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Saturday, 29 July
21:00
Weekend reads: The black market for papers; the secret life of retractions; a troublesome pattern Retraction Watch
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The week at Retraction Watch featured:
- Science rescinds expression of concern issued last month
- Exclusive: Public health journal says it will retract vaping paper for questions authors say were addressed in peer review
- Exclusive: City of Hope cancer researcher goes to court to fight misconduct finding
- Meet the author who has published more than 500 letters to the editor in a year
Our list of retracted or withdrawn COVID-19 papers is up to nearly 350. There are now 41,000 retractions in our database which powers retraction alerts in Edifix, ...
20:45
BREAKING: White House/US Surgeon General Pressured FB to Censor True Vaccine Harms GreenMedInfo
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In the wake of the recent Select Subcommittee on the Weaponization of the Federal Government, internal documents produced by Mark Zuckerberg of Facebook, tell a horrid story of the White House (through the office of the Surgeon General Vivek H. Murthy) directing tech platforms to censor and label as 'misinformation' true stories of vaccine injury and side effects -- the very definition of a disinformation campaign.
20:00
Causality in Mental Disturbance: A Review of the Neuroscience Mad In America
Editors Note: The following is an original research article by Peter Sterling, Professor of Neuroscience at the Perelman School of Medicine, University of Pennsylvania. We are presenting it in its native format as a scientific paper.
Here I comment on the 2022 review, Causal Mapping of Human Brain Function by Siddiqi et al., which appeared in Nature Reviews Neuroscience. I place its reasoning in the historical context of psychosurgery and other physical manipulations of brain functionand also in the present context of new understandings from brain imaging, genome-wide studies, and longitudinal studies of mental disturbance. Here are the Reviews stated goals:
This Review focuses on the objective of symptom localization, which aims to identify causal links between symptoms and neuroanatomy. When a symptom is successfully localized, it may potentially be treated by modulating the corresponding neuroanatomy. The second objective, mapping the direction of information flow, aims to understand how one brain region can causally influence another. These experiments attempt to estimate the direction of information flow between two or more nodes in the brain using various measures of effective connectivitySimilar approaches have now been used to map the causal neuroanatomy of movement disorders, mood disorders, anxiety-related disorders, psychotic disorders, disorders of consciousness and various other neuropsychiatric phenomena.
The Review opens by considering identified neurological disorders with identified causes and identified therapies grounded in identified neuroscience. Its primary exemplar is Parkinsons disease, whose immediate cause is loss of dopaminergic neurons in the substantia nigra, and whose treatment involves providing the dopamine precursor to the remaining dopaminergic synapses so that they continue making and releasing dopamine in response to natural stimuli as part of the natural circuit. All good. But then the Review pulls a fast one: it inverts the argument.
Whereas neurology starts with known damage that causes known symptoms and finds effective therapies based on known neuroscience, this Review starts with mental disturbances that it claims to be symptoms of an underlying brain disorder, which it claims to localize neuroanatomically in order to treat with brain manipulations for which there is no foundation in neuroscience. Thus, the Review reasons by asserting an equivalence between something not known to something that is known, apparently hoping that the difference will go unnoticed.
To be clear: there is no neuroscience to suggest that any mental function would be improved by ablating or stimu...
11:25
Lycium barbarum glycopeptide prevents stress-induced anxiety disorders. GreenMedInfo
PMID: Phytomedicine. 2023 Jul 25 ;116:154864. Epub 2023 May 9. PMID: 37182278 Abstract Title: Lycium barbarum (Wolfberry) glycopeptide prevents stress-induced anxiety disorders by regulating oxidative stress and ferroptosis in the medial prefrontal cortex. Abstract: BACKGROUND: Lycium barbarum (Wolfberry) extract has been shown to be effective in neuroprotection against aging or neural injury. Knowledge of its potential roles and biological mechanisms in relieving mental disorders, however, remains limited.PURPOSE: To investigate the potency of Lycium barbarum glycopeptide (LbGp) in alleviating anxiety disorders and the related biological mechanisms.METHODS: LbGp was administrated to mice subjected to 14 days of chronic restrain stress (CRS) via the intragastric route. The anxiolytic effect was evaluated by a battery of behavioral assays. The morphology of neurons and glial cells was evaluated, and cortical neuronal calcium transients were recorded in vivo. The molecular mechanism of LbGp was also investigated.RESULTS: LbGp effectively relieved anxiety-like and depressive behaviors under CRS. Mechanistic studies further showed that LbGp treatment relieved oxidative stress and lipid peroxidation in the medial prefrontal cortex (mPFC). In particular, the ferroptosis pathway was inhibited by LbGp, revealing a previously unrecognized mechanism of the anxiolytic role of wolfberry extract.CONCLUSION: In summary, our results supported the future development of LbGp to prevent or ameliorate stress-induced anxiety disorders. Our work provides a promising strategy for early intervention for pateitents with mental disorders by applying natural plant extracts.
11:04
Exercise interventions can be recommended for menopausal women to improve their sleep. GreenMedInfo
PMID: Front Med (Lausanne). 2023 ;10:1092294. Epub 2023 Apr 25. PMID: 37181372 Abstract Title: The effect of exercise intervention on improving sleep in menopausal women: a systematic review and meta-analysis. Abstract: BACKGROUND: Sleep disturbance is common in menopausal women and negatively affects their quality of life and could cause increased risks of other menopause-related diseases.OBJECTIVE: This systematic review aims to synthesize evidence regarding the effects of exercise interventions on improving sleep in menopausal women.METHODS: A comprehensive search in seven electronic databases for randomized controlled trials (RCTs) was performed on June 3, 2022. The systematic review included seventeen trials, ten of which provided data for the meta-analysis. The effects on outcomes were presented as mean differences (MDs) or standard mean differences (SMDs) and their 95% confidence intervals (CI). Cochrane risk-of-bias tool was used in quality assessment.RESULTS: The results suggest that exercise intervention significantly reduces insomnia severity (SMD = -0.91, 95% CI = -1.45 to -0.36,= 3.27,= 0.001) and alleviates sleep problems (MD = -0.09, 95% CI = -0.17 to -0.01,= 2.20,= 0.03). For sleep quality, the results showed that insignificant differences were found between the exercise intervention and the control groups (MD = -0.93, 95% CI = -2.73 to 0.87, Z = 1.01,= 0.31). The results of the subgroup analysis indicated that more apparent effects of exercise intervention were found among women with sleep disorders than among women without sleep disorders. Which exercise intervention duration was more beneficial to sleep outcomes could not be judged. Overall, there was a moderate risk of bias in the primary studies.CONCLUSION: According to this meta-analysis, exercise interventions can be recommended for menopausal women to improve their sleep. High-quality RCTs applying different types of exercise (e.g., walking, yoga, meditative exercise and so on) with different intervention durations as well as subjective and objective sleep assessment are warranted.SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022342277, identifier: CRD42022342277.
10:26
Influence of routine exercise on the peripheral immune system to prevent and alleviate pain. GreenMedInfo
PMID: Neurobiol Pain. 2023 ;13:100126. Epub 2023 Mar 21. PMID: 37179769 Abstract Title: Influence of routine exercise on the peripheral immune system to prevent and alleviate pain. Abstract: Routine physical activity reduces the onset of pain and exercise is a first line treatment for individuals who develop chronic pain. In both preclinical and clinical research regular exercise (routine exercise sessions) produces pain relief through multiple mechanisms such as alterations in the central and peripheral nervous system. More recently, it has been appreciated that exercise can also alter the peripheral immune system to prevent or reduce pain. In animal models, exercise can alter the immune system at the site of injury or pain model induction, in the dorsal root ganglia, and systemically throughout the body to produce analgesia. Most notably exercise shows the ability to dampen the presence of pro-inflammatory immune cells and cytokines at these locations. Exercise decreases M1 macrophages and the cytokines IL-6, IL-1, and TFN, while increasing M2 macrophages and the cytokines IL-10, IL-4, and IL-1ra. In clinical research, a single bout of exercise produces an acute inflammatory response, however repeated training can lead to an anti-inflammatory immune profile leading to symptom relief. Despite the clinical and immune benefits of routine exercise, the direct effect of exercise on immune function in clinical pain populations remains unexplored. This review will discuss in more detail the preclinical and clinical research which demonstrates the numerous ways through which multiple types of exercise alter the peripheral immune system. This review closes with the clinical implications of these findings along with suggestions for future research directions.
10:16
Treadmill exercise could effectively alleviate cognitive disorders. GreenMedInfo
PMID: Int J Mol Sci. 2023 Apr 25 ;24(9). Epub 2023 Apr 25. PMID: 37175535 Abstract Title: Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of IntegrinV/5 in Parkinson's Disease. Abstract: Parkinson's disease with cognitive impairment (PD-CI) results in several clinical outcomes for which specific treatment is lacking. Although the pathogenesis of PD-CI has not yet been fully elucidated, it is related to neuronal plasticity decline in the hippocampus region. The dopaminergic projections from the substantia nigra to the hippocampus are critical in regulating hippocampal plasticity. Recently, aerobic exercise has been recognized as an effective therapeutic strategy for enhancing plasticity through the secretion of various muscle factors. The exact role of FNDC5-an upregulated, newly identified myokine produced after exercise-in mediating hippocampal plasticity and regional dopaminergic projections in PD-CI remains unclear. In this study, the effect of treadmill exercise on hippocampal synaptic plasticity was evaluated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced chronic PD models. The results showed that treadmill exercise substantially alleviated the motor dysfunction, cognition disorder, and dopaminergic neuron degeneration induced by MPTP. Here, we discovered that the quadriceps, serum, and brain FNDC5 levels were lower in PD mice and that intervention with treadmill exercise restored FNDC5 levels. Moreover, treadmill exercise enhanced the synaptic plasticity of hippocampal pyramidal neurons via increased dopamine levels and BDNF in the PD mice. The direct protective effect of FNDC5 is achieved by promoting the secretion of BDNF in the hippocampal neurons via binding the integrinV5 receptor, thereby improving synaptic plasticity. Regarding the indirect protection effect, FNDC5 promotes the dopaminergic connection from the substantia nigra to the hippocampus by mediating the interaction between the integrinV5 of the hippocampal neurons and the CD90 molecules on the membrane of dopaminergic terminals. Our findings demonstrated that treadmill exercise could effectively alleviate cognitive disorders via the activation of the FNDC5-BDNF pathway and enhance the dopaminergic synaptic connection from SNpc to the hippocampus in the MPTP-induced chronic PD model.
10:01
Exercise alleviates neovascular age-related macular degeneration by inhibiting AIM2 inflammasome in myeloid cells. GreenMedInfo
PMID: Metabolism. 2023 Jul ;144:155584. Epub 2023 May 5. PMID: 37150437 Abstract Title: Exercise alleviates neovascular age-related macular degeneration by inhibiting AIM2 inflammasome in myeloid cells. Abstract: The neovascular form of age-related macular degeneration (nvAMD) is the leading cause of blindness in the elderly population. Vascular endothelial growth factor (VEGF) plays a crucial role in choroidal neovascularization (CNV), and anti-VEGF therapy is recommended as first-line therapy for nvAMD. However, many patients do not radically benefit from this therapy. Epidemiological data suggest that physical exercise is beneficial for many human diseases, including nvAMD. Yet, its protective mechanism and therapeutic potential remain unknown. Here, using clinical samples and mouse models, we found that exercise reduced CNV and enhanced anti-angiogenic therapy efficacy by inhibiting AIM2 inflammasome activation. Furthermore, transfusion of serum from exercised mice transferred the protective effects to sedentary mice. Proteomic data revealed that exercise promoted the release of adiponectin, an anti-inflammatory adipokine from adipose tissue into the circulation, which reduced ROS-mediated DNA damage and suppressed AIM2 inflammasome activation in myeloid cells of CNV eyes through AMPK-p47phox pathway. Simultaneous targeting AIM2 inflammasome product IL-1and VEGF produced a synergistic effect for treating choroidal neovascularization. Collectively, this study highlights the therapeutic potential of an exercise-AMD axis and uncovers the AIM2 inflammasome and its product IL-1as potential targets for treating nvAMD patients and enhancing the efficacy of anti-VEGF monotherapy.
10:00
Affirmative Action in Medicine Articles
Diversity equity and inclusion (DEI) is an immensely controversial subject. I believe this controversy has arisen since people have strong reasons to support either side of the argument and because it is being forced upon us by both the government and multinational corporations.
For example, ESG scores have been used as a metric to calculate the social value of corporations, and a vital component of an ESG score is the company's commitment to advancing diversity both within the company and in society.
Since ESG scores are used by many (such as Blackrock the largest asset holder in the world) to determine which corporation to invest in, a lot of money is at stake, and many corporations have gone to great lengths in promoting left-wing causes to attract ESG-focused investors.
Note: In 2023, Vanguard (the second largest asset holder) distanced itself from ESG investing, with its CEO arguing that ESG investing is incompatible with Vanguard's fiduciary duties to the investors. Fewer than 1 in 7 of Vanguard's active equity managers outperformed the broad market in any five-year period, and none of them relied exclusively on a net-zero (ESG) investment methodology.
Depending on how one looks at it, I believe any of the following can be argued about DEI:
- It's an attempt to address a legitimate issue.
- It's a smokescreen.
- It's a power play.
- It's a mass formation.
Although many of the initial justifications for DEI were valid, at this point, it has transformed into something accomplishing the opposite of what was initially intended. In many cases, the harm of DEI is only evident if you are actively involved in the field it affects. Since I am in medicine, my focus will be on how DEI has affected medicine, but much of what I say holds for other fields as well.
Inequality and Discrimination
There are two ways to amass wealth and power:
- Producing something of immense value.
- Stealing from others.
The first sometimes happens. For example, after World War 2, since the war didn't touch America's soil, America had an intact industrial base the rest of the world was eager to purchase from and America rapidly experienced a boon in wealth that saturated the society. For context, in the 1950s, a black high school dropout working reasonable hours in a factory could afford to buy a house and support a stay-at-home wife raising his family.
Typically, however, the second happens. One of the primary issues of our era (which became much worse during the pandemic) is that the wealth that used to be ava...
Swimming in Circles: Aquaculture and the End of Wild Oceans Articles
Editor's Note: This article is a reprint. It was originally published September 30, 2018.
In this interview, investigative journalist and fishing industry insider Paul Molyneaux discusses aquaculture and the dangers of farmed fish, which are also the topics of his book "Swimming in Circles: Aquaculture and the End of Wild Oceans."
From my perspective, the two most dangerous foods served in most restaurants are factory farmed chicken, which is responsible for a majority of foodborne illnesses, and farmed fish, especially farmed salmon, which is among the most toxic foods on the planet.
Salmon Farming in Cobscook Bay
At the age of 17, Molyneaux left home and got a job in commercial fishing, which led to work in aquaculture in the late '70s.
"I always had an interest in aquaculture, although I primarily was a commercial fisherman. In the late '80s, I ran a fish processing plant for the Passamaquoddy tribe in Eastport, Maine, on Cobscook Bay. There was a sudden push to do salmon farming in the bay.
The way the promoters at the time, a company called Ocean Products sold it to us was [by] saying, 'You can become farmers of the sea. You can start giving back to the ocean.' We bought it hook, line and sinker Last summer, there were about six of us standing on the dock in Eastport, saying, 'Geez, we thought this was going to be great.'"
As fisheries had dwindled, they believed aquafarming would be the answer to keeping the fishing industry alive. Alas, the industry was rapidly consolidated into the hands of just a few players. "Now, it's in the hands of one," Molyneaux says.
What's worse, it didn't take long before the environmental downsides of aquaculture became readily apparent as well. In the late 1990s, infectious salmon anemia virus spread like wildfire among the salmon pens in Cobscook Bay, wiping out the fishery as 2 million fish had to be discarded overnight.
"That set the industry back. Now, it's owned by one company Cooke Aquaculture and pretty much everything is automated. They have a tremendous sea lice problem.
They're pouring tons of SLICE into those pens, and they're coming up with new systems now because they're finding the sea lice medication is now in the mollusks, like the scallops that are also harvested from the bay. Cooke has been fined twice in the last five years for using an illegal chemical, cypermethrin, to fight sea lice."
Industrialized Food Supply Encouraged Switch to Aquaculture
...Treasure Trove of Damning Evidence Surrounding COVID Origin Articles
According to a July 12, 2023, article by Ryan Grim published by The Intercept,1 U.S. House Republicans investigating the origin of COVID-19 appear to have inadvertently released a trove of new documents ... that shed light on deliberations among the scientists who drafted a key paper in February and March of 2020.
The paper in question is The Proximal Origin of Sars-Cov-2,2 a letter to the editor of Nature Medicine published March 17, 2020. This letter ended up being widely cited by the media as evidence of a scientific consensus that the virus emerged naturally and jumped species.
The House Subcommittee on the origin of COVID-19 devoted an entire report to this paper, showing how the authors presented a false conclusion to the public while privately believing the virus had escaped from the Wuhan Institute of Virology (WIV).
The report was published July 11, 2023, the same day the subcommittee also held a hearing on the Proximal Origin paper, in which they questioned Robert Garry, Ph.D., of Tulane University and Kristian Andersen, Ph.D., of Scripps, two of the scientists involved in its creation. The Intercept explains how more information than intended ended up out in the open:3
According to the metadata in the PDF of the report, it was created using Acrobat PDFMaker 23 for Word, indicating that the report was originally drafted as a Word document. Word, however, retains the original image when an image is cropped, as do many other apps ...
The Intercept was able to extract the original, complete images from the PDF using freely available tools, following the work of a Twitter sleuth. All the files can be found here.4
The original subcommittee report has now been taken down.
Background
February 1, 2020, Dr. Anthony Fauci, then-director of the National Institutes of Allergies and Infectious Diseases (NIAID) and Dr. Francis Collins, then-director of the National Institutes of Health (NIH) convened a conference call with 11 scientists to discuss COVID-19.
On that conference call, Drs. Fauci and Collins were warned that COVID-19 may have leaked from the Wuhan Institute of Virology (WIV) and that the virus appeared to be the result of genetic engineering. Minutes from the cal...
09:56
Higher serum vitamin C concentrations were significantly associated with lower risk of mortality in participants with T2D. GreenMedInfo
PMID: Eur J Nutr. 2023 May 17. Epub 2023 May 17. PMID: 37195485 Abstract Title: Associations of serum vitamin C concentrations with risk of all-cause and cause-specific mortality among individuals with and without type 2 diabetes. Abstract: PURPOSE: Compared with people without diabetes, people with type 2 diabetes (T2D) are at higher risk of both subnormal vitamin C status and increased oxidative stress. We aimed to investigate the associations of serum vitamin C concentrations with all-cause and cause-specific mortality among adults with and without T2D.METHODS: The current analysis included 20,045 adults (2691 people with T2D and 17,354 without T2D) from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 2003-2006. Cox proportional hazards regression models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline analyses were used to examine the dose-response relationship.RESULTS: After a median follow-up of 17.3 years, 5211 deaths were documented. Individuals with T2D had a lower level of serum vitamin C concentrations compared with those without T2D (the median value: 40.1 vs. 44.9 mol/L). Furthermore, the dose-response relationship between serum vitamin C and mortality showed different patterns between participants with and without T2D. In individuals without T2D, there was a nonlinear association of serum vitamin C concentrations with all-cause, cancer, and CVD mortality, with the lowest risk around a serum vitamin C concentration of 48.0 mol/L (all P
09:20
The effect of FMT and vitamin C on immunity-related genes in antibiotic-induced dysbiosis. GreenMedInfo
PMID: PeerJ. 2023 ;11:e15356. Epub 2023 May 11. PMID: 37193034 Abstract Title: The effect of FMT and vitamin C on immunity-related genes in antibiotic-induced dysbiosis in mice. Abstract: Antibiotics are double-edged swords. Although antibiotics are used to inhibit pathogenic bacteria, they also run the risk of destroying some of the healthy bacteria in our bodies. We examined the effect of penicillin on the organism through a microarray dataset, after which 12 genes related to immuno-inflammatory pathways were selected by reading the literature and validated using neomycin and ampicillin. The expression of genes was measured using qRT-PCR. Several genes were significantly overexpressed in antibiotic-treated mice, including CD74 and SAA2 in intestinal tissues that remained extremely expressed after natural recovery. Moreover, transplantation of fecal microbiota from healthy mice to antibiotic-treated mice was made, where GZMB, CD3G, H2-AA, PSMB9, CD74, and SAA1 were greatly expressed; however, SAA2 was downregulated and normal expression was restored, and in liver tissue, SAA1, SAA2, SAA3 were extremely expressed. After the addition of vitamin C, which has positive effects in several aspects, to the fecal microbiota transplantation, in the intestinal tissues, the genes that were highly expressed after the fecal microbiota transplantation effectively reduced their expression, and the unaffected genes remained normally expressed, but the CD74 gene remained highly expressed. In liver tissues, normally expressed genes were not affected, but the expression of SAA1 was reduced and the expression of SAA3 was increased. In other words, fecal microbiota transplantation did not necessarily bring about a positive effect of gene expression restoration, but the addition of vitamin C effectively reduced the effects of fecal microbiota transplantation and regulated the balance of the immune system.
08:59
Fecal microbiota transplantation holds the secret to youth. GreenMedInfo
PMID: Mech Ageing Dev. 2023 Jun ;212:111823. Epub 2023 May 14. PMID: 37192676 Abstract Title: Fecal microbiota transplantation holds the secret to youth. Abstract: Aging shows itself not just at the cellular level, with shortened telomeres and cell cycle arrest, but also at the organ and organismal level, with diminished brainpower, dry eyes, intestinal inflammation, muscular atrophy, wrinkles, etc. When the gut microbiota, often called the "virtual organ of the host," fails to function normally, it can lead to a cascade of health problems including, but not limited to, inflammatory bowel disease, obesity, metabolic liver disease, type II diabetes, cardiovascular disease, cancer, and even neurological disorders. An effective strategy for restoring healthy gut bacteria is fecal microbiota transplantation (FMT). It can reverse the effects of aging on the digestive system, the brain, and the vision by transplanting the functional bacteria found in the excrement of healthy individuals into the gut tracts of patients. This paves the way for future research into using the microbiome as a therapeutic target for disorders associated with aging.
08:43
Gut microbiota is an impact factor based on the brain-gut axis to Alzheimer's disease. GreenMedInfo
PMID: Aging Dis. 2023 Jun 1 ;14(3):964-1678. Epub 2023 Jun 1. PMID: 37191418 Abstract Title: Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer's Disease: A Systematic Review. Abstract: Alzheimer's disease (AD) is a degenerative disease of the central nervous system. The pathogenesis of AD has been explained using cholinergic,-amyloid toxicity, tau protein hyperphosphorylation, and oxidative stress theories. However, an effective treatment method has not been developed. In recent years, with the discovery of the brain-gut axis (BGA) and breakthroughs made in Parkinson's disease, depression, autism, and other diseases, BGA has become a hotspot in AD research. Several studies have shown that gut microbiota can affect the brain and behavior of patients with AD, especially their cognitive function. Animal models, fecal microbiota transplantation, and probiotic intervention also provide evidence regarding the correlation between gut microbiota and AD. This article discusses the relationship and related mechanisms between gut microbiota and AD based on BGA to provide possible strategies for preventing or alleviating AD symptoms by regulating gut microbiota.
08:21
Fecal microbiota transplantation in inflammatory bowel disease. GreenMedInfo
PMID: Biomedicines. 2023 Mar 27 ;11(4). Epub 2023 Mar 27. PMID: 37189634 Abstract Title: Fecal Microbiota Transplantation in Inflammatory Bowel Disease. Abstract: Inflammatory bowel diseases represent a complex array of diseases of incompletely known etiology that led to gastrointestinal tract chronic inflammation. In inflammatory bowel disease, a promising method of treatment is represented by fecal microbiota transplantation (FMT), FMT has shown its increasing effectiveness and safety in recent years for recurrent CDI; moreover, it showed real clinical benefits in treating SARS-CoV-2 and CDI co-infection. Crohn's disease and ulcerative colitis are characterized by immune dysregulation, resulting in digestive tract damage caused by immune responses. Most current therapeutic strategies are associated with high costs and many adverse effects by directly targeting the immune response, so modifying the microbial environment by FMT offers an alternative approach that could indirectly influence the host's immune system in a safe way. Studies outline the endoscopic and clinical improvements in UC and CD in FMT patients versus control groups. This review outlines the multiple benefits of FMT in the case of IBD by improving patients unbalanced gut, therefore improving endoscopic and clinical symptomatology. We aim to emphasize the clinical importance and benefits of FMT in order to prevent flares or complications of IBD and to highlight that further validation is needed for establishing a clinical protocol for FMT in IBD.
08:04
08:00
The gut microbiota, its relationship to the immune system, and possibilities of its modulation. GreenMedInfo
PMID: Epidemiol Mikrobiol Imunol. 2023 ;72(1):40-53. PMID: 37185024 Abstract Title: The gut microbiota, its relationship to the immune system, and possibilities of its modulation. Abstract: Research of the gut microbiota allows a better understanding of its composition and function and reveals the links between changes in the composition of bacteria and various intestinal but also systemic diseases. The gut microbiota performs several of important functions in the host body and influences many physiological processes. Gut bacteria synthesize many compounds needed for the proper function of the body (e.g., vitamins, short-chain fatty acids, and amino acids). They help maintain the integrity of the intestinal barrier and protect against pathogens. The gut microbiota plays a crucial role in the development and function of the immune system. Significant changes in the composition of the intestinal microbiota led to a dysbiotic state and the loss of its beneficial functions for humans. The review article summarizes the basic knowledge about the composition and function of the bacterial gut microbiota in healthy people, its role in the development of the immune system, and the mechanisms involved in maintaining homeostasis. It also presents current knowledge about the possibility of targeted modulation of the bacterial gut microbiota and faecal transplantation.
07:34
Do Ginkgo biloba supplements have any effect on dementia? Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
There are many claims that the ginkgo biloba supplement has a positive effect on cognitive health including reducing the effects of dementia.
07:21
Fecal microbiota transplantation in the treatment of systemic lupus erythematosus. GreenMedInfo
PMID: J Autoimmun. 2023 May 11:103058. Epub 2023 May 11. PMID: 37179170 Abstract Title: Fecal microbiota transplantation in the treatment of systemic lupus erythematosus: What we learnt from the explorative clinical trial. Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease with the characterized presence of autoantibodies and resulting in multiple organ damage, which is incurable and can be lethal. The current treatments are limited and less progress has been made in drug discovery for the last few decades. Researches imply that gut dysbiosis exists in both patients and murine models with SLE, taking part in the pathogenesis of SLE through multiple mechanisms such as microbiota translocation and molecular mimicry. Intestinal interventions on the gut microbiome by fecal transplantations to reconstitute the gut-immunity homeostasis serve as a novel therapeutic option for SLE patients. Fecal microbiota transplantation (FMT), which is usually used in intestinal diseases, has been firstly demonstrated to be safe and efficient in recovering gut microbiota structure of SLE patients and reducing lupus activity in our recent clinical trial, which is the first trial testing FMT therapy in SLE treatment. In this paper, we reviewed the results of the single-arm clinical trial and made recommendations on FMT practice in SLE treatment including therapeutic indications, screening items and dosage regimen, trying to provide references for future study and clinical practice. We also came up with the unanswered questions that need to be solved by the ongoing randomized controlled trial as well as the future expectations for the intestinal intervention strategies of SLE patients.
06:36
Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection. GreenMedInfo
PMID: Cell Host Microbe. 2023 May 10 ;31(5):695-711. PMID: 37167952 Abstract Title: Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection. Abstract: Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood. Herein, we provide an overview of rCDI pathogenesis followed by a discussion of potential mechanisms of action focusing on the current understanding of trans-kingdom microbial, metabolic, immunological, and epigenetic mechanisms. We then outline the current research gaps and offer methodological recommendations for future studies to elevate the quality of research and advance knowledge translation. By combining interventional trials with multiomics technology and host and environmental factors, analyzing longitudinally collected biospecimens will generate results that can be validated with animal and other models. Collectively, this will confirm causality and improve translation, ultimately to develop targeted therapies to replace FMT.
06:28
The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease. GreenMedInfo
PMID: Front Physiol. 2023 ;14:1166685. Epub 2023 Apr 21. PMID: 37153213 Abstract Title: The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease. Abstract: Diabetic kidney disease (DKD) is a common complication in patients with diabetes mellitus (DM). Increasing evidence suggested that the gut microbiota participates in the progression of DKD, which is involved in insulin resistance, renin-angiotensin system (RAS) activation, oxidative stress, inflammation and immunity. Gut microbiota-targeted therapies including dietary fiber, supplementation with probiotics or prebiotics, fecal microbiota transplantation and diabetic agents that modulate the gut microbiota, such as metformin, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose transporter-2 (SGLT-2) inhibitors. In this review, we summarize the most important findings about the role of the gut microbiota in the pathogenesis of DKD and the application of gut microbiota-targeted therapies.
06:24
Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells. GreenMedInfo
n/a PMID: In Vitro Cell Dev Biol Anim. 2023 Apr ;59(4):264-276. Epub 2023 May 12. PMID: 37173557 Abstract Title: Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells: the role of PGC1-SIRT3 axis. Abstract: Resveratrol (Res) is a bioactive dietary component and alleviates apoptosis in multiple cell types. However, its effect and mechanism on lipopolysaccharide (LPS)-induced bovine mammary epithelial cells (BMEC) apoptosis, which commonly happens in dairy cows with mastitis, is unknown. We hypothesized that Res would inhibit LPS-induced apoptosis in BMEC through SIRT3, a NAD+-dependent deacetylase activated by Res. To test the dose-response effect on apoptosis, 0-50 M Res were incubated with BMEC for 12 h, followed by 250 g/mL LPS treatment for 12 h. To investigate the role of SIRT3 in Res-mediated alleviation of apoptosis, BMEC were pretreated with 50 M Res for 12 h, then incubated with si-SIRT3 for 12 h and were finally treated with 250 g/mL LPS for 12 h. Res dose-dependently promoted the cell viability and protein levels of Bcl-2 (Linear P<0.001) but decreased protein levels of Bax, Caspase-3 and Bax/Bcl-2 (Linear P<0.001). TUNEL assays indicated that cellular fluorescence intensity declined with the rising doses of Res. Res also dose-dependently upregulated SIRT3 expression, but LPS had the opposite effect. SIRT3 silencing abolished these results with Res incubation. Mechanically, Res enhanced the nuclear translocation of PGC1, the transcriptional cofactor for SIRT3. Further molecular docking analysis revealed that Res could directly bind to PGC1by forming a hydrogen bond with Tyr-722. Overall, our data suggested that Res relieved LPS-induced BMEC apoptosis through the PGC1-SIRT3 axis, providing a basis for further in vivo investigations of applying Res to relieve mastitis in dairy cows.
06:10
Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart. GreenMedInfo
PMID: J Pharmacol Sci. 2023 Jun ;152(2):112-122. Epub 2023 Apr 11. PMID: 37169475 Abstract Title: Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice. Abstract: Aging is associated with impairment of multiple organs, including skeletal muscle and heart. In this study, we investigated whether resveratrol, an activator of an NAD-dependent protein deacetylase Sirtuin-1 (SIRT1), attenuates age-related sarcopenia and cardiomyocyte hypertrophy in mice. Treatment of mice with resveratrol (0.4 g/kg diet) from 28 weeks of age for 32 weeks prevented aging-associated shortening of rotarod riding time. In the tibialis anterior (TA) muscle, histogram analysis showed that the atrophic muscle was increased in 60-week-old (wo) mice compared with 20-wo mice, which was attenuated by resveratrol. In the heart, resveratrol attenuated an aging-associated increase in the cardiomyocyte diameter. Acetylated proteins were increased and autophagic activity was reduced in the TA muscle of 60-wo mice compared with those of 20-wo mice. Resveratrol treatment reduced levels of acetylated proteins and restored autophagic activity in the TA muscle. Aging-related reduction in myocardial autophagy was also suppressed by resveratrol. Skeletal muscle-specific SIRT1 knockout mice showed increases in acetylated proteins and atrophic muscle fibers and reduced autophagic activity in the TA muscle. These results suggest that activation of SIRT1 by treatment with resveratrol suppresses sarcopenia and cardiomyocyte hypertrophy by restoration of autophagy in mice.
06:10
The science of red meat and cancer what does it say? Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
This article will review the evidence that may support or reject the claim that red meat is linked to cancer.
06:04
Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells. GreenMedInfo
PMID: Breast Cancer. 2023 May 11. Epub 2023 May 11. PMID: 37166625 Abstract Title: Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells. Abstract: BACKGROUND: Triple-negative breast cancer (TNBC) has an aggressive phenotype and poor outcome, however no specific targeted therapy has been established for TNBC lacking germline BRCA1/2 pathogenic variants. To develop a novel therapeutic strategy, we explored the potential of resveratrol (RSV) for TNBC treatment.METHODS: We investigated the effects of RSV on malignant phenotypes of TNBC cells as well as on apoptosis induced by ABT263, a specific inhibitor of BCL-2 and BCL-xL, using morphological observation, migration assay,-galactosidase staining, and Hoechst staining. To elucidate the underlying mechanisms of RSV-mediated effects, expression levels and histone acetylation levels of cadherin 1 (CDH1, E-cadherin) and cyclin dependent kinase inhibitor 1A (CDKN1A, p21) were determined by RT-qPCR, western blotting, and chromatin immunoprecipitation. Furthermore, knockdown analysis was conducted to evaluate the involvement of E-cadherin and/or p21 in RSV potentiation on cytotoxic activity of ABT263.RESULTS: RSV treatment induced epithelial-like cellular morphology and suppressed the migration capacity in MDA-MB-231 and BT-549-Luc TNBC cells.-galactosidase-positive cells were increased after RSV treatment, indicating the induction of cellular senescence, in MDA-MB-231 cells but not in BT-549-Luc cells. RSV increased the expression and histone acetylation of CDH1 and CDKN1A in both cells. Interestingly, pre-treatment with RSV enhanced the induction of apoptosis in the ABT263-treated MDA-MB-231 and BT-549-Luc cells, and knockdown of CDKN1A decreased ABT263-induced apoptosis in RSV-treated MDA-MB-231 cells.CONCLUSIONS: RSV represses the metastatic capacity and enhances the cytotoxic activity of ABT263 in TNBC cells. Our results suggested that RSV can potentially be used as a repressor of metastasis or a sensitizer to ABT263 for TNBC treatment via up-regulation of CDH1 and CDKN1A through epigenetic mechanisms.
06:02
Nanoparticles enhance solubility and neuroprotective effects of resveratrol in demyelinating disease. GreenMedInfo
PMID: Neurotherapeutics. 2023 May 9. Epub 2023 May 9. PMID: 37160530 Abstract Title: Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease. Abstract: Resveratrol is a natural polyphenol which may be useful for treating neurodegenerative diseases such as multiple sclerosis (MS). To date, current immunomodulatory treatments for MS aim to reduce inflammation with limited effects on the neurodegenerative component of this disease. The purpose of the current study is to develop a novel nanoparticle formulation of resveratrol to increase its solubility, and to assess its ability to prevent optic nerve and spinal cord degeneration in an experimental autoimmune encephalomyelitis (EAE) mouse model of MS. Resveratrol nanoparticles (RNs) were made using a thin rehydration technique. EAE mice received a daily oral administration of vehicle, RNs or unconjugated resveratrol for one month. They were assessed daily for clinical signs of paralysis and weekly for their visual acuity with optokinetic responses (OKR). After one month, their spinal cords and optic nerves were stained for inflammation and demyelination and retinal ganglion cells immunostained for Brn3a. RNs were stable for three months. The administration of RNs did not have any effect on clinical manifestation of EAE and did not preserve OKR scores but reduced the intensity of the disease. It did not reduce inflammation and demyelination in the spinal cord and the optic nerve. However, RNs were able to decrease RGC loss compared to the vehicle. Results demonstrate that resveratrol is neuroprotective by reducing RGC loss. Interestingly, neuroprotective effects and decreased disease severity occurred without reduction of inflammation or demyelination, suggesting this therapy may fill an unmet need to limit the neurodegenerative component of MS.
05:52
NEW! Expedition Decoding the Mystery of the Great Pyramid and Homeopathy Begins This Fall GreenMedInfo
Visit our Re-post guidelines
This fall, in a series of ground-breaking water memory experiments to be conducted legendary CymaScope instrument is set to reveal insights into the mechanisms of homeopathy, as well shedding light on what the real purpose of the King's Chamber may be.
To learn how you can contribute to this important research mission, join the upcoming AUREA event on June 9-11th, and please read on...
05:44
Is Mental Illness Actually the Brain Trying to Protect Itself? Mad In America
From Emergent Divergence: People hold on tightly to the idea that they are mentally ill, and understandably so. The deficit model of mental health has been pushed on us quite successfully, but what if its not the person who is ill?
Consider depression. A person experiences a traumatic event . . . and starts to feel as though nothing goes well for them. They withdraw from their environment and isolate. Is this an illness, or is this the human brain doing its best to protect itself from trauma?
Now consider that the cultures [we] live with, particular in Western society, actively punish people who have experienced trauma. There is a lack of welfare benefits, inadequate and under-resourced wellbeing services, and lets not forget that humans are effectively judged by whether or not they make the right amount of profit while performing a neurotypical display so as to not make others uncomfortable.
To me it seems clear where the suffering is actually stemming from, and it isnt the person.
***
Back to Around the Web
The post Is Mental Illness Actually the Brain Trying to Protect Itself? appeared first on Mad In America.
05:43
Unbeloved by Anonymous Mad In America
In a bid for peace
Silence was key
I hated the the role
He forced on me
No longer a child
I was deemed as property
A beast that
Needed to be broken
To fit in his society
Even animals learn to hate
When broken so violently
I remember his roses
I remembered I loved him
Once upon a time
When I was a child.
****
Back to Poetry Gallery
The post Unbeloved by Anonymous appeared first on Mad In America.
05:35
The effects of resveratrol and melatonin on cardiac dysfunction in diabetic elderly female rats. GreenMedInfo
PMID: Physiol Res. 2023 Apr 30 ;72(2):187-198. PMID: 37159853 Abstract Title: The effects of resveratrol and melatonin on cardiac dysfunction in diabetic elderly female rats. Abstract: We aimed to investigate the effects of melatonin and resveratrol on diabetes-related papillary muscle dysfunction and structural heart disorders. The protective effect of resveratrol and melatonin supplementation on cardiac functions was investigated in a diabetic elderly female rat model. 16-month-old rats (n=48) were allocated into 8 groups. Group1: Control, Group2: Resveratrol Control, Group3: Melatonin Control, Group4: Resveratrol and Melatonin Control, Group5: Diabetes, Group6: Diabetes Resveratrol, Group7: Diabetes Melatonin, Group8: Diabetes Resveratrol and Melatonin. Streptozotocin was injected intraperitoneally to the rats for experimental diabetes induction. Thereafter, resveratrol (intraperitoneal) and melatonin (subcutaneous) were administered for 4 weeks. Resveratrol and melatonin had a protective effect on the contractile parameters and structural properties of the papillary muscle, which was impaired by diabetes. it has been presented that diabetes impairs the contractile function of the papillary muscle for each stimulus frequency tested and the responses obtained as a result of Ca+2 uptake and release mechanisms from the Sarcoplasmic reticulum, and it has been observed that these effects are improved with resveratrol and melatonin injection. The decrease in myocardial papillary muscle strength in the diabetic elderly female rat can be reversed with the combination of resveratrol, melatonin and resveratrol+melatonin. Melatonin+resveratrol supplementation is no different from melatonin and/or resveratrol supplementation. Resveratrol and melatonin supplementation may have a protective effect on cardiac functions in a diabetic elderly female rat model.
05:30
Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury. GreenMedInfo
PMID: Int Immunopharmacol. 2023 May ;118:110111. Epub 2023 Apr 5. PMID: 37028275 Abstract Title: Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3/caspase-1/gasdermin D-mediated pyroptosis. Abstract: BACKGROUND: Sodium tanshinone IIA sulfonate (STS) has been reported to protect organ function in sepsis. However, the attenuation of sepsis-associated brain injury and its underlying mechanisms by STS has not been established.METHODS: C57BL/6 mice were used to establish the cecal ligation perforation (CLP) model, and STS was injected intraperitoneally 30 min before the surgery. The BV2 cells were stimulated by lipopolysaccharide after being pre-treated with STS for 4 h. The STS protective effects against brain injury and in vivo anti-neuroinflammatory effects were investigated using the 48-hour survival rate and body weight changes, brain water content, histopathological staining, immunohistochemistry, ELISA, RT-qPCR, and transmission electron microscopy. The pro-inflammatory cytokines of BV2 cells were detected by ELISA and RT-qPCR. At last, the levels of NOD-like receptor 3 (NLRP3) inflammasome activation and pyroptosis in brain tissues of the CLP model and BV2 cells were detected using western blotting.RESULTS: STS increased the survival rate, decreased brain water content, and improved brain pathological damage in the CLP models. STS increased the expressions of tight junction proteins ZO-1 and Claudin5 while reducing the expressions of tumor necrosis factor(TNF-), interleukin-1(IL-1), and interleukin-18 (IL-18) in the brain tissues of the CLP models. Meanwhile, STS inhibited microglial activation and M1-type polarization in vitro and in vivo. The NLRP3/caspase-1/ gasdermin D (GSDMD)-mediated pyroptosis was activated in the brain tissues of the CLP models and lipopolysaccharide (LPS)-treated BV2 cells, which was significantly inhibited by STS.CONCLUSIONS: The activation of NLRP3/caspase-1/GSDMD-mediated pyroptosis and subsequent secretion of proinflammatory cytokines may be the underlying mechanisms of STS against sepsis-associated brain injury and neuroinflammatory response.
04:53
Video: How To Perform Vertical Mattress Sutures
In this video episode in a series on how to perform suture closures, Dr. Joe Alton discusses and demonstrates the very useful vertical mattress suture. Use for areas under tension and other applications, the vertical mattress suture is another tool in the woodshed for the family medic in times of trouble. To watch, click below:[Read More]
The post Video: How To Perform Vertical Mattress Sutures first appeared on .04:37
Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth. GreenMedInfo
PMID: Cell Death Discov. 2023 May 19 ;9(1):172. Epub 2023 May 19. PMID: 37202382 Abstract Title: Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth. Abstract: Glioblastomas are a highly aggressive cancer type which respond poorly to current pharmaceutical treatments, thus novel therapeutic approaches need to be investigated. One such approach involves the use of the bioactive natural product Tanshinone IIA (T2A) derived from the Chinese herb Danshen, where mechanistic insight for this anti-cancer agent is needed to validate its use. Here, we employ a tractable model system, Dictyostelium discoideum, to provide this insight. T2A potently inhibits cellular proliferation of Dictyostelium, suggesting molecular targets in this model. We show that T2A rapidly reduces phosphoinositide 3 kinase (PI3K) and protein kinase B (PKB) activity, but surprisingly, the downstream complex mechanistic target of rapamycin complex 1 (mTORC1) is only inhibited following chronic treatment. Investigating regulators of mTORC1, including PKB, tuberous sclerosis complex (TSC), and AMP-activated protein kinase (AMPK), suggests these enzymes were not responsible for this effect, implicating an additional molecular mechanism of T2A. We identify this mechanism as the increased expression of sestrin, a negative regulator of mTORC1. We further show that combinatory treatment using a PI3K inhibitor and T2A gives rise to a synergistic inhibition of cell proliferation. We then translate our findings to human and mouse-derived glioblastoma cell lines, where both a PI3K inhibitor (Paxalisib) and T2A reduces glioblastoma proliferation in monolayer cultures and in spheroid expansion, with combinatory treatment significantly enhancing this effect. Thus, we propose a new approach for cancer treatment, including glioblastomas, through combinatory treatment with PI3K inhibitors and T2A.
04:30
Fucoidan promotes angiogenesis and accelerates wound healing. GreenMedInfo
PMID: Int Wound J. 2023 May 18. Epub 2023 May 18. PMID: 37203309 Abstract Title: Fucoidan promotes angiogenesis and accelerates wound healing through AKT/Nrf2/HIF-1signalling pathway. Abstract: After skin injury, wound repair involves a complex process in which angiogenesis plays a crucial role. Previous research has indicated that fucoidan may aid in wound healing; we therefore hypothesised that fucoidan may speed up the process by promoting angiogenesis. In this study, we investigated the potential molecular mechanism underlying fucoidan's ability to accelerate wound healing by promoting angiogenesis. Using a full-cut wound model, we observed that fucoidan significantly intensified wound closure and promoted granulation formation and collagen deposition. Immunofluorescence staining revealed that fucoidan also promoted wound angiogenesis, specifically by accelerating the migration of new blood vessels to the middle area of the wound. Furthermore, fucoidan demonstrated the ability to enhance the proliferation of human umbilical vein endothelial cells (HUVECs) damaged by hydrogen peroxide (HO) and to improve the formation of endothelial tubes. Mechanistic studies revealed that fucoidan upregulated the protein levels of the AKT/Nrf2/HIF-1signalling pathway, which plays a crucial role in angiogenesis. This was further confirmed using the inhibitor LY294002, which reversed the promotion of endothelial tube formation by fucoidan. Overall, our findings suggest that fucoidan can promote angiogenesis via the AKT/Nrf2/HIF-1signalling pathway and accelerate wound healing.
04:19
Sayer Ji: Anti-Vaxx Extremist or Whistleblower? The SECRET to How I Survive GreenMedInfo
Being targeted by my own government for exercising protected speech, and especially for telling the truth about the mRNA jabs in an attempt to warn the public before their roll-out has not been easy.
03:45
The Key to the Psych Unit Mad In America
My grandmother was a caregiver, an artist, and a ruthless bingo player. I always sought to understand how she experienced the world and learn from her. We talked about almost everything. When I came out as bi+/pansexual, we had a conversation. She shared that her sister might be gay and that she just wanted me to be happy. Her love felt strong and unconditional. She had a sweetness to her that was undeniable. I liked being in her presence and enjoyed the time we spent together sharing, playing cards, and laughing, always laughing.
It was not unusual that I also shared what I was learning in my post-secondary studies, but one time, the conversation was different. It was the late 90s and as an undergraduate psychology major, I was reading a book on electroconvulsive therapy (ECT). I was horrified to learn psychiatrists still conducted ECT, and I said as much to my grandma. She was quiet. Quieter than usual. She listened, but when I paused, she didnt respond. I directly asked her, Can you believe they still do this to people?!? She shared that she could. She shared that it was done to her.
We had talked about a lot over the years, but I had no idea she lived through that. Perhaps I should have. Our family was no stranger to mental health symptoms and clinical diagnoses. It was not a secret that my grandmothers sister lived in a psychiatric institution for most of her life, and my uncle spoke freely about how he drank because reading peoples thoughts was too overwhelming for him. Plus, most of the family had been in therapy at some point to deal with depression, abuse, or whatever the diagno...
03:27
Breaking: Jordan Releases 'Smoking Gun Docs' Confirming Facebook Bowed to White House Censorship Demands GreenMedInfo
Unredacted Facebook emails released by Rep. Jim Jordan today expose White House demands to quash narratives, and remove memes and posts contradicting the governments COVID-19 messaging.
03:18
Breaking: Jordan Releases 'Smoking Gun Docs' Confirming Facebook Bowed to White House Censorship Demands GreenMedInfo
Originally published on www.childrenshealthdefense.org by John-Michael Dumais
Unredacted Facebook emails released by Rep. Jim Jordan today expose White House demands to quash narratives, and remove memes and posts contradicting the government's COVID-19 messaging.
Go Back:30 Days | 7 Days | 2 Days | 1 Day
Friday, 28 July
17:04
Conspirituality: A Book Recommendation Science-Based Medicine
Conspirituality is a must-read for anyone who seeks to understand the daunting task we face in repairing the damage done by disinformation doctors.
The post Conspirituality: A Book Recommendation first appeared on Science-Based Medicine.12:07
People Actually Trying to Stop Child Trafficking are Often Murdered The CENSORED Linda Collins-Smith Story Medical Kidnap
How would you feel if you were fighting for the custody of your granddaughter after your daughter was killed, and before you had a chance to be heard in court about why you, as the granddparents, were in the best position to raise her, and then you saw that your granddaughter had already been adopted out to another family? One person who tried to expose this corruption is former Arkansas State Senator Linda Collins-Smith, who can no longer talk about this topic today because she was murdered.
by Brian Shilhavy
Editor, Health Impact News
In 2019 we interviewed Kathy Hall on KFNX Talk Radio out of Phoenix regarding the kidnapping of her granddaughter after her daughter was killed in Arkansas. She was close friends with Arkansas State Senator Linda Collins-Smith, who was working on her case and attempting to help her get custody of her granddaughter.
But after returning to Arkansas after a trip to Arizona, Arkansas State Senator Linda Collins-Smith was murdered.
Here is the episode:
This became a huge national story, and late last year ABCs 20/20 ran a documentary on the Linda Collins-Smith story, spinning the story in a specific direction that they obviously wanted the public to believe. You can watch it here (let us know if this video disappears):
https://abc.com/shows/2020/episode-guide/2022-10/28-red-handed
Kathy Hall, who was a close friend of Linda, had been interviewed by ABC during the filming of this show, but then ABC decided to exclude her testimony after her house burned down, the day before Rebecca ODonnell, who was being held as the suspect in Senator Smiths...
12:06
People Actually Trying to Stop Child Trafficking are Often Murdered The CENSORED Linda Collins-Smith Story Vaccine Impact
How would you feel if you were fighting for the custody of your granddaughter after your daughter was killed, and before you had a chance to be heard in court about why you, as the granddparents, were in the best position to raise her, and then you saw that your granddaughter had already been adopted out to another family? One person who tried to expose this corruption is former Arkansas State Senator Linda Collins-Smith, who can no longer talk about this topic today because she was murdered.
by Brian Shilhavy
Editor, Health Impact News
In 2019 we interviewed Kathy Hall on KFNX Talk Radio out of Phoenix regarding the kidnapping of her granddaughter after her daughter was killed in Arkansas. She was close friends with Arkansas State Senator Linda Collins-Smith, who was working on her case and attempting to help her get custody of her granddaughter.
But after returning to Arkansas after a trip to Arizona, Arkansas State Senator Linda Collins-Smith was murdered.
Here is the episode:
This became a huge national story, and late last year ABCs 20/20 ran a documentary on the Linda Collins-Smith story, spinning the story in a specific direction that they obviously wanted the public to believe. You can watch it here (let us know if this video disappears):
https://abc.com/shows/2020/episode-guide/2022-10/28-red-handed
Kathy Hall, who was a close friend of Linda, had been interviewed by ABC during the filming of this show, but then ABC decided to exclude her testimony after her house burned down, the day before Rebecca ODonnell, who was being held as the suspect in Senator Smiths...
11:20
People Actually Trying to Stop Child Trafficking are Often Murdered The CENSORED Linda Collins-Smith Story Health Impact News
How would you feel if you were fighting for the custody of your granddaughter after your daughter was killed, and before you had a chance to be heard in court about why you, as the granddparents, were in the best position to raise her, and then you saw that your granddaughter had already been adopted out to another family? One person who tried to expose this corruption is former Arkansas State Senator Linda Collins-Smith, who can no longer talk about this topic today because she was murdered.
by Brian Shilhavy
Editor, Health Impact News
In 2019 we interviewed Kathy Hall on KFNX Talk Radio out of Phoenix regarding the kidnapping of her granddaughter after her daughter was killed in Arkansas. She was close friends with Arkansas State Senator Linda Collins-Smith, who was working on her case and attempting to help her get custody of her granddaughter.
But after returning to Arkansas after a trip to Arizona, Arkansas State Senator Linda Collins-Smith was murdered.
Here is the episode:
This became a huge national story, and late last year ABCs 20/20 ran a documentary on the Linda Collins-Smith story, spinning the story in a specific direction that they obviously wanted the public to believe. You can watch it here (...
10:00
Elon Musk Puts Brakes on CISA Censorship Articles
July 1, 2023, Elon Musk announced new limits to the number of Twitter posts users could view in a day. The number varied by user, with verified accounts initially able to read 6,000 posts a day, unverified accounts 600 posts a day and new unverified accounts 300 per day.1
The number has fluctuated since, increasing to 10,000, 1,000 and 500, respectively,2 but the sentiment is the same. Gone are the days where unlimited post viewing was possible at least temporarily. While much pushback has ensued from users, theres a reason why this move is actually a major win for your privacy and online freedom. Its stopped mega censorship operatives in their tracks.
Twitter Viewing Limits Address Extreme Data Scraping
We dont know why Musk instituted limits to the number of tweets users could view. It could simply be a business move, one aimed at boosting verified accounts. He also tweeted at one point, "The reason I set a View Limit is because we are all Twitter addicts and need to go outside. Im doing a good deed for the world here. Also, thats another view you just used."3
But in his official tweet about the change, Musk stated the limits were applied "to address extreme levels of data scraping & system manipulation."4 In a video posted to Twitter, Mike Benz, a former State Department diplomat responsible for formulating and negotiating U.S. foreign policy on international communications and information technology matters,5 stated, "Musk has no idea the DARPA rattlesnake he just stepped on by doing this."6
Benz also shared what he believes will be wide-reaching implications for the science of censorship, since Musks view limit cuts off intelligence agencies "censorship death star" AI at the knees.
"AI censorship is where all of the magic happens," he explains,7 referencing Elon Musks Twitter Files, which exposed the many ways social media platforms censored Americans at the behest of the U.S. government. Benz says:8
"The Twitter Files showed how the FBI might come in and get 22 tweets censored. But AI was how EIP [Election Integrity Partnership] and other third-party censorship groups were able to get 22 million tweets censored Its a completely different animal. You could not censor the internet before 2016 at the...
The Wide-Ranging Health Benefits of Taurine Articles
The amino acid taurine is found in animal foods such as seafood, grass-fed red meat, dairy products, pastured eggs, and poultry. Of the amino acids, its the most abundant source of sulfur, and is required for a wide range of physiological processes, including the healthy function of your immune system, nervous system,1,2 metabolism and digestion.3
As noted in a 2021 scientific review titled The Role of Taurine in Mitochondrial Health: More Than Just an Antioxidant:4
Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in excitatory tissues, such as the heart, brain, retina and skeletal muscles ...
Accumulating studies have shown that taurine supplementation also protects against pathologies associated with mitochondrial defects, such as aging, mitochondrial diseases, metabolic syndrome, cancer, cardiovascular diseases, and neurological disorders.
Mechanisms of Action
More specific mechanisms of action of taurine include but are not limited to:
...|
Stabilizing proteins5 |
|
Enhancing the function of endogenous antioxidants, thereby supporting your bodys ability to defend against oxidative/reductive damage.6 It protects your antioxidant status in several ways, including by neutralizing hypochlorous acid,7 diminishing the generation of superoxide by the mitochondria,8 and by minimizing oxidative stress,9 including mitochondrial oxidative stress induced by toxins10 |
|
Reducing insulin resistance, hyperglycemia, and glucose serum concentrations11,12 |
Does Full-Fat Dairy Promote Heart Disease? Research Says No Articles
Editor's Note: This article is a reprint. It was originally published July 30, 2018.
Whole milk, cheese and butter have long been demonized as unhealthy, their saturated fat content incorrectly identified as a driver of obesity, heart disease and related health problems. We now know eating fat does not make you fat. Science has also demolished the idea that saturated fats clog your arteries and promote heart disease. On the contrary, these fats are important for optimal health, and combat many of today's chronic diseases, including heart disease.
While the low-fat myth still lives, the 2015 Dietary Guidelines for Americans1 does recognize that reducing TOTAL fat intake has no bearing on obesity or heart disease risk.
Instead, the guidelines rightfully warn that sugar and refined grains are the primary culprits. Unfortunately, the guidelines fall far short by still suggesting a 10% limit on saturated fats especially, and the low-fat dairy recommendation remains. This, even though mounting research supports consumption of full-fat dairy products over low-fat ones.
Full-Fat Dairy Consumption Has No Influence on Mortality Rates
In a recent article in The Atlantic,2 senior editor Dr. James Hamblin discusses "the vindication" of full-fat dairy, and the research that's tossing low-fat recommendations by the wayside. One of the most recent studies,3 which analyzed the blood fats in more than 2,900 adults, found the mortality rate during a 22-year period was identical regardless of their levels. "The implication is that it didn't matter if people drank whole or skim or 2-percent milk " Hamblin writes.
At the end of the day, consumption of dairy fats either high or low does not appear to influence your risk of death.
Corresponding author Marcia de Oliveira Otto, assistant professor of epidemiology, human genetics, and environmental science at the University of Texas School of Public Health, told Hamblin, "I think the big news here is that even though there is this conventional wisdom that whole-fat dairy is bad for heart disease, we didn't find that. And it's not only us. A number of recent studies have found the same thing."
For example, a systematic review and meta-analysis4 published in 2014, which looked at 32 observational studies with well over half a million participants, concluded that, "Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids and low consumption of total saturated fats."
Otto did note, however, that whole milk is likel...
09:37
Fucoidan mitigates gastric ulcer injury through managing inflammation, oxidative stress, and NLRP3-mediated pyroptosis. GreenMedInfo
PMID: Int Immunopharmacol. 2023 Jul ;120:110335. Epub 2023 May 16. PMID: 37201406 Abstract Title: Fucoidan mitigates gastric ulcer injury through managing inflammation, oxidative stress, and NLRP3-mediated pyroptosis. Abstract: This study aimed to elucidate the gastro-protective effect of fucoidan against ethanol-induced gastric ulcer mediated via NLRP3-induced pyroptosis as an underlying mechanism, not yet assessed in prior research. Forty-eight male Albino mice were divided into six groups: Group I (normal control), group II (Ulcer/ethanol control), group III (Omeprazole + ethanol), group IV (fucoidan 25 mg + ethanol), group V (fucoidan 50 mg + ethanol) and group VI (fucoidan only). Fucoidan was administered orally for seven consecutive days followed by ulcer induction by a single oral dose of ethanol. Using colorimetric analysis, ELISA, qRT-PCR, histological assessment, and immunohistochemical studies, the results revealed that ethanol-induced ulcer exhibited an ulcer score of 42.5 5.1 and a significant increase (p
09:13
Revealed: Dark Money Funders Behind 'Disinformation Dozen' Report GreenMedInfo
A new expos by GreenMedInfo's Sayer Ji traces the donors to the Center for Countering Digital Hate to media empires, government and political influence networks
09:12
Revealed: Dark Money Funders Behind 'Disinformation Dozen' Report GreenMedInfo
Originally published on www.childrenshealthdefense.org
by Brenda Baletti, Ph.D.
A new expos by GreenMedInfo's Sayer Ji traces the donors to the Center for Countering Digital Hate to media empires, government and political influence networks.
09:12
Inhibitory effect of fucoidan on TNF--induced inflammation in human retinal pigment epithelium cells. GreenMedInfo
PMID: Front Nutr. 2023 ;10:1162934. Epub 2023 Apr 12. PMID: 37125026 Abstract Title: Inhibitory effect of fucoidan on TNF--induced inflammation in human retinal pigment epithelium cells. Abstract: () is a brown seaweed that contains a fucose-rich sulfated polysaccharide called fucoidan and is known to possess beneficial bioactivities, such as anti-inflammatory, antiviral, antioxidative, and antitumoral effects. This study aimed to determine the anti-inflammatory effects of AB_SH (hydrothermal extracts from) and its bioactive compound (fucoidan) against tumor necrosis factor alpha (TNF-)-induced inflammation in human retinal pigment epithelial (RPE) cells. AB_SH did not exhibit any cytotoxicity, and it decreased the mRNA expression of interleukin (IL)-6 and IL-8 and the production of the cytokines IL-6 and TNF-. It also suppressed the expression levels of phosphorylated nuclear factor kappa B (NF-B) and mitogen-activated protein kinases (MAPKs), including c-Jun amino-terminal kinases (JNK), p38 protein kinases (p38), and extracellular signal-regulated kinase (ERK) proteins, suggesting that AB_SH inhibits activation of the NF-kB/MAPK signaling pathway. Since fucoidan was identified in the composition analysis of AB_SH, it was additionally shown to be required for its anti-inflammatory effects in TNF--stimulated human RPE cells. In line with the AB_SH results, fucoidan reduced the mRNA levels of IL-6, IL-1, and IL-8 and production of the cytokines IL-6, TNF-, and IL-8 through the downregulation of the NF-kB/MAPK signaling pathway in a dose-dependent manner. Collectively, the ability of AB_SH fromhydrothermal extracts to reduce inflammation indicates that it may be a good functional ingredient for managing ocular disorders.
09:05
Optimize Your Health With Opti Supplements Dr. Tenpenny
Have you heard about my Opti line of supplements? For my entire medical career, I have strived to transform the practice of medicine. I use the foundations of osteopathy, functional []
08:53
Anti-atopic activities of Sargassum horneri hot water extracts. GreenMedInfo
PMID: J Microbiol Biotechnol. 2023 Mar 28 ;33(3):363-370. Epub 2023 Jan 13. PMID: 36775854 Abstract Title: Anti-Atopic Activities ofHot Water Extracts in 2,4-Dinitrochlorobezene-Induced Mouse Models. Abstract: Atopic dermatitis (AD) is a chronic inflammation associated with skin hypersensitivity caused by environmental factors. The objent of this study was to assess the hot water extracts of(SHHWE) on AD. AD was induced by spreading 2,4-dinitrochlorobenzene (DNCB) on the BALB/c mice. The efficacy of SHHWE was tested by observing the immunoglobulin E (IgE), cytokine, skin clinical severity score and cytokine secretions in concanavalin A (Con A)-stimulated splenocytes. The levels of interleukine (IL)-4, IL-5 and IgE, the pro-inflammatory cytokines that are closely related, were notably suppressed in a does-dependent manner by SHHWE, whereas the level of interferon(IFN-), the atopy-related Th1 cytokine inhibiting the production of Th2 cytokines, was increased. Therefore, these results show that SHHWE has a potent anti-inhibitory effect on AD and is highly valuable for cosmetic development.
08:33
Fucoxanthin suppresses the malignant progression of ovarian cancer. GreenMedInfo
PMID: Am J Transl Res. 2023 ;15(4):2528-2540. Epub 2023 Apr 15. PMID: 37193140 Abstract Title: Fucoxanthin suppresses the malignant progression of ovarian cancer by inactivating STAT3/c-Myc signaling. Abstract: OBJECTIVES: Ovarian cancer is a frequent malignancy among women. Fucoxanthin has been discovered to exert anti-tumor impacts on numerous tumors. Herein, the current work was carried out to identify the biological function of fucoxanthin on the malignant progression of ovarian cancer and to explore the underlying molecular mechanisms.METHODS: In this study, cell counting kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU) staining, wound healing, as well as transwell assays were employed to assess the malignant cell phenotypes, including cell proliferation, migration and invasion in ovarian cancer. The expression of related proteins was evaluated using western blot. Additionally, the glucose uptake, intracellular adenosine triphosphate (ATP), extracellular acidifications rates (ECAR) and glycolysis-associated enzymes were measured to evaluate glycolysis level.RESULTS: It was demonstrated that fucoxanthin restrained the proliferative, migratory and invasive capabilities in both A2780 and OVCAR3 cells. Fucoxanthin could inhibit glycolysis and inactivate signal transducers and activators of transcription 3 (STAT3)/c-Myc signaling. In addition, Colivelin, a STAT3 activator, greatly weakened the suppressive effects of fucoxanthin on ovarian cancer cell proliferation, migration, invasion and glycolysis.CONCLUSION: Fucoxanthin exerts anti-tumor activity in ovarian cancer, possibly via inactivation of the STAT3/c-Myc signaling pathway, and thus provides a novel therapeutic strategy for the treatment of ovarian cancer.
08:31
In Mississippi, Mental Health Problems Can Land You in Jail Without Charges Mad In America
From ProPublica: In every state, people who present a threat to themselves or others can be ordered to receive mental health treatment. Most states allow people with substance abuse problems to be ordered into treatment, too. The process is called civil commitment.
But Mississippi Today and ProPublica could not find any state other than Mississippi where people are routinely jailed without charges for days or weeks during that process.
. . . All told, people [in 19 Mississippi counties] were jailed at least 2,000 times for civil commitments alone from 2019 to 2022. None had been charged with a crime.
. . . Since 2006, at least 13 people have died in Mississippi county jails as they awaited treatment for mental illness or substance abuse, Mississippi Today and ProPublica found. Nine of the 13 killed themselves. At least 10 hadnt been charged with a crime.
. . . Many [people who had been committed and jailed] said they or their family members had been housed alongside criminal defendants. Nobody knew how long they would be there. They were often shackled when they left their cells. Some of them said they couldnt access prescribed psychiatric medications or had minimal medical care as they experienced withdrawal from illegal drugs.
It felt more criminal than, like, they were trying to help me, said Richard Millwood, who was booked into the DeSoto County jail in 2020 following an attempted suicide. I got the exact same treatment in there as I did when I was in jail facing charges. In fact worse, in my opinion, because at least when I was facing charges I could bond out.'
***
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The post In Mississippi, Mental Health Problems Can Land You in Jail Without Charges appeared first on Mad In America.
08:12
The role of fucoxanthin in non-alcoholic fatty liver disease. GreenMedInfo
PMID: Int J Mol Sci. 2023 May 3 ;24(9). Epub 2023 May 3. PMID: 37175909 Abstract Title: The Role of Fucoxanthin in Non-Alcoholic Fatty Liver Disease. Abstract: Chronic liver disease (CLD) has emerged as a leading cause of human deaths. It caused 1.32 million deaths in 2017, which affected men more than women by a two-to-one ratio. There are various causes of CLD, including obesity, excessive alcohol consumption, and viral infection. Among them, non-alcoholic fatty liver disease (NAFLD), one of obesity-induced liver diseases, is the major cause, representing the cause of more than 50% of cases. Fucoxanthin, a carotenoid mainly found in brown seaweed, exhibits various biological activities against NAFLD. Its role in NAFLD appears in several mechanisms, such as inducing thermogenesis in mitochondrial homeostasis, altering lipid metabolism, and promoting anti-inflammatory and anti-oxidant activities. The corresponding altered signaling pathways are the3-adorenarine receptor (3Ad), proliferator-activated receptor gamma coactivator (PGC-1), adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor (PPAR), sterol regulatory element binding protein (SREBP), nuclear factor kappa B (NF-B), mitogen-activated protein kinase (MAPK), protein kinase B (AKT), SMAD2/3, and P13K/Akt pathways. Fucoxanthin also exhibits anti-fibrogenic activity that prevents non-alcoholic steatohepatitis (NASH) development.
08:00
Happy Hour Spirit of the Antichrist series Pt 4 with JB Hixson Dr. Tenpenny
07-27-2023 Listen to audio here. If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-27-23-HHr-JBHixson-Pt4.mp4 Spirit of the Antichrist: The Gathering Cloud of Deception This []
07:31
A Review of the Effects of Fucoxanthin on NAFLD. GreenMedInfo
PMID: Nutrients. 2023 Apr 19 ;15(8). Epub 2023 Apr 19. PMID: 37111187 Abstract Title: A Review of the Effects of Fucoxanthin on NAFLD. Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease. Fucoxanthin, a red-orange marine carotenoid, is found in natural marine seaweeds with high antioxidant activity and several other remarkable biological features. The aim of this review is to gather evidence of the positive benefits of fucoxanthin on NAFLD. Fucoxanthin provides an extensive list of physiological and biological properties, such as hepatoprotective, anti-obesity, anti-tumor, and anti-diabetes properties, in addition to antioxidant and anti-inflammatory properties. This review focuses on published research on the preventative effects of fucoxanthin on NAFLD from the perspective of human clinical trials, animal experiments, andcell investigations. Using a variety of experimental designs, including treatment dosage, experiment model, and experimental periods, the positive effects of fucoxanthin were demonstrated. Fucoxanthin's biological activities were outlined, with an emphasis on its therapeutic efficacy in NAFLD. Fucoxanthin showed beneficial effects in modulating lipid metabolism, lipogenesis, fatty acid oxidation, adipogenesis, and oxidative stress on NAFLD. A deeper comprehension of NAFLD pathogenesis is essential for the development of novel and effective therapeutic strategies.
07:25
Reduce Belly Fat With This Seed GreenMedInfo
Excess belly fat is not only uncomfortable -- its associated with heart disease, inflammation, insulin resistance and other chronic diseases. Adding this seed to your daily meals may help
07:24
Reduce Belly Fat With This Seed GreenMedInfo
Visit our Re-post guidelines
Excess belly fat is not only uncomfortable -- it's associated with heart disease, inflammation, insulin resistance and other chronic diseases. Adding this seed to your daily meals is a simple way to target abdominal obesity
Need to eliminate stubborn belly fat? You may be thinking in terms of what to cut from your diet, but it may be time to switch gears. Adding flaxseed -- an annual herb rich in alpha-linolenic acid (ALA), fiber, and lignans -- may be key to reducing belly fat and maintaining a flat stomach.
07:18
Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis. GreenMedInfo
PMID: Chin Med. 2023 May 15 ;18(1):54. Epub 2023 May 15. PMID: 37189204 Abstract Title: Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation. Abstract: Rheumatoid arthritis (RA) is characterized by bone destruction in the afflicted joints, and during the process of bone destruction, osteoclasts play a crucial role. Tanshinone IIA (Tan IIA) has shown anti-inflammatory effects in RA. However, the exact molecular mechanisms by which it delays bone destruction remain largely unexplained. Here, we found that Tan IIA decreased the severity of and ameliorated bone loss in an AIA rat model. In vitro, Tan IIA inhibited RANKL-induced osteoclast differentiation. By activity-based protein analysis (ABPP) combined with LCMS/MS, we discovered that Tan IIA covalently binds to the lactate dehydrogenase subunit LDHC and inhibits its enzymatic activity. Moreover, we found that Tan IIA inhibits the generation of osteoclast-specific markers by reducing the accumulation of reactive oxygen species (ROS), thus reducing osteoclast differentiation. Finally, our results reveal that Tan IIA suppresses osteoclast differentiation via LDHC-mediated ROS generation in osteoclasts. Tan IIA can thus be regarded as an effective drug for the treatment of bone damage in RA.
07:08
Impact of Habitual yogurt intake in mother-child dyads on incidence of childhood otitis media. GreenMedInfo
PMID: Probiotics Antimicrob Proteins. 2023 May 17. Epub 2023 May 17. PMID: 37195509 Abstract Title: Impact of Habitual Yogurt Intake in Mother-Child Dyads on Incidence of Childhood Otitis Media: The Japan Environment and Children's Study (JECS). Abstract: Otitis media, one of the most common childhood diseases, is characterized by inflammation or infection of the middle ear. Due to their ease of access, daily probiotics are recommended for the prevention of early childhood otitis media. This study aimed to assess the impact of probiotics on the incidence of otitis media using a dataset (n=95,380) from the Japan Environment and Children's Study, a nationwide birth cohort study. After multiple imputations, the association between the incidence of otitis media in early childhood and the daily frequency of yogurt intake in children and mothers was examined using a generalized linear model after adjusting for several confounders. Repeated incidence of otitis media during the 2 years after birth was found in 14,874 participants (15.6%). Based on participants with the lowest frequency of yogurt intake ("almost never") as the reference group, risk ratios for otitis media incidence decreased with higher frequencies of yogurt intake in children at one year of age, but also independently in mothers during pregnancy. The lowest risk ratio (95% confidence interval) for otitis media incidence at six months of age was observed with the most frequent yogurt intake (once/day or more) (0.54 [0.46-0.63]). Additionally, although a similar association was observed in the subgroup of those with cleft lip and/or palate (CL/P), a high-risk group for severe recurrent otitis media, no statistical significance was observed. Thus, increased regular yogurt intake in both children and mothers was associated with a decrease of otitis media during early childhood.
06:39
The effects of probiotics on cholesterol levels in patients with metabolic syndrome. GreenMedInfo
PMID: Cureus. 2023 Apr ;15(4):e37567. Epub 2023 Apr 14. PMID: 37193478 Abstract Title: The Effects of Probiotics on Cholesterol Levels in Patients With Metabolic Syndrome: A Systematic Review. Abstract: The prevalence of metabolic syndrome has been increasing over the past few years, especially in the United States. As a result, it increases the risk of heart disease, stroke, and diabetes mellitus, thus causing significant health issues. Probiotics have been studied to have effects on maintaining blood cholesterol levels by altering the gut microbiota. This systematic review aims to find the effects that probiotics would have on lipid levels when given to patients with metabolic syndrome. In total, articles collected from PubMed, Google Scholar, and ScienceDirect were analysed. The results of the majority of the studies revealed that probiotics have some significant effects on cholesterol levels. It has shown a reduction in triglycerides and lower-density lipoprotein (LDL), thereby decreasing cholesterol levels in the blood. However, further investigations must be carried out so in order to create a more detailed and specific explanation of the effects and mechanisms of probiotics on maintaining cholesterol levels in the blood.
06:05
The application of probiotic after antibiotics treatment promotes the recovery of pediatric bronchopneumonia infection. GreenMedInfo
PMID: Eur Rev Med Pharmacol Sci. 2023 May ;27(9):4103-4107. PMID: 37203836 Abstract Title: The application of probiotic after antibiotics treatment promotes the recovery of pediatric bronchopneumonia infection. Abstract: OBJECTIVE: We aim to investigate the treatment efficacy of combinational applications of oral probiotic with intravenous infusion of antibiotics in pediatric bronchopneumonia infection.PATIENTS AND METHODS: A total of 76 pediatric patients with bronchopneumonia infection were included in the study. We divided the patients into observation group (n=38) and control group (n=38). The patients in control group received intravenous infusion of antibiotics and symptomatic treatments. In the observation group, in addition to the treatments of the control group, the patients also received oral probiotic. We compared the effective times of treatment, including the durations of wet rale in lung auscultation, cough, fever, and the total time of hospitalization. Additionally, we also recorded the occurrence of adverse reaction, including rash and gastrointestinal reaction. Meanwhile, laboratory tests for systemic inflammation were recorded at different time points.RESULTS: The durations of rale in lung auscultation (p=0.006), cough (p=0.019), fever (p=0.012), and the total time of hospitalization (p=0.046) in observation group were significantly shorter than those in the control group. The incidence rate of diarrhea was 10.5% (4/38) in the observation group, and 34.2% (13/38) in the control group, with a significantly statistical difference (p=0.013). In the laboratory tests, we found that blood lymphocyte (p=0.034) and high-sensitive C reactive protein (p=0.004) were significantly higher in the control group than that in the observation group at 7th day after the treatments.CONCLUSIONS: The combinational applications of probiotic and antibiotics in pediatric bronchopneumonia infection were safe and effective and can lower the diarrhea rate.
05:57
Anti-vaccine crackpots lie about Sinead OConnors death Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
We do not know why popular singer Sinead O'Connor died, but it probably wasn't a vaccine. Sadly, anti-vaxxers are blaming vaccines
05:01
Why Do Bananas Turn Brown And How Do We Stop Them? Healthy Holistic Living
Bananas, the globally beloved fruit or more accurately, berry, clock in an annual production of a staggering 105 million tonnes. Grown on a herb rather than a tree, as often mistaken, bananas are a nutritious and versatile snack. However, these appealing fruits have a rather temperamental nature, staying ripe for only a couple of days. This leads us to two main queries, why do bananas brown so quickly, and more importantly, how can we delay this process?
The Science Behind Bananas Turning Brown
The primary factor responsible for the browning of bananas is an airborne hormone called ethylene. This hormone accelerates the ripening process in fruits. Some fruits and vegetables are mere absorbers of ethylene, but others, like bananas, are active producers.
- Ethylene Producers: Climacteric and Non-Climacteric FruitsProducers of ethylene can be split into two categories climacteric fruits and non-climacteric fruits. Climacteric fruits, such as bananas, undergo a burst of ethylene production during ripening. On the other hand, non-climacteric fruits like citrus fruits and melons cease producing ethylene once theyre removed from the plant or vine.This distinction means that climacteric fruits continue to ripen after being harvested. When these fruits are stored next to non-climacteric or ethylene-absorbing fruit and vegetables, the latter continue to ripen due to the proximity to the ethylene source.
- The Role of Ethylene in Fruit Ripening Upon contact with ethylene, the acids within the fruit begin to break down, leading to a softening of its flesh and a breakdown of green chlorophyll pigments. This alters the fruits appearance, making it softer and sweeter. As ethylene continues to interact with bananas, the yellow pigment breaks dow...
04:50
You Probably Have Fake Cinnamon In Your Cupboard Healthy Holistic Living
Cinnamon, the warming spice we all love and associate with the comforting and joyous festivities of Christmas, is an integral component in countless recipes, from the well-loved pumpkin spice lattes to mouthwatering cinnamon rolls and rich, aromatic spice cakes. Yet, you might be taken aback to learn that the cinnamon youre using to infuse your homemade treats with delicious flavors might not be the true cinnamon after all.
The Roots of True Cinnamon
Cinnamomum verum, or as it is more commonly known, Ceylon cinnamon, traces its roots back to the bark of evergreen trees in the laurel family. Indigenous to Sri Lanka (formerly Ceylon, hence its name), Burma, and the Malabar coast of India, Ceylon cinnamon is also grown in South America and the West Indies.
Ceylon cinnamon stands out due to its delicate, sweet flavor, a characteristic that has made it a sought-after ingredient in culinary practices for centuries. Its not just its delightful taste that makes it noteworthy; it once held a value surpassing that of gold and was used in various religious rituals across cultures.
Ceylon cinnamon has also made a name for itself in the world of medicine. Studies have highlighted its potential as an insulin mimetic, showcasing its potential health benefits. But when an ingredient is in high demand, a less expensive substitute is bound to emerge.
The Imitator Cassia Cinnamon
...
04:40
People Are Just Learning How Asparagus Actually Grows Healthy Holistic Living
Asparagus, an illustrious vegetable, holds a unique place in our diets and conversations, especially with its peculiar ability to give one green and somewhat smelly pee. However, its fame extends beyond just its amusing side effect. Many people are growing curious about how this famous vegetable actually grows and the various benefits it offers. The asparagus family, or genus, houses about 300 species, but the most widely known and consumed is the garden asparagus.
Asparagus Growth: How Does Asparagus Grow?
Asparagus is a herbaceous perennial vegetable, which means it can be an exceptionally long-term crop, possibly lasting up to 20 years. It can be grown from dormant plants known as crowns or from seeds. The Royal Horticultural Society provides in-depth information on how to grow your own asparagus.
I learned this is how Asparagus grows through this meme, and I think about it more often than is probably healthy pic.twitter.com/cEEntjXZCf
Chris (@r3mnar) April 19, 2020
An important tip for beginners: its best to avoid harvesting your asparagus for the first couple of years. This restraint allows the plant to establish a strong root system. Once the initial period is over, you can anticipate enjoying homegrown asparagus each spring for many years. These green spears grow upright from the soil and are harvested by a simple cut at the bottom.
Moreover, asparagus plants can be male...
04:30
Fluoridation Weekly Review #25 Fluoride Action Network
Fluoride-Containing Voriconazole Can Cause Arthritis, Case Study Concludes
A patient with COVID-19 related aspergillosis of the lungs who was placed on the anti-fungal drug voriconazole has developed arthritis from the fluoride-containing drug, according to a new report from physicians at the Westmead Hospital in Australia.
Whole-body bone scans of the patient, a male in his early 60s who had been hospitalized for five months for COVID infection, showed that the mans shoulders and wrists were particularly affected by inflammatory polyarthritis, according to the report in Proceedings of Singapore Healthcare.
Voriconazole contains fluoride which can be deposited within the bony matrix causing musculoskeletal symptoms, report the authors
The constellation of widespread pain, polyarthritis with upper limb predominance occurring eight weeks while on voriconazole and nearly 16 weeks after initial COVID-19 infection, presence of periostitis and raised serum ALP and fluoride support the diagnosis of voriconazole-induced musculoskeletal event instead of post COVID-19 reactive arthritis, conclude the authors.
Clinical symptoms resolved four weeks after cessation of the voriconazole treatment, they report.
Source: https://doi.org/10.1177/20101058221149575
Mexican Study Finds Children With Low BMI Are More Susceptible to Severe Dental Fluorosis
A study of over 500 schoolchildren from Oaxaca, Mxico, that focused on the drinking of bottled water, found that children with a low Body Mass Index (BMI) score, which researchers attributed to poor nutritional status, showed more severe development of dental fluorosis.
[P]revious studies in Nigeria, India, and Mexico indicate that undernourished children are more likely to have dental fluorosis than well-nourished children. In a study in a central region in Mexico underweight children had higher levels of urinary fluoride and dental fluorosis, and fluoride excretion was consistently higher in the children with dental fluorosis, noted the authors from several Mexican and Spanish dental schools.
The authors report that little is known about the importance of...
04:28
These 10 Amazing Things Happen To Your Body When You Dont Eat For 16 Hours Healthy Holistic Living
Over the past few years, intermittent fasting, a dietary routine of cycling between periods of fasting and eating, has taken the health and wellness world by storm. Its broad spectrum of health benefits, coupled with its flexibility, makes it an appealing approach to weight management and overall health optimization. Among various patterns of intermittent fasting, the 16-hour fast stands out for its accessibility and potential benefits.
Understanding Intermittent Fasting
Intermittent fasting (IF) is not a diet, but rather a pattern of eating that alternates between periods of fasting and periods of eating. It focuses less on what you eat and more on when you eat. Despite its recent popularity, IF echoes our ancestors lifestyle, who often faced periods of scarcity and limited access to food. This cyclic dietary pattern comes in multiple forms, including:
- Time-Restricted Feeding (TRF): Limiting your daily eating window to a specific number of hours. For instance, you may fast for 16 hours and consume all your daily calories within an 8-hour window.
- Alternate-Day Fasting: Alternating between fasting days, where you consume very few or no calories, and regular eating days.
- 5:2 Diet: Eating normally for five days a week and significantly reducing your calorie intake (around 500-600 calories) on two non-consecutive days.
- Eat-Stop-Eat: Fasting for a full 24 hours once or twice a week.
- The Warrior Diet: Fasting for 20 hours each day and eating one large meal during the remaining 4-hour window.
Among the above, the 16:8 method, characterized by 16 hours of fasting and an 8-hour eating window, has gained the most traction. If implemented correctly, it can boost metabolism, increase energy levels, and lead to potential health improvements. However, while the benefits of IF can be profound, its important to remember that it may not be suitable for everyone. Pregnant or breastfeeding individuals, those with certain medical conditions, or people with specific nutritional requirements should consult a healthcare professional before starting IF.
The Science Behind 16-hour Intermittent Fasting
...
04:23
This One Hidden Nutrient is Crucial For Magnesium, Vitamin D and Calcium Absorption Healthy Holistic Living
The Essential Quartet for Optimal Bone Health: Magnesium, Calcium, and Vitamins D and K2
When it comes to bone health, its not a solo act but rather a symphony of nutrients working together harmoniously. For decades, the limelight has been primarily on calcium. However, a broader view has emerged, revealing that magnesium and vitamins D and K2 also play starring roles. This understanding of their collective importance and interdependence for optimal absorption and function has fundamentally changed how we approach bone health. Lets delve deeper into these relationships and the importance of balancing these essential nutrients for the greatest benefit.
The Crucial Comrades: Calcium and Vitamin D
Research, particularly in postmenopausal women, has illuminated the pivotal role that Vitamin D plays in bone health. While Vitamin D3 supplements positively impact bone health, even greater benefits are evident when calcium is included (1). Vitamin D aids in calcium absorption, a critical component of maintaining robust bone health.
However, the prevalence of Vitamin D deficiencies or insufficiencies is worryingly high. National survey data indicates that over 40% of U.S. adults are vitamin D deficient (2, 3), defined as serum 25(OH)D levels below 20 ng/mL. On a brighter note, data shows that 37% of U.S. adults report using Vitamin D supplements (2-4).
Roles of Vitamin K2 and Magnesium
Beyond calcium and Vitamin D, Vitamin K2 and Magnesium are crucial contributors to effective bone health.
Vitamin Ds role is to facilitate calcium absorption, integral to supporting bone health. Vitamin K2, meanwhile, ensures the calcium is directed to the bones and not the soft tissues, such as blood vessels and kidneys (5). Unfortunately, many diets may not provide enough Vitamin K2 to support optimal bone health. Factors such as malabsorption, liver disease, alcoholism, and the use of certain medications can also result in low Vitamin K2 levels (5).
Magnesium plays an equally significant role. A review in The Journal of the American Osteopathic Association shows that Vitamin D cannot be metabolized efficiently without sufficient magnesium (6). However, World Health Organization data reveals that almost 75% of U.S. adults do not meet the FDAs Recommended Daily Intake of 420 mg of magnesium (7).
The Interplay of Magnesium and Vitamin D
Given the integral role of magnesium in Vitamin D metabolism, its vital to ensure your magnesium levels are sufficient when supplementing with Vitamin D. Without enough magnesium, Vitamin D metabolism can be impaired. Conversely, individuals with adequate magnesium levels have been found to need less Vitamin D supplementation to maintain suitable levels of the vitamin (6). Higher magnesium intake has been correlated with lower instan...
04:04
Move Over Lemons, Adding This Fruit To Your Water Every Morning Can Relieve Joint & Muscle Pain, Inflammation & Helps You Lose Weight Healthy Holistic Living
For quite some time, the health benefits of lemons have been celebrated worldwide. However, another tropical gem has come to lightpineapple. With a delightful taste and sun-kissed exterior, this fruit packs a punch of phenomenal health benefits, becoming an antidote to common health problems that permeate our daily lives. Its time to move over, lemons!
Consider kick-starting your day with a potent yet straightforward elixira tall glass of water accentuated with the golden sweetness of pineapple. This tangy mixture goes beyond refreshing your palateit initiates a chain reaction of health-boosting effects. Whether its alleviating joint and muscle pain, battling inflammation, or promoting weight loss, the pineapple is a veritable key to a rejuvenated, healthier you.
Lets embark on an adventure to uncover the enchanting realm of this tropical marvel and unravel the secrets behind its therapeutic prowess. In this comprehensive article, well delve into the scientific evidence that portrays pineapple as a formidable ally in our quest for wellness, exploring how this modest fruit can transform our daily routines into a delightful journey towards improved vitality and longevity.
Nutritional Breakdown of Pineapple
Pineapple isnt just a delicious tropical fruitits also packed full of important vitamins, minerals, and antioxidants that play a crucial role in overall health and well-being. Heres a detailed nutritional breakdown of what you get from one cup of pineapple chunks (approximately 165g):
- Calories: Pineapple is low in calories, with a single cup containing around 82 calories. This makes it an excellent choice for those aiming for weight loss or maintaining a healthy weight.
- Carbohydrates: A cup of pineapple provides approximately 21.6 grams of carbohydrates, a vital source of energy for the body.
- Fiber: Pineapple is a good source of dietary fiber, offering about 2.3 grams per cup. This aids in maintaining healthy digestion and can contribute to weight loss by promoting feelings of fullness.
- Protein: Although not a significant source of protein, a cup of pineapple provides about 0.9 grams.
- Vitamin C: Pineapple is an excellent source of Vitamin C, with a cup providing a whopping 78.9 milligrams, which is more than the daily recommended intake for adults.
- Manganese: This mineral, essential for bone health, is abundant in pineapple. One cup provides about 1.5 milligrams, which is more than half of the daily recommended intake for adults.
- Vitamin A: Pineapple provides about 95 IU of vitamin A per cup, contributing to skin health and vision.
- Vitamin B6: Pineapple provides about 0.2 milligrams of Vitamin B6 per cup, a vitamin important f...
04:00
Science rescinds expression of concern issued last month Retraction Watch
Science has rescinded an expression of concern it issued one month ago after the authors provided data that addressed concerns about the integrity of the paper.
The journal had published the expression of concern for the 2021 article Light-induced mobile factors from shoots regulate rhizobium-triggered soybean root nodulation after two separate readers contacted the editorial team about an issue in the paper, as we reported at the time. The expression of concern noted that that data presented in Fig. 5 assessed GmNSP1 expression rather than GmNIN expression.
The article has been cited 43 times, according to Clarivates Web of Science.
The journal is publishing the newly submitted data as a correction, as well as an editors note explaining the removal of the expression of concern. The new notice states:
These changes have addressed concerns about the integrity of the paper. Therefore, Science has removed the Editorial Expression of Concern and posted this notification in its place to indicate the editors confidence in the Research Articles data an...
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Thursday, 27 July
08:34
Federal Judge Orders Consolidation of Two Landmark Cases Against Government Censorship of Citizens Children's Health Defense
Press Release
For Immediate Release
RFK Jr., Childrens Health Defense v. Biden and Missouri v. Biden will move forward as one effort to preserve freedom of speech
Washington, DC Federal Judge Terry A. Doughty, United States District Court for the Western District of Louisiana, issued an order on Monday consolidating the class action lawsuit, Robert F. Kennedy Jr., Childrens Health Defense, et al v. Biden, et al., and Missouri, et al. v. Biden, et al. Both cases are actions against the Biden administration for allegedly colluding with social media platforms to censor the speech of citizens on many topics including COVID-19.
Robert F. Kennedy Jr., Childrens Health Defense, et al. v. Biden, et al., filed on March 23, 2023, alleges that the defendants, including President Biden, White House Press Secretary Karine Jean-Pierre, Surgeon General Vivek Murthy, and a number of agencies including the CDC, HHS, DHS, CISA, NIAID, Census Bureau, and the FBI colluded with and pressured social media companies to suppress speech that runs counter to government narratives and silence specific speakers who are critical of federal policy. The case additionally alleges a violation of the First Amendment right to receive information and ideas on behalf of Childrens Health Defense (CHD), a nonprofit organization representing consumers of health information nationwide.
Missouri, et al. v. Biden, et al., filed in May 2022 by Missouri Attorney General Eric Schmitt (now U.S. Senator Schmitt) and Louisiana Attorney General Jeff Landry, seeks to expose how top Biden Administration officials allegedly colluded with social media companies to censor freedom of speech, according to a joint statement filed by Landry and Schmitt in September 2022.
Judge Doughty ordered the consolidation of the two cases for all purposes including discovery.
What weve witnessed over the past three years is the most intense assault on free speech in the history of our nation, said Kennedy, CHDs chairman on leave. Consolidating these two cases is a turning point, allowing us to better...
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Wednesday, 26 July
04:55
Dental Association anonymously welcomes fluoride in NP water Fluoride Action Network
The Taranaki branch of the New Zealand Dental Association (NZDA) has anonymously backed next weeks introduction of fluoride into New Plymouths water.
The branch took the unusual step of issuing a media release without attributing any statements because of the intimidating tactics of anti-fluoride groups.
Those alleged tactics had left staff at the branch anxious for their safety according to a spokesperson, who would not be named.
The statement was released a fortnight after a packed extraordinary meeting of the New Plymouth District Council where a number of people voiced their anger about the director-general of healths decision to make fluoride compulsory in the water supply.
Following the meeting, NPDC requested the name of one if its employee be removed from a photo caption contained in a media release about fluoride equipment being tested because of the threats he had received.
The Health (Fluoridation of Drinking Water) Amendment Bill, which was passed in November 2021, removed the decision for water fluoridation away from councils.
It is due to be re-introduced into New Plymouths water on July 31.
This was a significant decision because the issue of fluoridation is now no longer subject to postcode variation and local body politics, the spokesperson for the Taranaki branch of NZDA said.
Increasing fluoride levels will deliver effective and safe oral health benefits to our residents, especially to our youngest tamariki and those most in need, who are the least able to afford dental care.
Dental disease continued to be the leading cause of preventable hospitalisations for children across New Zealand, the spokesperson said.
In Taranaki, hospital waiting lists for dental extractions for children had ballooned, with most children now waiting more than 12 months to have their dental treatment undertaken under general anaesthetic.
We know that around half of New Zealanders currently avoid regular visits to the dentist, many of those due to cost, so with the cost of l...
04:42
Community Consultation Fluoridation of the Marulan Water Supply Fluoride Action Network
Goulburn Mulwaree Council are currently working to upgrade the Marulan water treatment plant to improve water quality for the community. As part of this upgrade, Council is assessing whether to add fluoridation to the upgraded water treatment plant.
Council currently does not dose the Marulan water supply with fluoride however can decide to add this to the new plant. Council is seeking feedback from the Marulan community about whether you would like your water supply fluoridated.
What is fluoride?
Fluoride is a naturally occurring mineral found naturally in our environment, and occurs in rocks, soils, salts, plants and many foods and beverages.
Why increase levels of fluoride in drinking water?
Fluoride helps to prevent tooth decay, which is why it is found in toothpastes and other oral health products. There are low natural levels of fluoride in drinking water, but these levels are too low to help prevent tooth decay. As such, water utilities often dose fluoride in drinking water to help make up this difference.
What will the fluoride levels in drinking water be?
Fluoride is dosed into the drinking water supply so that the treated water has a concentration of between 0.9mg/L and 1.1mg/L, in line with the National Health and Medical Research Council (NHMRC) recommendations. This includes the natural fluoride concentrations already in the water. This level of fluoride has been deemed by the NHMRC to be beneficial for dental health without having adverse effects on customers.
How long has fluoride been dosed in Australia?
Yass was the first town in Australia to begin dosing fluoride, in 1956. Goulburn followed soon after this.
Where can I find more information?
*Original full-text article online at: https://www.nationaltribune.com.au/community-consultation-fluoridation-of-the-marulan-water-supply/
04:25
Branson aldermen examine water fluoridation Fluoride Action Network
The Branson Board of Aldermen hosted a special meeting on Thursday, July 13, to examine the issue of fluoridation of the citys water supply.
The meeting was arranged to have three experts on each side of the debate make a presentation to the board. Some of the speakers addressed the aldermen through video sharing services because they dont live in the Branson area.
Branson-based dentist Dr. Gabriel Harr endorsed the use of fluoridation of public water supplies.
Tuesday, 25 July
05:05
Council plans to add fluoride to water across more areas of Nottinghamshire Fluoride Action Network
To enhance the oral health of all residents the council is taking the lead in advocating for the expansion of water fluoridation to the whole of the county.
Water fluoridation, a scientifically proven method of adding small amounts of fluoride to drinking water, is a key player in the fight against tooth decay.
Already, 30% of Nottinghamshire residents, around 247,000 people, are reaping the benefits of this public health measure.
The Council is now setting its sights on extending these benefits to other areas of the County.
The potential rewards are impressive: a 35% reduction in decayed, missing and filled teeth in fiver-year-old children, a 56% decrease in hospital admissions for tooth extractions in children from the most deprived areas, and a remarkable return of 12.71 after five years and 21.98 after ten years for every 1 invested in fluoridation.
Councillor Dr John Doddy, Chairman of the Health and Wellbeing Board, who proposed the approved motion to champion the oral health agenda, stated:
This is a health inequality that is completely preventable.
If we fluoridated the water across Nottinghamshire, we would see a 15% increase in five-year-old children who are completely free of dental decay at all and there would be a significant reduction of people going into hospital for tooth extractions.
The evidence for fluoridation is irrefutable, its backed by the World Health Organisation, the British dental associations are calling out for it as well. We want to bring together partners and organisations across our county, to work together to improve the oral health of everyone in our county.
The County Council will foster collaboration with partners across the county, including district and borough councils, Nottingham City Council, Integrated Care Boards, Integrated Care System, and the water companies to delve into the benefits of the wate fluoridations scheme. While the final decision rests with Central Government, Nottinghamshire County Council is actively lobbying for new or varied schemes.
Any changes to water fluoridation will involve a public consultation led by the Government.
*Original full-text article online at: https://westbridgfordwire.com/council-plans-to-add-fluoride-to-water-across-more-area-of-nottinghamshire/
04:51
Parents urged to take precautions to prevent Fluorosis in children Fluoride Action Network
Editor:
We just received the 2022 annual drinking water quality report. Fluoride content of the Refugio municipal water supply was an alarming 1.51 ppm. This is a warning to ALL parents in the region with children under ten years of age. Having tested many water supplies over the last four decades, Fluoride is generally in excess of 0.5 ppm in most of our regional water supplies These are levels that can and will cause staining of the teeth that will range from white spots to brown discoloration of the permanent teeth particularly if your children are drinking tea, which is high in Fluoride content. You need to take precautions with children six years of age or younger to prevent Fluorosis, with particular attention paid to banning your children from drinking tea.
Developing permanent teeth in children under the age of six are particularly susceptible to this staining referred to as Fluorosis. Fluoride is a natural trace element necessary for the development of the tea mint. Levels of Fluoride in drinking water that exceed 1 ppm are associated with increased developmental staining in teeth. A glass of tea will have a Fluoride level of 8 ppm in addition to the water with which it was brewed. Using this water for cooking also increases the concentration of Fluoride from evaporation, all of which can contribute to Fluorosis.
Considering the other contaminants reported in our local water samples including Arsenic, it would be wise to install a point-of-use filter or a reverse osmosis drinking water system, but keep in mind that Fluoride cannot be filtered out with most reverse osmosis systems despite what these companies will tell you to sell their product. You will still need to restrict your children to drinking bottled water, and it may be necessary to cook with bottled water or water from a known source.
If you are on a rural water system, the shallow wells are extremely erratic in Fluoride content and can be dangerously high in Arsenic, Fluoride, radioactive materials or farm waste contaminates. For our patients of record, you can contact our office and we will supply you with a water sample test kit. This analysis would be a wise move for any of our patients on any of the local city water and any of the school systems. In the past, the municipal supplies of Austwell/Tivoli and especially Bayside have been high enough to cause severe damage to the developing permanent teeth in children. A good word of advice for our parents living anywhere else, if you dont know what the Fluoride level is in the water your children are drinking, have it tested, or contact the local water department for a copy of the mandatory tests.
J. Tim Rainey, DDS, MAGD
Dr. Rainey can be reached at jtimrainey@tiads.com, or drrainey@jtimrainey.com, or 361-526-4695.
*Original full-text article online at:...