5 days per week, with each session lasting 3 minutes. The intervention was conducted at school during semesters and at home during winter and summer vacations. Children in the control group continued usual activities.MAIN OUTCOMES AND MEASURES: The primary outcome was the 12-month incidence rate of myopia (defined as SER-0.50 D). Secondary outcomes included the changes in SER, axial length, vision function, and optical coherence tomography scan results over 12 months. Data from the more myopic eyes were analyzed. Outcomes were analyzed by means of an intention-to-treat method and per-protocol method. The intention-to-treat analysis included participants in both groups at baseline, while the per-protocol analysis included participants in the control group and those in the intervention group who were able to continue the intervention without interruption by the COVID-19 pandemic.RESULTS: There were 139 children (mean [SD] age, 8.3 [1.1] years; 71 boys [51.1%]) in the intervention group and 139 children (mean [SD] age, 8.3 [1.1] years; 68 boys [48.9%]) in the control group. The 12-month incidence of myopia was 40.8% (49 of 120) in the intervention group and 61.3% (68 of 111) in the control group, a relative 33.4% reduction in incidence. For children in the intervention group who did not have treatment interruption secondary to the COVID-19 pandemic, the incidence was 28.1% (9 of 32), a relative 54.1% reduction in incidence. The RLRL intervention significantly reduced the myopic shifts in terms of axial length and SER compared with the control group (mean [SD] axial length, 0...
06:22
These studies are encouraging and may demonstrate the potential benefits of Spirulina supplementation in athletes. GreenMedInfo
PMID: J Diet Suppl. 2023 May 4:1-32. Epub 2023 May 4. PMID: 37143238 Abstract Title: A Review of the Health-Promoting Properties of Spirulina with a Focus on athletes' Performance and Recovery. Abstract: Spirulina species are photosynthetic and filamentous bacteria, commonly called 'blue-green microalgae'. Spirulina has a high nutrient content. It contains 60-70% protein with all essential amino acids present, and is rich in several vitamins, minerals, and bioactive compounds. Spirulina is also rich in essential fatty acids, and antioxidants. This rich nutritional content provides to Spirulina several health benefits including antioxidant, anti-inflammatory, immunomodulation, and insulin-sensitizing properties as well as positive effects in various diseases which could be also interesting for athletes. This paper mainly aims to review the interest and effects of Spirulina supplementation in athletes at rest, and in relation to exercise/training. Spirulina's biochemical composition, health properties/effects in humans, and effects in athletes including nutritional status, body composition, physical performance and intense exercise-related disorders were discussed in this review. Literature data showed that Spirulina seems to have positive effects on body composition especially in overweight and obese subjects which could not be the case in other pathologies and athletes. Spirulina appears to be also effective in improving aerobic fitness especially in untrained and moderately trained subjects. Results reported in the literature suggest that Spirulina may improve strength and power performance despite the minor or no significant effects in highly trained subjects. Most studies have shown that Spirulina improves antioxidant status, prevents and accelerates the recovery of exercise-induced lipid peroxidation, muscle damage and inflammation in trained and untrained subjects. Taken together, the results from these studies are encouraging and may demonstrate the potential benefits of Spirulina supplementation in athletes despite methodological differences.
06:00
live_Ep494Flosstheteethyouwanttokeep_20230724_103405 Dr Ron Unfiltered Uncensored
The importance of oral health.
03:00
How Does Untreated Burnout Manifest? Mad In America
Wir wrden das al Burnout nennen, the woman told me.
Translation from German: We would call that burnout.
Last November, I was riding on a train from Basel,
Switzerland, to Hanover, Germany. As the train left Basel, I
settled into my window seat and enjoyed watching the countryside as
the train rolled along. A couple hours into the trip, a woman
boarded the train and asked me if the seat next to me was free. I
nodded yes and adjusted the bag at my feet to make a little more
room for her. As the train pulled away from the station, we began
chatting in German, asking the typical questions such as where are
you traveling to and where are you from.
I am from the US. I was in Basel and am now heading to Berlin. Years ago, I lived in Basel for eight months while studying at the university, I said. As we continued to chat, I told her that I get a lot of synchronicity and improbable connections that are often a lot of fun. I then told her how synchronicity is related to Basel. Swiss psychiatrist, Carl Jung, who coined the term synchronicity, grew up near Basel. In addition, he studied at the University of Basel and for a few years, he was a professor there. So even my relationship to Basel has a much deeper meaning and connection for me. As we continued chatting, I shared a few of my goofy synchronicity stories as I call them. She enjoyed them, and we laughed together.
At some point in the conversation, the woman asked me what I do for a living. I told her that I have worked as a statistician, a technical writer, a knowledge engineer, and as a software tester. I then said that I really want to get into writing and public speaking to help bring about change to the mental health system. I told her of the severe stress breakdown that I endured back in 1998...
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Tuesday, 25 July
23:00
Morning Coffee Jul 25 Dr. Tenpenny
07-25-2023 Audio Track: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-25-23-MorningCoffee.mp4 In this episode, Dr.Tenpenny shares insight about when colonoscopies should be done []
21:37
7 Simple Ways to Unclog Your Arteries Naturally GreenMedInfo
Visit our Re-post guidelines
(ILEISH
ANNA/Shutterstock)
We all want to live a long life, but did you know eating these simple foods has been proven scientifically to prevent and in some cases reverse the #1 cause of death in the modern world?
17:00
The Grand Debunk of the antivaxxer book Turtles All the Way Down (part 3/10) Science-Based Medicine
The third installment in debunking the antivaxxer book Turtles All the Way Down: Chapter 3, Deficient by Design: The Vaccine Adverse Event Reporting System (VAERS).
The post The Grand Debunk of the antivaxxer book Turtles All the Way Down (part 3/10) first appeared on Science-Based Medicine.11:28
Mangosteen vinegar from Garcinia mangostana: quality improvement and antioxidant properties. GreenMedInfo
PMID: Heliyon. 2022 Dec ;8(12):e11943. Epub 2022 Dec 13. PMID: 36590574 Abstract Title: Mangosteen vinegar from Garcinia mangostana: quality improvement and antioxidant properties. Abstract: Mangosteen (Linn.) fruit is rich in phenolic compounds which function as antioxidants and play a role in anti-inflammation, anti-hyperlipidemia, and anti-diabetic nephropathy. To investigate mangosteen vinegar (MV) by steaming under high pressure, explore the effects of fermentation, antioxidant activity, and sensory evaluation acceptable using the 9 -point Hedonic scale. Steamed mangosteen was processed to produce 3 types of mangosteen vinegar: mangosteen rind vinegar (MRV), mangosteen flesh vinegar (MFV), and mangosteen rind plus flesh vinegar (MRFV). All 3 kinds of mangosteen vinegar were obtaining>4% acetic acid and significantly higher total phenolic content (TPC), total flavonoid content (TFC), and free radical scavenging ABTS+ and DPPH- antioxidant activity than apple cider vinegar (ACV) (
11:23
These gut-derived findings provide evidence for a regulatory role of vitamin K2 on glycemic homeostasis. GreenMedInfo
PMID: BMC Med. 2023 May 5 ;21(1):174. Epub 2023 May 5. PMID: 37147641 Abstract Title: Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites. Abstract: BACKGROUND: There is insufficient evidence for the ability of vitamin K2 to improve type 2 diabetes mellitus symptoms by regulating gut microbial composition. Herein, we aimed to demonstrate the key role of the gut microbiota in the improvement of impaired glycemic homeostasis and insulin sensitivity by vitamin K2 intervention.METHODS: We first performed a 6-month RCT on 60 T2DM participants with or without MK-7 (a natural form of vitamin K2) intervention. In addition, we conducted a transplantation of the MK-7-regulated microbiota in diet-induced obesity mice for 4 weeks. 16S rRNA sequencing, fecal metabolomics, and transcriptomics in both study phases were used to clarify the potential mechanism.RESULTS: After MK-7 intervention, we observed notable 13.4%, 28.3%, and 7.4% reductions in fasting serum glucose (P=0.048), insulin (P=0.005), and HbA1c levels (P=0.019) in type 2 diabetes participants and significant glucose tolerance improvement in diet-induced obesity mice (P=0.005). Moreover, increased concentrations of secondary bile acids (lithocholic and taurodeoxycholic acid) and short-chain fatty acids (acetic acid, butyric acid, and valeric acid) were found in human and mouse feces accompanied by an increased abundance of the genera that are responsible for the biosynthesis of these metabolites. Finally, we found that 4 weeks of fecal microbiota transplantation significantly improved glucose tolerance in diet-induced obesity mice by activating colon bile acid receptors, improving host immune-inflammatory responses, and increasing circulating GLP-1 concentrations.CONCLUSIONS: Our gut-derived findings provide evidence for a regulatory role of vitamin K2 on glycemic homeostasis, which may further facilitate the clinical implementation of vitamin K2 intervention for diabetes management.TRIAL REGISTRATION: The study was registered at https://www.chictr.org.cn (ChiCTR1800019663).
11:11
The results to date indicate a beneficial contribution of the use of probiotics in Alzheimer's disease. GreenMedInfo
PMID: Arq Gastroenterol. 2023 ;60(1):144-154. PMID: 37194773 Abstract Title: ALZHEIMER'S DISEASE AND ITS RELATIONSHIP WITH THE MICROBIOTA-GUT-BRAIN AXIS. Abstract: BACKGROUND: Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. Several pathways enable bidirectional communication between the central nervous system (CNS), the intestine and its microbiota, constituting the microbiota-gut-brain axis.OBJECTIVE: Review the pathophysiology of AD, relate it to the microbiota-gut-brain axis and discuss the possibility of using probiotics in the treatment and/or prevention of this disease.METHODS: Search of articles from the PubMed database published in the last 5 years (2017 to 2022) structure the narrative review.RESULTS: The composition of the gut microbiota influences the CNS, resulting in changes in host behavior and may be related to the development of neurodegenerative diseases. Some metabolites produced by the intestinal microbiota, such as trimethylamine N-oxide (TMAO), may be involved in the pathogenesis of AD, while other compounds produced by the microbiota during the fermentation of food in the intestine, such as D-glutamate and fatty acids short chain, are beneficial in cognitive function. The consumption of live microorganisms beneficial to health, known as probiotics, has been tested in laboratory animals and humans to evaluate the effect on AD.CONCLUSION: Although there are few clinical trials evaluating the effect of probiotic consumption in humans with AD, the results to date indicate a beneficial contribution of the use of probiotics in this disease.
11:05
Combined probiotic and vitamin D3 supplementation enhanced lactate utilization and beneficially affected anaerobic performance in MMA athletes. GreenMedInfo
PMID: Sports Med Open. 2023 May 16 ;9(1):31. Epub 2023 May 16. PMID: 37193828 Abstract Title: Effects of Probiotics and Vitamin DSupplementation on Sports Performance Markers in Male Mixed Martial Arts Athletes: A Randomized Trial. Abstract: BACKGROUND: Strategies targeted at the intestine microbiome seem to be beneficial for professional athletes. The gut-muscle axis is associated with the inflammatory state, glucose metabolism, mitochondrial function, and central nervous system health. All these mechanisms may affect maximal oxygen uptake, muscle strength, and training adaptation. Moreover, the positive effect of certain bacterial strains may be enhanced by vitamin D. Thus, this study aimed to assess and compare the level of selected markers of sports performance of mixed martial arts (MMA) athletes supplemented with vitamin Dor probiotics combined with vitamin D.METHODS: A 4-week randomized double-blind placebo-controlled clinical trial was conducted with 23 MMA male athletes assigned to the vitamin Dgroup (Vit D; n=12) or probiotics+vitamin Dgroup (PRO+VitD; n=11). Repeated measures of the creatine kinase level, lactate utilization ratio, and anaerobic performance were conducted.RESULTS: After 4 weeks of supplementation, we found lower lactate concentrations 60 min after the acute sprint interval in the PRO+VitD group when compared to the Vit D group (4.731.62 and 5.881.55 mmol/L; p
10:59
Immunomodulatory activity of probiotics in models of bacterial infections. GreenMedInfo
PMID: Probiotics Antimicrob Proteins. 2023 May 16. Epub 2023 May 16. PMID: 37191780 Abstract Title: Immunomodulatory Activity of Probiotics in Models of Bacterial Infections. Abstract: As resistance to conventional antibiotics among bacteria continues to increase, researchers are increasingly focusing on alternative strategies for preventing and treating bacterial infections, one of which is microbiota modulation. The objective of this review is to analyze the scientific literature on the immunomodulatory effects of probiotics in bacterial infections. This is an integrative review of the literature based on systematic steps, with searches performed in the databases Medline, PubMed, Scopus, Embase, and ScienceDirect. The most prevalent bacterial genera used to evaluate infectious processes were Salmonella, Escherichia, Klebsiella, and Streptococcus. Lactobacillus was the most commonly used probiotic genus, with Lactobacillus delbrueckii subsp. bulgaricus is the most frequently used species. In most studies, prophylactic treatment with concentrations of probiotics equal to or greater than 8 log CFU/mL was chosen. However, there was considerable heterogeneity in terms of effective treatment duration, indicating that the results cannot be generalized across all studies. This review found that probiotics interact with the immune system through different mechanisms and have a positive effect on preventing different types of bacterial infections.
10:03
Pterostilbene and probiotic complex in chemoprevention of putative precursor lesions for colorectal cancer. GreenMedInfo
PMID: Cancers (Basel). 2023 Apr 21 ;15(8). Epub 2023 Apr 21. PMID: 37190329 Abstract Title: Pterostilbene and Probiotic Complex in Chemoprevention of Putative Precursor Lesions for Colorectal Cancer in an Experimental Model of Intestinal Carcinogenesis with 1,2-Dimethylhydrazine. Abstract: Dietary supplementation with pterostilbene (PS) and/or a probiotic (PRO) may ameliorate the intestinal microbiota in disease conditions. This study aims to evaluate PS and PRO for the chemoprevention of putative precursor lesions for colorectal cancer (CRC) in an experimental model of intestinal carcinogenesis with 1,2-dimethylhydrazine (1,2-DMH). Sixty male Wistar rats were equally divided into five groups: Sham, 1,2-DMH, 1,2-DMH + PS, 1,2-DMH + PRO, and 1,2-DMH + PS + PRO. PRO (510/mL) was offered in water, and PS (300 ppm) was provided in the diet ad libitum. 1,2-DMH (20 mg/kg/week) was administered for 15 consecutive weeks. In the 25th week, proctocolectomy was conducted. PRO alone and PRO combined with PS were the best intervention strategies to improve experimental 1,2-DMH-induced CRC regarding several parameters of carcinogenesis. Our findings may contribute to the development of novel preventive strategies for CRC and may help to identify novel modulators of colon carcinogenesis.
10:00
How Curcumin Targets Cancer Articles
Editor's Note: This article is a reprint. It was originally published September 17, 2018.
Turmeric, a yellow curry spice used in Indian cuisine, has a long history of medicinal use in traditional Chinese medicine (TCM) and Ayurvedic medicine. Curcumin is one of the most well-studied bioactive ingredients in turmeric,1 having over 150 potentially therapeutic activities, including anti-inflammatory, antimicrobial and powerful anticancer actions.
Cancer has an incredible global impact and places a vast financial and emotional burden on the families it touches. Nearly 40% of American men and women will be diagnosed with cancer in their lifetime and over $125 billion is spent annually on medical treatment and patient care.2
The American Cancer Society estimated there would be over 1.6 million new cases diagnosed in 2017, equating to 4,630 new cases and 1,650 deaths every day.3 The most common types of cancer include breast, colon, lung and prostate.4
Despite advances in cancer treatment protocols, scientists realize prevention plays an essential role in reducing the number of people who die from the disease. After 30 years of testing more than 1,000 different possible anticancer substances, the National Cancer Institute announced that curcumin has joined an elite group that will now be used in clinical trials for chemoprevention.5
Curcumin May Play a Multitargeted Role Against Cancer Cells
In this interview, Dr. William LaValley discusses the interaction curcumin has on cancer and the multiple ways this molecule affects cancer growth. If you have ever been diagnosed with cancer, it may feel as if it grew overnight when, in fact, cancer cells take years to develop.
The progression of a cell from normal growth to cancer happens through several stages. Deregulation of physiological and mechanical processes that initiate and promote the growth of cancer cells makes use of h...
COVID Censorship Proved To Be Deadly Articles
Weve just witnessed the biggest attack on freedom of speech in U.S. history. And it appears the writing is on the wall for the most important free speech lawsuit of this generation, in which the federal government was sued for working with social media companies to censor Americans.1
U.S. District Judge Terry A. Doughty issued a preliminary injunction, siding with the plaintiffs that the U.S. government colluded with social media companies to censor free speech.
If the allegations made by Plaintiffs are true, the present case arguably involves the most massive attack against free speech in United States history, Doughty wrote. In their attempts to suppress alleged disinformation, the federal government, and particularly the defendants named here, are alleged to have blatantly ignored the First Amendments right to free speech.2
Government Tried to Get Case Dismissed, but Failed
The lawsuit Missouri et al v. Biden et al was filed May 2022 by the attorneys general of Missouri and Louisiana, and plaintiffs Dr. Jayanta Bhattacharya and Dr. Martin Kulldorff co-authors of the Great Barrington Declaration, which scientifically critiqued the effects of prolonged lockdowns in response to COVID-19.3
The lawsuit alleges the Biden administration "colluded with social media giants Meta, Twitter and YouTube to censor free speech in the name of combating so-called disinformation and misinformation." In so doing, it suppressed and censored the truth on a scale never before seen on topics relating to COVID-19 shots, COVID-19s potential laboratory origins and Hunter Bidens laptop.4
Judge Doughty denied a motion from the government to dismiss the case,5 which called on Dr. Anthony Fauci and other officials, including CISA director Jen Easterly and former White House press secretary Jen Psaki, to testify under oath.6 The New Civil Liberties Alliance (NCLA), which represents Bhattacharya and Kulldorff in the case, stated:7
Social media platforms, acting at the federal governments behest, repeatedly censored NCLAs clients for articulating views on those platforms in opposition to government-approved views on Covid-19 restrictions. This insidious censorship was the direct result of the federal governments ongoing campaign to silence those who voice perspectives that deviate from those of the Biden Admini...
Was COVID a Bioweapon That Targets Certain Races? Articles
According to mainstream media, Presidential candidate Robert F. Kennedy Jr. recently made claims about COVID-19 being an ethnically targeted bioweapon. Yahoo! News,1 for example, reported that Robert F. Kennedy Jr. baselessly claimed COVID-19 may have been ethnically targeted ... He said Caucasians and black people were most susceptible, and Ashkenazi Jews and Chinese people were most immune.
The New York Post claimed RKF Jr. Says COVID May Have Been Ethnically Targeted to Spare Jews.2
According to Yahoo! News, Kennedy did not cite any specific sources, but this whole story turns out to be wrong. Kennedy was in fact citing a very specific scientific paper, and his comments about that paper were then taken out of context.
Wild Claims Taken Out of Context
Kennedys comments, which have been taken out of context by mainstream media to paint him as an anti-Semite, were made during a July 13, 2023, after-hours campaign dinner at an Upper East Side restaurant.3,4 In a July 17, 2023, Instagram video,5 Kennedy tried to set straight the inaccurate distortion of his comments.
As explained by Kennedy, he was discussing the threat posed by bioweapons development, which is being done by the U.S., China, Russia and many other countries, and the urgent need to regulate this kind of research and resuscitate the 1972 international bioweapons charter (the Convention on the Prohibition of Biological Weapons,6,7 which took effect in March 1975) that forbids much of this research.
Because we now have synthetic biology and a wide variety of genetic engineering techniques, theres a whole new retinue and generation of bioweapons, Kennedy said in his Instagram reply, and among the worst of those are bioweapons that target ethnicities.
Research Has Identified Genetic Predispositions to COVID
During the dinner in question, Kennedy cited a July 2020 study8 in BMC Medicine, which reported that, based on ACE2 and TMPRSS2 polymorphism analysis, certain races, as well as people with certain diseases, are more susceptible to COVID-19. As noted in that paper:9
We found unique genetic suscep...
09:36
Probiotic supplementation could be a complementary therapeutic strategy in T1DM. GreenMedInfo
PMID: Diabetes Metab Res Rev. 2023 May 14:e3655. Epub 2023 May 14. PMID: 37183580 Abstract Title: Probiotics, prebiotics, and synbiotics in type 1 diabetes mellitus: A systematic review and meta-analysis of clinical trials. Abstract: Dysbiosis or imbalance of microbes in the gut has been associated with susceptibility and progression of type 1 diabetes mellitus (T1DM). The present systematic review and meta-analysis examined the effects of probiotics, prebiotics, and synbiotics on fasting blood glucose (FBG), haemoglobin A1c (HbA1c), C-peptide, and insulin requirements in T1DM patients. A systematic search for trials published up to October 2022 was conducted in PubMed, EMBASE, Scopus, Google Scholar, ScienceDirect, Web of Science, and the Central Cochrane Library. Random effect models were used to synthesise quantitative data by STATA. After the evaluation of 258 identified entries, five randomised controlled trials (n = 356; mean age = 11.7 years old) were included. The pooled effect size showed that FBG decreased following probiotic supplementation (weighted mean difference = -31.24 mg/dL; 95% confidence interval = -45.65, -16.83; p
09:09
Fermented vegetables as a potential treatment for irritable bowel syndrome. GreenMedInfo
PMID: Curr Dev Nutr. 2023 Mar ;7(3):100039. Epub 2023 Feb 18. PMID: 37181929 Abstract Title: Fermented Vegetables as a Potential Treatment for Irritable Bowel Syndrome. Abstract: Foods and supplements containing microorganisms with expected beneficial effects are increasingly investigated and utilized in the treatment of human illness, including irritable bowel syndrome (IBS). Research points to a prominent role of gut dysbiosis in the multiple aberrations in gastrointestinal function, immune balance, and mental health seen in IBS. The proposition of the current Perspective is that fermented vegetable foods, in combination with a healthy and stable diet, may be particularly useful for addressing these disturbances. This is based on the recognition that plants and their associated microorganisms have contributed to shaping human microbiota and adaptation over evolutionary time. In particular, lactic acid bacteria with immunomodulatory, antipathogenic, and digestive properties are prevalent in products such as sauerkraut and kimchi. Additionally, by adjusting the salt content and fermentation time, products with a microbial and therapeutic potential beyond that of regular ferments could potentially be produced. Although more clinical data are required to make firm assertions, the low-risk profile, combined with biological considerations and reasoning and considerable circumstantial and anecdotal evidence, indicate that fermented vegetables are worthy of consideration by health professionals and patients dealing with IBS-related issues. To maximize microbial diversity and limit the risk of adverse effects, small doses of multiple products, containing different combinations of traditionally fermented vegetables and/or fruits, is suggested for experimental research and care.
09:07
Regular consumption of pickled vegetables and fermented bean curd reduces the risk of diabetes. GreenMedInfo
PMID: Front Public Health. 2023 ;11:1155989. Epub 2023 Apr 27. PMID: 37181698 Abstract Title: Regular consumption of pickled vegetables and fermented bean curd reduces the risk of diabetes: a prospective cohort study. Abstract: OBJECTIVE: The global incidence of diabetes is rising, in part due to the widespread adoption of poor dietary habits. Fermented vegetables have numerous health benefits and are generally affordable. Here, we examined whether regular consumption of pickled vegetables or fermented bean curd reduces the risk of diabetes.METHODS: A total of 9,280 adults (18 years of age) were recruited via multi-stage sampling from 48 townships in China between 2010 and 2012 for this 10-year prospective study. In addition to demographic information, monthly consumption levels of pickled vegetables and fermented bean curd were recorded. Participants were then monitored for diabetes onset. After the final follow-up, logistic regression analyses with multiple covariant corrections were conducted to estimate the changes in diabetes risk associated with consumption of pickled vegetables and fermented bean curd compared to non-consumption.RESULTS: A total of 6,640 subjects without diabetes at the start of the study were followed up for a median period of 6.49 years, among whom 714 were diagnosed with diabetes during the study. According to a regression model with multivariable adjustment, diabetes risk was significantly reduced by consumption of 0-0.5 kg/month of pickled vegetables (OR = 0.77, 95% CI: 0.63, 0.94) and further reduced by consumption of>0.5 kg/month of pickled vegetables (OR = 0.37, 95% CI: 0.23, 0.60) compared to no consumption (both-trend
09:04
Metabolite profiling, hypolipidemic, and anti-atherosclerosis activity of mixed vegetable fermentation extract. GreenMedInfo
PMID: Saudi Pharm J. 2023 May ;31(5):639-654. Epub 2023 Mar 10. PMID: 37181140 Abstract Title: Metabolite profiling, hypolipidemic, and anti-atherosclerosis activity of mixed vegetable fermentation extract. Abstract: Although positive association between fermented vegetables intake with the risk of coronary heart disease (CHD) has increased attention nowadays, the metabolite profiling and the mechanism of action are still elusive. This study designed to investigate the secondary metabolites, hypolipidemic, and anti-atherogenic effect of mixed vegetable fermentation extract (MVFE). The metabolite screening of the MVFE was assessed using the Liquid Chromatography Tandem Mass Spectrophotometer (LC-MS/MS) method. The result of LC-MS/MS was used as ligands to inhibit the binding of oxidized LDL (oxLDL) and Cluster Differentiation 36 (CD36), Scavenger Receptor A1 (SRA1), Lectin-type oxidized LDL receptor 1 (LOX1). This work was performed with molecular docking using Discovery Studio 2021, PyRx 0.9, and Autodock Vina 4.2 followed by analyzing Network Pharmacology, Protein Protein Interaction (PPI) using Cytoscape 3.9.1 and String 2.0.0. Finally, the clinical effect of MVFE was evaluated usingstudy. Twenty rabbits were assigned to normal, negative control, and MVFE group that were fed with standard diet, high fat diet (HFD), HFD supplemented with MVFE 100, 200 mg/kg BW, respectively. The serum level of Total Cholesterol (TC) and Low-Density Lipoprotein (LDL-c) were detected at the end of week 4. The LC-MS/MS analysis identified 17 compounds categorized as peptides, fatty acids, polysaccharides, nucleoside, flavonoids, flavanols, and phenolic compounds. Based on the docking study, more negative binding affinity was observed in the interaction between metabolites with the scavenger receptors (SR) than simvastatin. The number of nodes and edges based on Network Pharmacology analysis were 268 and 482, respectively. The PPI network showed that MVFE metabolites exerts its athero-protective effect by modulating various cellular processes including inflammation, improvement of endothelial function, and modulation of lipid metabolism. Blood TC and LDL-c concentrations in the negative control (458.82 82.03; 191.87 92.16 mg/dL) were higher significantly compared to the normal group (87.03 29.27; 43.33 5.75 mg/dL). The MVFE administration decreased the TC (100, 200 mg/kg BW MVFE: 269.96 85.34; 130.17 45.02 mg/dL) and LDL-c level (100, 200 mg/kg BW MVFE = 87.24 22.85; 41.82 11.08 mg/dL) dose-dependently (p
09:00
On Your Health-Jul 24 2023 Dr. Miriam Grossman Dr. Tenpenny
07-24-2023 Listen to audio of interview here. Click on the video below to watch this episode: https://drtenpenny.b-cdn.net/2023/07-25-23-OYH.mp4 About my guest: Dr. Miriam Grossman is a child and []
08:07
In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts. GreenMedInfo
PMID: BMC Res Notes. 2023 May 18 ;16(1):82. Epub 2023 May 18. PMID: 37202827 Abstract Title: In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts. Abstract: OBJECTIVE: Ganoderma extracts have the potential to be used as anti-cancer, anti-inflammatory, immunomodulator, and antimicrobial agents, as evaluated in numerous studies. This study was aimed to determine the lethal and inhibitory effects of aqueous, hydroalcoholic, and alcoholic extracts of Ganoderma lucidum on Toxoplasma gondii RH strain tachyzoites, in vitro.RESULTS: All three types of extracts showed toxoplasmacidal effects. The highest percentage of mortality was related to hydroalcoholic extract. The EC50 of Ganoderma extracts for tachyzoites were 76.32, 3.274, and 40.18 for aqueous, hydroalcoholic and alcoholic extracts, respectively. The selectivity index obtained for hydroalcoholic extract was 71.22, showing the highest activity compared to other extracts. According to our findings, the hydroalcoholic part was the most effective substance among the extracts. This basic study showed obvious anti-toxoplasma effect of Ganoderma lucidum extracts. These extracts can be used as candidates for further in-depth and comprehensive studies especially In vivo experiments to prevent toxoplasmosis.
07:58
Reishi medicinal mushroom can combat cytokine storm and other COVID-19 related pathologies. GreenMedInfo
PMID: Int J Med Mushrooms. 2023 ;25(5):1-15. PMID: 37183915 Abstract Title: The Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Can Combat Cytokine Storm and Other COVID-19 Related Pathologies: A Review. Abstract: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is characterized by acute respiratory distress syndrome (ARDS) facilitated by cytokine storm and other risk factors that increase susceptibility and complications leading to death. Emerging as a major global public health challenge, the disease has claimed more than 6 million lives and caused catastrophic global economic disruptions. However, there are concerns about the safety as well as the efficacy of drugs and vaccines presently used to control the pandemic, therefore necessitating intense global search for safe natural products that can effectively and safely combat it. This work reviews studies on lingzhi or reishi medicinal mushroom, Ganoderma lucidum and its properties that may potentially combat SARS-CoV-2 infection and the co-morbidities. Available evidence suggests that medicinal properties of the Ganoderma mushroom can combat the complications of SARS-CoV-2 infection and the co-morbidities that can aggravate the severity of the disease. Preclinical and clinical evaluation to establish dose, efficacy, and potential toxicity and possible use in the management of COVID-19 is recommended.
07:52
Structural characterization of polysaccharides after fermentation from Ganoderma lucidum and its antioxidant activity in HepG2 cells. GreenMedInfo
PMID: Food Chem X. 2023 Jun 30 ;18:100682. Epub 2023 Apr 23. PMID: 37168720 Abstract Title: Structural characterization of polysaccharides after fermentation fromand its antioxidant activity in HepG2 cells induced by HO. Abstract: In this study,ATCC14917 was used to fermentspore powder. Two polysaccharides were purified from unfermented (GLP) and fermented (FGLP)spore powder. The chemical structure and antioxidant activity of the polysaccharides were studied. Finally, the effect of GLP and FGLP on the oxidative stress regulation pathway in HepG2 cells was explored. The results showed that the main structural characteristics ofpolysaccharides remained unchanged during the fermentation. However, the average molecular weight () ofpolysaccharides decreased from 1.12 10 Da to 0.89 10 Da. Besides this, the contents of mannose, galactose, and glucuronic acid increased, while the contents of xylose and glucose were decreased. In addition, the content of uronic acid was raised, and the apparent structure was changed from smooth and hard to porous and loose. In antioxidant studies, intracellular ROS and MDA contents in the oxidative stress model were decreased, and-AOC content was increased under GLP and FGLP intervention. In the investigation of the regulation pathway, Nrf-1 gene expression was up-regulated, and Keap1 gene expression was down-regulated under GLP and FGLP intervention. The antioxidant genes NQO1 and NO-1 expressions were increased to activate the activities of antioxidant enzymes CAT, SOD and GSH-PA to resist oxidative stress. Compared with GLP, FGLP has a stronger regulatory role in this pathway, thus showing more potent antioxidant activity. This experiment is beneficial to the further utilization ofspore powder.
07:50
Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma. GreenMedInfo
PMID: Chin J Cancer Res. 2023 Apr 30 ;35(2):176-190. PMID: 37180834 Abstract Title: Aqueous-soluble components of sporoderm-removedspore powder promote ferroptosis in oral squamous cell carcinoma. Abstract: OBJECTIVE: Ferroptosis is a novel cell death process which displays a promising role in cancer treatment. However, clinically available drugs targeting ferroptosis are rarely used, and yet there are no studies reporting on inducing ferroptosis via Chinese herbal extracts. Here we explored the tumor inhibition effects of() on oral squamous cell carcinoma (OSCC). Specifically, we aimed to clarify the biological mechanism of components in the dietary, aqueous-soluble sporoderm-removedspore powder (A-GSP).METHODS: Preliminary transcriptome analysis revealed the significant enrichment of the ferroptosis pathway. Cellular Fe, glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS) and lipid peroxide levels were measured to identify ferroptosis occurrence. Western blotting was used to measure ferroptosis-related proteins. Changes in mitochondria morphology and function were observed with transmission electron microscopy (TEM) and ATP detection assays. Ferroptosis inhibitor ferrostatin-1 was then used to verify the anti-tumor effects of A-GSP. Finally, nude mice xenograft models of oral cancer confirmed that A-GSP inhibited tumor growth.RESULTS: A-GSP promoted ferroptosis in oral cancer cells by inducing Feinflux, GSH depletion, as well as lipid peroxide and ROS accumulation. Ferroptosis-related proteins exhibited corresponding changes, particularly Acyl-coA synthetase long chain family member 4 (ACSL4) increase and glutathione peroxidase 4 (GPX4) decrease. A-GSP considerably lowered mitochondrial volume and ridge number, while significantly decreasing ATP production. Ferrostatin-1 reversed all of these A-GSP-induced changes., A-GSP exerted a ferroptosis-mediated tumor-suppressing effect without observable adverse reactions.CONCLUSIONS: Our findings demonstrate the therapeutic potential of A-GSP for treating patients with OSCC by targeting ferroptosis.
07:45
These results proved the potential of P. fossulatus against the side effects of diabetes. GreenMedInfo
PMID: Dis Markers. 2023 ;2023:1520132. Epub 2023 Apr 14. PMID: 37091893 Abstract Title: Evaluation ofMushroom Effects on Histopathological Changes in Organs of Diabetic Rats. Abstract: Diabetes mellitus (DM) is a metabolic disorder that can be categorized mainly into type 1 and type 2. Diabetes type 1 is caused due to-cell destruction, whereas type 2 is caused by the resistance of cell receptors. Many therapies are available for the management of diabetes, but they have some side effects, and as a result of this, people are attracted to natural treatments.mushrooms are well documented for their medicinal attributes and their role in the treatment of diseases like cancer, infectious disease, neurodiseases, and inflammatory disease. The protective mechanism of the() mushroom and its detailed histological study on kidneys and the liver in diabetic conditions were unexplored. The present study evaluated the effects ofaqueous extract on histological changes in the diabetic rat model. Male Wistar albino rats were used to create the diabetic model by using streptozotocin (STZ) intraperitoneal (IP) injection. The animals were separated into five different groups, with six animals in each. Only group I, animals that did not receive STZ, was considered a normal control. Group II was a diabetic control and received normal saline, and group III was a drug control and received metformin as a standard drug. Groups IV and V were dosing groups, which received the aqueous extract ofin 250mg/kg and 500mg/kg of body weight concentrations, labeled as T1 and T2 groups, respectively. The T1 and T2 groups clearly showed their potential to reverse the histopathological changes in the kidney and liver. However, the T2 group was more effective than the T1 group, as results indicate that functions of the glomerulus and its structural deformity were restored to their near-natural form in the T2 group. In the case of the liver, the histological changes like the dilatation of sinusoids, more numbers of the Kupffer cell formation, and necrosis were restored in the T2 group. All these results proved the potential ofagainst the side effects of diabetes. It could protect the organs from developing diabetic nephropathy (DN) and liver-related diseases like cirrhosis and nonalcoholic fatty liver disease (NAFLD).
07:27
Many Patients Take to Online Forum to Vent About SSRIs Mad In America
From MedPage Today: Discontinuation or dosage change of selective serotonin reuptake inhibitors (SSRIs) may be more common than one would think, according to a qualitative study of online drug reviews.
Out of 667 SSRI reviews posted to an online health forum by patients or caregivers, 335 posts were about discontinuing their medication the most common type of medication change, reported Su Golder, PhD, of the University of York in England, and colleagues.
The most common reason for discontinuing SSRIs was adverse events, which was cited 231 times. Among the seven SSRIs included escitalopram (Lexapro), sertraline (Zoloft), citalopram (Celexa), paroxetine (Paxil), fluvoxamine (Luvox), vortioxetine (Trintellix), and fluoxetine (Prozac) discontinuation rates ranged from 41% to 54% among the WebMD health forum reviews.
Of the adverse events mentioned in the reviews, the most common were psychiatric-related, the researchers noted in JAMA Network Open.
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07:23
Scientific review of fluoride in water benefits and risks Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
A systematic study examines the benefits and risks of adding fluoride to water. It appears that the benefits outweigh the risks
06:58
Maternal supplementation with human milk-derived Lactiplantibacillus plantarum WLPL04 affects the immunity and gut microbiota of offspring rats. GreenMedInfo
PMID: Food Funct. 2023 Jun 6 ;14(11):5326-5341. Epub 2023 Jun 6. PMID: 37204244 Abstract Title: Maternal supplementation with human milk-derivedWLPL04 affects the immunity and gut microbiota of offspring rats. Abstract: Pregnancy and lactation are a window period during which interventions on mothers bring beneficial effects to newborns. This study aims to investigate the effects of maternal supplementation with human-milk-derivedWLPL04-36e during pregnancy and lactation on the physiology, immunity and gut microbiota of dams and their offspring. We found that after maternal supplementation,WLPL04-36e could be detected in the intestines and extraintestinal tissues (liver, spleen, kidneys, mammary gland, MLN and brain) of dams, as well as in the intestines of their offspring. Maternal supplementation withWLPL04-36e could significantly increase the body weights of dams and their offspring during the middle to late lactation period, elevate the serum levels of IL-4, IL-6, and IL-10 of dams and IL-6 level of offspring, and increase the proportion of spleen CD4+ T lymphocytes of the offspring. Moreover,WLPL04-36e supplementation could increase the alpha diversity of milk microbiota during early and middle lactation periods, and elevated the abundance ofin the intestines of offspring at week 2 and week 3 after birth. These results suggest that maternal supplementation with human-milk-derivedcan regulate the immunity and intestinal microbiota composition of offspring and play positive roles in the growth of offspring.
06:46
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury. GreenMedInfo
PMID: Food Funct. 2023 Jun 6 ;14(11):5167-5181. Epub 2023 Jun 6. PMID: 37184519 Abstract Title: Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-B signaling pathway. Abstract: Ginsenoside Rh4, a bioactive component extracted from, exhibits various pharmacological activities, such as anti-inflammatory, anti-oxidation, anti-diabetes, anti-obesity, antitumor and immunity enhancement. However, the gastroprotective effect of ginsenoside Rh4 remains unknown. The present study evaluated the gastroprotective effect and potential mechanism of ginsenoside Rh4 in an ethanol-induced gastric ulcer model. Ginsenoside Rh4 (15, 30, and 60 mg kg) and omeprazole (30 mg kg) were administered orally for 7 days. The results showed that pretreatment with ginsenoside Rh4 reduced the gastric injury area and percentage of mucosal lesions in gastric tissue. Besides, treatment with ginsenoside Rh4 increased superoxide dismutase (SOD) activity, glutathione (GSH) and nitric oxide (NO) levels, reduced the content of malonaldehyde (MDA), tumor necrosis factor-(TNF-), interleukin-6 (IL-6), and interleukin-1(IL-1), mediated the prostaglandin E-2-cyclooxygenase-2 (PGE2-Cox-2) pathway, and mitigated inflammation and oxidative stressblockade of proinflammatory mitogen-activated protein kinase-nuclear factorB (MAPK/NF-B) signaling pathways. Furthermore, ginsenoside Rh4 significantly enhanced the protein expression of B-cell lymphoma gene 2 (Bcl-2), decreased the protein expression of Bcl-2-associated X protein (Bax) and tumor necrosis factor receptor superfamily member 6 (Fas), and inhibited the number of apoptotic cells in gastric tissues. The present work demonstrated that ginsenoside Rh4 exerted a considerable gastroprotective effect against ethanol-induced gastric ulcers in rats.
06:41
Hypolipidemic effect and molecular mechanism of ginsenosides. GreenMedInfo
PMID: Front Pharmacol. 2023 ;14:1166898. Epub 2023 Apr 28. PMID: 37188264 Abstract Title: Hypolipidemic effect and molecular mechanism of ginsenosides: a review based on oxidative stress. Abstract: Hyperlipidemia is considered a risk factor for cardiovascular and endocrine diseases. However, effective approaches for treating this common metabolic disorder remain limited. Ginseng has traditionally been used as a natural medicine for invigorating energy or "Qi" and has been demonstrated to possess antioxidative, anti-apoptotic, and anti-inflammatory properties. A large number of studies have shown that ginsenosides, the main active ingredient of ginseng, have lipid-lowering effects. However, there remains a lack of systematic reviews detailing the molecular mechanisms by which ginsenosides reduce blood lipid levels, especially in relation to oxidative stress. For this article, research studies detailing the molecular mechanisms through which ginsenosides regulate oxidative stress and lower blood lipids in the treatment of hyperlipidemia and its related diseases (diabetes, nonalcoholic fatty liver disease, and atherosclerosis) were comprehensively reviewed. The relevant papers were search on seven literature databases. According to the studies reviewed, ginsenosides Rb1, Rb2, Rb3, Re, Rg1, Rg3, Rh2, Rh4, and F2 inhibit oxidative stress by increasing the activity of antioxidant enzymes, promoting fatty acid-oxidation and autophagy, and regulating the intestinal flora to alleviate high blood pressure and improve the body's lipid status. These effects are related to the regulation of various signaling pathways, such as those of PPAR, Nrf2, mitogen-activated protein kinases, SIRT3/FOXO3/SOD, and AMPK/SIRT1. These findings suggest that ginseng is a natural medicine with lipid-lowering effects.
06:38
06:35
Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor. GreenMedInfo
n/a PMID: Biomed Pharmacother. 2023 Jul ;163:114870. Epub 2023 May 13. PMID: 37187019 Abstract Title: Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor. Abstract: Ginsenosides are the major and key components for ginseng to exert its wide and beneficial therapeutic efficacy in clinic. Meanwhile, many ginsenosides and their metabolites showed in vitro an in vivo anti-tumor activity, among which ginsenoside Rb1 has attracted much attention due to its good solubility and amphipathy. In this study, the self-assembly behavior of Rb1 was investigated and the Rb1 nano-assembly could further stabilize or encapsulated hydrophobic drugs such as protopanaxadiol (PPD) and paclitaxel (PTX) to form nanoparticles, based on which, a natural nanoscale drug delivery system, ginsenoside Rb1 stabilized and PTX/PPD co-loaded nanoparticles (GPP NPs) were prepared. The resultant GPP NPs exhibited a small particle size of 126.2 nm, a narrow size distribution (PDI=0.145), and a zeta potential of -27.3 mV. PTX loading content was 11.06% with an encapsulation efficiency of 93.86%. GPP NPs were spherical and stable in normal saline, 5% glucose, PBS, plasma, or on-shelf storage for 7 days. Both PTX and PPD existed in an amorphous state in GPP NPs and were released in a sustained pattern. GPP NPs showed 10-fold higher in vitro anti-tumor activity of than PTX injections. In the in vivo experiment, GPP NPs achieved a much higher tumor inhibition rate than PTX injections (64.95% vs 43.17%, P < 0.01) and certain tumor target ability. In conclusion, GPP NPs had significantly enhanced anti-tumor efficacy and improved tumor microenvironment, thus were promising to be developed into a novel anti-tumor agent for the treatment of breast tumor.
06:32
Any amount of exercise is good for cardiovascular health Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
New research shows that any amount of exercise can reduce the risk of cardiovascular disease like heart attack.
06:28
Ginsenoside Rg1 activates brown adipose tissue to counteract obesity in high-fat diet. GreenMedInfo
PMID: Food Funct. 2023 May 22 ;14(10):4696-4705. Epub 2023 May 22. PMID: 37186251 Abstract Title: Ginsenoside Rg1 activates brown adipose tissue to counteract obesity in high-fat diet-fed mice by regulating gut microbes and bile acid composition. Abstract: Obesity is a global health problem strongly linked to gut microbes and their metabolites. In this study, ginsenoside Rg1 (Rg1) reduced lipid droplet size and hepatic lipid accumulation by activating uncoupling protein 1 expression in brown adipose tissue (BAT), which in turn inhibited high-fat diet (HFD)-induced weight gain in mice. Furthermore, the intestinal flora of mice was altered, the abundance of,,,andwas upregulated, and the concentrations of fecal bile acids were altered, with cholic acid and taurocholic acid concentrations being significantly increased. In addition, the beneficial effects of Rg1 were eliminated in mice treated with a combination of antibiotics. In conclusion, these results suggest that Rg1 activates BAT to counteract obesity by regulating gut microbes and bile acid composition in HFD-fed mice.
06:23
Immunomodulatory, anti-Inflammatory, and anti-cancer properties of ginseng. GreenMedInfo
PMID: Molecules. 2023 May 3 ;28(9). Epub 2023 May 3. PMID: 37175273 Abstract Title: Immunomodulatory, Anti-Inflammatory, and Anti-Cancer Properties of Ginseng: A Pharmacological Update. Abstract: Ginseng, a medicinal plant of the genus, boasts a rich historical record of usage that dates back to the Paleolithic period. This botanical is extensively acknowledged and consumed in Eastern countries for its therapeutic properties, and, in Western countries, it is becoming increasingly popular as a remedy for fatigue and asthenia. This review provides an update on current research pertaining to ginseng and its isolated compounds, namely, ginsenosides and polysaccharides. The primary focus is on three crucial pharmacological activities, namely, immunomodulation, anti-inflammatory, and anti-cancer effects. The review encompasses studies on both isolated compounds and various ginseng extracts obtained from the root, leaves, and berries.
05:52
Effect of the Lingzi or Reishi medicinal mushroom Ganoderma lucidum on hyperglycemia and dyslipidemia. GreenMedInfo
PMID: Int J Med Mushrooms. 2023 ;25(5):17-30. PMID: 37183916 Abstract Title: Effect of the Lingzi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on Hyperglycemia and Dyslipidemia with Experimental Metabolic Syndrome. Abstract: The effect of Ganoderma lucidum hot water extract of submerged cultivated mycelium suspensia on carbohydrate metabolism and lipid profile during fructose-induced metabolic syndrome in rats was studied. The outbred white male Wistar rats, in which metabolic syndrome was induced by consuming a 10% fructose solution instead of drinking water for 42 days, were used. After the induction of metabolic syndrome, the mycelium of G. lucidum in the form of water suspension (a dose of 1 g/kg of the animal's body weight) was administered to animals per os for 7 and 14 days. Glucose concentration was determined using the glucose oxidase method. The content of glycosylated hemoglobin in erythrocytes was determined by the colorimetric method. The concentration of triglycerides, cholesterol, high-density lipoproteins, and low-density lipoproteins in blood plasma was determined by enzymatic methods. A significant decrease in the content of glycosylated hemoglobin was established in animals with metabolic syndrome against the background of administration of the studied suspension. Under the conditions of experimental metabolic syndrome, the administration of mycelium for 7 and 14 days led to a decrease in the concentration of triglycerides by 17.8 and 44.8%, cholesterol by 10.7 and 21.3%, low-density lipoproteins by 14.8 and 28.4%, and to an increase in high-density lipoproteins concentration by 11.9 and 21.5%, compared with metabolic syndrome. The obtained results demonstrate the corrective effect of the suspension of the G. lucidum powdered mycelium on carbohydrate and lipid metabolism, which was directly proportional to the duration of administration.
05:44
Moringa oleifera leaf polysaccharides exert anti-lung cancer effects. GreenMedInfo
PMID: Food Funct. 2023 May 22 ;14(10):4607-4620. Epub 2023 May 22. PMID: 37158366 Abstract Title: leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration. Abstract: Tumor-associated macrophages (TAMs) participate in tumorigenesis, growth, invasion as well as metastasis by facilitating an immunosuppressive tumor microenvironment. Reversing the pro-tumoral M2 phenotype of TAMs has become a hot spot in advancing cancer immunotherapy. In the current study, the content ofleaf polysaccharides (MOLP) was determined and characterized, along with the anti-cancer mechanism of MOLP studied in a Lewis lung cancer (LLC) tumor-bearing mouse model and bone marrow-derived macrophages. The monosaccharide composition and gel permeation chromatography analyses show that MOLP are mainly composed of galactose, glucose, and arabinose, with approximately 17.35 kDa average molecular weight ().studies demonstrate that MOLP convert TAMs from the immunosuppressive M2 phenotype to the antitumor M1 phenotype, thus inducing CXCL9 and CXCL10 expression and increasing T-cell infiltration in the tumor. Furthermore, macrophage depletion and T cell suppression demonstrated that the tumor suppressive effect of MOLP was reliant on reprogramming macrophage polarization and T cell infiltration.studies revealed that MOLP could induce the phenotypic switch from M2 macrophages to M1 by targeting TLR4. The current study highlights that MOLP are promising anticancer plant-derived polysaccharides with potential in modulating the immune microenvironment and have a bright application prospect in the immunotherapy of lung cancer.
05:42
05:39
Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism. GreenMedInfo
PMID: Food Funct. 2023 May 22 ;14(10):4621-4631. Epub 2023 May 22. PMID: 37158592 Abstract Title: Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism. Abstract: The abnormal accumulation of fused in sarcoma (FUS) is a pathological hallmark in a proportion of patients with frontotemporal dementia and amyotrophic lateral sclerosis. Therefore, the clearance of FUS aggregates is a possible therapeutic strategy for FUS-associated neurodegenerative diseases. This study reports that curcumin can strongly suppress FUS droplet formation and stress granule aggregation of FUS. Fluorescence spectra and isothermal titration calorimetry showed that curcumin can bind FUS through hydrophobic interactions, thereby reducing the-sheet content of FUS. Aggregated FUS sequesters pyruvate kinase, leading to reduced ATP levels. However, results from a metabolomics study revealed that curcumin changed the metabolism pattern and differentially expressed metabolites were enriched in glycolysis. Curcumin attenuated FUS aggregation-mediated sequestration of pyruvate kinase and restored cellular metabolism, consequently increasing ATP levels. These results indicate that curcumin is a potent inhibitor of FUS liquid-liquid phase separation and provide novel insights into the effect of curcumin in ameliorating abnormal metabolism.
05:33
This study provides theoretical support for the research and development of hyperoside in fat-reducing functional foods. GreenMedInfo
PMID: Food Funct. 2023 May 22 ;14(10):4763-4776. Epub 2023 May 22. PMID: 37128768 Abstract Title: Hyperoside inhibits pancreatic lipase activityand reduces fat accumulation. Abstract: Hyperoside, the main component of many anti-obesity plants, might exhibit a lipase inhibition effect to reduce fat accumulation. The anti-obesity effect of hyperoside was investigated by studying its inhibitory effect and mechanism on pancreatic lipaseand evaluating its ability to reduce lipid accumulation. Hyperoside is a mixed-type inhibitor of lipase with an ICof 0.670.02 mmol L. Hyperoside changed the secondary conformation of lipase, increased the-helix content, and changed the microenvironment of lipase through static quenching. The interaction between hyperoside and lipase results from a strong binding spontaneous exothermic reaction, mainly through hydrogen bonding, van der Waals force and electrostatic force. Hyperoside protected hepatic lipid accumulation and adipose tissue hypertrophy and reduced the expression of inflammatory factors in high-fat diet-induced rats. Moreover, hyperoside had a good inhibitory effect on lipase activity in serum and increased fecal fat excretion, thereby reducing lipid absorption. This study provides theoretical support for the research and development of hyperoside in fat-reducing functional foods.
05:26
Molecular mechanism of green tea polyphenol epicatechin gallate attenuating Staphylococcus aureus pathogenicity. GreenMedInfo
PMID: Food Funct. 2023 May 22 ;14(10):4792-4806. Epub 2023 May 22. PMID: 37128867 Abstract Title: Molecular mechanism of green tea polyphenol epicatechin gallate attenuatingpathogenicity by targeting Ser/Thr phosphatase Stp1. Abstract: In this study, through virtual screening andbioactivity assays, we discovered that (-)-epicatechin gallate (ECG), a polyphenol compound extracted from green tea, demonstrated marked anti-Ser/Thr phosphatase (Stp1) activity towards() with an ICvalue of 8.35M. By targetingStp1, ECG prevented the up-regulation of virulence gene and the formation of antibody membrane and protected the mice frominfection. Through MD simulation, the allosteric inhibitory mechanism of ECG on Stp1 was determined. The Stp1-ECG complex model underwent a significant change in conformation; its flap subdomain changed from opening to closing, whereas Stp1 activity was lost when bound to ECG. In addition, the MD simulation results of Stp1 and several tea polyphenol compounds showed that gallate groups and fewer adjacent phenolic hydroxyl groups contributed to the binding of Stp1 and inhibitors. As an inhibitor targetingStp1, ECG reduced the pathogenicity ofwithout inhibiting, which largely reduced the possibility of drug resistance. Our findings demonstrated a novel molecular mechanism of green tea as the usual drink againstinfection and elucidated the future design of allosteric inhibitors targeting Stp1.
05:22
Hyperoside alleviates postmenopausal osteoporosis. GreenMedInfo
PMID: Am J Reprod Immunol. 2023 Jul ;90(1):e13709. Epub 2023 May 8. PMID: 37157916 Abstract Title: Hyperoside alleviates postmenopausal osteoporosis via regulating miR-19a-5p/IL-17A axis. Abstract: PROBLEM: Postmenopausal osteoporosis (PMO) is a common osteoporosis. Hyperoside (Hyp), a natural flavonoid compound, has anti-osteoporotic effects, but the underlying mechanisms remain poorly understood. Inflammatory cytokine IL-17A is upregulated in PMO and plays vital roles in bone loss, but the upstream regulatory factors and mechanisms are still unknown.METHOD OF STUDY: Twenty PMO patients and 20 healthy control subjects were included to analyze IL-17A expression changes and screen dys-regulated miRNAs in the peripheral blood of PMO patients. miR-19a-5p mimics and inhibitor were transfected into RAW264.7 osteoclasts, and injected into bilateral ovariectomized (OVX) mice to explore the regulatory effect of miR-19a-5p on IL-17A. OVX mice were randomly grouped and treated with different doses of Hyp to uncover the effective targets for the medicine in PMO disease.RESULTS: MiR-19a-5p was downregulated in PMO patients and the expression level was negatively correlated with that of IL-17A. miR-19a-5p could directly bind to the 3'UTR of IL-17A and regulate its expression. Both in vitro and in vivo studies demonstrated that miR-19a-5p mimics decreased the expression of IL-17A, RANK and Cathepsin K, while miR-19a-5p inhibitor significantly increased the expression of IL-17A, RANK, and Cathepsin K. Importantly, the Hyp could improve bone structure of OVX mice by enhancing miR-19a-5p-mediated IL-17A downregulation.CONCLUSION: Overall, these data demonstrated that miR-19a-5p/IL-17A axis might serve as novel therapeutic candidate for PMO. Hyp could relieve bone resorption by targeting the miR-19a-5p/IL-17A axis in OVX mice and exhibited prospective for the treatment of PMO.
05:05
Development of Moringa oleifera as functional food targeting NRF2 signaling: antioxidant and anti-inflammatory activity. GreenMedInfo
PMID: Food Funct. 2023 May 22 ;14(10):4734-4751. Epub 2023 May 22. PMID: 37114361 Abstract Title: Development ofas functional food targeting NRF2 signaling: antioxidant and anti-inflammatory activity in experimental model systems. Abstract: Pharmacological activation of nuclear factor erythroid 2 related factor 2 (NRF2) provides protection against several environmental diseases by inhibiting oxidative and inflammatory injury. Besides high in protein and minerals,leaves contain several bioactive compounds, predominantly isothiocyanate moringin and polyphenols, which are potent inducers of NRF2. Hence,leaves represent a valuable food source that could be developed as a functional food for targeting NRF2 signaling. In the current study, we have developed a palatableleaf preparation (henceforth referred as ME-D) that showed reproducibly a high potential to activate NRF2. Treatment of BEAS-2B cells with ME-D significantly increased NRF2-regulated antioxidant genes (,) and total GSH levels. In the presence of brusatol (a NRF2 inhibitor), ME-D-induced increase in NQO1 expression was significantly diminished. Pre-treatment of cells with ME-D mitigated reactive oxygen species, lipid peroxidation and cytotoxicity induced by pro-oxidants. Furthermore, ME-D pre-treatment markedly inhibited nitric oxide production, secretory IL-6 and TNF-levels, and transcriptional expression of,, andin macrophages exposed to lipopolysaccharide. Biochemical profiling by LC-HRMS revealed glucomoringin, moringin, and several polyphenols in ME-D. Oral administration of ME-D significantly increased NRF2-regulated antioxidant genes in the small intestine, liver, and lungs. Lastly, prophylactic administration of ME-D significantly mitigated lung inflammation in mice exposed to particulate matter for 3-days or 3-months. In conclusion, we have developed a pharmacologically active standardized palatable preparation ofleaves as a functional food to activate NRF2 signaling, which can be consumed as a beverage (hot soup) or freeze-dried powder for reducing the risk from environmental respiratory disease.
04:44
The consumption of green tea is associated with a reduced risk of hypertension in premenopausal women. GreenMedInfo
PMID: Food Funct. 2023 May 11 ;14(9):4406-4413. Epub 2023 May 11. PMID: 37097224 Abstract Title: Green tea intake and the risk of hypertension in premenopausal women: the TCLSIH cohort study. Abstract: : Tea polyphenols, such as green tea polyphenols, have been extensively studied as agents that ameliorate cardiovascular disease and blood pressureand in animal studies. However, epidemiological evidence for the association of green tea consumption with hypertension (HTN) is inconsistent. In addition, such an association has not been prospectively examined in the general adult population, particularly among young women. Therefore, we designed a cohort study to examine whether green tea consumption increases the risk of HTN in premenopausal women.: This prospective cohort study investigated 6633 premenopausal female participants without hypertension, cardiovascular disease, and cancer at the baseline. Green tea consumption was measured at the baseline using a validated food frequency questionnaire. Hypertension was confirmed with the SBP140 mm Hgor with the DBP90 mm Hg. Cox proportional hazards regression models were used to examine the association of green tea consumption with incident hypertension. A total of 488 first incident cases of hypertension occurred during 24957 person-years of follow-up (median follow-up of 4.0 years). After adjustment for potential confounding variables, the multivariable hazard ratios (95% confidence intervals) for incident hypertension in premenopausal female participants with different green tea consumption frequencies were 1.00 (reference) for almost never, 0.84 (0.67, 1.07) for 1 cup per week, 1.02 (0.77, 1.35) for 2-6 cups per week, and 0.65 (0.44, 0.96) for1 cup per day.: The results from our prospective study indicate that the consumption of green tea is associated with a reduced risk of HTN in premenopausal women.
04:21
Sudden Onset Self-Injury and Autism - The Dark Reality Age of Autism The Rebel Alliance!
His name is Connor. His name is every boy and girl
name you can dream up. Grandmother feels "She is failing
him..." She isn't. But we know who did. We know who
continues to fail all the Connors of the world. Yesterday, I toured
a group day program. If it was a kennel, you'd think twice. Dark
secrets are everywhere. It's up to US to disinfect them with
harsh light. This is why we exist. Anne Dachel immerses
herself in this darkness EVERY DAY. It's like being an FBI profiler
for the worse crimes. Kim
By Anne Dachel
A story from East Peoria, Illinois really impacted me recently. On
July 19th I saw the headline, Family still faces
tough choices to help 10-year-old boy with autism,
self-harming
This is what the video said:
News 25: We told the Goodwin familys story back in April when 10 year old Connor started self-harming for reasons they cant understand. Theyre trying to chase down the cause of his behavior, trying different methods and medications to keep him safe.
Now they believe he needs a live-in care facility, and its another challenge to find one to fit his needs in the state of Illinois.
Grandmother: We just feel like we are failing him 100 percent, but we dont know what to do.
News 25: This has been Carol Goodwins life recently. Her 10 year old grandson Connor has autism. He was doing well for most of his life, even attending school .
In just over a year, he started hitting himself on the head leading to bruises and cuts on his face.
Connor is essentially in need of 24/7 care. His family is looking for a facility that can take him in, but keep finding dead ends in Illinois.
Grandmother: Theyre full.
Chuck Hartseil, Consultant, Advocate: Central Illinois really does not have many residential facilities available within it.
News 25: Its at least a six month process to apply to a facility and a long road if you need to seek help outside Illi...
03:00
Critical Psychiatry Textbook, Chapter 8: Depression and Mania (Affective Disorders) (Part Thirteen) Mad In America
Editors Note: Over the next several months, Mad in Gtzsches book, Critical Psychiatry Textbook. In this blog, he discusses how network meta-analyses spin the data on antidepressants, especially when financed by the pharmaceutical industry. Each Monday, a new section of the book is published, and all chapters are archived here.
The different treatments and combinations
In case of insufficient response in patients with depression or anxiety, one textbook suggested adding another drug (so-called augmentation), e.g. mirtazapine in the evening if the patient cannot sleep.17:661 It noted that augmentation with lithium, thyroxine, or lamotrigine is reserved for doctors with particular experience, and it suggested that a depression pill can be combined with a psychosis pill and that it is often a problem that the patients are underdosed. This advice increases drug harms for no benefit.
The literature is full of studies and meta-analyses claiming that some depression pills are better than others. Almost all of them are financed by the drug industry, either directly or indirectly. Many of the academic authors are on industry payroll as advisors, consultants, or lecturers and have little to do with writing the manuscript but just lend their well-known names to it.2,6,7 This is called guest authorship and those who write the manuscript are often ghost authors, as their names are not in the byline.140 When a person is acknowledged for her help without specifying for what, or is thanked for editorial assistance, this person is usually the real author of the paper.
I shall mention a recent network meta-analysis by
Cipriani and colleagu...
02:30
Meet the author who has published more than 500 letters to the editor in a year Retraction Watch
Hyperprolific authors have been drawing attention for some time. In 2018, for example, a Nature article reported that thousands of scientists have published a paper every five days. And earlier this year El Pais noted that a now-suspended scientist was publishing a paper every 37 hours.
What about an author who publishes more than once a day, on average?
Viroj Wiwanitkit has published 543 items indexed in PubMed in the last 12 months, the vast majority of them letters to the editor. Most of Wiwanitkits letters with colleagues appear to be only a single paragraph. Many concern COVID-19 and vaccinations, but the catalog includes letters about monkeypox, knee replacement surgery, bipolar disorder, even ChatGPT.
To be clear, most definitions of hyperprolific authors exclude such work. But the volume seemed noteworthy. We asked Wiwanitkit, now an adjunct professor at Joseph Ayobabalola University in Nigeria, some questions over the course of several emails. Below is an edited version; we have made the entire exchange available here. We have not made spelling or grammatical changes anywhere in either version. (And a researcher who flagged a May 2020...
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Saturday, 22 July
03:13
Chemists close in on the holy grail for avoiding one of industrys most toxic chemicals Fluoride Action Network
Chemists might have found a way to avoid the use of one of the most toxic substances in wide use: hydrogen fluoride.
Made from the mineral fluorspar (CaF2), hydrogen fluoride (HF) is used in both gaseous and liquid form.
A small splash of HF on skin is enough to be fatal and coming into the contact with the gas can cause blindness, severe burns, and serious lung damage.
But hydrogen fluoride is also the only effective way to make fluorine-containing substances. These fluorochemicals are crucial in a range of products including refrigerants, lithium batteries, pharmaceuticals, agrochemicals, and non-stick materials.
A team of UK chemists has figured out a way to make fluorochemicals with just fluorspar, which is much less dangerous.
The direct use of CaF2 for fluorination is a holy grail in the field, and a solution to this problem has been sought for decades, says Professor Vronique Gouverneur, a chemist at the University of Oxford and senior author on a paper describing the research, published in Science.
This study represents an important step in this direction because the method developed in Oxford has the potential to be implemented anywhere in academia and industry.
Their method, inspired by the biomineralization that builds up teeth and bones in nature, involves grinding CaF2 in a ball mill for three hours with a salt powdered potassium phosphate.
This generates a powder containing fluorine and potassium, which theyve called Fluoromix
Using high precision techniques, such as X-ray diffraction, the researchers unlocked key insights into the composition of Fluoromix and structures of the fluorinating species. This diagram shows structures of crystalline constituents of Fluoromix, which serve as fluorinating reagents. Credit: Professor Michael Hayward.
The researchers have shown that their fluorspar-based Fluoromix can create more than 50 different fluorochemicals, with the potential for making many more.
Gouverneur says that the method could also minimise carbon emissions by shortening supply chains, s...
02:36
Skeleton Toothpaste Mineral Is as Effective as Fluoride Fluoride Action Network
Move over fluoride, theres a new toothpaste in town.
The naturally occurring mineral has been used in toothpaste since 1956 to strengthen the protective enamel around our teeth and prevent the formation of cavities, or casies. Fluoride has been studied extensively and is considered a safe and effective way to protect our teeth.
However, excessive fluoride exposure can cause dental fluorosis, a condition that causes changes in the appearance of tooth enamel. Some studies have raised tentative concerns about the effects of fluoride exposure on the developing human brain.
More and more studies show neurotoxic effects of fluoride as well as other side effects of fluorides, Elzbieta Paszynska, a professor in integrated dentistry at the Poznan University of Medical Sciences in Poland, told Newsweek. There are generally recommendations about very low doses of fluoride [being used] for young children. However, from a preventive point of view, this is too low to defend against caries.
Today, toothpastes that carry the American Dentistry Association Seal of Acceptance must contain fluoride. However, research by Paszynska and her team has demonstrated that there may be a safe and equally effective alternative to fluoride. The results of their study were published in the journal Frontiers in Public Health on July 18.
The active ingredient hydroxyapatite is inspired by the natural tooth-enamel crystallites, Paszynska said. In our study, we found that hydroxyapatite was as effective as fluoride regarding caries prevention.
Hydroxyapatite is a calcium-based mineral found in human teeth and bones. It can also be made in a lab to be used in oral-care products like toothpaste and mouth wash.
The compound has previously been shown to be an effective treatment for oral conditions like gum disease and may also relieve tooth sensitivity. As it is already found inside our bones, this compound appears to be highly compatible with the human body. Hydroxyapatite systems show no side effects and do not cause adverse allergic or toxic reactions in children and adults, Paszynska said.
Paszynska and her team recruited 171 adult patients to participate in the 18-month-long study. Half of the participants were given 1450ppm [parts per million] fluoride toothpaste, while the other half were given hydroxyapatite toothpaste. Patients were provided with...
Wednesday, 19 July
04:55
Homemade Honey Roasted Peanuts The Healthy Home Economist
Easy recipe for honey-roasted peanuts that is a healthy substitute for commercial versions with sketchy additives. Honey-roasted peanuts are a popular commercial snack. They are especially prevalent in airports as a semi-healthy munchie while waiting to board your plane or in flight. However, if youve ever checked the ingredients, you were likely in for a
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