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Sunday, 30 July
23:18
First Honey from My Backyard Beehive! The Healthy Home Economist
How quickly a new beehive produces its first batch of honey with a video of the process unfolding in a backyard organic colony. I am very excited to share that my new beehive is starting to produce its first honey! Those of you following my journey as a new beekeeper may recall that I received
The post First Honey from My Backyard Beehive! appeared first on The Healthy Home Economist.
10:37
Africa Strengthens Ties with Russia as Coups Against Western-Backed Governments Spread Across Africa Continent Medical Kidnap
Reading from a statement, Colonel Amadou Abdramane, seated and flanked by nine other officers, said defense and security forces had decided: Put an end to the regime that you know due to the deteriorating security situation and bad governance. via REUTERS
by Brian Shilhavy
Editor, Health Impact News
Niger became the latest African nation to topple its democratically elected U.S.-backed government this week, as civil unrest spreads from coast to coast across the continent.
Coast to Coast, a Corridor of Coups Brings Turmoil in Africa
Africas coup belt spans the continent: a line of six countries crossing 3,500 miles, from coast to coast, that has become the longest corridor of military rule on Earth.
This past weeks military takeover in the West African nation of Niger toppled the final domino in a band across the girth of Africa, from Guinea in the west to Sudan in the east, now controlled by juntas that came to power in a coup all but one in the past two years.
The last leader to fall was Nigers Mohamed Bazoum, a democratically elected American ally who disappeared on Wednesday when his own guards detained him at the presidential palace in the capital, Niamey. His security chief now claims to be running the country.
We have decided to intervene, Gen. Abdourahmane Tchiani, Nigers new self-appointed ruler, said in a televised address on Friday.
Until this past week, Niger was the cornerstone of the Pentagons regional strategy. At least 1,100 American troops are stationed in the country, where the U.S. military built drone bases in Niamey and the northern city of Agadez, one at a cost of $110 million. Now, all of that is in jeopardy. (Full article.)
Bazoum is reportedly being held by his own presidential guard, and the coup leaders claim that the nations army, gendarmerie, and police forces were all united in taking control of the government in Niger. (Source.)
Local reporters are claiming that the coup is also supported by the people of Niger.
Citizens in Niger have expressed hope in the future th...
10:36
Africa Strengthens Ties with Russia as Coups Against Western-Backed Governments Spread Across Africa Continent Vaccine Impact
Reading from a statement, Colonel Amadou Abdramane, seated and flanked by nine other officers, said defense and security forces had decided: Put an end to the regime that you know due to the deteriorating security situation and bad governance. via REUTERS
by Brian Shilhavy
Editor, Health Impact News
Niger became the latest African nation to topple its democratically elected U.S.-backed government this week, as civil unrest spreads from coast to coast across the continent.
Coast to Coast, a Corridor of Coups Brings Turmoil in Africa
Africas coup belt spans the continent: a line of six countries crossing 3,500 miles, from coast to coast, that has become the longest corridor of military rule on Earth.
This past weeks military takeover in the West African nation of Niger toppled the final domino in a band across the girth of Africa, from Guinea in the west to Sudan in the east, now controlled by juntas that came to power in a coup all but one in the past two years.
The last leader to fall was Nigers Mohamed Bazoum, a democratically elected American ally who disappeared on Wednesday when his own guards detained him at the presidential palace in the capital, Niamey. His security chief now claims to be running the country.
We have decided to intervene, Gen. Abdourahmane Tchiani, Nigers new self-appointed ruler, said in a televised address on Friday.
Until this past week, Niger was the cornerstone of the Pentagons regional strategy. At least 1,100 American troops are stationed in the country, where the U.S. military built drone bases in Niamey and the northern city of Agadez, one at a cost of $110 million. Now, all of that is in jeopardy. (Full article.)
Bazoum is reportedly being held by his own presidential guard, and the coup leaders claim that the nations army, gendarmerie, and police forces were all united in taking control of the government in Niger. (Source.)
Local reporters are claiming that the coup is also supported by the people of Niger.
Citizens in Niger have expressed hope in the future th...
10:16
Africa Strengthens Ties with Russia as Coups Against Western-Backed Governments Spread Across Africa Continent Health Impact News
Reading from a statement, Colonel Amadou Abdramane, seated and flanked by nine other officers, said defense and security forces had decided: Put an end to the regime that you know due to the deteriorating security situation and bad governance. via REUTERS
by Brian Shilhavy
Editor, Health Impact News
Niger became the latest African nation to topple its democratically elected U.S.-backed government this week, as civil unrest spreads from coast to coast across the continent.
Coast to Coast, a Corridor of Coups Brings Turmoil in Africa
Africas coup belt spans the continent: a line of six countries crossing 3,500 miles, from coast to coast, that has become the longest corridor of military rule on Earth.
This past weeks military takeover in the West African nation of Niger toppled the final domino in a band across the girth of Africa, from Guinea in the west to Sudan in the east, now controlled by juntas that came to power in a coup all but one in the past two years.
The last leader to fall was Nigers Mohamed Bazoum, a democratically elected American ally who disappeared on Wednesday when his own guards detained him at the presidential palace in the capital, Niamey. His security chief now claims to be running the country.
We have decided to intervene, Gen. Abdourahmane Tchiani, Nigers new self-appointed ruler, said in a televised address on Friday.
Until this past week, Niger was the cornerstone of the Pentagons regional strategy. At least 1,100 American troops are stationed in the country, where the U.S. military built drone bases in Niamey and the northern city of Agadez, one at a cost of $110 million. Now, all of that is in jeopardy. (Full article.)
Bazoum is reportedly being held by his own presidential guard, and the coup leaders claim that the nations arm...
10:00
Why a Low-Sodium Diet Might Wreck Your Health Articles
Editor's Note: This article is a reprint. It was originally published December 3, 2017.
Is salt bad for your blood pressure? James DiNicolantonio, Pharm.D., answers this and many other questions relating to salt in his book, "The Salt Fix: Why the Experts Got It All Wrong and How Eating More Might Save Your Life." DiNicolantonio is a doctor of pharmacy, and it was during his work as a community pharmacist that his interest in this culinary staple emerged.
"[P]atients were put on this low-salt diet and were having all these symptoms like muscle fatigue, muscle spasms, cramps and heart palpitations. They said their doctors ordered them to not add salt to their food because they have high blood pressure. Yet they were suffering from all these new symptoms symptoms of salt deficiency.
What I ended up doing is kind of pushing back and telling my patients, 'You know, you really need to go to your doctor's office. Tell them these symptoms that you're having, and get your blood-sodium levels drawn because you might be deficient in salt.'
Sure enough, these people were severely dehydrated. They had low sodium levels in the blood. Within a few days of just upping their salt intake, all of these symptoms went away. Right there, I knew that this low salt advice was just not panning out in the real world."
In some cases, the patients' sodium levels were so low their doctors actually ended up reducing or eliminating their prescription for diuretics, which are commonly prescribed for high blood pressure, and instructed them to start adding salt back to their food.
This is an important lesson because, while it's actually hard to consume harmful amounts of sodium, it's easy to end up with too little. These real-world experiences prompted DiNicolantonio to write his book, in which he also provides a historical perspective about the use of salt.
Historical Usage of Salt
Salt has been widely and...
Why KAATSU Is a Fitness Game Changer Articles
Blood flow restriction (BFR) training, which I perceive to be the greatest innovation in exercise training in the last century, was developed in Japan by Dr. Yoshiaki Sato in 1966. There, it's known as KAATSU, which means "additional pressure." KAATSU was brought to the U.S. just over a decade ago by Steven Munatones, after he completed a 13-year mentorship by Sato.
In summary, BFR involves partially obstructing blood flow to your extremities while exercising. This intermittent hypoxia generates an increase in anti-inflammatory myokines, the muscle beneficial hormonal responses.
Aside from dramatically improving muscle tone and preventing sarcopenia100 (age-related muscle loss), KAATSU is also a wonderful tool for post-surgical rehabilitation, allowing you to regain physical function in a fraction of the time that you would normally anticipate.
Importantly, it will also improve your metabolic flexibility, so that you can seamlessly transition between burning fat and glucose as your primary fuel. It does this by increasing the number of glucose transporters, which absorb and lower your blood sugar in your cell membranes. As a result, your insulin level won't go up and you won't develop insulin resistance.
KAATSU is really a specific type of BFR therapy, as it uses a device that automatically inflates and deflates the cuffs you place around your extremities. "Conventional" BFR uses static pressure from elastic or inflatable bands, and while that can provide benefits when used correctly, KAATSU is far superior for several reasons, which we'll review here.
How KAATSU Builds Muscle
One of the reasons I'm so excited about KAATSU is it's ability to help build muscle mass and prevent sarcopenia. Sarcopenia is a progressive decline in muscle mass as you age, primarily due to the decrease in blood flow supply to muscle stem cells which are called satellite cells.
When your satellite cells don't get the nourishment they require, it becomes very difficult to build muscle. Once you are over 50, this is always working against you, even if you're doing hardcore resistance training. KAATSU solves this problem. It increases the blood supply to your satellite stem cells, which provides the necessary metabolic support needed to increase muscle protein synthesis and grow your muscles.
KAATSU has the added benefit of allowing older people, like me, to engage in relatively aggressive exercise wit...
Dr. Mercola Interviews Dr. Karen Becker Articles
Dr. Karen Becker in my view is the best integrative veterinarian out there. What youll notice first is the striking artwork behind her in the video. The art is a photomicrograph of the minerals in her precious pets that have passed on. The breathtaking artwork is created from the cremated remains of some of her companion animals.
So, it's interesting that you can actually get a hint of an animal's health and wellness status by looking at mineral composition, even in death, Dr. Becker says. They do a beautiful job of helping you see vividly upfront and every day the beautiful aspects that our animals continue to give us and the lessons that they continue to teach us.
Dr. Becker, whos been out veterinary consultant for 14 years, and recently expanded it to bark & whiskers, shares her deep philosophical views on how pets enrich our lives from teaching us how to grieve to offering unconditional love in ways that even humans typically cannot.
She also offers a wealth of knowledge on bark & whiskers about how to keep your pet optimally healthy at any life stage, with a focus on proper nutrition and other key elements of well-being movement, fresh air, detoxification, and stress management, including chemical stress, emotional and physical stress. If you havent visited her new site, I encourage you to do it now.
Pets Poor Nutrition Starts With Vet School Indoctrination
Dr. Becker was fortunate to come from a nutritionally minded family, which taught her the importance of healthy food from a young age:
If you go in [to veterinary school] with the foundation of nutrition, you have something to balance it with. And that was, thankfully for me, my situation. My parents are wildly proactive.
I grew up, my Grandma Shaw taught me how to grow and juice wheatgrass when I was 12. My parents and my mama made three homemade organic garden, fresh meals a day. We never had soda, we never had white bread. So, I went to vet school understanding the power of food. That is not true of my peers.
When she went to veterinary school, her nutrition class wasnt taught by an independent, board-certified veterinary nutritionist, but...
09:18
Geoengineering Watch Global Alert News, July 29, 2023, #416 Geoengineering Watch
Dane Wigington GeoengineeringWatch.org "Earth
is at catastrophic risk of collapse by 2025", even mainstream
sources are now admitting to what is becoming all but impossible to
hide or deny. Over a dozen countries are enduring catastrophic
wildfires, primary heat distributing ocean currents are shutting
down and the ozone layer is collapsing. While matrix media attempts
to
08:49
To Protect One Another Age of Autism The Rebel Alliance!
By Cathy Jameson
When Polly Tommey set out on the road a few years ago, she was
determined to give families the chance to share their
story. Thanks to Polly and her mobile TV crew, so
many people got to do that, including me. My sons name, among
thousands of others, is on the VAXXED bus.
Just a few days ago, I read an article announcing that Polly Tommey would be back on the road again. Shes determined to help even more people tell their story. Shes also very fast! I hadnt signed up for any alerts, but while prepping this post late Friday night, I saw that she had started documenting stories for the new VAX-UNVAX bus.
Come September Children's Health Defenses year-long Vax-Unvax bus tourwill travel the U.S. with the aim of raising awareness of vaccine harms by gathering stories from the vaccine-injured. Updates of the tour and knowing where the VAX-UNVAX bus will be can found on the CHD site.
The Latest Video, posted July 28th, chronicles a few familiar names. It also introduces us to some people who were injured by Pfizer and Moderna covid vaccines. The first story was of 16 year old Ernesto Ramirez, Jr. Days after getting the Pfizer vaccine,...
06:01
Physical exercise prevented the alterations caused by polycystic ovary syndrome. GreenMedInfo
PMID: Life Sci. 2023 Jul 15 ;325:121754. Epub 2023 May 7. PMID: 37156395 Abstract Title: Physical exercise alleviates oxidative stress in brown adipose tissue and causes changes in body composition and nutritional behavior in rats with polycystic ovary syndrome. Abstract: AIM: Polycystic Ovary Syndrome (PCOS) is a very common endocrine disorder in women. We investigate the effect of physical exercise on body composition, nutritional parameters, and oxidative stress in rats with PCOS.METHODS: Female rats were into three groups: Control, PCOS, and PCOS + Exercise. PCOS was induced by letrozole (1 mg/kg via p.o.) for 21 days consecutively. Physical exercise was swimming, for 21 consecutive days, 1 h/day with 5 % load. In all groups, we assessed the nutritional and murinometric parameters, body composition, thermography, and oxidative stress in brown adipose tissue (BAT) and peri-ovarian adipose tissue (POAT).KEY FINDINGS: In PCOS we observed an increase (P
Saturday, 29 July
21:00
Weekend reads: The black market for papers; the secret life of retractions; a troublesome pattern Retraction Watch
Would you consider a donation to support Weekend Reads, and our daily work?
The week at Retraction Watch featured:
- Science rescinds expression of concern issued last month
- Exclusive: Public health journal says it will retract vaping paper for questions authors say were addressed in peer review
- Exclusive: City of Hope cancer researcher goes to court to fight misconduct finding
- Meet the author who has published more than 500 letters to the editor in a year
Our list of retracted or withdrawn COVID-19 papers is up to nearly 350. There are now 41,000 retractions in our database which powers retraction alerts in Edifix, ...
20:45
BREAKING: White House/US Surgeon General Pressured FB to Censor True Vaccine Harms GreenMedInfo
Visit our Re-post guidelines
In the wake of the recent Select Subcommittee on the Weaponization of the Federal Government, internal documents produced by Mark Zuckerberg of Facebook, tell a horrid story of the White House (through the office of the Surgeon General Vivek H. Murthy) directing tech platforms to censor and label as 'misinformation' true stories of vaccine injury and side effects -- the very definition of a disinformation campaign.
20:00
Causality in Mental Disturbance: A Review of the Neuroscience Mad In America
Editors Note: The following is an original research article by Peter Sterling, Professor of Neuroscience at the Perelman School of Medicine, University of Pennsylvania. We are presenting it in its native format as a scientific paper.
Here I comment on the 2022 review, Causal Mapping of Human Brain Function by Siddiqi et al., which appeared in Nature Reviews Neuroscience. I place its reasoning in the historical context of psychosurgery and other physical manipulations of brain functionand also in the present context of new understandings from brain imaging, genome-wide studies, and longitudinal studies of mental disturbance. Here are the Reviews stated goals:
This Review focuses on the objective of symptom localization, which aims to identify causal links between symptoms and neuroanatomy. When a symptom is successfully localized, it may potentially be treated by modulating the corresponding neuroanatomy. The second objective, mapping the direction of information flow, aims to understand how one brain region can causally influence another. These experiments attempt to estimate the direction of information flow between two or more nodes in the brain using various measures of effective connectivitySimilar approaches have now been used to map the causal neuroanatomy of movement disorders, mood disorders, anxiety-related disorders, psychotic disorders, disorders of consciousness and various other neuropsychiatric phenomena.
The Review opens by considering identified neurological disorders with identified causes and identified therapies grounded in identified neuroscience. Its primary exemplar is Parkinsons disease, whose immediate cause is loss of dopaminergic neurons in the substantia nigra, and whose treatment involves providing the dopamine precursor to the remaining dopaminergic synapses so that they continue making and releasing dopamine in response to natural stimuli as part of the natural circuit. All good. But then the Review pulls a fast one: it inverts the argument.
Whereas neurology starts with known damage that causes known symptoms and finds effective therapies based on known neuroscience, this Review starts with mental disturbances that it claims to be symptoms of an underlying brain disorder, which it claims to localize neuroanatomically in order to treat with brain manipulations for which there is no foundation in neuroscience. Thus, the Review reasons by asserting an equivalence between something not known to something that is known, apparently hoping that the difference will go unnoticed.
To be clear: there is no neuroscience to suggest that any mental function would be improved by ablating or stimu...
11:25
Lycium barbarum glycopeptide prevents stress-induced anxiety disorders. GreenMedInfo
PMID: Phytomedicine. 2023 Jul 25 ;116:154864. Epub 2023 May 9. PMID: 37182278 Abstract Title: Lycium barbarum (Wolfberry) glycopeptide prevents stress-induced anxiety disorders by regulating oxidative stress and ferroptosis in the medial prefrontal cortex. Abstract: BACKGROUND: Lycium barbarum (Wolfberry) extract has been shown to be effective in neuroprotection against aging or neural injury. Knowledge of its potential roles and biological mechanisms in relieving mental disorders, however, remains limited.PURPOSE: To investigate the potency of Lycium barbarum glycopeptide (LbGp) in alleviating anxiety disorders and the related biological mechanisms.METHODS: LbGp was administrated to mice subjected to 14 days of chronic restrain stress (CRS) via the intragastric route. The anxiolytic effect was evaluated by a battery of behavioral assays. The morphology of neurons and glial cells was evaluated, and cortical neuronal calcium transients were recorded in vivo. The molecular mechanism of LbGp was also investigated.RESULTS: LbGp effectively relieved anxiety-like and depressive behaviors under CRS. Mechanistic studies further showed that LbGp treatment relieved oxidative stress and lipid peroxidation in the medial prefrontal cortex (mPFC). In particular, the ferroptosis pathway was inhibited by LbGp, revealing a previously unrecognized mechanism of the anxiolytic role of wolfberry extract.CONCLUSION: In summary, our results supported the future development of LbGp to prevent or ameliorate stress-induced anxiety disorders. Our work provides a promising strategy for early intervention for pateitents with mental disorders by applying natural plant extracts.
11:04
Exercise interventions can be recommended for menopausal women to improve their sleep. GreenMedInfo
PMID: Front Med (Lausanne). 2023 ;10:1092294. Epub 2023 Apr 25. PMID: 37181372 Abstract Title: The effect of exercise intervention on improving sleep in menopausal women: a systematic review and meta-analysis. Abstract: BACKGROUND: Sleep disturbance is common in menopausal women and negatively affects their quality of life and could cause increased risks of other menopause-related diseases.OBJECTIVE: This systematic review aims to synthesize evidence regarding the effects of exercise interventions on improving sleep in menopausal women.METHODS: A comprehensive search in seven electronic databases for randomized controlled trials (RCTs) was performed on June 3, 2022. The systematic review included seventeen trials, ten of which provided data for the meta-analysis. The effects on outcomes were presented as mean differences (MDs) or standard mean differences (SMDs) and their 95% confidence intervals (CI). Cochrane risk-of-bias tool was used in quality assessment.RESULTS: The results suggest that exercise intervention significantly reduces insomnia severity (SMD = -0.91, 95% CI = -1.45 to -0.36,= 3.27,= 0.001) and alleviates sleep problems (MD = -0.09, 95% CI = -0.17 to -0.01,= 2.20,= 0.03). For sleep quality, the results showed that insignificant differences were found between the exercise intervention and the control groups (MD = -0.93, 95% CI = -2.73 to 0.87, Z = 1.01,= 0.31). The results of the subgroup analysis indicated that more apparent effects of exercise intervention were found among women with sleep disorders than among women without sleep disorders. Which exercise intervention duration was more beneficial to sleep outcomes could not be judged. Overall, there was a moderate risk of bias in the primary studies.CONCLUSION: According to this meta-analysis, exercise interventions can be recommended for menopausal women to improve their sleep. High-quality RCTs applying different types of exercise (e.g., walking, yoga, meditative exercise and so on) with different intervention durations as well as subjective and objective sleep assessment are warranted.SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022342277, identifier: CRD42022342277.
10:26
Influence of routine exercise on the peripheral immune system to prevent and alleviate pain. GreenMedInfo
PMID: Neurobiol Pain. 2023 ;13:100126. Epub 2023 Mar 21. PMID: 37179769 Abstract Title: Influence of routine exercise on the peripheral immune system to prevent and alleviate pain. Abstract: Routine physical activity reduces the onset of pain and exercise is a first line treatment for individuals who develop chronic pain. In both preclinical and clinical research regular exercise (routine exercise sessions) produces pain relief through multiple mechanisms such as alterations in the central and peripheral nervous system. More recently, it has been appreciated that exercise can also alter the peripheral immune system to prevent or reduce pain. In animal models, exercise can alter the immune system at the site of injury or pain model induction, in the dorsal root ganglia, and systemically throughout the body to produce analgesia. Most notably exercise shows the ability to dampen the presence of pro-inflammatory immune cells and cytokines at these locations. Exercise decreases M1 macrophages and the cytokines IL-6, IL-1, and TFN, while increasing M2 macrophages and the cytokines IL-10, IL-4, and IL-1ra. In clinical research, a single bout of exercise produces an acute inflammatory response, however repeated training can lead to an anti-inflammatory immune profile leading to symptom relief. Despite the clinical and immune benefits of routine exercise, the direct effect of exercise on immune function in clinical pain populations remains unexplored. This review will discuss in more detail the preclinical and clinical research which demonstrates the numerous ways through which multiple types of exercise alter the peripheral immune system. This review closes with the clinical implications of these findings along with suggestions for future research directions.
10:16
Treadmill exercise could effectively alleviate cognitive disorders. GreenMedInfo
PMID: Int J Mol Sci. 2023 Apr 25 ;24(9). Epub 2023 Apr 25. PMID: 37175535 Abstract Title: Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of IntegrinV/5 in Parkinson's Disease. Abstract: Parkinson's disease with cognitive impairment (PD-CI) results in several clinical outcomes for which specific treatment is lacking. Although the pathogenesis of PD-CI has not yet been fully elucidated, it is related to neuronal plasticity decline in the hippocampus region. The dopaminergic projections from the substantia nigra to the hippocampus are critical in regulating hippocampal plasticity. Recently, aerobic exercise has been recognized as an effective therapeutic strategy for enhancing plasticity through the secretion of various muscle factors. The exact role of FNDC5-an upregulated, newly identified myokine produced after exercise-in mediating hippocampal plasticity and regional dopaminergic projections in PD-CI remains unclear. In this study, the effect of treadmill exercise on hippocampal synaptic plasticity was evaluated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced chronic PD models. The results showed that treadmill exercise substantially alleviated the motor dysfunction, cognition disorder, and dopaminergic neuron degeneration induced by MPTP. Here, we discovered that the quadriceps, serum, and brain FNDC5 levels were lower in PD mice and that intervention with treadmill exercise restored FNDC5 levels. Moreover, treadmill exercise enhanced the synaptic plasticity of hippocampal pyramidal neurons via increased dopamine levels and BDNF in the PD mice. The direct protective effect of FNDC5 is achieved by promoting the secretion of BDNF in the hippocampal neurons via binding the integrinV5 receptor, thereby improving synaptic plasticity. Regarding the indirect protection effect, FNDC5 promotes the dopaminergic connection from the substantia nigra to the hippocampus by mediating the interaction between the integrinV5 of the hippocampal neurons and the CD90 molecules on the membrane of dopaminergic terminals. Our findings demonstrated that treadmill exercise could effectively alleviate cognitive disorders via the activation of the FNDC5-BDNF pathway and enhance the dopaminergic synaptic connection from SNpc to the hippocampus in the MPTP-induced chronic PD model.
10:01
Exercise alleviates neovascular age-related macular degeneration by inhibiting AIM2 inflammasome in myeloid cells. GreenMedInfo
PMID: Metabolism. 2023 Jul ;144:155584. Epub 2023 May 5. PMID: 37150437 Abstract Title: Exercise alleviates neovascular age-related macular degeneration by inhibiting AIM2 inflammasome in myeloid cells. Abstract: The neovascular form of age-related macular degeneration (nvAMD) is the leading cause of blindness in the elderly population. Vascular endothelial growth factor (VEGF) plays a crucial role in choroidal neovascularization (CNV), and anti-VEGF therapy is recommended as first-line therapy for nvAMD. However, many patients do not radically benefit from this therapy. Epidemiological data suggest that physical exercise is beneficial for many human diseases, including nvAMD. Yet, its protective mechanism and therapeutic potential remain unknown. Here, using clinical samples and mouse models, we found that exercise reduced CNV and enhanced anti-angiogenic therapy efficacy by inhibiting AIM2 inflammasome activation. Furthermore, transfusion of serum from exercised mice transferred the protective effects to sedentary mice. Proteomic data revealed that exercise promoted the release of adiponectin, an anti-inflammatory adipokine from adipose tissue into the circulation, which reduced ROS-mediated DNA damage and suppressed AIM2 inflammasome activation in myeloid cells of CNV eyes through AMPK-p47phox pathway. Simultaneous targeting AIM2 inflammasome product IL-1and VEGF produced a synergistic effect for treating choroidal neovascularization. Collectively, this study highlights the therapeutic potential of an exercise-AMD axis and uncovers the AIM2 inflammasome and its product IL-1as potential targets for treating nvAMD patients and enhancing the efficacy of anti-VEGF monotherapy.
10:00
Treasure Trove of Damning Evidence Surrounding COVID Origin Articles
According to a July 12, 2023, article by Ryan Grim published by The Intercept,1 U.S. House Republicans investigating the origin of COVID-19 appear to have inadvertently released a trove of new documents ... that shed light on deliberations among the scientists who drafted a key paper in February and March of 2020.
The paper in question is The Proximal Origin of Sars-Cov-2,2 a letter to the editor of Nature Medicine published March 17, 2020. This letter ended up being widely cited by the media as evidence of a scientific consensus that the virus emerged naturally and jumped species.
The House Subcommittee on the origin of COVID-19 devoted an entire report to this paper, showing how the authors presented a false conclusion to the public while privately believing the virus had escaped from the Wuhan Institute of Virology (WIV).
The report was published July 11, 2023, the same day the subcommittee also held a hearing on the Proximal Origin paper, in which they questioned Robert Garry, Ph.D., of Tulane University and Kristian Andersen, Ph.D., of Scripps, two of the scientists involved in its creation. The Intercept explains how more information than intended ended up out in the open:3
According to the metadata in the PDF of the report, it was created using Acrobat PDFMaker 23 for Word, indicating that the report was originally drafted as a Word document. Word, however, retains the original image when an image is cropped, as do many other apps ...
The Intercept was able to extract the original, complete images from the PDF using freely available tools, following the work of a Twitter sleuth. All the files can be found here.4
The original subcommittee report has now been taken down.
Background
February 1, 2020, Dr. Anthony Fauci, then-director of the National Institutes of Allergies and Infectious Diseases (NIAID) and Dr. Francis Collins, then-director of the National Institutes of Health (NIH) convened a conference call with 11 scientists to discuss COVID-19.
On that conference call, Drs. Fauci and Collins were warned that COVID-19 may have leaked from the Wuhan Institute of Virology (WIV) and that the virus appeared to be the result of genetic engineering. Minutes from the cal...
Swimming in Circles: Aquaculture and the End of Wild Oceans Articles
Editor's Note: This article is a reprint. It was originally published September 30, 2018.
In this interview, investigative journalist and fishing industry insider Paul Molyneaux discusses aquaculture and the dangers of farmed fish, which are also the topics of his book "Swimming in Circles: Aquaculture and the End of Wild Oceans."
From my perspective, the two most dangerous foods served in most restaurants are factory farmed chicken, which is responsible for a majority of foodborne illnesses, and farmed fish, especially farmed salmon, which is among the most toxic foods on the planet.
Salmon Farming in Cobscook Bay
At the age of 17, Molyneaux left home and got a job in commercial fishing, which led to work in aquaculture in the late '70s.
"I always had an interest in aquaculture, although I primarily was a commercial fisherman. In the late '80s, I ran a fish processing plant for the Passamaquoddy tribe in Eastport, Maine, on Cobscook Bay. There was a sudden push to do salmon farming in the bay.
The way the promoters at the time, a company called Ocean Products sold it to us was [by] saying, 'You can become farmers of the sea. You can start giving back to the ocean.' We bought it hook, line and sinker Last summer, there were about six of us standing on the dock in Eastport, saying, 'Geez, we thought this was going to be great.'"
As fisheries had dwindled, they believed aquafarming would be the answer to keeping the fishing industry alive. Alas, the industry was rapidly consolidated into the hands of just a few players. "Now, it's in the hands of one," Molyneaux says.
What's worse, it didn't take long before the environmental downsides of aquaculture became readily apparent as well. In the late 1990s, infectious salmon anemia virus spread like wildfire among the salmon pens in Cobscook Bay, wiping out the fishery as 2 million fish had to be discarded overnight.
"That set the industry back. Now, it's owned by one company Cooke Aquaculture and pretty much everything is automated. They have a tremendous sea lice problem.
They're pouring tons of SLICE into those pens, and they're coming up with new systems now because they're finding the sea lice medication is now in the mollusks, like the scallops that are also harvested from the bay. Cooke has been fined twice in the last five years for using an illegal chemical, cypermethrin, to fight sea lice."
Industrialized Food Supply Encouraged Switch to Aquaculture
...Affirmative Action in Medicine Articles
Diversity equity and inclusion (DEI) is an immensely controversial subject. I believe this controversy has arisen since people have strong reasons to support either side of the argument and because it is being forced upon us by both the government and multinational corporations.
For example, ESG scores have been used as a metric to calculate the social value of corporations, and a vital component of an ESG score is the company's commitment to advancing diversity both within the company and in society.
Since ESG scores are used by many (such as Blackrock the largest asset holder in the world) to determine which corporation to invest in, a lot of money is at stake, and many corporations have gone to great lengths in promoting left-wing causes to attract ESG-focused investors.
Note: In 2023, Vanguard (the second largest asset holder) distanced itself from ESG investing, with its CEO arguing that ESG investing is incompatible with Vanguard's fiduciary duties to the investors. Fewer than 1 in 7 of Vanguard's active equity managers outperformed the broad market in any five-year period, and none of them relied exclusively on a net-zero (ESG) investment methodology.
Depending on how one looks at it, I believe any of the following can be argued about DEI:
- It's an attempt to address a legitimate issue.
- It's a smokescreen.
- It's a power play.
- It's a mass formation.
Although many of the initial justifications for DEI were valid, at this point, it has transformed into something accomplishing the opposite of what was initially intended. In many cases, the harm of DEI is only evident if you are actively involved in the field it affects. Since I am in medicine, my focus will be on how DEI has affected medicine, but much of what I say holds for other fields as well.
Inequality and Discrimination
There are two ways to amass wealth and power:
- Producing something of immense value.
- Stealing from others.
The first sometimes happens. For example, after World War 2, since the war didn't touch America's soil, America had an intact industrial base the rest of the world was eager to purchase from and America rapidly experienced a boon in wealth that saturated the society. For context, in the 1950s, a black high school dropout working reasonable hours in a factory could afford to buy a house and support a stay-at-home wife raising his family.
Typically, however, the second happens. One of the primary issues of our era (which became much worse during the pandemic) is that the wealth that used to be ava...
09:56
Higher serum vitamin C concentrations were significantly associated with lower risk of mortality in participants with T2D. GreenMedInfo
PMID: Eur J Nutr. 2023 May 17. Epub 2023 May 17. PMID: 37195485 Abstract Title: Associations of serum vitamin C concentrations with risk of all-cause and cause-specific mortality among individuals with and without type 2 diabetes. Abstract: PURPOSE: Compared with people without diabetes, people with type 2 diabetes (T2D) are at higher risk of both subnormal vitamin C status and increased oxidative stress. We aimed to investigate the associations of serum vitamin C concentrations with all-cause and cause-specific mortality among adults with and without T2D.METHODS: The current analysis included 20,045 adults (2691 people with T2D and 17,354 without T2D) from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 2003-2006. Cox proportional hazards regression models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline analyses were used to examine the dose-response relationship.RESULTS: After a median follow-up of 17.3 years, 5211 deaths were documented. Individuals with T2D had a lower level of serum vitamin C concentrations compared with those without T2D (the median value: 40.1 vs. 44.9 mol/L). Furthermore, the dose-response relationship between serum vitamin C and mortality showed different patterns between participants with and without T2D. In individuals without T2D, there was a nonlinear association of serum vitamin C concentrations with all-cause, cancer, and CVD mortality, with the lowest risk around a serum vitamin C concentration of 48.0 mol/L (all P
09:20
The effect of FMT and vitamin C on immunity-related genes in antibiotic-induced dysbiosis. GreenMedInfo
PMID: PeerJ. 2023 ;11:e15356. Epub 2023 May 11. PMID: 37193034 Abstract Title: The effect of FMT and vitamin C on immunity-related genes in antibiotic-induced dysbiosis in mice. Abstract: Antibiotics are double-edged swords. Although antibiotics are used to inhibit pathogenic bacteria, they also run the risk of destroying some of the healthy bacteria in our bodies. We examined the effect of penicillin on the organism through a microarray dataset, after which 12 genes related to immuno-inflammatory pathways were selected by reading the literature and validated using neomycin and ampicillin. The expression of genes was measured using qRT-PCR. Several genes were significantly overexpressed in antibiotic-treated mice, including CD74 and SAA2 in intestinal tissues that remained extremely expressed after natural recovery. Moreover, transplantation of fecal microbiota from healthy mice to antibiotic-treated mice was made, where GZMB, CD3G, H2-AA, PSMB9, CD74, and SAA1 were greatly expressed; however, SAA2 was downregulated and normal expression was restored, and in liver tissue, SAA1, SAA2, SAA3 were extremely expressed. After the addition of vitamin C, which has positive effects in several aspects, to the fecal microbiota transplantation, in the intestinal tissues, the genes that were highly expressed after the fecal microbiota transplantation effectively reduced their expression, and the unaffected genes remained normally expressed, but the CD74 gene remained highly expressed. In liver tissues, normally expressed genes were not affected, but the expression of SAA1 was reduced and the expression of SAA3 was increased. In other words, fecal microbiota transplantation did not necessarily bring about a positive effect of gene expression restoration, but the addition of vitamin C effectively reduced the effects of fecal microbiota transplantation and regulated the balance of the immune system.
08:59
Fecal microbiota transplantation holds the secret to youth. GreenMedInfo
PMID: Mech Ageing Dev. 2023 Jun ;212:111823. Epub 2023 May 14. PMID: 37192676 Abstract Title: Fecal microbiota transplantation holds the secret to youth. Abstract: Aging shows itself not just at the cellular level, with shortened telomeres and cell cycle arrest, but also at the organ and organismal level, with diminished brainpower, dry eyes, intestinal inflammation, muscular atrophy, wrinkles, etc. When the gut microbiota, often called the "virtual organ of the host," fails to function normally, it can lead to a cascade of health problems including, but not limited to, inflammatory bowel disease, obesity, metabolic liver disease, type II diabetes, cardiovascular disease, cancer, and even neurological disorders. An effective strategy for restoring healthy gut bacteria is fecal microbiota transplantation (FMT). It can reverse the effects of aging on the digestive system, the brain, and the vision by transplanting the functional bacteria found in the excrement of healthy individuals into the gut tracts of patients. This paves the way for future research into using the microbiome as a therapeutic target for disorders associated with aging.
08:43
Gut microbiota is an impact factor based on the brain-gut axis to Alzheimer's disease. GreenMedInfo
PMID: Aging Dis. 2023 Jun 1 ;14(3):964-1678. Epub 2023 Jun 1. PMID: 37191418 Abstract Title: Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer's Disease: A Systematic Review. Abstract: Alzheimer's disease (AD) is a degenerative disease of the central nervous system. The pathogenesis of AD has been explained using cholinergic,-amyloid toxicity, tau protein hyperphosphorylation, and oxidative stress theories. However, an effective treatment method has not been developed. In recent years, with the discovery of the brain-gut axis (BGA) and breakthroughs made in Parkinson's disease, depression, autism, and other diseases, BGA has become a hotspot in AD research. Several studies have shown that gut microbiota can affect the brain and behavior of patients with AD, especially their cognitive function. Animal models, fecal microbiota transplantation, and probiotic intervention also provide evidence regarding the correlation between gut microbiota and AD. This article discusses the relationship and related mechanisms between gut microbiota and AD based on BGA to provide possible strategies for preventing or alleviating AD symptoms by regulating gut microbiota.
08:21
Fecal microbiota transplantation in inflammatory bowel disease. GreenMedInfo
PMID: Biomedicines. 2023 Mar 27 ;11(4). Epub 2023 Mar 27. PMID: 37189634 Abstract Title: Fecal Microbiota Transplantation in Inflammatory Bowel Disease. Abstract: Inflammatory bowel diseases represent a complex array of diseases of incompletely known etiology that led to gastrointestinal tract chronic inflammation. In inflammatory bowel disease, a promising method of treatment is represented by fecal microbiota transplantation (FMT), FMT has shown its increasing effectiveness and safety in recent years for recurrent CDI; moreover, it showed real clinical benefits in treating SARS-CoV-2 and CDI co-infection. Crohn's disease and ulcerative colitis are characterized by immune dysregulation, resulting in digestive tract damage caused by immune responses. Most current therapeutic strategies are associated with high costs and many adverse effects by directly targeting the immune response, so modifying the microbial environment by FMT offers an alternative approach that could indirectly influence the host's immune system in a safe way. Studies outline the endoscopic and clinical improvements in UC and CD in FMT patients versus control groups. This review outlines the multiple benefits of FMT in the case of IBD by improving patients unbalanced gut, therefore improving endoscopic and clinical symptomatology. We aim to emphasize the clinical importance and benefits of FMT in order to prevent flares or complications of IBD and to highlight that further validation is needed for establishing a clinical protocol for FMT in IBD.
08:04
08:00
The gut microbiota, its relationship to the immune system, and possibilities of its modulation. GreenMedInfo
PMID: Epidemiol Mikrobiol Imunol. 2023 ;72(1):40-53. PMID: 37185024 Abstract Title: The gut microbiota, its relationship to the immune system, and possibilities of its modulation. Abstract: Research of the gut microbiota allows a better understanding of its composition and function and reveals the links between changes in the composition of bacteria and various intestinal but also systemic diseases. The gut microbiota performs several of important functions in the host body and influences many physiological processes. Gut bacteria synthesize many compounds needed for the proper function of the body (e.g., vitamins, short-chain fatty acids, and amino acids). They help maintain the integrity of the intestinal barrier and protect against pathogens. The gut microbiota plays a crucial role in the development and function of the immune system. Significant changes in the composition of the intestinal microbiota led to a dysbiotic state and the loss of its beneficial functions for humans. The review article summarizes the basic knowledge about the composition and function of the bacterial gut microbiota in healthy people, its role in the development of the immune system, and the mechanisms involved in maintaining homeostasis. It also presents current knowledge about the possibility of targeted modulation of the bacterial gut microbiota and faecal transplantation.
07:34
Do Ginkgo biloba supplements have any effect on dementia? Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
There are many claims that the ginkgo biloba supplement has a positive effect on cognitive health including reducing the effects of dementia.
07:21
Fecal microbiota transplantation in the treatment of systemic lupus erythematosus. GreenMedInfo
PMID: J Autoimmun. 2023 May 11:103058. Epub 2023 May 11. PMID: 37179170 Abstract Title: Fecal microbiota transplantation in the treatment of systemic lupus erythematosus: What we learnt from the explorative clinical trial. Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease with the characterized presence of autoantibodies and resulting in multiple organ damage, which is incurable and can be lethal. The current treatments are limited and less progress has been made in drug discovery for the last few decades. Researches imply that gut dysbiosis exists in both patients and murine models with SLE, taking part in the pathogenesis of SLE through multiple mechanisms such as microbiota translocation and molecular mimicry. Intestinal interventions on the gut microbiome by fecal transplantations to reconstitute the gut-immunity homeostasis serve as a novel therapeutic option for SLE patients. Fecal microbiota transplantation (FMT), which is usually used in intestinal diseases, has been firstly demonstrated to be safe and efficient in recovering gut microbiota structure of SLE patients and reducing lupus activity in our recent clinical trial, which is the first trial testing FMT therapy in SLE treatment. In this paper, we reviewed the results of the single-arm clinical trial and made recommendations on FMT practice in SLE treatment including therapeutic indications, screening items and dosage regimen, trying to provide references for future study and clinical practice. We also came up with the unanswered questions that need to be solved by the ongoing randomized controlled trial as well as the future expectations for the intestinal intervention strategies of SLE patients.
06:36
Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection. GreenMedInfo
PMID: Cell Host Microbe. 2023 May 10 ;31(5):695-711. PMID: 37167952 Abstract Title: Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection. Abstract: Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood. Herein, we provide an overview of rCDI pathogenesis followed by a discussion of potential mechanisms of action focusing on the current understanding of trans-kingdom microbial, metabolic, immunological, and epigenetic mechanisms. We then outline the current research gaps and offer methodological recommendations for future studies to elevate the quality of research and advance knowledge translation. By combining interventional trials with multiomics technology and host and environmental factors, analyzing longitudinally collected biospecimens will generate results that can be validated with animal and other models. Collectively, this will confirm causality and improve translation, ultimately to develop targeted therapies to replace FMT.
06:28
The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease. GreenMedInfo
PMID: Front Physiol. 2023 ;14:1166685. Epub 2023 Apr 21. PMID: 37153213 Abstract Title: The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease. Abstract: Diabetic kidney disease (DKD) is a common complication in patients with diabetes mellitus (DM). Increasing evidence suggested that the gut microbiota participates in the progression of DKD, which is involved in insulin resistance, renin-angiotensin system (RAS) activation, oxidative stress, inflammation and immunity. Gut microbiota-targeted therapies including dietary fiber, supplementation with probiotics or prebiotics, fecal microbiota transplantation and diabetic agents that modulate the gut microbiota, such as metformin, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose transporter-2 (SGLT-2) inhibitors. In this review, we summarize the most important findings about the role of the gut microbiota in the pathogenesis of DKD and the application of gut microbiota-targeted therapies.
06:24
Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells. GreenMedInfo
n/a PMID: In Vitro Cell Dev Biol Anim. 2023 Apr ;59(4):264-276. Epub 2023 May 12. PMID: 37173557 Abstract Title: Resveratrol inhibits LPS-induced apoptosis in bovine mammary epithelial cells: the role of PGC1-SIRT3 axis. Abstract: Resveratrol (Res) is a bioactive dietary component and alleviates apoptosis in multiple cell types. However, its effect and mechanism on lipopolysaccharide (LPS)-induced bovine mammary epithelial cells (BMEC) apoptosis, which commonly happens in dairy cows with mastitis, is unknown. We hypothesized that Res would inhibit LPS-induced apoptosis in BMEC through SIRT3, a NAD+-dependent deacetylase activated by Res. To test the dose-response effect on apoptosis, 0-50 M Res were incubated with BMEC for 12 h, followed by 250 g/mL LPS treatment for 12 h. To investigate the role of SIRT3 in Res-mediated alleviation of apoptosis, BMEC were pretreated with 50 M Res for 12 h, then incubated with si-SIRT3 for 12 h and were finally treated with 250 g/mL LPS for 12 h. Res dose-dependently promoted the cell viability and protein levels of Bcl-2 (Linear P<0.001) but decreased protein levels of Bax, Caspase-3 and Bax/Bcl-2 (Linear P<0.001). TUNEL assays indicated that cellular fluorescence intensity declined with the rising doses of Res. Res also dose-dependently upregulated SIRT3 expression, but LPS had the opposite effect. SIRT3 silencing abolished these results with Res incubation. Mechanically, Res enhanced the nuclear translocation of PGC1, the transcriptional cofactor for SIRT3. Further molecular docking analysis revealed that Res could directly bind to PGC1by forming a hydrogen bond with Tyr-722. Overall, our data suggested that Res relieved LPS-induced BMEC apoptosis through the PGC1-SIRT3 axis, providing a basis for further in vivo investigations of applying Res to relieve mastitis in dairy cows.
06:10
Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart. GreenMedInfo
PMID: J Pharmacol Sci. 2023 Jun ;152(2):112-122. Epub 2023 Apr 11. PMID: 37169475 Abstract Title: Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice. Abstract: Aging is associated with impairment of multiple organs, including skeletal muscle and heart. In this study, we investigated whether resveratrol, an activator of an NAD-dependent protein deacetylase Sirtuin-1 (SIRT1), attenuates age-related sarcopenia and cardiomyocyte hypertrophy in mice. Treatment of mice with resveratrol (0.4 g/kg diet) from 28 weeks of age for 32 weeks prevented aging-associated shortening of rotarod riding time. In the tibialis anterior (TA) muscle, histogram analysis showed that the atrophic muscle was increased in 60-week-old (wo) mice compared with 20-wo mice, which was attenuated by resveratrol. In the heart, resveratrol attenuated an aging-associated increase in the cardiomyocyte diameter. Acetylated proteins were increased and autophagic activity was reduced in the TA muscle of 60-wo mice compared with those of 20-wo mice. Resveratrol treatment reduced levels of acetylated proteins and restored autophagic activity in the TA muscle. Aging-related reduction in myocardial autophagy was also suppressed by resveratrol. Skeletal muscle-specific SIRT1 knockout mice showed increases in acetylated proteins and atrophic muscle fibers and reduced autophagic activity in the TA muscle. These results suggest that activation of SIRT1 by treatment with resveratrol suppresses sarcopenia and cardiomyocyte hypertrophy by restoration of autophagy in mice.
06:10
The science of red meat and cancer what does it say? Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
This article will review the evidence that may support or reject the claim that red meat is linked to cancer.
06:04
Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells. GreenMedInfo
PMID: Breast Cancer. 2023 May 11. Epub 2023 May 11. PMID: 37166625 Abstract Title: Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells. Abstract: BACKGROUND: Triple-negative breast cancer (TNBC) has an aggressive phenotype and poor outcome, however no specific targeted therapy has been established for TNBC lacking germline BRCA1/2 pathogenic variants. To develop a novel therapeutic strategy, we explored the potential of resveratrol (RSV) for TNBC treatment.METHODS: We investigated the effects of RSV on malignant phenotypes of TNBC cells as well as on apoptosis induced by ABT263, a specific inhibitor of BCL-2 and BCL-xL, using morphological observation, migration assay,-galactosidase staining, and Hoechst staining. To elucidate the underlying mechanisms of RSV-mediated effects, expression levels and histone acetylation levels of cadherin 1 (CDH1, E-cadherin) and cyclin dependent kinase inhibitor 1A (CDKN1A, p21) were determined by RT-qPCR, western blotting, and chromatin immunoprecipitation. Furthermore, knockdown analysis was conducted to evaluate the involvement of E-cadherin and/or p21 in RSV potentiation on cytotoxic activity of ABT263.RESULTS: RSV treatment induced epithelial-like cellular morphology and suppressed the migration capacity in MDA-MB-231 and BT-549-Luc TNBC cells.-galactosidase-positive cells were increased after RSV treatment, indicating the induction of cellular senescence, in MDA-MB-231 cells but not in BT-549-Luc cells. RSV increased the expression and histone acetylation of CDH1 and CDKN1A in both cells. Interestingly, pre-treatment with RSV enhanced the induction of apoptosis in the ABT263-treated MDA-MB-231 and BT-549-Luc cells, and knockdown of CDKN1A decreased ABT263-induced apoptosis in RSV-treated MDA-MB-231 cells.CONCLUSIONS: RSV represses the metastatic capacity and enhances the cytotoxic activity of ABT263 in TNBC cells. Our results suggested that RSV can potentially be used as a repressor of metastasis or a sensitizer to ABT263 for TNBC treatment via up-regulation of CDH1 and CDKN1A through epigenetic mechanisms.
06:02
Nanoparticles enhance solubility and neuroprotective effects of resveratrol in demyelinating disease. GreenMedInfo
PMID: Neurotherapeutics. 2023 May 9. Epub 2023 May 9. PMID: 37160530 Abstract Title: Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease. Abstract: Resveratrol is a natural polyphenol which may be useful for treating neurodegenerative diseases such as multiple sclerosis (MS). To date, current immunomodulatory treatments for MS aim to reduce inflammation with limited effects on the neurodegenerative component of this disease. The purpose of the current study is to develop a novel nanoparticle formulation of resveratrol to increase its solubility, and to assess its ability to prevent optic nerve and spinal cord degeneration in an experimental autoimmune encephalomyelitis (EAE) mouse model of MS. Resveratrol nanoparticles (RNs) were made using a thin rehydration technique. EAE mice received a daily oral administration of vehicle, RNs or unconjugated resveratrol for one month. They were assessed daily for clinical signs of paralysis and weekly for their visual acuity with optokinetic responses (OKR). After one month, their spinal cords and optic nerves were stained for inflammation and demyelination and retinal ganglion cells immunostained for Brn3a. RNs were stable for three months. The administration of RNs did not have any effect on clinical manifestation of EAE and did not preserve OKR scores but reduced the intensity of the disease. It did not reduce inflammation and demyelination in the spinal cord and the optic nerve. However, RNs were able to decrease RGC loss compared to the vehicle. Results demonstrate that resveratrol is neuroprotective by reducing RGC loss. Interestingly, neuroprotective effects and decreased disease severity occurred without reduction of inflammation or demyelination, suggesting this therapy may fill an unmet need to limit the neurodegenerative component of MS.
05:52
NEW! Expedition Decoding the Mystery of the Great Pyramid and Homeopathy Begins This Fall GreenMedInfo
Visit our Re-post guidelines
This fall, in a series of ground-breaking water memory experiments to be conducted legendary CymaScope instrument is set to reveal insights into the mechanisms of homeopathy, as well shedding light on what the real purpose of the King's Chamber may be.
To learn how you can contribute to this important research mission, join the upcoming AUREA event on June 9-11th, and please read on...
05:44
Is Mental Illness Actually the Brain Trying to Protect Itself? Mad In America
From Emergent Divergence: People hold on tightly to the idea that they are mentally ill, and understandably so. The deficit model of mental health has been pushed on us quite successfully, but what if its not the person who is ill?
Consider depression. A person experiences a traumatic event . . . and starts to feel as though nothing goes well for them. They withdraw from their environment and isolate. Is this an illness, or is this the human brain doing its best to protect itself from trauma?
Now consider that the cultures [we] live with, particular in Western society, actively punish people who have experienced trauma. There is a lack of welfare benefits, inadequate and under-resourced wellbeing services, and lets not forget that humans are effectively judged by whether or not they make the right amount of profit while performing a neurotypical display so as to not make others uncomfortable.
To me it seems clear where the suffering is actually stemming from, and it isnt the person.
***
Back to Around the Web
The post Is Mental Illness Actually the Brain Trying to Protect Itself? appeared first on Mad In America.
05:43
Unbeloved by Anonymous Mad In America
In a bid for peace
Silence was key
I hated the the role
He forced on me
No longer a child
I was deemed as property
A beast that
Needed to be broken
To fit in his society
Even animals learn to hate
When broken so violently
I remember his roses
I remembered I loved him
Once upon a time
When I was a child.
****
Back to Poetry Gallery
The post Unbeloved by Anonymous appeared first on Mad In America.
05:35
The effects of resveratrol and melatonin on cardiac dysfunction in diabetic elderly female rats. GreenMedInfo
PMID: Physiol Res. 2023 Apr 30 ;72(2):187-198. PMID: 37159853 Abstract Title: The effects of resveratrol and melatonin on cardiac dysfunction in diabetic elderly female rats. Abstract: We aimed to investigate the effects of melatonin and resveratrol on diabetes-related papillary muscle dysfunction and structural heart disorders. The protective effect of resveratrol and melatonin supplementation on cardiac functions was investigated in a diabetic elderly female rat model. 16-month-old rats (n=48) were allocated into 8 groups. Group1: Control, Group2: Resveratrol Control, Group3: Melatonin Control, Group4: Resveratrol and Melatonin Control, Group5: Diabetes, Group6: Diabetes Resveratrol, Group7: Diabetes Melatonin, Group8: Diabetes Resveratrol and Melatonin. Streptozotocin was injected intraperitoneally to the rats for experimental diabetes induction. Thereafter, resveratrol (intraperitoneal) and melatonin (subcutaneous) were administered for 4 weeks. Resveratrol and melatonin had a protective effect on the contractile parameters and structural properties of the papillary muscle, which was impaired by diabetes. it has been presented that diabetes impairs the contractile function of the papillary muscle for each stimulus frequency tested and the responses obtained as a result of Ca+2 uptake and release mechanisms from the Sarcoplasmic reticulum, and it has been observed that these effects are improved with resveratrol and melatonin injection. The decrease in myocardial papillary muscle strength in the diabetic elderly female rat can be reversed with the combination of resveratrol, melatonin and resveratrol+melatonin. Melatonin+resveratrol supplementation is no different from melatonin and/or resveratrol supplementation. Resveratrol and melatonin supplementation may have a protective effect on cardiac functions in a diabetic elderly female rat model.
05:30
Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury. GreenMedInfo
PMID: Int Immunopharmacol. 2023 May ;118:110111. Epub 2023 Apr 5. PMID: 37028275 Abstract Title: Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3/caspase-1/gasdermin D-mediated pyroptosis. Abstract: BACKGROUND: Sodium tanshinone IIA sulfonate (STS) has been reported to protect organ function in sepsis. However, the attenuation of sepsis-associated brain injury and its underlying mechanisms by STS has not been established.METHODS: C57BL/6 mice were used to establish the cecal ligation perforation (CLP) model, and STS was injected intraperitoneally 30 min before the surgery. The BV2 cells were stimulated by lipopolysaccharide after being pre-treated with STS for 4 h. The STS protective effects against brain injury and in vivo anti-neuroinflammatory effects were investigated using the 48-hour survival rate and body weight changes, brain water content, histopathological staining, immunohistochemistry, ELISA, RT-qPCR, and transmission electron microscopy. The pro-inflammatory cytokines of BV2 cells were detected by ELISA and RT-qPCR. At last, the levels of NOD-like receptor 3 (NLRP3) inflammasome activation and pyroptosis in brain tissues of the CLP model and BV2 cells were detected using western blotting.RESULTS: STS increased the survival rate, decreased brain water content, and improved brain pathological damage in the CLP models. STS increased the expressions of tight junction proteins ZO-1 and Claudin5 while reducing the expressions of tumor necrosis factor(TNF-), interleukin-1(IL-1), and interleukin-18 (IL-18) in the brain tissues of the CLP models. Meanwhile, STS inhibited microglial activation and M1-type polarization in vitro and in vivo. The NLRP3/caspase-1/ gasdermin D (GSDMD)-mediated pyroptosis was activated in the brain tissues of the CLP models and lipopolysaccharide (LPS)-treated BV2 cells, which was significantly inhibited by STS.CONCLUSIONS: The activation of NLRP3/caspase-1/GSDMD-mediated pyroptosis and subsequent secretion of proinflammatory cytokines may be the underlying mechanisms of STS against sepsis-associated brain injury and neuroinflammatory response.
04:53
Video: How To Perform Vertical Mattress Sutures
In this video episode in a series on how to perform suture closures, Dr. Joe Alton discusses and demonstrates the very useful vertical mattress suture. Use for areas under tension and other applications, the vertical mattress suture is another tool in the woodshed for the family medic in times of trouble. To watch, click below:[Read More]
The post Video: How To Perform Vertical Mattress Sutures first appeared on .04:37
Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth. GreenMedInfo
PMID: Cell Death Discov. 2023 May 19 ;9(1):172. Epub 2023 May 19. PMID: 37202382 Abstract Title: Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth. Abstract: Glioblastomas are a highly aggressive cancer type which respond poorly to current pharmaceutical treatments, thus novel therapeutic approaches need to be investigated. One such approach involves the use of the bioactive natural product Tanshinone IIA (T2A) derived from the Chinese herb Danshen, where mechanistic insight for this anti-cancer agent is needed to validate its use. Here, we employ a tractable model system, Dictyostelium discoideum, to provide this insight. T2A potently inhibits cellular proliferation of Dictyostelium, suggesting molecular targets in this model. We show that T2A rapidly reduces phosphoinositide 3 kinase (PI3K) and protein kinase B (PKB) activity, but surprisingly, the downstream complex mechanistic target of rapamycin complex 1 (mTORC1) is only inhibited following chronic treatment. Investigating regulators of mTORC1, including PKB, tuberous sclerosis complex (TSC), and AMP-activated protein kinase (AMPK), suggests these enzymes were not responsible for this effect, implicating an additional molecular mechanism of T2A. We identify this mechanism as the increased expression of sestrin, a negative regulator of mTORC1. We further show that combinatory treatment using a PI3K inhibitor and T2A gives rise to a synergistic inhibition of cell proliferation. We then translate our findings to human and mouse-derived glioblastoma cell lines, where both a PI3K inhibitor (Paxalisib) and T2A reduces glioblastoma proliferation in monolayer cultures and in spheroid expansion, with combinatory treatment significantly enhancing this effect. Thus, we propose a new approach for cancer treatment, including glioblastomas, through combinatory treatment with PI3K inhibitors and T2A.
04:30
Fucoidan promotes angiogenesis and accelerates wound healing. GreenMedInfo
PMID: Int Wound J. 2023 May 18. Epub 2023 May 18. PMID: 37203309 Abstract Title: Fucoidan promotes angiogenesis and accelerates wound healing through AKT/Nrf2/HIF-1signalling pathway. Abstract: After skin injury, wound repair involves a complex process in which angiogenesis plays a crucial role. Previous research has indicated that fucoidan may aid in wound healing; we therefore hypothesised that fucoidan may speed up the process by promoting angiogenesis. In this study, we investigated the potential molecular mechanism underlying fucoidan's ability to accelerate wound healing by promoting angiogenesis. Using a full-cut wound model, we observed that fucoidan significantly intensified wound closure and promoted granulation formation and collagen deposition. Immunofluorescence staining revealed that fucoidan also promoted wound angiogenesis, specifically by accelerating the migration of new blood vessels to the middle area of the wound. Furthermore, fucoidan demonstrated the ability to enhance the proliferation of human umbilical vein endothelial cells (HUVECs) damaged by hydrogen peroxide (HO) and to improve the formation of endothelial tubes. Mechanistic studies revealed that fucoidan upregulated the protein levels of the AKT/Nrf2/HIF-1signalling pathway, which plays a crucial role in angiogenesis. This was further confirmed using the inhibitor LY294002, which reversed the promotion of endothelial tube formation by fucoidan. Overall, our findings suggest that fucoidan can promote angiogenesis via the AKT/Nrf2/HIF-1signalling pathway and accelerate wound healing.
04:19
Sayer Ji: Anti-Vaxx Extremist or Whistleblower? The SECRET to How I Survive GreenMedInfo
Being targeted by my own government for exercising protected speech, and especially for telling the truth about the mRNA jabs in an attempt to warn the public before their roll-out has not been easy.
03:45
The Key to the Psych Unit Mad In America
My grandmother was a caregiver, an artist, and a ruthless bingo player. I always sought to understand how she experienced the world and learn from her. We talked about almost everything. When I came out as bi+/pansexual, we had a conversation. She shared that her sister might be gay and that she just wanted me to be happy. Her love felt strong and unconditional. She had a sweetness to her that was undeniable. I liked being in her presence and enjoyed the time we spent together sharing, playing cards, and laughing, always laughing.
It was not unusual that I also shared what I was learning in my post-secondary studies, but one time, the conversation was different. It was the late 90s and as an undergraduate psychology major, I was reading a book on electroconvulsive therapy (ECT). I was horrified to learn psychiatrists still conducted ECT, and I said as much to my grandma. She was quiet. Quieter than usual. She listened, but when I paused, she didnt respond. I directly asked her, Can you believe they still do this to people?!? She shared that she could. She shared that it was done to her.
We had talked about a lot over the years, but I had no idea she lived through that. Perhaps I should have. Our family was no stranger to mental health symptoms and clinical diagnoses. It was not a secret that my grandmothers sister lived in a psychiatric institution for most of her life, and my uncle spoke freely about how he drank because reading peoples thoughts was too overwhelming for him. Plus, most of the family had been in therapy at some point to deal with depression, abuse, or whatever the diagno...
03:27
Breaking: Jordan Releases 'Smoking Gun Docs' Confirming Facebook Bowed to White House Censorship Demands GreenMedInfo
Unredacted Facebook emails released by Rep. Jim Jordan today expose White House demands to quash narratives, and remove memes and posts contradicting the governments COVID-19 messaging.
03:18
Breaking: Jordan Releases 'Smoking Gun Docs' Confirming Facebook Bowed to White House Censorship Demands GreenMedInfo
Originally published on www.childrenshealthdefense.org by John-Michael Dumais
Unredacted Facebook emails released by Rep. Jim Jordan today expose White House demands to quash narratives, and remove memes and posts contradicting the government's COVID-19 messaging.