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Thursday, 06 July
22:00
The effects of vitamin D supplementation on major cardiac events Science-Based Medicine
A large randomized controlled trial of vitamin D supplementation generates good data to show there is likely no benefit.
The post The effects of vitamin D supplementation on major cardiac events first appeared on Science-Based Medicine.20:07
Adults With Autism Need Everything Students Needed and More Age of Autism The Rebel Alliance!
This meme stopped me in my tracks. It's so true. Adults with autism
are being disappeared, even as the number of those over 18 grows.
Its a dirty secret. After 22, families are on special needs.
Quality care. Meaningful days. Safe nights. Required, skilled care,
not the take it or leave it system in place now. Students
with autism have trained teachers and staff working with them.
Adults with autism have few trained people around them to help them
hold down a job, live independently, attend a day program or live
in shared housing. It's bad and going to get worse. Because parents
are growing older. And their parents are already quite old. This
sandwich generation is the toughest to imagine. Yet here we are. No
flag. No special color. No puzzle piece. No social outrage. We're
too complicated. Too nuanced. TOO REAL.
###
Order today, from Skyhorse Publishing.
The Wuhan Cover Up How Health
Officials Conspired with the Chinese Military to Hide the Origins
of COVID-19 (Childrens Health Defense)
The Wuhan Cover-Up pulls back the curtain on how the US
government's increase in biosecurity spending after the 2001 terror
attacksfacilitated by Dr. Anthony Fauci, director of the National
Institute of Allergy and Infectious Diseases (NIAID)set in motion a
plan to transform the NIAID into a de facto Defense Department
agency.
While Dr. Fauci zealously funded and pursued gain-of-function
research, concern grew among some scientists and government
officials about the potential for accidental or deliberate release
of weaponized viruses from labs that might trigger worldwide
pandemics. A moratorium was placed on this resear...
11:07
A comprehensive review of herbal supplements used for persistent symptoms attributed to lyme disease. GreenMedInfo
PMID: Integr Med (Encinitas). 2023 Mar ;22(1):30-38. PMID: 37101730 Abstract Title: A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease. Abstract: CONTEXT: Lyme disease is the most common, tick-borne disease in the USA. While most patients successfully recover with antibiotics, some patients experience persistent symptoms for months to years. Patients who attribute chronic symptoms to Lyme disease commonly use herbal supplements. The complexity, variability in dose and formulation, and lack of data for these herbal compounds make it difficult to assess their efficacy and safety.OBJECTIVE: This review examines the evidence for the antimicrobial activity, safety, and drug-drug interactions of 18 herbal supplements that patients commonly use for treatment of persistent symptoms attributed to Lyme disease.DESIGN: The research team performed a narrative review by searching the PubMed, Embase, Scopus, Natural Medicines databases, and NCCIH website. The search used the keywords for 18 herbal compounds: (1) andrographis (Andrographis paniculate), (2) astragalus (Astragalus propinquus), (3) berberine, (4) cat's claw bark (Uncaria tomentosa), (5) cordyceps (Cordyceps sinensis), (6) cryptolepis (Cryptolepis sanguinolenta), (7) Chinese skullcap (Scutellaria baicalensis), (8) garlic (Allium sativum), (9) Japanese knotwood (Polygonum cuspidatum), (10) reishi mushrooms (Ganoderma lucidum), (11) sarsaparilla (Smilax medica), (12) Siberian ginseng (Eleutherococcus senticosus), (13) sweet wormwood (Artemisia annua), (14) teasle root (Dipsacus fullonum), (15) lemon balm (Melissa officinalis), (16) oil of oregano (Origanum vulgare), (17) peppermint (Mentha x piperita), and (18) thyme (Thymus vulgaris). The team also searched for terms related to protocols, including Dr. Rawls' protocol and the Buhner protocol.SETTING: University of Maryland Medical Center, Baltimore MD.RESULTS: Seven of the 18 herbs reviewed had evidence for in-vitro activity against. These compounds included: (1) cat's claw (2) cryptolepis, (3) Chinese skullcap, (4) Japanese knotweed, (5) sweet wormwood, (6) thyme, and (7) oil of oregano. With the exception of oil of oregano these compounds also have anti-inflammatory activity. In vivo data and clinical trials are lacking. Clinicians should be cautious as many of the identified compounds have drug interactions and additive effects that could lead to increased risks for bleeding, hypotension, and hypoglycemia.CONCLUSIONS: Many of the herbs that alternative and integrative practitioners use to treat Lyme disease have anti-inflammatory effects that may contribute to patients' perceptions of symptomatic improvement. Some herbs have limited demonstrated anti-borrelial activity in vitro, but in-vivo data and clinical trial...
10:00
How China Is Destroying American Farmland Articles
North Carolina is the home of more than 2,000 large-scale hog farms, primarily clustered in the rural eastern region of the state. As illustrated in the Vox video above, factory scale hog farming takes a tremendous toll on the surrounding environment, as hog excrement ends up polluting waterways, land and air.
More than 200 of these North Carolina hog farms are owned or operated by Smithfield Foods,1 the largest pork producer in the world, which in 2013 was acquired by the WH Group, a Chinese pork conglomerate that had previously been accused of feeding its hogs illegal chemicals.2
But as reported by Rolling Stone magazine in 2018, that wasnt the only safety concern raised by the sale:3
The Chinese government had a track record of using nominally private entities as proxies for state power ... In 2011 ... the government issued a plan directing Chinese companies to buy foreign food producers and farmland. In two years, Chinese nationals went from owning $81 million worth of American farmland to nearly $1.4 billion ...
The investigative news organization Reveal uncovered documents showing that WH Group receives guidance from the government, which a company executive explained was because pork is considered a national-security issue in China ...
Part of what made the company such an attractive target is that its about 50% cheaper to raise hogs in North Carolina than in China. This is due to less-expensive pig-feed prices and larger farms, but its also because of loose business and environmental regulations ... which have made the U.S. an increasingly attractive place for foreign companies to offshore costly and harmful business practices.
China Dumps Its Agricultural Waste in the US
In years past, the U.S. outsourced dirty industry processes to poorer countries. Today, China is doing the same, and its treating the U.S. as a developing nation. Granted, U.S. environmental policies which have gotten increasingly lax over time due to regulatory capture by industry are what allows for this hostile takeover in the first place.
Believe it or not, China doesnt allow hog waste to be sprayed on fields as a means of disposal, as is routinely done here in the U.S. In China, hog farmers are forced to spend big bucks on wastewater treatment, digeste...
Suicide Is on the Rise Know the Warning Signs Articles
Editor's Note: This article is a reprint. It was originally published June 21, 2018.
The suicides of fashion designer Kate Spade and celebrity chef and TV personality Anthony Bourdain,1 which occurred within days of each other, in 2018 reignited a much-needed public discussion about suicide, mental illness and its treatment. As noted by Dr. Anne Schuchat, then-principal deputy director of the U.S. Centers for Disease Control and Prevention, depression "is not a condition that is related to success or failure. No one is immune."2
Statistics also reveal suicide rates have risen sharply across the U.S. since the early 2000s, prompting health authorities to call for "a comprehensive approach to addressing depression."3 Since the pandemic suicide in 2023 is the 11th leading cause of death in the U.S., with an average132 suicides per day.4
However, while a number of headlines scream for new drug treatment,5 I believe we'll get nowhere fast unless we start to address mental health from a more holistic perspective. It seems quite clear that antidepressants, in addition to not working very well (or in some cases at all), are actually part of the problem thanks to their side effects.
Meanwhile, nutritional deficiencies, a decline in social interaction brought about by increasing reliance on social media and technology, excessive exposure to electromagnetic fields (EMFs), lack of sleep, "lack of life purpose" or spiritual connection, and chronic, unresolved stress are just some of the factors that can contribute to depression, none of which can be addressed by new or more drugs.
Specific medical conditions, such as cancer, heart disease, diabetes and stroke are also linked to a higher risk of major depressive disorder.
Spade's Suicide Took Those Closest to Her by Surprise
According to Spade's husband and business partner, Andy Spade, Kate had struggled with depression and anxiety for several years, and was taking medication for these issues.6,7 When she killed herself, the couple had been separated 10 months, but lived within blocks of each other...
Is This a Natural Option for Harmful Skinny Injections? Articles
Berberine is a naturally occurring compound found in certain plants, which some are calling "natures Ozempic."1 It is a once-weekly injectable diabetes medication that has grown in popularity as a weight loss product. However, as popularity has grown, so have shortages.2 In response, some are posting information about alternatives, such as other diabetic drugs, generic Ozempic (semaglutide) made at compounding pharmacies or berberine.
Prescriptions for semaglutide have doubled since mid-2021, rising to more than 1.2 million. In April 2023, a spokesperson for Novo Nordisk, maker of semaglutide, said the drugs are now available in pharmacies nationwide. Semaglutide is sold under the name Ozempic as a diabetes drug and under the name Wegovy as a weight loss prescription drug.
Berberine has received a lot of media attention as it gains momentum on social media as a weight loss supplement. Berberine is a compound that's extracted from goldenseal, barberry, Oregon grape and tree turmeric. It has traditionally been used in Ayurvedic medicine and traditional Chinese medicine3 for nearly 2,000 years.4
Recent research has analyzed the effect berberine may have on hypertension and insulin resistance. The yellow-colored alkaloid has antibacterial, anti-inflammatory, antiproliferative, antidiarrheal, antineoplastic, antidiabetic and immune-enhancing properties.5
However, the property that appears to have piqued peoples interest is the weight loss potential. While the news media does offer some information about berberine in relation to Ozempic and Wegovy, the vast majority of the information cautions readers.6
The list of potential issues includes that supplements are not reviewed or approved by the FDA, may not be safe for consumption and that people who experience weight loss with berberine should stop immediately and consult with their physician as it suggests the supplement may have been adulterated.
Berberine Helps Regulate Blood Sugar and Aids Gut Microbiome
Research data shows that berberine helps to regulate blood sugar and may help with weight loss. A 2022 systematic review of the literature7 evaluated randomized controlled trials of adults who were given berberine supplementation. The pooled results demonstrated that berberine did reduce insulin levels and the optimal dose given in these studies was 1 gram per day.
...09:35
Citing 'Orwellian' Tactics, Federal Judge Orders White House to Stop Censoring Americans' Social Media Posts GreenMedInfo
Judge Terry Doughty said there is "substantial evidence" the government violated the First Amendment by engaging in a large-scale censorship
09:34
Citing 'Orwellian' Tactics, Federal Judge Orders White House to Stop Censoring Americans' Social Media Posts GreenMedInfo
Originally published on www.childrenshealthdefense.org by Michael
Nevradakis, Ph.D.
In his 155-page ruling, Judge Terry Doughty said there is "substantial evidence" the government violated the First Amendment by engaging in a large-scale censorship campaign targeting content that questioned or countered establishment narratives on COVID-19.
07:08
Popular Benzo Drugs Linked to Suicide, Brain Damage Even If You Stop Taking Them: Study Mad In America
From The New York Post: Over 30 million Americans a year use benzodiazepines, or benzos, including Xanax, Valium, Ativan and Klonopin. Benzodiazepines are prescribed to treat anxiety disorders, insomnia, muscle spasms, schizophrenia, bipolar disorder, seizures and epilepsy. But this widely used class of drugs is linked to severe side effects and life impacts that can last for years even after people have stopped taking the drugs a new study finds.
. . . The researchers have coined the term BIND, or benzodiazepine-induced neurological dysfunction, to describe the long-lasting effects of benzo use. Though BIND is a new term and the condition is not yet well-defined or universally accepted by doctors, the study authors believe it could be a result of brain changes resulting from benzodiazepine use. BIND could occur in roughly one in five long-term users of benzodiazepines.
***
Back to Around the Web
The post Popular Benzo Drugs Linked to Suicide, Brain Damage Even If You Stop Taking Them: Study appeared first on Mad In America.
07:04
This review summarizes the hepatoprotective properties of G. lucidum. GreenMedInfo
PMID: Nutrients. 2023 Apr 13 ;15(8). Epub 2023 Apr 13. PMID: 37111092 Abstract Title: : Novel Insight into Hepatoprotective Potential with Mechanisms of Action. Abstract: () has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries. It is currently used as a nutraceutical and functional food owing to its major bioactive compounds, polysaccharides and triterpenoids.exhibits a broad range of hepatoprotective impacts in various liver disorders, such as hepatic cancer, nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease, hepatitis B, hepatic fibrosis, and liver injury induced by carbon tetrachloride (CCl4) and-amanitin.protects the liver through a broad range of mechanisms that include the modulation of liver Phase I and II enzymes, the suppression of-glucuronidase, antifibrotic and antiviral actions, the regulation of the production of nitric oxide (NO), the maintenance of hepatocellular calcium homeostasis, immunomodulatory activity, and scavenging free radicals.could signify an encouraging approach for the management of various chronic hepatopathies, and its potential mechanisms make it a distinctive agent when used alone or with other drugs and applied as a functional food, nutraceutical supplement, or adjuvant to modern medicine. This review summarizes the hepatoprotective properties ofwith its various mechanisms of action on different liver ailments. Biologically active substances derived fromare still being studied for their potential benefits in treating different liver ailments.
06:54
Anthony Holland PhD: Destroying Cancer Cells with Music Frequencies Medical Kidnap
by Brian Shilhavy
Editor, Health Impact News
If you are someone who has contributed charitable funds to help find a cure for cancer for the past 50+ years, I am sorry to inform you that you have probably been defrauded by being fooled into contributing funds to Big Pharma and cancer drug research, where a cancer drug is considered successful if it can extend the life of a cancer patient for up to 5 years.
There are no pharmaceutical products that actually cure cancer, because treating cancer is too profitable of an industry for Big Pharma to allow cures. See:
The Cancer Industry is Too Prosperous to Allow a Cure
But the fact is that there are literally hundreds of cures for cancer worldwide, although the FDA has outlawed almost all of them in the U.S. when they became too effective and interfered with drug profits.
A great documentary to watch if this is new topic to you, is Cancer: The Forbidden Cures The Original Big Pharma Playbook Long Before COVID.
This is on our Bitchute Channel.
For a review of unapproved but effective cancer cures that we published back in 2014, see:
Unapproved but Effective Cancer Cures
Another person who has had success in curing cancer with ongoing research here in 2023, is Anthony G. Holland, who has a PhD in musical arts, is a renowned composer who has conducted at Carnegie Hall, and has been a Professor of Music and Director of Music Technology at Skidmore College for over 3 decades. (Bio here.)
Dr. Holland gained some attention to his work with a presentation in 2013 in a TED Talk, titled Shattering cancer with resonant frequencies, that has over 2 million views and is, remarkably, still up on YouTube:
06:53
Anthony Holland PhD: Destroying Cancer Cells with Music Frequencies Vaccine Impact
by Brian Shilhavy
Editor, Health Impact News
If you are someone who has contributed charitable funds to help find a cure for cancer for the past 50+ years, I am sorry to inform you that you have probably been defrauded by being fooled into contributing funds to Big Pharma and cancer drug research, where a cancer drug is considered successful if it can extend the life of a cancer patient for up to 5 years.
There are no pharmaceutical products that actually cure cancer, because treating cancer is too profitable of an industry for Big Pharma to allow cures. See:
The Cancer Industry is Too Prosperous to Allow a Cure
But the fact is that there are literally hundreds of cures for cancer worldwide, although the FDA has outlawed almost all of them in the U.S. when they became too effective and interfered with drug profits.
A great documentary to watch if this is new topic to you, is Cancer: The Forbidden Cures The Original Big Pharma Playbook Long Before COVID.
This is on our Bitchute Channel.
For a review of unapproved but effective cancer cures that we published back in 2014, see:
Unapproved but Effective Cancer Cures
Another person who has had success in curing cancer with ongoing research here in 2023, is Anthony G. Holland, who has a PhD in musical arts, is a renowned composer who has conducted at Carnegie Hall, and has been a Professor of Music and Director of Music Technology at Skidmore College for over 3 decades. (Bio here.)
Dr. Holland gained some attention to his work with a presentation in 2013 in a TED Talk, titled Shattering cancer with resonant frequencies, that has over 2 million views and is, remarkably, still up on YouTube:
06:43
Neuroprotective, neurogenic, and anticholinergic evidence of Ganoderma lucidum cognitive effects. GreenMedInfo
PMID: Med Res Rev. 2023 Apr 13. Epub 2023 Apr 13. PMID: 37052237 Abstract Title: Neuroprotective, neurogenic, and anticholinergic evidence of Ganoderma lucidum cognitive effects: Crucial knowledge is still lacking. Abstract: Ganoderma lucidum is a mushroom that has been widely used for centuries in Asian countries for its antiaging properties. It is popularly known as "Ling Zhi," "Reishi," and "Youngzhi," and because of its benefits, it is known as the "immortality mushroom." Pharmacological assays have revealed that G. lucidum ameliorates cognitive impairments through inhibition of-amyloid and neurofibrillary tangle formation, antioxidant effect, reduction of inflammatory cytokine release and apoptosis, genic expression modulation, among other activities. Chemical investigations on G. lucidum have revealed the presence of metabolites such as triterpenes, which are the most explored in this field, as well as flavonoids, steroids, benzofurans, and alkaloids; in the literature, these have also been reported to have mnemonic activity. These properties of the mushroom make it a potential source of new drugs to prevent or reverse memory disorders, as actual medications are able to only alleviate some symptoms but are unable to stop the progress of cognitive impairments, with no impact on social, familiar, and personal relevance. In this review, we discuss the cognitive findings of G. lucidum reported in the literature, converging the proposed mechanisms through the several pathways that underlie memory and cognition processes. In addition, we highlight the gaps that deserve particular attention to support future studies.
06:29
RFK Jr is still wrong vaccines do NOT cause autism Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
Despite the false claims from Robert F Kennedy Jr and other anti-vaxxers, the scientific facts is vaccines do not cause autism.
06:25
Anthony Holland PhD: Destroying Cancer Cells with Music Frequencies Health Impact News
by Brian Shilhavy
Editor, Health Impact News
If you are someone who has contributed charitable funds to help find a cure for cancer for the past 50+ years, I am sorry to inform you that you have probably been defrauded by being fooled into contributing funds to Big Pharma and cancer drug research, where a cancer drug is considered successful if it can extend the life of a cancer patient for up to 5 years.
There are no pharmaceutical products that actually cure cancer, because treating cancer is too profitable of an industry for Big Pharma to allow cures. See:
The Cancer Industry is Too Prosperous to Allow a Cure
But the fact is that there are literally hundreds of cures for cancer worldwide, although the FDA has outlawed almost all of them in the U.S. when they became too effective and interfered with drug profits.
A great documentary to watch if this is new topic to you, is Cancer: The Forbidden Cures The Original Big Pharma Playbook Long Before COVID.
This is on our Bitchute Channel.
For a review of unapproved but effective cancer cures that we published back in 2014, see:
Unapproved but Effective Cancer Cures
Another person who has had success in curing cancer with ongoing research here in 2023, is Anthony G. Holland, who has a PhD in musical arts, is a renowned composer who has conducted at Carnegie Hall, and has been a Professor of Music and Director of Music Technology at Skidmore College for over 3 decades. (Bio here.)
Dr. Holland gained some attention to his work with a presentation in 2013 in a TED Talk, titled Shatt...
06:15
Oral administration of human FGF21 expressed by mycelium of Cordyceps militaris improves blood glucose and lipid in type II diabetes mellitus. GreenMedInfo
PMID: Cell Mol Biol (Noisy-le-grand). 2022 Sep 30 ;68(10):54-62. Epub 2022 Sep 30. PMID: 37114272 Abstract Title: Oral administration of human FGF21 expressed by mycelium of Cordyceps militaris improves blood glucose and lipid in type II diabetes mellitus. Abstract: The purpose of this study was to express human FGF21 (hFGF21) using Cordyceps militaris (C. militaris) as a bioreactor and to observe its hypoglycemic and lipid-lowering effects on type II diabetes. The recombinant plasmid pCB130-hFGF21 was transformed into C. militaris to form recombinant recombinant C. militaris (RhFGF21), the stability of RhFGF21 in vitro and in vivo was analyzed. RhFGF21 significantly promoted glucose uptake in a dose-dependent manner in adipocytes and increased the levels of p-PLC, p-FRS2 and p-ERK, which was consistent with the commercial hFGF21. In animal experiments, oral RhFGF21 obviously reduced the levels of glucose, insulin, TG, T-CHO, NEFA, and LDL-C in the blood, the contents of ALT, AST, TNF-, MCP-1, F4/80, CD68 and CD11b in the fatty liver, and the apoptosis of pancreatic cells. C. militaris is an excellent carrier that can stabilize the expression of hFGF21 and protect the biological activity of hFGF21 during oral administration, which provides a theoretical basis for the development of hFGF21 oral preparations for type II diabetes.
05:46
Editors of public health journal resign over differences with publisher Retraction Watch
The co-editors in chief and most editorial board members of the journal Critical Public Health have resigned their roles to start a new, independent journal, citing differences with their publisher, Taylor & Francis.
While there are inevitable tensions for a critically oriented scholarly journal that is also a commodity marketed by a commercial publisher, over the last year or so it has become increasingly difficult to hold together these two different versions of the journal, co-editors Judith Green of the University of Exeter in the UK and Lindsay McLaren of the University of Calgary in Canada said in a press release announcing the mass resignation.
It is simply a relationship that hasnt worked out and we need to find other ways to continue the spirit of the community, McLaren told us.
Earlier this year, the entire editorial boards of the open-access Elsevier journals NeuroImage and NeuroImage: Reports resigned to start a new, non-profit journal after the publisher rebuffed their request to reduce the journals fees for authors to publish their work. Editors of another Elsevier journal, Design Studies, have also threatened to resign following the publisher replacing the editor-in-chief and pushing the editorial team to publish more papers.
The press release and resignation letter from the Critical Public Health editors posted online cited a 2021 editorial by Green, McLaren, and two other board members discussing the history of the journal and consolidation in the academic publishing industry that led to Taylor & Francis owning the journal. They also cited the publisher pushing the editors to move the journal from a hybrid subscription/open-access model to a fully open-access model funded by char...
02:00
The Wuhan Cover-Up: How US Health Officials Conspired with the Chinese Military to Hide the Origins of COVID-19 Children's Health Defense
Gain-of-function experiments are often conducted to deliberately develop highly virulent, easily transmissible pathogens for the stated purpose of developing preemptive vaccines for animal viruses before they jump to humans. More insidious is the dual use nature of this research, specifically directed toward bioweapons development.
The Wuhan Cover-Up pulls back the curtain on how the U.S. governments increase in biosecurity spending after the 2001 terror attacks facilitated by Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID) to set in motion a plan to transform the NIAID into a de facto Defense Department agency.
While Fauci zealously funded and pursued gain-of-function research, concern grew among some scientists and government officials about the potential for accidental or deliberate release of weaponized viruses from labs that might trigger worldwide pandemics. A moratorium was placed on this research, but true to form, Fauci found ways to continue unperturbed outsourcing some of the most controversial experiments offshore to China and providing federal funding to Wuhan Institute of Virologys (WIVs) leading researchers for gain-of-function studies in partnership with the Chinese military and the Chinese Communist Party.
Robert F. Kennedy, Jr., whose meticulously researched and rigorously sourced analysis, leads readers on a staggering journey to learn about the:
- Key enablers and henchmen pushing for gain-of-function research
- Economic motives behind gain-of-function research.
- Successfully engineered chimeric viruses that can infect and kill humans.
- Coordinated effort to silence speculation of COVID-19s laboratory genesis.
- Complicity of scientific journals to hide the origins of COVID-19.
- Role of the Wuhan Institute of Virology in Chinas biowarfare/biodefense program.
- Relationships between U.S. health, military and intelligence bureaucracies and scientists and their Chinese counterparts.
- Roles of Bill Gates and Sir Jeremy Farrar in helping to orchestrate Chinas global cover-up.
The Wuhan Cover-Up unveils a global U.S.-Chinese conspiracy of epic proportion and lethal consequence.
The post The Wuhan Cover-Up: How US Health Officials Conspired with the Chinese Military to Hide the Origins of COVID-19 appeared first on Children's Health Defense.
01:01
The Intriguing Science Behind Rains Aroma: Can You Smell When The Rain Is Coming? Healthy Holistic Living
Have you ever found yourself standing at the threshold of your home on a sizzling summer day, or on a crisp, bone-chilling winter afternoon, convinced you could smell the rain coming? As it turns out, this phenomenon isnt universally experienced, leading many to question if its rooted in scientific fact or if it merely exists as a whimsical myth.
If youve browsed through social media on a particularly cloudy day, you might have noticed a polarizing debate: there are those who assertively proclaim their unique ability to predict rainfall through olfactory cues, while others appear notably doubtful. However, regardless of which camp youre in, theres some fascinating evidence that supports the concept of pre-rain odors. Numerous factors contribute to this olfactory phenomenon, with a primary component being the enchanting scent known as petrichor.
The Mesmerizing Mystique of Petrichor
Petrichor, a term rooted in Greek with petros meaning stone and ichor standing for the ethereal fluid coursing through the veins of ancient gods, represents the intoxicating, earthy aroma that pervades the atmosphere post rainfall, especially following a prolonged dry spell. Mineralogists Isabel Joy Bear and Richard Thomas first introduced this term to the world in 1964, unwittingly kindling widespread fascination with this mysterious smell.
Though petrichor consistently ranks among favorite natural
fragrances for many people, the reason behind its appealing allure
wasnt understood until recently. In an enlightening 2020 study,
researchers discovered the tantalizing scent of petrichor wasnt
just enticing to humans but proved irresistible to a variety of
other animals as well.
The Alluring Call of Geosmin
The intriguing answe...
00:09
The Y chromosome is disappearing so what will happen to men? Healthy Holistic Living
Darren Griffin, University of Kent and Peter Ellis, University of Kent
The Y chromosome may be a symbol of masculinity, but it is becoming increasingly clear that it is anything but strong and enduring. Although it carries the master switch gene, SRY, that determines whether an embryo will develop as male (XY) or female (XX), it contains very few other genes and is the only chromosome not necessary for life. Women, after all, manage just fine without one.
Whats more, the Y chromosome has degenerated rapidly, leaving females with two perfectly normal X chromosomes, but males with an X and a shrivelled Y. If the same rate of degeneration continues, the Y chromosome has just 4.6m years left before it disappears completely. This may sound like a long time, but it isnt when you consider that life has existed on Earth for 3.5 billion years.
The Y chromosome hasnt always been like this. If we rewind the clock to 166m years ago, to the very first mammals, the story was completely different. The early proto-Y chromosome was originally the same size as the X chromosome and contained all the same genes. However, Y chromosomes have a fundamental flaw. Unlike all other chromosomes, which we have two copies of in each of our cells, Y chromosomes are only ever present as a single copy, passed from fathers to their sons.
This means that genes on the Y chromosome cannot undergo genetic recombination, the shuffling of genes that occurs in each generation which helps to eliminate damaging gene mutations. Deprived of the benefits of recombination, Y chromosomal genes degenerate over time and are eventually lost from the genome.
Go Back:30 Days | 7 Days | 2 Days | 1 Day
Wednesday, 05 July
22:56
Asparagus as a Hangover Cure? Healthy Holistic Living
Recently, a claim has been making its rounds on the popular social media platform TikTok, suggesting that asparagus holds the secret to preventing the effects of a hangover. Several videos promoting this idea have amassed millions of views, with TikTokers lauding the green vegetable as a miracle hangover stopper. But does the science support this claim? Can asparagus genuinely shield you from the unpleasant aftermath of excessive alcohol consumption? The answer, it appears, is not quite as straightforward.
@louislevanti *chases shot of tequila with asparagus* #learnontiktok #hangovercure #tiktokhacks Monkeys Spinning Monkeys Kevin MacLeod & Kevin The Monkey
As per some TikTokers, the minerals and amino acids in asparagus help protect your liver from toxins. They argue that the enzymes in asparagus help break down alcohol and alleviate hangovers. However, the scientific evidence supporting these statements remains murky and inconclusive.
Scientific Analysis: Asparagus and Hangovers
...
22:21
Aspartame and Cancer Science-Based Medicine
Despite the leaked new classification as a "possible" carcinogen, the evidence still shows aspartame is safe.
The post Aspartame and Cancer first appeared on Science-Based Medicine.20:00
Challenging Western-Centric Child Psychology: An Interview with Nandita Chaudhary Mad In America
Nandita Chaudhary is a foremost expert on child psychology. She served as a professor at Lady Irwin College in India for over 35 years and teaches in Brazil.
Dr. Chaudhary has an impressive record of over 70 publications and several books. Her work challenges mainstream views of parenting, child-rearing, and child health. Given recent debates concerning child research conducted primarily in WEIRD nations (Western Educated Industrialized Rich and Democratic) and subsequently applied universally, her work carries significant relevance.
How we understand and shape the lives of children is crucial to how we perceive suffering, healing, and mental disorders. In this interview, we delve into how global organizations like UNICEF may unintentionally harm those they aim to help, how children raised with multiple caregivers can be misclassified as problematic by psychology, and how our comprehension of families, children, and mothers is severely limited.
Most importantly, we discuss how studying childcare across various cultures can enlighten us about different ways of living, loving, and understanding one of the most vulnerable among us children. This might allow us to examine our own biases, practices, and narratives more effectively.
The transcript below has been edited for length and clarity.
Listen to the audio of the interview here.
Ayurdhi Dhar: Why are you interested in studying the lives of children and their caregivers?
Nandita Chaudhary: My interest in developmental psychology began during my undergraduate studies. Youre striving to understand the formation of a human being, and we know the significance of an environment that complements, resists, and promotes various aspects of development. Then I got married and had my own children, which solidified my interest I became curious about their behaviors, alternative possibilities, and how I could excel as a parent to raise my children.
Dhar: When did you realize that what you had studied about children in psychology did not align with what you were observing in India?
Chaudhary: It was a gradual realization. My postgraduate study was designed with an eclectic perspective where we had courses on social anthropology, sociology, physiology It was this innovative curriculum that aided me in developing the idea that there was...
20:00
Scientist sues publisher to block expression of concern Retraction Watch
A gastroenterology researcher has sued a scientific journal to stop it from publishing an expression of concern for one of her papers.
Soudamani Singh, an assistant professor in the Department of Clinical and Translational Sciences at Marshall Universitys Joan C. Edwards School of Medicine in Huntington, W. Va., is the middle author of Cyclooxygenase pathway mediates the inhibition of Na-glutamine co-transporter B0AT1 in rabbit villus cells during chronic intestinal inflammation, published in PLOS ONE in September 2018. The article has been cited nine times, according to Clarivates Web of Science.
We previously reported that the corresponding author of the paper, Uma Sundaram, vice dean of research and graduate education at the Edwards School and chair of its department of clinical and translational science, told us he had contacted PLOS to request a correction to the article.
A comment on another of our posts had identified a duplicated image in the paper, but Sundaram said he and his coauthors had noticed the accidental error independently and notified the journal. The committee that conducted a subsequent research misconduct inquiry into the matter decided not to pursue an investigation because Sundaram had already contacted the journal to make the correction.
PLOS spokesperson David Knutson told us at the time that the journal had not decided what type of notice to issue.
According to Singhs lawsuit against PLOS, filed in federal court in April and...
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Cordyceps polysaccharide could be a potential anti-tumor product with strong regulatory effects in H22 liver cancer. GreenMedInfo
PMID: Molecules. 2023 Apr 10 ;28(8). Epub 2023 Apr 10. PMID: 37110586 Abstract Title: The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice. Abstract: Cordyceps has anti-cancer effects; however, the bioactive substance and its effect are still unclear. Polysaccharides extracted from, the fugus of Cordyceps, have been reported to have anti-cancer properties. Thus, we speculated that polysaccharides might be the key anti-tumor active ingredients of Cordyceps because of their larger molecular weight than that of polysaccharides in. In this study, we aimed to investigate the effects of wild Cordyceps polysaccharides on H22 liver cancer and the underlying mechanism. The structural characteristics of the polysaccharides of WCP were analyzed by high-performance liquid chromatography, high-performance gel-permeation chromatography, Fourier transform infrared spectrophotometry, and scanning electron microscopy. Additionally, H22 tumor-bearing BALB/c mice were used to explore the anti-tumor effect of WCP (100 and 300 mg/kg/d). The mechanism by WCP inhibited H22 tumors was uncovered by the TUNEL assay, flow cytometry, hematoxylin-eosin staining, quantitative reverse transcription-polymerase chain reaction, and Western blotting. Here, our results showed that WCP presented high purity with an average molecular weight of 2.110Da and 2.1910Da. WCP was determined to be composed of mannose, glucose, and galactose. Notably, WCP could inhibit the proliferation of H22 tumors not only by improving immune function, but also by promoting the apoptosis of tumor cells, likely through the IL-10/STAT3/Bcl2 and Cyto-c/Caspase8/3 signaling pathways, in H22 tumor-bearing mice. Particularly, WCP had essentially no side effects compared to 5-FU, a common drug used in the treatment of liver cancer. In conclusion, WCP could be a potential anti-tumor product with strong regulatory effects in H22 liver cancer.
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These data suggest that cordycepin can be used as a novel substance for the clinical treatment of cholangiocarcinoma and to improve the prognosis. GreenMedInfo
PMID: Life Sci. 2023 Aug 15 ;327:121698. Epub 2023 Apr 18. PMID: 37080351 Abstract Title: Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma. Abstract: Cholangiocarcinoma (CCA) with a high malignancy is usually diagnosed as advanced and is prone to metastasis and leads to a poor prognosis. It is reported that cordycepin has anti-tumor effect. However, the molecular targets and mechanisms of cordycepin in inhibiting CCA metastasis remains unclear. In order to evaluate the therapeutic effect of cordycepin on CCA metastasis, experiments were conducted in vivo and in vitro. The results showed that cordycepin inhibited the migration and EMT progression of HuCCT1 and QBC939 cells. Cordycepin has a strong hypolipidemic effects, therefore, we examined its effect on lipid metabolism in CCA. Cordycepin inhibits SREBP1 mediated fatty acid synthesis through the AKT/mTOR signaling pathway. Meanwhile, cordycepin can reduce ERO1A expression in HuCCT1 and QBC939 cells. ERO1A plays a role in malignant tumors. ERO1A promotes migration and lipid metabolism of CCA cells through AKT/mTOR signaling pathway. In addition, cordycepin significantly inhibited the tumor metastasis and the serum levels of TG and T-CHO in mice. Taken together, we demonstrate that cordycepin mediated ERO1A/mTOR/SREBP1 axis inhibits lipid metabolism and metastasis in CCA cells in vitro and in vivo. These data suggest that cordycepin can be used as a novel drug for the clinical treatment of CCA and to improve the prognosis.
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Protective effects of cordycepin pretreatment against liver ischemia/reperfusion injury. GreenMedInfo
PMID: Immun Inflamm Dis. 2023 Mar ;11(3):e792. PMID: 36988254 Abstract Title: Protective effects of cordycepin pretreatment against liver ischemia/reperfusion injury in mice. Abstract: INTRODUCTION: Cordycepin has been reported to exhibit hepatic protective and anti-inflammatory properties. Here, we investigated the role of cordycepin in ischemia/reperfusion (IR)-induced liver injury in a mouse model.METHODS: Mice were pretreated with cordycepin by gavage for 3 weeks, followed by the establishment of the IR modeling. Liver injury, Suzuki's histological grading, hepatic apoptosis, and inflammatory responses were evaluated by biochemical and pathological analysis.RESULTS: It was found that Cordycepin pretreatment at 50mg/kg for 3 weeks attenuated IR-induced liver injury, as reflected by the significant decrease of the levels of aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, and low-density lipoprotein. Cordycepin pretreatment also reduced histopathological changes, attenuated hepatocyte apoptosis, inflammatory responses in the livers of IR mice. Mechanically, toll-like receptor 4/nuclear factor kappa-B signaling in liver tissues was inhibited by Cordycepin pretreatment.CONCLUSIONS: In conclusion, Cordycepin pretreatment protects IR-induced liver injury, which demonstrates its potential for the treatment of IR in the liver.
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Nanoencapsulated cordyceps extract enhances collagen synthesis and skin cell regeneration through antioxidation and autophagy. GreenMedInfo
PMID: J Microencapsul. 2023 Apr 8:1-15. Epub 2023 Apr 8. PMID: 36999274 Abstract Title: Nanoencapsulated cordyceps extract enhances collagen synthesis and skin cell regeneration through antioxidation and autophagy. Abstract: Oxidative stress from reactive oxygen species is the main cause of skin ageing. Cordycepin, a bioactive compound of, contains antioxidant activity. This study examined extracellular matrix, antioxidant effect, autophagy activity, and skin regeneration in human dermal fibroblasts (HDFs) under normal and oxidative stress conditions. Slow disintegration was used to create nano-encapsulated cordyceps extract. HDFs were cultured and treated with 1M cordycepin, 1M medium, 0.1M cordyceps medium loaded nanoparticles (CMP), or 1mM HO. HDFs' senescent phenotypes were assessed, including cell proliferation, ROS scavenging, collagen and elastin synthesis, antioxidant activity, and wound healing. CMP size averaged 184.595.2nm increased cell proliferation and reduced HO-induced ROS. Thus, HDFs treated for 48h increased skin regeneration activity 2.76-fold by expressing extracellular matrix and rescuing HO-induced damaged cells. It was significant that this CMP inhibited HO-induced oxidative stress and induced autophagy to regenerate HDFs. The developed CMP could be used in cosmetics.
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Cordycepin-induced keratinocyte secretome promotes skin cell regeneration. GreenMedInfo
PMID: In Vivo. 2023 ;37(2):574-590. PMID: 36881050 Abstract Title: Cordycepin-induced Keratinocyte Secretome Promotes Skin Cell Regeneration. Abstract: BACKGROUND/AIM: Skin regeneration is the intrinsic ability to repair damaged skin tissues to regaining skin well-being. Processes of wound healing, a major part of skin regeneration, involve various types of cells, including keratinocytes and dermal fibroblasts, through their autocrine/paracrine signals. The releasable factors from keratinocytes were reported to influence dermal fibroblasts behavior during wound-healing processes. Here, we developed a strategy to modulate cytokine components and improve the secretome quality of HaCaT cells, a nontumorigenic immortalized keratinocyte cell line, via the treatment of cordycepin, and designated as cordycepin-induced HaCaT secretome (CHS).MATERIALS AND METHODS: The bioactivities of CHS were investigated in vitro on human dermal fibroblasts (HDF). The effects of CHS on HDF proliferation, reactive oxygen species-scavenging, cell migration, extracellular matrix production and autophagy activation were investigated by 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide cell viability assay, dichloro-dihydro-fluorescein diacetate, the wound-healing assay, reverse transcription polymerase chain reaction and immunofluorescent microscopy. Finally, Proteome ProfilerArray was used to determine the composition of the secretome.RESULTS: CHS induced fibroblast proliferation/migration, reactive oxygen species-scavenging property, regulation of extracellular matrix synthesis, and autophagy activation. Such enhanced bioactivities of CHS were related to the increase of some key cytokines, including C-X-C motif chemokine ligand 1, interleukin 1 receptor A, interleukin 8, macrophage migration-inhibitory factor, and serpin family E member 1.CONCLUSION: These findings highlight the implications of cordycepin alteration of the cytokine profile of the HaCaT secretome, which represents a novel biosubstance for the development of wound healing and skin regeneration products.
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Cordycepin inhibited apoptosis, inflammation and oxidative stress of thoracic aortic aneurysm. GreenMedInfo
PMID: Int Immunopharmacol. 2023 Mar ;116:109759. Epub 2023 Jan 31. PMID: 36731150 Abstract Title: Cordycepin suppresses vascular inflammation, apoptosis and oxidative stress of arterial smooth muscle cell in thoracic aortic aneurysm with VEGF inhibition. Abstract: BACKGROUND: Thoracic aortic aneurysm (TAA) is a type of common and serious vascular disease, in which inflammation, apoptosis and oxidative stress are strongly involved in the progression. Cordycepin, a bioactive compound from Cordyceps militaris, exhibits anti-inflammatory and anti-oxidative activities. This study aimed to address the role and mechanism of cordycepin in TAA.METHODS: The thoracic aortas were perivascularly administrated with calcium chloride (CaCl), and human aortic smooth muscle cells (HASMCs) were incubated with angiotensin II (Ang II) to simulate the TAA model in vivo and in vitro, respectively. The effect and mechanism of cordycepin in TAA were explored by hematoxylin and eosin (HE) staining, immunohistochemistry (IHC), immunofluorescence (IF), western blot, biochemical test, cell counting kit-8 (CCK-8), and terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) assays.RESULTS: Cordycepin improved the CaCl-induced the aneurysmal alteration and disappearance of normal wavy elastic structures of the aorta tissues, TAA incidence and thoracic aortic diameter in rats, and Ang II-induced the cell viability of HASMCs. Cordycepin reversed the CaCl-induced the relative protein expression of cleaved caspase 9, cleaved caspase 3, interleukin (IL)-6, tumor necrosis factor (TNF)-and IL-1, and the relative levels of glutathione (GSH), malonaldehyde (MDA) and reactive oxygen species (ROS) in vivo, or Ang II-induced these changes in vitro. Mechanically, cordycepin reduced the relative protein expressions of vascular endothelial growth factor (VEGF), VEGF receptor 2 (VEGFR2), cluster of differentiation 31 (CD31) and endothelial nitric oxide synthase (eNOS) in the Ang II-induced HASMCs. Correspondingly, overexpression of VEGF increased the levels of the indicators involved in apoptosis, inflammation and oxidative stress, which were antagonized with the cordycepin incubation in the Ang II-induced HASMCs.CONCLUSION: Cordycepin inhibited apoptosis, inflammation and oxidative stress of TAA through the inhibition of VEGF.
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Boswellia serrata inhibits LPS-induced cardiotoxicity in H9c2 cells. GreenMedInfo
PMID: Toxicon. 2023 Jun 15 ;229:107132. Epub 2023 Apr 21. PMID: 37086900 Abstract Title: Boswellia serrata inhibits LPS-induced cardiotoxicity in H9c2 cells: Investigating role of anti-inflammatory and antioxidant effects. Abstract: Sepsis-induced myocardial dysfunction is the main reason for mortality and morbidity. Recent investigations have shown that inflammation and oxidative stress play a central role in lipopolysaccharide (LPS)-induced cardiac injury pathophysiology. Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. The present study aimed to investigate the effects of B. serrata pretreatment on LPS-induced cardiac damage in H9c2 cells. The cells were pretreated with various concentrations of B. serrata (5-45 g/ml) for 24 h and then stimulated with LPS (10 g/ml) for another 24 h. Afterward, the levels of cell viability, tumor necrosis factor (TNF)-, prostaglandin (PGE)-2, interleukin (IL)-1, IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, nitric oxide (NO) and glutathione (GSH) were determined using enzyme-linked immunosorbent assay (ELISA), real time-PCR or appropriated biochemical methods. Our results demonstrated that LPS treatment caused a remarkable decrease in cell viability and GSH, and on the contrary, it led to a significant increase in the levels of gene and protein expression of inflammatory markers and NO. However, pretreatment of B. serrata (5, 15, and 45 g/ml) decreased the levels of TNF-, PGE2, IL-1, COX-2, iNOS, IL-6, and NO production, while cell viability and GSH levels were increased. Taken together, our results demonstrated that B. serrata might be a potential therapeutic agent against LPS and endotoxemia-induced cardiac injury, through its anti-inflammatory and antioxidant properties.
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A supplement with Ribes Nigrum, Boswellia Serrata, bromelain and vitamin D to stop local inflammation in chronic sinusitis. GreenMedInfo
PMID: J Clin Med. 2023 Apr 18 ;12(8). Epub 2023 Apr 18. PMID: 37109265 Abstract Title: A Supplement with Ribes Nigrum, Boswellia Serrata, Bromelain and Vitamin D to Stop Local Inflammation in Chronic Sinusitis: A Case-Control Study. Abstract: Although chronic sinusitis widely affects the adult population, the treatments currently used did not always satisfactorily solve the symptoms. Traditional therapy with steroids and antibiotics presents risks and benefits and the new drugs, i.e., monoclonal antibody, are valid solutions despite being quite expensive. Natural molecules could be a valid treatment that combines good efficacy and low price. We conducted a case -control study to evaluate the benefit of an oral supplement with Ribes nigrum, Boswellia serrata, Bromelain and Vitamin D on chronic sinusitis symptoms. 60 patients were randomly assigned to one of the three groups: control using nasal steroids only, treatment 1 using nasal steroid and 1 dose of the oral supplement for 30 days and treatment 2 in which patients used nasal steroid and two oral supplement doses daily for 15 days. Conditions of the nasal mucosa and a blood sample (WBC, IgE and CRP) were analyzed at T0, T1 (15 days after treatment) and T2 (30 days after treatment. Patients treated with the supplement improved their nasal findings (hyperemia of mucosa and rhinorrhea) with statistically significant differences from the control. Our preliminary data suggest that the addition of supplement containing Ribes nigrum, Boswellia serrata, Vitamin D and Bromelain to the traditional local therapy (nasal spray with cortisone) can be a supporting therapy to modulate the local inflammation in the nose in patients affected by chronic sinusitis.
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The flavonoid rich black currant ethanolic gemmotherapy extract elicits neuroprotective effects. GreenMedInfo
PMID: Molecules. 2023 Apr 19 ;28(8). Epub 2023 Apr 19. PMID: 37110805 Abstract Title: The Flavonoid Rich Black Currant () Ethanolic Gemmotherapy Extract Elicits Neuroprotective Effect by Preventing Microglial Body Swelling in Hippocampus and Reduces SerumLevel: Pilot Study. Abstract: Many plant-derived flavonoids are known for their anti-neuroinflammatory and anti-neurodegenerative effects. The fruits and leaves of the black currant (BC,) contain these phytochemicals with therapeutic benefits. The current study presents a report on a standardized BC gemmotherapy extract (BC-GTE) that is prepared from fresh buds. It provides details about the phytoconstituent profile specific to the extract as well as the associated antioxidant and anti-neuroinflammatory properties. The reported BC-GTE was found to contain approximately 133 phytonutrients, making it unique in its composition. Furthermore, this is the first report to quantify the presence of significant flavonoids such as luteolin, quercetin, apigenin, and kaempferol.-based tests revealed no cytotoxic but nutritive effects. We also demonstrated that adult male Wistar rats, pretreated with the analyzed BC-GTE and assessed after lipopolysaccharide (LPS) injection, did not show any apparent increase in body size in the microglial cells located in the hippocampal CA1 region, while in control experiments, the activation of microglia was evident. Moreover, no elevated levels of serum-specificwere observed under the LPS-induced neuroinflammatory condition. The analyzed BC-GTE's specific flavonoid content, along with the experimental data based on an LPS-induced inflammatory model, suggest that it possesses anti-neuroinflammatory/neuroprotective properties. This indicates that the studied BC-GTE has the potential to be used as a GTE-based complementary therapeutic approach.
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A minor metabolite from Curcuma longa effective against metabolic syndrome. GreenMedInfo
PMID: Food Funct. 2023 May 22 ;14(10):4722-4733. Epub 2023 May 22. PMID: 37114318 Abstract Title: A minor metabolite fromeffective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study. Abstract: Metabolic syndrome (MetS) is characterized by the presence of at least three interrelated risk factors, including central obesity, hypertension, elevated serum triglycerides, low serum high-density lipoproteins, and insulin resistance. Abdominal obesity is considered a predominant risk factor. Lifestyle changes with medications to lower cholesterol, blood sugar, and hypertension are the general treatment approaches. Functional foods and bioactive food ingredients represent versatile tools for addressing different aspects of MetS. In a randomized placebo-controlled clinical study, we evaluated the effect of Calebin A, a minor bioactive phytochemical from, on metabolic syndrome in obese adults (= 100), and 94 individuals completed the study (= 47 in both groups). They were subjected to Calebin A supplementation for 90 days, which resulted in a statistically significant reduction in their body weight, waist circumference, body mass index, low-density lipoprotein-cholesterol, and triglyceride levels compared to those with the placebo. A small but significant increase in high-density lipoprotein-cholesterol levels was also observed in these individuals. Furthermore, Calebin A showed a positive effect on adipokines by reducing circulating leptin levels. Finally, C-reactive protein levels were significantly reduced in Calebin A-supplemented individuals, suggesting a beneficial impact on managing MetS-induced inflammation. Blood glucose levels, insulin resistance, and blood pressure levels were not affected by Calebin A. In conclusion, Calebin A may be an effective supplement for managing abdominal obesity, dyslipidemia, and systemic inflammation in individuals with metabolic syndrome. This study was prospectively registered on the Clinical Trial Registry of India (CTRI) with the registration number CTRI/2021/09/036495. https://ctri.nic.in/Clinicaltrials/advancesearchmain.php.
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Curcumin and its derivatives as potential antimalarial and anti-inflammatory agents. GreenMedInfo
PMID: Pharmaceuticals (Basel). 2023 Apr 18 ;16(4). Epub 2023 Apr 18. PMID: 37111366 Abstract Title: Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure-Activity Relationship and Mechanism of Action. Abstract: Curcumin, one of the major ingredients of turmeric (), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin's low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Therefore, research on the design and synthesis of novel curcumin derivatives is being actively pursued to improve the pharmacokinetic profile and efficacy of curcumin. This review discusses the antimalarial and anti-inflammatory activities and the structure-activity relationship (SAR), as well as the mechanisms of action of curcumin and its derivatives in malarial treatment. This review provides information on the identification of the methoxy phenyl group responsible for the antimalarial activity and the potential sites and functional groups of curcumin for structural modification to improve its antimalarial and anti-inflammatory actions, as well as potential molecular targets of curcumin derivatives in the context of malaria and inflammation.
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Effects of turmeric extract on age-related skeletal muscle atrophy. GreenMedInfo
PMID: Life (Basel). 2023 Apr 3 ;13(4). Epub 2023 Apr 3. PMID: 37109470 Abstract Title: Effects of Turmeric Extract on Age-Related Skeletal Muscle Atrophy in Senescence-Accelerated Mice. Abstract: Muscle atrophy is one of the main causes of sarcopenia-the age-related loss of skeletal muscle. In this study, we investigated the effect of turmeric () extract (TE) supplementation on age-related muscle atrophy in a senescence-accelerated mouse model and explored the underlying mechanisms. Twenty-six-week-old male, senescence-accelerated mouse resistant (SAMR) mice received the AIN-93G basal diet, while twenty-six-week-old male, senescence-accelerated mouse prone 8 (SAMP8) mice received the AIN-93G basal diet or a 2% TE powder-supplemented diet for ten weeks. Our findings revealed that TE supplementation showed certain effects on ameliorating the decrease in body weight, tibialis anterior weight, and mesenteric fat tissue weight in SAMP8 mice. TE improved gene expression in the glucocorticoid receptor-FoxO signaling pathway in skeletal muscle, including,,,, and. Furthermore, TE might have the certain potential on improving the dynamic balance between anabolic and catabolic processes by inhibiting the binding of glucocorticoid receptor or FoxO1 to the glucocorticoid response element or FoxO-binding element in the MuRF1 promoter in skeletal muscle, thereby promoting muscle mass and strength, and preventing muscle atrophy and sarcopenia prevention. Moreover, TE may have reduced mitochondrial damage and maintained cell growth and division by downregulating the mRNA expression of the genesand. Thus, the results indicated TE's potential for preventing age-related muscle atrophy and sarcopenia.
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Anti-neuroinflammatory and neuroprotective effect of Intermedin B isolated from the Curcuma longa. GreenMedInfo
PMID: Int J Mol Sci. 2023 Apr 17 ;24(8). Epub 2023 Apr 17. PMID: 37108568 Abstract Title: Anti-Neuroinflammatory and Neuroprotective Effect of Intermedin B Isolated from theL. via NF-B and ROS Inhibition in BV2 Microglia and HT22 Hippocampal Cells. Abstract: Compounds derived fromL. () have been extensively studied and reported to be effective and safe for the prevention and treatment of various diseases, but most research has been focused on curcuminoids derived from. As neurodegenerative diseases are associated with oxidation and inflammation, the present study aimed to isolate and identify active compounds other than curcuminoids fromto develop substances to treat these diseases. Seventeen known compounds, including curcuminoids, were chromatographically isolated from the methanol extracts of, and their chemical structures were identified using 1D and 2D NMR spectroscopy. Among the isolated compounds, intermedin B exhibited the best antioxidant effect in the hippocampus and anti-inflammatory effect in microglia. Furthermore, intermedin B was confirmed to inhibit the nuclear translocation of NF-B p-65 and IB, exerting anti-inflammatory effects and inhibiting the generation of reactive oxygen species, exerting neuroprotective effects. These results highlight the research value of active components other than curcuminoids in-derived compounds and suggest that intermedin B may be a promising candidate for the prevention of neurodegenerative diseases.
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-Elemene enhances erlotinib sensitivity through induction of ferroptosis. GreenMedInfo
PMID: Pharmacol Res. 2023 May ;191:106739. Epub 2023 Mar 21. PMID: 36948327 Abstract Title: -Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancer. Abstract: Nearly half of all Asian non-small cell lung cancer (NSCLC) patients harbour epidermal growth factor receptor (EGFR) mutations, and first-generation EGFR tyrosine kinase inhibitors (TKIs) are one of the first-line treatments that have improved the outcomes of these patients. Unfortunately, 20% of these patients can not benefit from the treatment. The basis of this primary resistance is poorly understood. Therefore, overcoming EGFR-TKI primary resistance and maintaining the efficacy of TKIs has become a key issue.-Elemene, a sesquiterpene compound extracted from Curcuma aromatica Salisb. (wenyujing), has shown potent antitumor effects. In this research, we found that-elemene combined with erlotinib enhanced the cytotoxicity of erlotinib to primary EGFR-TKI-resistant NSCLC cells with EGFR mutations and that ferroptosis was involved in the antitumor effect of the combination treatment. We found that lncRNA H19 was significantly downregulated in primary EGFR-TKI-resistant NSCLC cell lines and was upregulated by the combination treatment. Overexpression or knockdown of H19 conferred sensitivity or resistance to erlotinib, respectively, in both in vitro and in vivo studies. The high level of H19 enhanced the cytotoxicity of erlotinib by inducing ferroptosis. In conclusion, our data showed that-elemene combined with erlotinib could enhance sensitivity to EGFR-TKIs through induction of ferroptosis via H19 in primary EGFR-TKI-resistant lung cancer, providing a promising strategy to overcome EGFR-TKI resistance in NSCLC patients.
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Heavy Screen Time Changes Children's Brains Articles
Editor's Note: This article is a reprint. It was originally published December 27, 2018.
Most people today live in a sea of radiofrequencies emitted from wireless technologies of all kinds, from routers to smartphones, tablets, baby monitors, TVs, appliances, smart meters and many more.
According to many experts, chronic, heavy exposure could have severe repercussions for our health, especially that of children, who are now exposed even before birth. Research also suggests interaction with social media, games and apps online produces a number of effects, both physical and psychological.
Heavy Use of Wireless Devices Changes Kids' Brain Structure
In the largest long-term study1,2,3 of brain development and youth health in the U.S., the Adolescent Brain Cognitive Development (ABCD) Study,4 reveals the brains of the most prolific users of electronic devices look different compared to those who use smartphones, tablets and video games less frequently.
In all, more than 11,000 children will be followed for a decade to assess how various childhood experiences and environments affect brain development and psychological health. As noted by the researchers,5 "The data will provide a resource of unprecedented scale and depth for studying typical and atypical development."
These preliminary findings, based on the brain scans of 4,500 9- to 10-year-olds, reveal children who use electronic devices for seven hours or more each day have premature thinning of the brain cortex, the outer brain layer that processes information from the five physical senses (taste, touch, sight, smell and sound).
The exact ramifications of this anomaly are still unknown. According to Dr. Gaya Dowling, a researcher with the National Institutes of Health, which is sponsoring the $300 million study, thinning of the cortex is thought to be part of the brain maturation process, so what these scans are showing is that this process is being sped up in children who get a lot of screen time6 (7-plus hours a day).
They cannot prove that the changes are definitively caused by the screen time, and the full effects won't be known until years from now, as the emotional and mental health outco...
Did Lou Gehrig Die Because of Low Omega-3s? Articles
Amyotrophic lateral sclerosis (ALS) is better known as Lou Gehrigs disease, named for the beloved New York Yankees baseball player who died of the condition. A number of factors may have played a role in Gehrigs health decline, including repeated head trauma,1 which is associated with ALS.
A lack of omega-3 fats may have also been involved, however, as research shows these healthy fats offer protection for ALS patients.2 The study, by Harvard researchers, found higher levels of omega-3s led to longer survival and slower functional decline in those with ALS.
However, what this study fails to point out, and that I discuss in my interview with Nils Hoem above, is the fact that reducing seed oil omega-6 in the form of linoleic acid is likely equally important. This is because when your body is loaded with omega-6, the enzymes that convert the omega-3 fat, ALA, are largely used up by the omega-6 fat, LA, and used to make arachidonic acid rather that the important EPA and DHA fats.
Eating Foods High in Omega-3s May Benefit ALS
Omega-3 fats are well-known for their neuroprotective effects, and research published in Neurology3 supports their favorable role in ALS. The study involved 449 people with ALS, whose symptom severity and disease progression were scored and tracked for 18 months. Blood levels of omega-3 fats were also measured, with participants divided into four groups, from lowest to highest.4
Higher levels of omega-3 fats, particularly the plant-based omega-3 fat alpha-linolenic acid (ALA), were linked to slowed decline and reduced risk of death.5 Among those who died during the study, 33% belonged to the group with the lowest levels of ALA, compared to 19% in the highest ALA group.
Even after adjusting for family history, age and other factors, people with the highest ALA levels had a 50% lower risk of death than those with the lowest.6 Eicosapentaenoic acid (EPA), another omega-3 fat thats found in fatty fish and krill oil, was also associated with lower death risk in the study.7
Lead study author Kjetil Bjornevik, assistant professor of epidemiology and nutrition with Harvard T.H. Chan School of Public Health, explained:...
Why the Bioengineered Salmon Project Got Paused Articles
The construction of AquaBountys largest GE salmon farm1 has hit a snag. Located in Pioneer, Ohio, the commercial salmon farm is slated to have an annual production capacity of 10,000 metric tons, and the company plans to invest up to $395 million in the project. Salmon were expected to be stocked in late 2024,2 but construction has been halted due to a steep rise in construction costs.3
While 75% of costs had already been established, costs for remaining items like piping and concrete have skyrocketed due to inflation. Speaking with The Village Reporter, AquaBounty CEO Sylvia Wulf said the company intends to proceed with the project, just at a later date:4
"We absolutely intend to continue construction of the farm. We are looking at the most prudent path forward. We have no intention of letting all the money go to waste. We will find another path forward. We are working with the construction firm to secure the site while we are working with them on value engineering, cost reduction and a phased approach. We are already well along into phase 1."
The company is hoping that construction will resume in August 2023,5 but for the sake of human health and the environment, lets hope it doesnt.
Genetically Engineered Salmon Churning Out in the Midwest
In November 2015, the U.S. Food and Drug Administration approved AquaBounty salmon, which contains the DNA from two other fish, a growth-promoting gene from a Chinook salmon and a "promoter" gene from the eel-like ocean pout.
This makes the fish grow faster, which means they reach harvesting size sooner and ultimately require less food a money-saver for the biotech companies behind these industrial salmon farms. GE salmon grow twice as fast as wild salmon, which means they reach market size of 8 to 12 pounds in just 18 months, compared to 36 in the wild.6 According to the FDA:7
"AquAdvantage Salmon has been genetically engineered to reach a growth marker important to the aquaculture industry more rapidly than its non-GE Atlantic salmon counterpart.
It does so because it contains an rDNA construct that is composed of the growth hormone gene from Chinook salmon under the control of a promoter (a sequence of DNA that turns on the expression of a gene) from ocean pout (another type of fi...
09:55
Elemene induces cell apoptosis via inhibiting glutathione synthesis in lung adenocarcinoma. GreenMedInfo
PMID: J Ethnopharmacol. 2023 Jul 15 ;311:116409. Epub 2023 Mar 30. PMID: 37003401 Abstract Title: Elemene induces cell apoptosis via inhibiting glutathione synthesis in lung adenocarcinoma. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: The rhizome of Curcuma wenyujin Y.H. Chen&C. Ling, also known as Wen-E-Zhu, has been used for cancer treatment since ancient times, with roots dating back to the Song Dynasty. Elemene (EE), a sesquiterpene extract with potent anticancer properties, is extracted from Wen-E-Zhu, with-elemene (BE) being its main active compound, along with trace amounts of-caryophyllene (BC),-elemene and-elemene isomers. EE has demonstrated broad-spectrum anti-cancer effects and is commonly used in clinical treatments for various types of malignant cancers, including lung cancer. Studies have shown that EE can arrest the cell cycle, inhibit cancer cell proliferation, and induce apoptosis and autophagy. However, the exact mechanism of its anti-lung cancer activity remains unclear and requires further research and investigation.AIM OF THE STUDY: In this study, the possible mechanism of EE and its main active components, BE and BC, against lung adenocarcinoma was investigated by using A549 and PC9 cell lines.MATERIALS AND METHODS: The subcutaneous tumor model of nude mice was constructed to evaluate the efficacy of EE in vivo, then the in vitro half-inhibitory concentration (IC) of EE and its main active components, BE and BC, on A549 and PC9 cells at different concentrations were determined by CCK-8. Flow cytometry was used to detect the apoptosis and cycle of A549 and PC9 cells treated with different concentrations of BE and BC for 24 h. Non-targeted metabolomics analysis was performed on A549 cells to explore potential target pathways, which were subsequently verified through kit detection and western blot analysis.RESULTS: Injection of EE in A549 tumor-bearing mice effectively suppressed cancer growth in vivo. The ICof EE and its main active components, BE and BC, was around 60 g/mL. Flow cytometry analysis showed that BE and BC blocked the G/M and S phases of lung adenocarcinoma cells and induced apoptosis, leading to a significant reduction in mitochondrial membrane potential (MMP). Results from non-targeted metabolomics analysis indicated that the glutathione metabolism pathway in A549 cells was altered after treatment with the active components. Kit detection revealed a decrease in glutathione (GSH) levels and an increase in the levels of oxidized glutathione (GSSG) and reactive oxygen (ROS). Supplementation of GSH reduced the inhibitory activity of the active components on lung cancer and also decreased the ROS content of cells. Analysis of glutathione synthesis-related proteins showed a decrease in the expression of glutaminase, cystine/glutamate reverse tran...
09:53
-elemene suppresses migration of esophageal squamous cell carcinoma. GreenMedInfo
PMID: Comb Chem High Throughput Screen. 2023 ;26(13):2304-2320. PMID: 36872359 Abstract Title: -elemene Suppresses Migration of Esophageal Squamous Cell Carcinoma by Modulating Expression of MMP9 through the PI3K/Akt/NF-B Pathway. Abstract: BACKGROUND AND OBJECTIVE: -elemene is a plant-derived drug with broad-spectrum anticancer activity. Studies have found that-elemene can inhibit tumor cell proliferation, induce tumor cell apoptosis, and resist tumor cell migration and invasion. Esophageal cancer is a common digestive tract malignant tumor. Progress has been made in the treatment of esophageal cancer, including the use of-elemene, but the mechanism of anti-migration is unclear. PI3K/Akt/NF-B/MMP9 signaling pathway is involved in the regulation of tumor cell proliferation, migration, extracellular matrix(ECM), and basement membrane(BM) degradation. This study aims to investigate the effect of-elemene on the migration of esophageal squamous cell carcinoma (ESCC) and its related mechanisms by bioinformatics, network pharmacology, and molecular docking methods.METHODS: In this study, the differentially expressed genes (DEGs) of ESCC were screened through GeneCards and BATMAN-TCM databases combined with the Gene Expression Omnibus (GEO) database (GSE17351). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to identify the functions and related pathways of the genes. The protein-protein interaction (PPI) network of these DEGs was constructed with the STRING database. Five hub genes were screened by CytoHubba plug-in Cytoscape according to the principle of degree value and the expressions of which were validated by the UALCAN database from the Cancer Genome Atlas (TCGA). The hub gene with the strongest binding energy was identified by molecular docking. A wound healing assay was subjected to assess the migration ability. RT-PCR was used to detect the content of migration-related mRNA. Western blotting was performed to examine the expression rates of Akt, NF-B, and MMP9 in ESCC tissues by-elemene and SC79.RESULTS: 71 target genes were obtained which were mainly involved in biological processes such as epidermal development and extracellular matrix decomposition. In addition, critical pathways, including PI3K/AKT signaling pathway and focal adhesion, were verified to be subject to-elemene regulation. It exhibited marked binding affinity between-elemene and MMP9 with an excellent docking score of -6.56 kcal/mol. The expression levels of Akt, NF-B, and MMP9 in ESCC tissues were significantly upregulated compared to normal tissues. Western blot detection demonstrated that-elemene specifically reduced the phosphorylation level of Akt, and its downstream target molecule NF-B, thus resulting in reduced levels of their target proteins,...
08:33
Our Raison dEtre Age of Autism The Rebel Alliance!
"Raison d'etre" is
a fancy, French way of saying "Why I am still keeping AofA online
despite everything." Wit, snark, humor, call it was you will.
We need it. And Twitter is a great place to be pithy and pointed.
Follow us www.twitter.com/ageofautism
Look whos back after seeming to have been boosted out of the static
during Covid. The King of False Promises himself. Oh, that moniker?
Before Dr. Peter Hotez wrote the cleverly titled "Vaccines Did Not
Cause Rachel's Autism," Dr. Offit wrote his own page turner called
"Autism's False Prophets" to lead parents AWAY from treatments and
cause (vaccines.) Like selling a broken compass.
We've written so many articles about Dr. Offit over the years. Mark
Blaxill has the highest batting average and most home runs
though. See four of his pieces below. These are from our
SPECIAL REPORTS section that you have probably never seen. Now that
we all view sites through our phones, all we see are those three
wee (Hi, Auntie Morag and Angus) bars at the top left.
They take you to our top bar on the main site. Special Reports
features categories, Laura Hayes' work, Teresa Conrick's Microbiome
series and some very "inside baseball" writing from 15+ years
ago.
January 2011: Offit Cashes In:
Closing the Books on the Vaccine Profits of a Merck-Made
Millionaire
January 2011: The Offit Index:
Tracking a Patent Owners Ongoing Financial Interest in One Vaccines
Sales
April 2012: Voting Himself Rich: CDC
Vaccine Adviser Made $29 Million Or More After Using Role to Create
Market
...
06:57
FBP1 induced by -elemene enhances the sensitivity of gefitinib in lung cancer. GreenMedInfo
PMID: Thorac Cancer. 2023 Feb ;14(4):371-380. Epub 2022 Dec 16. PMID: 36525508 Abstract Title: FBP1 induced by-elemene enhances the sensitivity of gefitinib in lung cancer. Abstract: BACKGROUND: -elemene is known to play a critical role in tumorigenesis as well as tyrosine kinase inhibitor (TKI) resistance in lung cancer. However, the biological function and molecular mechanism remain largely unknown.METHODS: In this study, the common genes involved in gefitinib resistance and-elemene were identified using bioinformatic analysis. The expression of FBP1 was examined by qRT-PCR and Western blot analysis. Cell proliferation, flow cytometry, clone formation and IC50 assays were performed to assess the effects of-elemene and FBP1. Western blot analysis was used to evaluate apoptosis-related gene expression. Finally, in vivo experiments were conducted to assess the crucial role of FBP1 in gefitinib-resistant HCC827/GR cells in nude mice.RESULTS: Screening analysis demonstrated that fructose-1,6-bisphosphatase (FBP1) was induced by-elemene and downregulated in gefitinib-resistant lung cells. Functionally, overexpression of FBP1 inhibited proliferation and gefitinib resistance and promoted apoptosis of PC9/GR and HCC827/GR cells in vitro. Mechanistically, FBP1 impeded the nuclear translocation of p-STAT3. The FBP1/STAT3 axis was required for FBP1-mediated apoptosis-related gene expression. In vivo experiments further confirmed the enhanced effects of FBP1 on lung cancer cell sensitivity to gefitinib.CONCLUSION: Our research indicated that-elemene suppressed proliferation and enhanced sensitivity to gefitinib by inducing apoptosis through the FBP1/STAT3 axis in gefitinib-resistant lung cancer cells.
06:54
Echinacea does it actually treat a cold or flu? Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
Despite the claims that echinacea can treat the common cold, there is no evidence that supports this claim. It's useless.
06:35
-Elemene regulates epithelial-mesenchymal transformation and inhibits invasion and metastasis of colorectal cancer cells. GreenMedInfo
PMID: J Complement Integr Med. 2023 Jun 1 ;20(2):425-430. Epub 2022 Dec 9. PMID: 36480470 Abstract Title: -Elemene regulates epithelial-mesenchymal transformation and inhibits invasion and metastasis of colorectal cancer cells. Abstract: OBJECTIVES: To study the inhibitory effect of-elemene on invasion and metastasis of colorectal cancer cells and its possible mechanism.METHODS: Human colon cancer HCT116 cells were treated with different concentrations of-elemene. The proliferation inhibition rate of the cells was detected by MTT assay, cell migration rate was detected by scratched assay, and cell invasion rate was evaluated by Transwell cell invasion assay. The expressions of Vimentin, E-cadherin, N-cadherin, and-catenin were detected by Western blotting. The mRNA expressions of Vimentin, E-cadherin, N-cadherin, and-catenin were detected by real-time PCR.RESULTS: Compared with the control group, the expressions of migration rate, invasion rate, scratch healing rate, N-cadherin, and Vimentin protein of HCT116 cells were decreased after-elemene treatment, while the expression of E-cadherin protein was increased, and the inhibition rate of cell proliferation was increased (p
06:33
-elemene induced apoptosis and senescence of triple-negative breast cancer cells. GreenMedInfo
PMID: Tissue Cell. 2022 Dec ;79:101914. Epub 2022 Sep 1. PMID: 36183441 Abstract Title: -elemene induced apoptosis and senescence of triple-negative breast cancer cells through IGF1/IGF1R pathway. Abstract: PURPOSE: -elemene has a wide range of anticancer effects and can be used in a variety of cancer types. This study mainly explored its mechanism of action on TNBC cells and provided theoretical basis for the treatment of TNBC.METHODS: Firstly, TNBC cells were treated with different concentrations of-elemene, and screened out an appropriate concentration for subsequent research. Then, through the bioinformatics website, predicted genes that have a binding relationship with-elemene. Then, the overexpression vector of the selected gene was transfected into the cell. The effects of-elemene and its target genes on the proliferation and apoptosis of TNBC cells were detected by CCK-8, Edu assay, and flow cytometry, and the senescence of cells was determined by SA--gal experiment. Western blotting was used to detect the expression of apoptosis and aging-related proteins.RESULTS: -elemene inhibited TNBC cell viability and proliferation in a concentration-dependent manner, and induces apoptosis and senescence. Through the screening of candidate genes, IGF1 was finally determined to be an effective target gene of-elemene. The expression level of IGF1 was decreased in cells treated with-elemene. Overexpression of IGF1 significantly alleviated ability of-elemene to inhibit cell viability, proliferation, and induced cell apoptosis and senescence. In addition,-elemene inhibited the expression of IGF1R and Bcl-2, and promoted the expression of Cleaved Caspase-3 and senescence-related proteins (p27, p16, p53 and p21), and these effects were reversed by overexpression of IGF1.CONCLUSION: -elemene induced apoptosis and senescence of triple-negative breast cancer cells through IGF1/IGF1R pathway.
06:31
Protective effect of Sargassum fusiforme fucoidan against ethanol-induced oxidative damage. GreenMedInfo
PMID: Polymers (Basel). 2023 Apr 17 ;15(8). Epub 2023 Apr 17. PMID: 37112059 Abstract Title: Protective Effect ofFucoidan against Ethanol-Induced Oxidative Damage in In Vitro and In Vivo Models. Abstract: Our previous studies have evaluated the bioactivities of a fucoidan isolated from(SF-F). To further investigate the health benefit of SF-F, in the present study, the protective effect of SF-F against ethanol (EtOH)-induced oxidative damage has been evaluated in in vitro and in vivo models. SF-F effectively improved the viability of EtOH-treated Chang liver cells by suppressing apoptosis. In addition, the in vivo test results indicate that SF-F significantly and dose-dependently increased the survival rate of zebrafish treated with EtOH. Further research results show that this action works through decreasing cell death via reduced lipid peroxidation by scavenging intracellular reactive oxygen species in EtOH-stimulated zebrafish. These results indicate that SF-F effectively protected Chang liver cells and zebrafish against EtOH-induced oxidative damage and suggest the potential of SF-F to be used as an ingredient in the functional food industry.
06:28
The role of seaweed polysaccharides in gastrointestinal health: protective effect against inflammatory bowel disease. GreenMedInfo
PMID: Life (Basel). 2023 Apr 16 ;13(4). Epub 2023 Apr 16. PMID: 37109555 Abstract Title: The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease. Abstract: Inflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they are often unsuccessful and have negative consequences on human health. Thus, there is a tremendous demand for using natural substances, such as seaweed polysaccharides, to treat IBD's main pathologic treatment targets. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae, and fucoidan in brown algae. These are effective candidates for drug development and functional nutrition products. Algal polysaccharides treat IBD through therapeutic targets, including inflammatory cytokines, adhesion molecules, intestinal epithelial cells, and intestinal microflora. This study aimed to systematically review the potential therapeutic effects of algal polysaccharides on IBD while providing the theoretical basis for a nutritional preventive mechanism for IBD and the restoration of intestinal health. The results suggest that algal polysaccharides have significant potential in complementary IBD therapy and further research is needed for fully understanding their mechanisms of action and potential clinical applications.
06:25
Sargassum filipendula, a source of bioactive compounds with antioxidant and matrix metalloproteinases inhibition activities. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Apr 4 ;12(4). Epub 2023 Apr 4. PMID: 37107251 Abstract Title: , a Source of Bioactive Compounds with Antioxidant and Matrix Metalloproteinases Inhibition Activities In Vitro with Potential Dermocosmetic Application. Abstract: The antioxidant and the potential inhibitory capacity of matrix metalloproteinases of the phlorotannin-type polyphenolic and fucoidan-type polysaccharides extracts obtained from the macroalgawere evaluated. Through chromatographic and spectroscopic techniques, the corresponding chemical structure of compounds present in the extracts was determined. Antioxidant capacity was evaluated using the methyl linoleate model for the inhibition of lipid peroxidation, and the free radical scavenging capacity was assessed using DPPH, ABTS,OH, Omethods. The matrix metalloproteinase inhibition potential was measured by collagenase and elastase inhibition tests, using epigallocatechin gallate as a positive control. The extracts exhibited a high scavenging capacity of radical species evaluated and inhibition of diene conjugate formation and thiobarbituric acid reactive substances. The results showed that the crude extracts presented dose-dependent collagenase and elastase inhibition, with ICvalues between 0.04 and 1.61 mg/mL. The structure of the residues of the polysaccharide was identified mainly as (13)-sulfated (13)-l-fucopyranose at carbon 4 and residues of-d-glucopyranose,-d-Mannopyranose, and-d-Galactopyranose, while in the polyphenol extract the presence of phloroglucinol was identified and the presence of eckol, bifuhalol, and trifuhalol was suggested. Our results allow us to infer thatis a potential source of bioactive ingredients with antioxidant and anti-aging activity.
06:19
Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer. GreenMedInfo
PMID: Int J Biol Macromol. 2023 Jun 30 ;241:124528. Epub 2023 Apr 20. PMID: 37086764 Abstract Title: Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer. Abstract: Fisetin (FS) is an anticancer drug having potential role in oral tumors management. However, its clinical application is limited due to its hydrophobicity and instability. Bioactive polymers-based nanosystems have a great potential in cancer therapy. Herein, different biopolymers were selected for their anticancer activity and targeting ability for nanoparticles preparation namely; fucoidan (FU), zein (Zn) and hyaluronic acid (HA). The selected FS-loaded cross-linked Zn nanoparticles (ZFH) which contains HA&FU for Zn nanoparticles stabilization showed the most suitable particle size (196 6.53 nm), mean surface net charge (-38.8 1.47 mV) and entrapment efficiency (98 1.2 %). This is the first study to utilize both HA&FU not only for stabilization but also for dual targeting effect due to their targeting ability to multiple tumor targets. In-vitro anticancer activity of ZHF revealed remarkable uptake by SCC-4 cells with significant cytotoxic action. Further, ZHF was appraised using 4-nitroquinoline 1-oxide (4-NQO)-induced oral cancer in-vivo; ZHF significantly reduced OSCC-specific serum biomarkers levels, histologic tumor grade and increased caspase-3 level. Moreover, potential of destroying two key tumor regulatory cells; TECs and CSCs, was evaluated using their specific markers. The elaborated ZFH nanoparticles could be considered as promising targeted nanotherapy for oral cancer treatment with enhanced efficacy and survival rate.
06:15
Uses of papaya leaf and seaweed supplementations for controlling glucose homeostasis in diabetes. GreenMedInfo
PMID: Int J Mol Sci. 2023 Apr 6 ;24(7). Epub 2023 Apr 6. PMID: 37047820 Abstract Title: Uses of Papaya Leaf and Seaweed Supplementations for Controlling Glucose Homeostasis in Diabetes. Abstract: Studies from laboratory animal models and complementary medical practices have implied that nutrients from special plants or herbs contain antidiabetic, antioxidant, anti-obese, anti-hypertensive, and anti-inflammatory properties. Seaweed and tropical papaya, which are widely available in Asian and Pacific countries, have been used as home remedies for centuries. The bioactive extracts from these plants contain vitamins A, C, B and E complexes, as well as polysaccharides, phenolic compounds, essential fatty acids, flavonoids, saponins, fucoidan, and phlorotannin. In this review, the authors examine the pathogenesis of diabetes characterized by hyperglycemia due to the dysregulation of glucose homeostasis, antidiabetic/antihyperglycemic seaweed or/and papaya derived bioactive phytochemicals and their proposed mechanisms of action in the management of Type 2 Diabetes Mellitus (T2DM). The authors also propose combining papaya and seaweed to enhance their antidiabetic effects, leveraging the advantages of herb-to-herb combination. Papaya and seaweed have demonstrated antidiabetic effects through in vitro assays, cellular models, and animal studies despite the limited clinical trials. Nutraceuticals with antidiabetic effects, such as secondary metabolites isolated from seaweed and papaya, could be combined for a synergistic effect on T2DM management. However, the application of these compounds in their purified or mixed forms require further scientific studies to evaluate their efficacy against diabetes-related complications, such as hyperlipidemia, elevated free radicals, pro-inflammatory molecules, insulin insensitivity, and the degeneration of pancreatic beta cells.
06:13
A combination of deep-sea water and fucoidan alleviates T2DM through modulation of gut microbiota and metabolic pathways. GreenMedInfo
PMID: Pharmaceuticals (Basel). 2023 Mar 20 ;16(3). Epub 2023 Mar 20. PMID: 36986561 Abstract Title: A Combination of Deep-Sea Water and Fucoidan Alleviates T2DM through Modulation of Gut Microbiota and Metabolic Pathways. Abstract: Fucoidan and deep-sea water (DSW) are attractive marine resources for treating type 2 diabetes (T2DM). In this study, the regulation and mechanism associated with the co-administration of the two were first studied using T2DM rats, induced by a high fat diet (HFD) and streptozocin (STZ) injection. Results demonstrate that, compared to those with DSW or FPS alone, the orally administered combination of DSW and FPS (CDF), especially the high dose (H-CDF), could preferably inhibit weight loss, decrease levels of fasting blood glucose (FBG) and lipids, and improve hepatopancreatic pathology and the abnormal Akt/GSK-3signaling pathway. The fecal metabolomics data show that H-CDF could regulate the abnormal levels of metabolites mainly through the regulation of linoleic acid (LA) metabolism, bile acid (BA) metabolism, and other related pathways. Moreover, H-CDF could adjust the diversity and richness of bacterial flora and enrich bacterial groups, such asand. In addition, Spearman correlation analysis illustrated that the interaction between the gut microbiota and BAs plays an essential role in the action of H-CDF. In the ileum, H-CDF was verified to inhibit activation of the farnesoid X receptor (FXR)-fibroblast growth factor 15 (FGF15) pathway, which is regulated by the microbiota-BA-axis. In conclusion, H-CDF enrichedand, thereby changing BA metabolism, linoleic acid metabolism, and other related pathways, as well as enhancing insulin sensitivity and improving glucose and lipid metabolism.
06:00
Ep 491 Fatigue, tired, brain fog and no energy. Tune in. Dr Ron Unfiltered Uncensored
If you are chronically ill you probably have chronic inflammation and it is damaging your mitochondria. The results can be devastating and include dementia, cancer, cardiovascular disease, and even depression. We'll start to explore how inflammation can wreak havoc on our health.
05:48
Combination of fucoidan and triterpene glycoside with radiotherapy might contribute to the development of highly effective method for melanoma therapy. GreenMedInfo
PMID: Biomolecules. 2023 Feb 23 ;13(3). Epub 2023 Feb 23. PMID: 36979354 Abstract Title: Combined Radiomodifying Effect of Fucoidan from the Brown Algaand Pacificusoside D from the Starfishin the Model of 3D Melanoma Cells. Abstract: Cancer is one of the main causes of human mortality worldwide. Despite the advances in the diagnostics, surgery, radiotherapy, and chemotherapy, the search for more effective treatment regimens and drug combinations are relevant. This work aimed to assess the radiomodifying effect and molecular mechanism of action of fucoidan from the brown alga(ScF) and product of its autohydrolysis (ScF_AH) in combination with pacificusoside D from the starfish(SpD) on the model of viability and invasion of three-dimension (3D) human melanoma cells SK-MEL-2. The cytotoxicity of ScF (ICJB6 Cl41>800g/mL; ICSK-MEL-2 = 685.7g/mL), ScF_AH (ICJB6 Cl41/SK-MEL-2>800g/mL), SpD (ICJB6 Cl41 = 22M; ICSK-MEL-2 = 5.5M), and X-ray (IDJB6 Cl41 = 11.7 Gy; IDSK-MEL-2 = 6.7 Gy) was determined using MTS assay. The efficiency of two-component treatment of 3D SK-MEL-2 cells was revealed for ScF in combination with SpD or X-ray but not for the combination of fucoidan derivative ScF_AH with SpD or X-ray. The pre-treatment of spheroids with ScF, followed by cell irradiation with X-ray and treatment with SpD (three-component treatment) at low non-toxic concentrations, led to significant inhibition of the spheroids' viability and invasion and appeared to be the most effective therapeutic scheme for SK-MEL-2 cells. The molecular mechanism of radiomodifying effect of ScF with SpD was associated with the activation of the initiator and effector caspases, which in turn caused the DNA degradation in SK-MEL-2 cells as determined by the Western blotting and DNA comet assays. Thus, the combination of fucoidan from brown algae and triterpene glycoside from starfish with radiotherapy might contribute to the development of highly effective method for melanoma therapy.
05:41
Fucoidan enhances the effect of chemotherapeutic drug against drug-resistant lung cancer cells. GreenMedInfo
PMID: Pak J Pharm Sci. 2023 Jan ;36(1):89-97. PMID: 36967501 Abstract Title: Fucoidan enhances the effect of chemotherapeutic drug against drug-resistant lung cancer cells. Abstract: Development of adjuvant chemotherapy drugs against drug-resistant lung cancer cells is necessary. The use of non-toxic adjuvant natural product combined with chemotherapy drugs will be an important treatment mode in the future. The purpose of the study investigates that fucoidan enhances chemotherapy drug poisoning drug-resistant lung cancer cell. Drug-resistant lung cancer cells are established in the study. Cell culture, MTT assay, wound healing assay, gelatin zymography assay, DNA fragmentation assay, apoptosis assay, reverse transcription polymerase chain reaction (RT-PCR) western blot analysis was adopted. The results showed that fucoidan synergized with doxorubicin increased efficacy of poisoning drug-resistant lung cancer cells and enhanced the ability of doxorubicin to inhibit the migration of drug-resistant lung cancer cells. It was observed that fucoidan synergized with doxorubicin induced the increase of apoptosis and inhibited expression of MMP-9, LC3, Beclin-1 and-catenin in drug-resistant lung cancer cells. Fucoidan synergized with doxorubicin significantly inhibited proliferation, migration and metastasis of drug-resistant lung cancer cells. Fucoidan strengthened doxorubicin to induce apoptosis and autophagy of drug-resistant lung cancer cells. This study confirms that the combined use of fucoidan and chemotherapeutic drugs can effectively poison drug-resistant lung cancer cells.
05:22
Starving cancer is another pseudoscientific myth Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
Starving cancer is another one of those internet myths pushed by pseudoscientific quacks who try to give people and "easy" cure for cancer.
05:14
Fucoidans inhibited tau interaction and cellular uptake GreenMedInfo
PMID: Carbohydr Polym. 2023 Jan 1 ;299:120176. Epub 2022 Sep 30. PMID: 36876791 Abstract Title: Fucoidans inhibited tau interaction and cellular uptake. Abstract: Tau spreading in Alzheimer's disease is mediated by cell surface heparan sulfate (HS). As a class of sulfated polysaccharides, fucoidans might compete with HS to bind tau, resulting in the cessation of tau spreading. The structural determinants of fucoidans for competition with HS binding to tau are not well understood. Sixty previously prepared fucoidans/glycans with different structural determinants were used to determine their binding abilities to tau using SPR and AlphaLISA. Finally, it was found that fucoidans had two fractions (sulfated galactofucan (SJ-I) and sulfated heteropolysaccharide (SJ-GX-3)), which exhibited strong binding abilities than heparin. Tau cellular uptake assays using wild type mouse lung endothelial cell lines were performed. It was shown SJ-I and SJ-GX-3 inhibited tau-cell interaction and tau cellular uptake, suggesting that fucoidans might be good candidates for inhibiting tau spreading. NMR titration mapped fucoidans binding sites, which could provide the theoretical basis for the design of tau spreading inhibitors.
05:13
This study concludes that different parts of the papaya can be beneficial for preventing diabetes and diabetes-related wound healing. GreenMedInfo
PMID: Nutrients. 2023 Apr 17 ;15(8). Epub 2023 Apr 17. PMID: 37111148 Abstract Title: Characterization of Green and Yellow Papaya () for Anti-Diabetic Activity in Liver and Myoblast Cells and Wound-Healing Activity in Fibroblast Cells. Abstract: Obesity and diabetes, often characterized as "metabolic syndrome", have been recognized as two of the most important public health issues worldwide. The objective of the present research was to evaluate green and yellow papaya for anti-oxidation and anti-diabetic properties. Leaves, skin, pulp, and seed samples from papayas were freeze-dried and then extracted in water or 80% methanol. The extracts were used to determine total polyphenolic content and anti-oxidation activities, and to determine biological activities, including glucose uptake, Glut-2 expression, triglyceride reduction, and wound-healing activity. Our data demonstrated that methanol and water extracts of green and yellow papaya have similar concentrations of polyphenols in skin (10-20 mg/g dry powder), leaf (25-30 mg/g dry powder), and pulp (1-3 mg/g dry powder) fractions. However, both methanol and water extracts of seeds from yellow papaya have substantially higher concentrations of polyphenols compared to green papaya. Both water and methanol extracts of yellow papaya exhibited higher anti-oxidation activity compared to green papaya in skin (50-60%), pulp (200-300%), and seeds (10-800%). Old leaves also showed greater anti-oxidation activity (30-40%) compared to new leaves. Pulp extracts from both yellow and green papaya stimulated greater glucose uptake, but only pulp from green papaya stimulated glucose uptake in muscle cells. Similarly, pulp extract stimulated glucose transporter Glut-2 expression in liver cells. The skin, pulp, and seeds of green or yellow papaya showed triglyceride-lowering activity in liver cells by 60-80%, but samples taken from yellow papaya had a more potent effect. Seeds from both green and yellow papaya significantly stimulated the migration of fibroblasts in the wounded area by 2-2.5-fold compared to the untreated control. Consistent with these data, seeds from both green and yellow papaya also significantly stimulated collagen synthesis in fibroblast cells by almost 3-fold. In conclusion, our data indicate that different parts of papaya produce stimulatory effects on glucose uptake, Glut-2 expression, TG reduction, and wound-healing activities. This study concludes that different parts of the papaya can be beneficial for preventing diabetes and diabetes-related wound healing.
05:11
Anthocyanin content in Hibiscus sabdariffa and their antiplatelet and vasorelaxant properties. GreenMedInfo
PMID: Plant Foods Hum Nutr. 2023 Apr 29. Epub 2023 Apr 29. PMID: 37120677 Abstract Title: Effect of Different Extraction Methods on Anthocyanin Content in Hibiscus sabdariffa L. and their Antiplatelet and Vasorelaxant Properties. Abstract: Hibiscus sabdariffa L. is a worldwide component for tea and beverages, being a natural source of anthocyanins, which are associated with cardiovascular activities. To investigate this relationship, we explored different methods of aqueous extraction on the anthocyanin content and antioxidant activity of H. sabdariffa L. calyx extract (HSCE). Pharmacological effects via platelet aggregation, calcium mobilization, cyclic nucleotide levels, vasodilator-stimulated phosphoprotein Ser157 and Ser239, and on the vasomotor response of aortic rings isolated from mice are studied herewith. We found that the application of ultrasonic turbolization, 20 min, combined with acidified water was significantly more effective in the extraction process, providing extracts with the highest levels of anthocyanins (8.73 and 9.63 mg/100 g) and higher antioxidant activity (6.66 and 6.78 M trolox/g of sample). HSCE significantly inhibited (100-1000 g/mL) arachidonic acid-induced platelet aggregation, reduced calcium mobilization, and increased cAMP and cGMP levels with VASPSer157 and VASPSer239 phosphorylation. Vasorelaxation reduction was confirmed by the aortic rings and endothelium assays treated with nitric oxide synthase inhibitors, soluble guanylyl cyclase (sGC) oxidizing agent, or Ca-activated Kchannel inhibitor. The increasing of cGMP levels could be understood considering the sGC stimulation by HSCE compounds in the specific stimulus domain, which allows an understanding of the observed antiplatelet and vasorelaxant properties of H. sabdariffa L. calyx extract.
05:08
Dietary supplements are not better than statins for heart disease Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
Dietary supplements, such as vitamins and other micronutrients, are not better than statins for the treatment or prevention of heart disease.
05:00
Fractured Soul Factory by K.G. Munro Mad In America
Many of us are broken
before we can even see the cracks
As we walk blindly through life
Enduring the fear and hatred
that we are steeped in daily
By the media and people who always think
that they are right
Just a number assigned to each of us
Treatment includes a concoction of drugs
To be numb and stay compliant
As our souls bleed for love and compassion
Society has become a factory
One that creates stress and anxiety
As each soul is broken and replaced
Like products on a conveyor belt
Mental illness is a sane response
To a very insane world.
****
K.G. Munro is an author and poet from Scotland. Here are a few of
her writing credits: Indian Periodical, Poetry Potion, Scarlet
Dragonfly Journal, Splendeur Magazine, AThinSliceofAnxiety,
Spillwords, Feversofthemind, Friday Flash Fiction, The Poet
Magazine, PoetryAsPromised, Scottish Book Trust, and Orange Peel
Magazine.
****
Back to Poetry Gallery
The post Fractured Soul Factory by K.G. Munro appeared first on Mad In America.
04:58
Quandries of Perpetual Dischord by Elizabeth Moroz Mad In America
Permanent irreversible Attatchment disorder
A lemonade stand at the Mexican Border
A traumatised disorganised old lady hoarder
The incriminating evidence on an old tape recorder
Elements of discontent shivering through a crowd
Firmaments of promises sent confirming love out loud
Innocents in recompense versus the indiscriminately Proud
Hallowed ground to walk a solemn pilgrimage
Mellowed kids found in a drugged up old orphanage
Shallow things in the ground as we discover archaeological
heritage
Waiting for you to come around after the last disagreeable
haemorrhage
Dont perpetuate the notions of those who deal in mis-truths
Allow the forward motion of the next generation of youths
Avoid the multi-syllabic commotions of the sub-cutaneous systematic
word-sleuths
Explore the promotion of legislative proof
Pay no heed to aristocracy lest you kneel before the crown
Histories of greed and animosity as First Nation people frown
Enhance the seed of meritocracy and do not let democracy down
Per chance the need of mediocrity is allowing dreams of progression
to literally drown
Distortions of perspective allowed too much time in
publication
Abortions and incentives disavowed by politically un -objective
legislation
Contortions of mis-directives allowed the resulting violent
instigations
Act with caution around detectives when they amount their
investigations
A conversation meant for only honest ears
An invitation sent to one who has accumulated the years of
Inclination that went to a pub to drink more beers
As the intimation to invent inclines financial systems into
arrears
Sunlit afternoons upon a golden prairie
Unfit old cartoons before it all became too contrary
The stark hit of high noon when viewing something extraordinary
The slow wit of a tycoon holding onto his self proclamations of
Legendary
A compromise of ethics for the sake of business running
An enterprise of genetics in the wake of scientific funding
A stealth disguise of frenetics formed by a hedonistic cunning
The wealth suprised by the systemics involved in the economic
collapses that are coming
The concentric inheritly biased comparisons that we make
The eccentric numerical silence of a mathematicians answer to a
Fake
The barbaric energetic violence of those who are only willing to
take
Marie Antoinette on the day she proclaimed Let them eat cake!
A latent virus that is mutating just under the skin
A patient silence that is waiting for the other team to win
Egypt turned to the God Osiris as Cleopatra started to grin
A thief conspires to other liars as Frank Sinatra sips on gin
Confusion as the narrative gets told by a country pop star
Intrusion as the explanative gets old when self grandiosity is
taken t...
04:54
American Dream by Adam Coale Mad In America
Sad, mad & feeling so defeated..
From this life long ago I retreated..
I long to come back ..
I long to start fresh
A new day maybe? Or shall I choose death.
They call me sensitive & say I feel too much..
I say theyre blind & dont feel nearly enough.
If they really knew the things & thoughts that grew , in this
twisted head a primal gmo stew.
A product of my world this problem child they hurled. Into their
mold I flew until my free thought grew.
Their mold I broke & their drugs they did soak.
Into my childs brain that surely increased the pain.
But a taste I sure did get for my future filled with regret.
Was this their plan all along ?
This all to familiar song?
But this they say is the American way.
Keep them sick & shorten their stay.
On this earth they claim their flagpole is our pain.
Shall we rise up & bring the fight to them?
Or just lay down & guilty we are as them.
****
Back to Poetry Gallery
The post American Dream by Adam Coale appeared first on Mad In America.
04:52
25 Years of Consciousness, and They Still Havent Cured My Suffering by Sarah Myers Mad In America
After I went to the Association for the Scientific Study of Consciousness conference this weekend, I sat down with all the consciousness researchers to discuss why I suffer.
Me: You say that youre trying to find the neural correlates of consciousness. What exactly does that mean?
Them: Well, it means we think there are specific brain regions and networks that correspond to the process of consciousness.
Me: And how do you figure that kind of shit out?
Them: I mean, there are two leading theories. One theory thinks that consciousness is located in the back region of the brain and has a consciousness structure formed by neuronal connectivity that is active while youre, say, looking at a picture. The other leading theory says that consciousness is broadcasted through information across the brain through an interconnected network, and it occurs at the front of the brain.
Me: Uh huh. My consciousness is pretty insufferable. Have you figured out if theres like, a network of suffering?
Them: No, we are still trying to just find a universal consciousness, like the difference between vegetative and wake states, not degrees of consciousness.
Me: Well, thats not really helpful. I dont appreciate that your scientific contributions dont apply specifically to me.
Them: Sorry! There is hope that we might be able to understand the different grades of consciousness, but thats a far ways off.
Me: Does that mean we really have to sit through another 25 years of chummy bets before we might potentially get to a cure? Though that might be great timing, Ill be having my midlife crisis then.
Them (philosopher): Well with my hunch that likely wont be the case at all!
Me: Im sure youre very sorry about that right now.
Them (scientists): Dont lose hope! We are very close to building a theory.
Me: Those study results that were released at the 25 Years of Consciousness public debate didnt seem to really confirm that any of your theories were correct.
Them (scientists): Yes, but there is plenty of hope. All in good fun. Thats what science is all about, eh? We have to make a logical progression through each discovery.
Me: Thats what privileged people say. Always talking about logic and money and time and NIH dollars. Im not familiar with any of these concepts. Are those things helpful?
Them: Er yes, well. Its what we use to conduct research.
Me: Eyes up here.
Them: Sorry, I just spotted a rat running underneath your feet.
Me: Its New York City, get over it. So anyway, are you gonna, like, find any neural correlates that can give me a will to live? Thatd be very helpful.
Them: Not yet but sorry to hear youre going through that.
Me: Enough about me. But wager this: my professor says he used to work on finding the neural correlates of PTSD. He says PTSD symptoms have changed over...
04:49
Bazooka Joe at the Shoe Store by Zak Mucha Mad In America
Walking past a construction site and through
the creosote cloud of a childhood
shoe store, a kid embarrassed by the clerks
gift of a hard square of pink gum wrapped in
a Bazooka Joe comic meant for some
other kid now long gone, leaving the first
kid ashamed to be wanting more than new
shoes, wanting to find more than the broken
pots and untoothed combs buried under the
centuries of ash and mud of textbooks
or the National Geographic map
of Mars circa 1973 meant
for some other kid who is also me
sending letters to the Papaya King
asking of allergens to prepare
for some new kids birthday party.
****
Zak Mucha, LCSW, is a psychoanalyst in Chicago. He is the author of
Emotional Abuse: A Manual for Self-Defense, a book of poetry Shadow
Box, and the forthcoming Swimming to the Horizon: Crack, Psychosis,
and Street-Corner Social Work.
****
Back to Poetry Gallery
The post Bazooka Joe at the Shoe Store by Zak Mucha appeared first on Mad In America.
04:47
To My New Shrink by M.J. Hudson Mad In America
A schizo still causing a commotion
long after being corrected by the law,
I, a jaded boozer, long unemployed,
after waking where madmen drown
waiting for a fair maiden of the ocean
to provide a sweet ride to the shore,
hoped you would keep me buoyed
upon a fresh image, not salt a clown
in seawater, but no, we poor fools
are crazily addicted to controversy
and cant be trusted to obey the rules
however long we beg you for mercy
and gasp for flair, feeling constricted
in the cold vice of crimes predicted.
****
Back to Poetry Gallery
The post To My New Shrink by M.J. Hudson appeared first on Mad In America.
04:46
Subhuman Schizo Sonnet by M.J. Hudson Mad In America
O feeling like a nigger denied the vote,
the brain behind my radical commotion
being coercively treated by the state,
I, torn out to where some schizos drown,
hoped the shrinks would see me afloat
on their vow to fairly patrol the ocean
and at last work to wholly exonerate
a benumbed poet of genius in town,
but no, such dreams gut us poor fools
like a delusion sharpened on a wheel,
we you cannot trust to obey the rules
however often the exhausting ordeal
of being drugged to stop crimes forecast
buries people deep in a cold blue past.
****
Back to Poetry Gallery
The post Subhuman Schizo Sonnet by M.J. Hudson appeared first on Mad In America.
04:43
Untitled by Louise Mad In America
I cant cope with living anymore
Leaving for good should be a choice
Should be empty of moral guilt
Ill never get over my Moms passing
Ill never accept the patriarch imposing the bully into my life
again
With his psychological games
And daily gaslighting
Die, I will
If not by my adding diseases
By my own crazy despair
I pitty my Dad though
I see through him
Id also want to abandon the heavy burdon I am in the nearest
landfil
****
Back to Poetry Gallery
The post Untitled by Louise appeared first on Mad In America.
04:08
What is the fear of missing out? | Causes and remedies Chipur
Addicted to social media, amped up depression and anxiety - you browsed for help. And, bingo, you found an article on the fear of missing out. Now its on to causes and remedies
The post What is the fear of missing out? | Causes and remedies first appeared on Chipur.
03:00
Sleepwalking My Life on Seroquel Mad In America
It was at the age of twenty-seven when I experienced my first psychosis. I worked as a financial analyst of banks and portfolio manager at a nice company in Amsterdam, and from the outside, my life looked pretty good. I had a cool job, lived in the center of the gorgeous city of Amsterdam, and was a member of the best sports club. I was living a dream life.
Due to my extremely difficult teenage years in my native Russia, the disaster would probably have struck eventually, but when it arrived, it came unexpectedly. Till the age of 27, I was suffering from awful stomach pain, constantly and terribly, which prevented me from forming a meaningful relationship with anyone. It was the stress of huge abandonments and losses in my youth, that was storing in my stomach, to release, I assume, when the time was right. Yes, I do believe that any manifestation of what is called mental illness is the trauma acquired when growing up. I suffered, felt unloved, and was absolutely insecure deep inside.
At the age of 27, however, I fell in love with a gorgeous French man, who, unfortunately, was in Amsterdam only for a couple of months. He did hint at the possibility of staying with me, but what could I offer, besides my constant stomach pain? Nothing. And so he left, because I was too scared to tell him the truth, that I was constantly experiencing terrible pain.
Once he left, I went to the Chinese medicine center to help me to find something to ease my pain. I knew I couldnt carry on like I was. I received a prescription of a very strong tea, but instead of following the recommended dose, I just drank almost all of it in one go, so desperate I was for my pain to go. I was also smoke free then from my cigarettes, and spending all my evenings in the gym, to wake up at 6 in the morning for a run, before my job would start, where I was often the first in the office, at 7:30, or 8 at the latest. The portfolio of shares I was supervising was doing well, while my mental health was getting worse and worse.
I stopped sleeping, and on the eleventh day of no sleep, I ended up in a psychosis. It was a liberation for me, from how I experienced it. I saw angels, I saw the manifestation of God, I fe...
01:07
Top 10 Gross American Foods That Foreigners Think Are Nasty! Healthy Holistic Living
When it comes to food, every culture has its own unique delicacies and preferences. The United States is no exception, and while Americans take pride in their diverse culinary traditions, there are certain dishes that foreigners find perplexing or even repulsive. The internet provides a platform for individuals from around the world to express their opinions on American cuisine, and weve gathered some fascinating insights from Redditors and Quora users regarding the foods they find appalling. In this article, well delve into these ten American foods and explore why foreigners might find them disgusting. Whether you agree or not, its interesting to discover the stark contrasts in food preferences across different cultures.
-
Root Beer: An Unusual Flavor Combination
Root beer, a popular carbonated soft drink in the United States, is
an acquired taste that often divides opinions, especially among
foreigners. Many Redditors and Quora users from other countries
find the flavor of root beer unusual and even off-putting. Some
describe it as a mix of licorice and wintergreen, which can be
jarring to those accustomed to different taste profiles. For
instance, a Redditor shared their cousins perspective from the
U.K., where root beer is not commonly consumed, explaining that the
combination of flavors in root beer seemed strange and unfamiliar.
This stark contrast in taste preferences highlights the diversity
of the global beverage landscape.
-
Chicken and Waffles: A Surprising Culinary Fusion
...
Tuesday, 04 July
23:12
Navigating Emotional Manipulation: Understanding and Combating Gaslighting in Relationships Healthy Holistic Living
Creating and maintaining a strong, healthy romantic relationship requires a tremendous amount of work, patience, and mutual understanding. It involves continuously building trust and ensuring both partners are respected. Nevertheless, there are instances when these relationships can transform into toxic environments, often due to manipulative tactics such as gaslighting.
Gaslighting, a troubling psychological phenomenon, typically involves one or both partners using deceptive phrases during everyday conversations or disagreements, gradually turning the relationship toxic. As gaslighting is a form of emotional abuse, awareness is paramount.
Understanding the Many Facets of Abuse
Abuse is not only physical harm. It can take several forms, including emotional, verbal, mental, and financial. Recognizing the different forms of abuse is crucial, especially since gaslighting falls under the umbrella of emotional abuse. Gaslighting can deeply affect an individuals mental health, self-esteem, and overall well-being, leading to long-lasting negative impacts. Its therefore crucial to understand the signs of gaslighting in order to protect your mental well-being.
Gaslighting: The Insidious Art of Psychological Manipulation
Gaslighting is an emotional abuse tactic where the abuser deliberately causes the victim to question their own sanity or perception of events. The manipulator often accomplishes this through denial, shifting blame, or making the victim feel responsible for the manipulators actions. This systematic dismantling of a victims self-confidence can result in significant emotional and psychological damage.
Methods of Gaslighting
Gaslighting can wreak havoc in a relationship, causing severe emotional turmoil. The manipulator uses gaslighting phrases to alter the narrative, casting themselves as harmless or blameless. These phrases are often wielded as tools to exert control, with the abuser using various manipulation techniques, such as countering, stonewalling, diverting/blocking, denial/intentional forgetting, and trivializing.
Identifying Gaslighting in Relationships
...
20:00
Pharma CEO, Others Attempt Contradictory Critiques of Serotonin-Debunking Study Mad In America
Last summer, a thorough analysis struck what Psychology Today called a decisive blow to the chemical imbalance myth of depression. That outdated theorythat a lack of serotonin causes depressionhas been debunked many times over the past few decades, but it clings to the public consciousness, perhaps largely due to pharmaceutical industry propaganda and media oversimplification. Indeed, prominent psychiatrists have even claimed that the serotonin theory is promoted by an anti-psychiatry conspiracy.
Given that position, one might think that psychiatry would welcome a large review of the evidence on the topicthe largest and most comprehensive ever conductedputting the supposed anti-psychiatry propaganda to rest. Instead, the reaction from psychiatry has been vitriolic against the authors.
Now, researchers who have staked their financial future on the serotonin theory have joined together to attempt a debunking of that study. The only problem? Their concerns are extremely technical, contradictory, and in some cases, outright false, according to the original study authors. None of them provide solid or consistent evidence for serotonins role in depression.
Indeed, the minor, paradoxical gripes by various critics, including a pharma CEO, illuminate a picture of industry-funded researchers clinging to a poorly supported, controversial, and outdated theory that is nevertheless likely to help their marketing of new drugs.
Responding to the criticism, the authors of the original study write of the serotonin theory, No one believes it, but no one wants to let it go, either.
The critics, and a response by the original authors of the serotonin-debunking study, were published in Molecular Psychiatry.
The authors of the original paper were Joanna Moncrieff, Ruth E. Cooper, Tom Stockmann, Simone Amendola, Michael P. Hengartner, Martin Plderl, and Mark A. Horowitz.
...
20:00
17:59
When Doctors Have Different Standards of Evidence for the Virus and the Vaccine Science-Based Medicine
817,000 thousand Americans had already died of COVID by December 23, 2021, and 244,000 more would die the next year. Millions more survived, but were injured. These numbers could have been lower if doctors had not become defense attorneys for SARSCoV2 and prosecutors against the vaccine, and instead applied similar standards of evidence to both.
The post When Doctors Have Different Standards of Evidence for the Virus and the Vaccine first appeared on Science-Based Medicine.10:00
Editor's Note: This article is a reprint. It was originally published March 17, 2018.
While genetically modified organisms (GMOS), and the pesticides that go along with them, are touted as the solution to feed the world, the reality is a far cry from this industry-spread ideal. In reality, 86% of the value of U.S. agricultural exports in 2015 went to 20 destinations with low numbers of hungry people and high rates of human development scores.1 The top recipient? Canada.
In 2013 as well, U.S. farms contributed only 2.3% of the food supply to the countries with the most starving people.2 Such countries, unbeknownst to many Americans, actually produce most of their own food already. What they need is not for the U.S. to step up its production of genetically engineered (GE) corn and soy, but to be given resources to distribute and increase access to food while helping local farmers to earn a good living.
If we took GMOs off the market today, we would still be feeding the world with the same inefficacy that we are today. We have starvation. We have the biggest famine in human history happening over in sub-Saharan Africa right now. However, the problem with GMOs is one much larger than failed promises or misguided expectations.
Instead, it's a form of technology that threatens human health, the environment and the very food supply we depend on. At the foundation, "GMOs Revealed" seeks to answer a question that's relevant to all of us:
"What if the desire to use technology to enhance our world and save lives has evolved into a lust that, when paired with corporate greed and politics, becomes a catastrophic mass experiment that harms you and your family? Genetically modified foods, also known as GMOs, represent one of the most controversial issues in the world today. What is more vital to humanity, to each of us, than our food supply?"
The Not-so-Green Revolution
As Zach Bush explains, many of the problems with industrialized agriculture began with the Green Revolution, which is not at all "green" as its name suggests. It's easy to forget that at one point, not so long ago, all food was organically grown in a way that supported the ecosystem and environment as a whole. This all changed in the 1940s when the Green Revolution took hold and industrial, chemical-dependent farming techniques quickly spread to become the norm.
When WWII ended, there was a glut of petroleum, and in pet...
It Is Time to Declare Our Independence From the Vaccinators Articles
On July 4, 2023, it will have been 247 years since the Declaration of Independence was drafted by Thomas Jefferson and signed by delegates of 13 American colonies formally declaring independence from political control by the King of England.1
Light and liberty go together said Jefferson2 and, in his final letter to John Adams before he and Adams both died on July 4, 1826, Jefferson predicted that no despot or tyrannical empire in the future would be able to crush the human spirit of resistance that guards liberty.
A fierce proponent of individual rights,3 Jefferson said, The flames kindled on the 4th of July 1776 have spread over too much of the globe to be extinguished by the feeble engines of despotism. On the contrary, they will consume these engines, and all who work them.4,5
Was Jeffersons prediction right? Or, as one of the earliest and most influential proponents of smallpox inoculation,6 could he never have imagined that the scientific and medical professions he loved so well7 would one day forge lucrative global business partnerships with industry and government and create a public health empire that has become a much greater threat to liberty than the monarchy he and his fellow revolutionaries rebelled against in 1776?8,9,10
After my son was injured in 1980 by the crude, toxic whole cell pertussis vaccine in DPT shots,11 I joined with other parents of DPT vaccine injured children in 1982 to establish the charity known today as the National Vaccine Information Center (NVIC) with the mission of preventing vaccine injuries and deaths through public education.12,13 We have defended the legal right to make voluntary decisions about vaccination for 41 years.14,15
Since then, I have watched the public health empire grow and use no exceptions vaccination laws as...
Deforesting the Amazon for Green Energy Windmills? Articles
Balsa, a tree thats native to South America, is a coveted resource. Growing up to 98 feet (30 meters) and ready for harvesting in just three to four years from planting, balsa holds the promise for high profits for those who grow them.1
Adding to its value, balsa wood is flexible and light yet very strong, making it an ideal material for manufacturing bridges, skis, boats and wind turbine propellers.2
In an ironic tragedy, however, the rapid expansion of wind energy has led to increasing demand for windmills and balsa wood to build them. Now, the tropical tree is facing exploitation and being cleared from Amazon forests, causing potentially more environmental problems than the windmills it creates can solve.
Rush for Balsa Wood Causes Devastating Deforestation
Wind turbine blades can be up to 328 feet (100 meters) long. Each blade requires 150 cubic meters of balsa wood, which is several tons. With demand on the rise from Europe and China, "balsa fever" set in, particularly in Ecuador, the No. 1 exporter of balsa wood, which produces 75% of the global market.3
Prices of balsa wood have also skyrocketed, rising 30% from 2015 to 2019, when balsa wood worth $219 million was exported from Ecuador.4 China is a major consumer of balsa wood, purchasing 85% of Ecuadors exports in 2020.5 In the Open Democracy video above, you can see how the rush for balsa wood to create "green" wind energy has destroyed local indigenous communities and decimated ecosystems.6
In June 2023, the Achuar Nationality of Ecuador (NAE) declared that it would not allow deforestation to obtain balsa wood in its territory. In a social media post, they wrote, "Don't make any investment, even if you cut down balsa you wont be able to extract it, it wont be sold."7 However, indigenous leaders bowed to pressure in some communities nonetheless, allowing loggers to retrieve the wood. According to Open Democracy:8
"Its a decision that has caused pain, rejection and division among families...
08:34
Wyoming Law Expands Food Freedom Act, Opens Market to Small Egg and Dairy Producers Medical Kidnap
by Mike Maharrey
Tenth Amendment Center
CHEYENNE, Wyo. (July 2, 2023) Yesterday, a Wyoming law went into effect that will further increase food freedom in the state, and potentially alleviate some of the recent price inflation on eggs and dairy.
Sen. Tim Salazar and 10 fellow cosponsors introduced Senate Bill 102 (SF102) on Jan. 12. The new law expands the Wyoming Food Freedom Act to allow a designated agent to facilitate sales transactions in the marketing, transport, storage, or delivery of food and beverage products. Under previous law, producers could only sell directly to consumers.
The new law will also add eggs and dairy products to the foods that can be sold at farmers markets, farms, ranches, producers homes or offices, and the retail location of the third-party sellers.
The House passed SF102 by a 62-0 vote. The Senate approved the measure by a 30-1 vote. With Gov. Mark Gordons signature, the law went into effect on July 1.
Expanding the market for eggs and dairy could provide some relief for Wyoming residents struggling to deal with price inflation. The price of both eggs and milk has increased precipitously over the last year. Opening up the market to more producers and sellers could help the people of Wyoming to get some relief from the money-printing frenzy of recent years.
WYOMING LEADS THE WAY
Wyoming was the first state to enact a comprehensive Food Freedom Act back in 2015. The law allows the sale of many foods and food products direct from the producer to the consumer without adhering to onerous state regulatory and licensing requirements.
The expansive law even allows poultry farmers with fewer than 1,000 birds to sell chicken and turkey, along with products made from their birds outside of the regulatory system.
It also authorizes the sale of raw milk, rabbit meat and most farm-raised fish.
In 2020,...
08:34
Wyoming Law Expands Food Freedom Act, Opens Market to Small Egg and Dairy Producers Vaccine Impact
by Mike Maharrey
Tenth Amendment Center
CHEYENNE, Wyo. (July 2, 2023) Yesterday, a Wyoming law went into effect that will further increase food freedom in the state, and potentially alleviate some of the recent price inflation on eggs and dairy.
Sen. Tim Salazar and 10 fellow cosponsors introduced Senate Bill 102 (SF102) on Jan. 12. The new law expands the Wyoming Food Freedom Act to allow a designated agent to facilitate sales transactions in the marketing, transport, storage, or delivery of food and beverage products. Under previous law, producers could only sell directly to consumers.
The new law will also add eggs and dairy products to the foods that can be sold at farmers markets, farms, ranches, producers homes or offices, and the retail location of the third-party sellers.
The House passed SF102 by a 62-0 vote. The Senate approved the measure by a 30-1 vote. With Gov. Mark Gordons signature, the law went into effect on July 1.
Expanding the market for eggs and dairy could provide some relief for Wyoming residents struggling to deal with price inflation. The price of both eggs and milk has increased precipitously over the last year. Opening up the market to more producers and sellers could help the people of Wyoming to get some relief from the money-printing frenzy of recent years.
WYOMING LEADS THE WAY
Wyoming was the first state to enact a comprehensive Food Freedom Act back in 2015. The law allows the sale of many foods and food products direct from the producer to the consumer without adhering to onerous state regulatory and licensing requirements.
The expansive law even allows poultry farmers with fewer than 1,000 birds to sell chicken and turkey, along with products made from their birds outside of the regulatory system.
It also authorizes the sale of raw milk, rabbit meat and most farm-raised fish.
In 2020,...
08:27
Wyoming Law Expands Food Freedom Act, Opens Market to Small Egg and Dairy Producers Health Impact News
by Mike Maharrey
Tenth Amendment Center
CHEYENNE, Wyo. (July 2, 2023) Yesterday, a Wyoming law went into effect that will further increase food freedom in the state, and potentially alleviate some of the recent price inflation on eggs and dairy.
Sen. Tim Salazar and 10 fellow cosponsors introduced Senate Bill 102 (SF102) on Jan. 12. The new law expands the Wyoming Food Freedom Act to allow a designated agent to facilitate sales transactions in the marketing, transport, storage, or delivery of food and beverage products. Under previous law, producers could only sell directly to consumers.
The new law will also add eggs and dairy products to the foods that can be sold at farmers markets, farms, ranches, producers homes or offices, and the retail location of the third-party sellers.
The House passed SF102 by a 62-0 vote. The Senate approved the measure by a 30-1 vote. With Gov. Mark Gordons signature, the law went into effect on July 1.
Expanding the market for eggs and dairy could provide some relief for Wyoming residents struggling to deal with price inflation. The price of both eggs and milk has increased precipitously over the last year. Opening up the market to more producers and sellers could help the people of Wyoming to get some relief from the money-printing frenzy of recent years.
WYOMING LEADS THE WAY
Wyoming was the first state to enact a comprehensive Food Freedom Act back in 2015. The law allows the sale of many foods and food products direct from the producer to the consumer without adhering to onerous state regulatory and licensing requirements.
The expansive law even allows poultry farmers with fewer than 1,000 birds to sell chicken and turkey, along with products made from their birds outside of the regulatory system.
It also authorizes the sale of raw milk, rabbit meat and...
07:15
UK Mental Health Review Must Address Lack of Compassion Towards Patients, Watchdog Says Mad In America
From The Independent: The governments national review of mental health hospitals must urgently address the lack of sympathy and compassion towards patients if safety is to improve, the health ombudsman has said.
Rob Berhens said the investigation, prompted by The Independents reporting on deaths and abuse of vulnerable patients, must look at three key issues, including a lack of empathy for those with mental health challenges, a lack of resources and poor working conditions for staff.
Health Secretary Steve Barclay announced on Wednesday that a new safety body, the Health Services Safety Investigations Body (HSIB), would look into the care of young people, examine staffing levels and scrutinise the quality of care within mental health units.
The review comes after The Independent exposed systemic abuse of children within private mental health hospitals run by the former Huntercombe Group, with more than 50 patients speaking out about treatment spanning a decade.
Mr Berhens said: I trust [HSIB] to be able to understand what are the key issues, theyre about the lack of sympathy and compassion for people who have mental health challenges, which to me is a human rights issue.
Theyre about the issue of resources available to the mental health sector. And theyre about the working conditions that staff in those organisations have to deal with. Those are three of the biggest issues where there may be more.'
***
Back to Around the Web
The post UK Mental Health Review Must Address Lack of Compassion’...
06:35
Whistleblower: Ukraine is Harvesting the Organs of Children in Laboratories New Films on Child Sex Trafficking Medical Kidnap
A poster from an awareness-raising campaign against human trafficking supported by OSCE Project Coordinator in Ukraine from 2013, showing that the human trafficking problem in Ukraine has existed for decades, and is not part of Russian Disinformation today. (Source.)
Comments by Brian Shilhavy
Editor, Health Impact News
A whistleblower from OSCE (Organization for Security and Co-operation in Europe) has recently gone public describing laboratories found in buildings in Ukraine bombed by Russians where children are being kept in basements where their organs are being harvested.
A whistleblower who worked with the Organization for Security and Co-operation in Europe (OSCE) revealed in a video interview that Ukrainian Nazi groups are harvesting the organs of children in basement adrenochrome labs that are being discovered after the buildings are destroyed by Russian strikes.
Vera Vayiman, who is a member of OSCE and worked in Ukraine as part of an international monitoring mission, made the horrifying revelations in a video interview that corroborates earlier reports from the Russian military and even from the Ukrainian military themselves, who have openly bragged that they harvest organs of children and body parts for cash.
According to Vera Vayiman, who shared her testimony about what she personally witnessed during her time in Ukraine, the children are shipped out of the country under a grain export code.
Warning: this is very disturbing information. (Source.)
&
06:35
Whistleblower: Ukraine is Harvesting the Organs of Children in Laboratories New Films on Child Sex Trafficking Vaccine Impact
A poster from an awareness-raising campaign against human trafficking supported by OSCE Project Coordinator in Ukraine from 2013, showing that the human trafficking problem in Ukraine has existed for decades, and is not part of Russian Disinformation today. (Source.)
Comments by Brian Shilhavy
Editor, Health Impact News
A whistleblower from OSCE (Organization for Security and Co-operation in Europe) has recently gone public describing laboratories found in buildings in Ukraine bombed by Russians where children are being kept in basements where their organs are being harvested.
A whistleblower who worked with the Organization for Security and Co-operation in Europe (OSCE) revealed in a video interview that Ukrainian Nazi groups are harvesting the organs of children in basement adrenochrome labs that are being discovered after the buildings are destroyed by Russian strikes.
Vera Vayiman, who is a member of OSCE and worked in Ukraine as part of an international monitoring mission, made the horrifying revelations in a video interview that corroborates earlier reports from the Russian military and even from the Ukrainian military themselves, who have openly bragged that they harvest organs of children and body parts for cash.
According to Vera Vayiman, who shared her testimony about what she personally witnessed during her time in Ukraine, the children are shipped out of the country under a grain export code.
Warning: this is very disturbing information. (Source.)
&
06:09
Whistleblower: Ukraine is Harvesting the Organs of Children in Laboratories New Films on Child Sex Trafficking Health Impact News
A poster from an awareness-raising campaign against human trafficking supported by OSCE Project Coordinator in Ukraine from 2013, showing that the human trafficking problem in Ukraine has existed for decades, and is not part of Russian Disinformation today. (Source.)
Comments by Brian Shilhavy
Editor, Health Impact News
A whistleblower from OSCE (Organization for Security and Co-operation in Europe) has recently gone public describing laboratories found in buildings in Ukraine bombed by Russians where children are being kept in basements where their organs are being harvested.
A whistleblower who worked with the Organization for Security and Co-operation in Europe (OSCE) revealed in a video interview that Ukrainian Nazi groups are harvesting the organs of children in basement adrenochrome labs that are being discovered after the buildings are destroyed by Russian strikes.
Vera Vayiman, who is a member of OSCE and worked in Ukraine as part of an international monitoring mission, made the horrifying revelations in a video interview that corroborates earlier reports from the Russian military and even from the Ukrainian military themselves, who have openly bragged that they harvest organs of children and body parts for cash.
According to Vera Vayiman, who shared her testimony about what she personally witnessed during her time in Ukraine, the children are shipped out of the country under a grain export code.
Warning: this is very disturbing information. (Source.)
06:08
Do vitamin D supplements prevent heart disease? Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
New research shows that high doses of vitamin D do not support improved heart health, although it may help a select subset of patients.
05:48
The isolation of anthocyanin monomers from blueberry pomace and their radical-scavenging mechanisms in DFT study. GreenMedInfo
PMID: Food Chem. 2023 Aug 30 ;418:135872. Epub 2023 Mar 6. PMID: 37001355 Abstract Title: The isolation of anthocyanin monomers from blueberry pomace and their radical-scavenging mechanisms in DFT study. Abstract: This study explored the isolation of anthocyanin monomers using a medium- and high-pressure separation technique as a means to increase the added value of a by-product of the blueberry juice industry. Six anthocyanin monomers were isolated with a purity of 95% and identified as mono-galactoside, glucoside, and isomers of delphinidin, malvidin, and even malvidin-3-O-arabinoside, malvidin-3-(6-acetyl)-O-glucoside by LC-MS andH NMR. Following the conformation search, the computer calculation manifested the active sites of six anthocyanins (C-OH) and their stabilities based on the structural and energy parameters. The DPPH tests demonstrated that delphinidin glycoside's free radical scavenging ability (89.93 2.03 % and 86.50 3.16 %) was significantly higher than that of malvidin (80.39 1.30 % and 81.02 0.45 %), and that malvidin's capacity was improved by conjugation arabinoside (87.48 2.39 %) and acetylated glucoside (88.39 1.37 %), which was compatible with the computer calculation.
05:41
Effect of maqui-berry extract in dry eye disease - A clinical and molecular analysis. GreenMedInfo
PMID: Indian J Ophthalmol. 2023 Apr ;71(4):1613-1618. PMID: 37026311 Abstract Title: Effect of maqui-berry extract in dry eye disease - A clinical and molecular analysis. Abstract: PURPOSE: This study aims to investigate the effects of maqui-berry extract (MBE) in improving signs and symptoms of dry eye disease (DED) along with ocular surface inflammation in patients with DED.METHODS: Twenty patients were randomly assigned to a MBE or a placebo group (PLC). DED parameters including Schirmer's test 1 (ST1), tear film break-up time (TBUT), ocular surface disease index (OSDI), and corneal staining were assessed before treatment and 2 months post-treatment. Tear fluid samples before and after treatment from a subset of these patients were collected from the study subjects using sterile Schirmer's strips, and the levels of interleukin (IL)-1, IL-10, IL-6, IL-17A, tumor necrosis factor-(TNF), matrix metalloproteinase-9 (MMP9), soluble intercellular adhesion molecule-1 (sICAM1), and vascular endothelial growth factor-A (VEGF-A) were measured using a microfluidic cartridge-based multiplex ELISA.RESULTS: The MBE group demonstrated a significant (p
05:28
CISA Was Behind the Attempt to Control Your Thoughts, Speech, and Life GreenMedInfo
The House Judiciary Committee released a report on how the Cybersecurity and Infrastructure Security Agency (CISA) "colluded with Big Tech and 'disinformation' partners to censor Americans
05:25
04:31
Joe Rogan Interview With Robert F. Kennedy Jr. GreenMedInfo
In this interview with Joe Rogan, Kennedy shares how he first got into vaccine safety and how he's now become the 2024 'anti-vaxxer' presidential candidate.
04:29
Joe Rogan Interview With Robert F. Kennedy Jr. GreenMedInfo
Originally published on www.mercola.com
In this interview with Joe Rogan, Kennedy shares how he first got into vaccine safety and how he's now become the 2024 'anti-vaxxer' presidential candidate.
STORY AT-A-GLANCE
03:00
Former UPenn prof faked more than 50 figures, says government watchdog Retraction Watch
A pharmacy researcher who left the University of Pennsylvania sometime last year has been found guilty of research misconduct in multiple federal grant applications and five published papers, four of which have already been retracted.
As we have reported, William Armstead, who is retired from Penn, was working among other things on the effects of brain injury on piglets experiments in which the animals were slaughtered. He has had seven papers retracted, and The Philadelphia Inquirer reported in September that he had left the university. Penn did not respond to several requests for comment when we attempted to reach officials there about Armsteads work.
According to the U.S. Office of Research Integrity, much of that work appears to have been suspect:
ORI found that Respondent engaged in research misconduct by knowingly and intentionally falsifying and/or fabricating fifty-one (51) figures and the methods, data, results, and conclusions reporting on the effects of various vasoactive agents on the neurologic response to traumatic brain injury in piglets of different ages and genders in the following five (5) published papers, one (1) unpublished manuscript, one (1) review article, three (3) posters, three (3) grant applications submitted for PHS funds, and four (4) NIH grant progress reports
Armstead, who has been part of NIH grants totaling $7.7 million during his career according to NIH records, has agreed to a seven-year ban on U.S. federal funding, as well as from serving as an advisor or consultant to the Public Health Service, which includes NIH peer review committees.
The notice states he also agreed to retraction of a fifth paper, Translational approach towards determining the role of cerebral autoregulation in outcome after traumatic brain injury, which appeared...
03:00
Critical Psychiatry Textbook, Chapter 8: Depression and Mania (Affective Disorders) (Part Ten) Mad In America
Editors Note: Over the next several months, Mad in Gtzsches book, Critical Psychiatry Textbook. In this blog, he discusses the diagnosis of bipolar disorder, including in children, and the lack of evidence for any benefit from lithium. Each Monday, a new section of the book is published, and all chapters are archived here.
Bipolar disorder
The hospital-based psychiatry center in one of the five regions in Denmark mentions on its homepage that Drugs for bipolar disordermood stabilising drugscan prevent and cure depression, mania and mixed conditions in most people.416
This is very misleading. Psychiatric drugs only have symptomatic effects. They are not disease-modifying and they cannot cure people; they can only lessen some of the symptoms of the emotional pain. Similarly, aspirin cannot cure a broken leg, only lessen the physical pain. Psychiatric drugs cannot prevent psychiatric disorders either.
About bipolar in children, a textbook said that the
risk is increased if the children have had hypomanic or manic
symptoms after treatment with a depression pill, and that there is
a family relation between ADHD and bipolar.19:216 It is
not clear what the authors meant by this, e.g. if it is a genetic
or environmental issue they describe. They did not mention that the
harms of ADHD drugs are much the same as the diagnostic criteria
for bipolar, and that many children will therefore get a false
diagnosis of bipolar that will harm them, as it will be treated
with lithium, psychosis pills, and antiepileptics.
These are serious omissions. In US, Joseph Biederman in particular has pushed the diagnosis of bipolar in children, which was virtual...
02:53
6 Common Causes of Hearing Loss in Adults Waking Science
No matter how our days look like, hearing what goes on around us is as natural as walking. In fact, all of your five senses are pivotal to the healthy functioning of your daily life. From the bustling noises of the city around you, to the serene sounds of a forest, hearing is critical. Sometimes, we may lose this ability to hear as we grow older.
While it may seem discomforting to know that your sense of hearing is decreasing, try to pinpoint the cause. Generally speaking, most adult causes of hearing loss have some sort of foundation that could be acted upon. Some sources may be hereditary, while others could be externally-located.
Here are the six common causes of hearing loss in adults:
Cause #1: Otosclerosis
Otosclerosis is one of the most common causes of
hearing loss in adults. As we age, our bodies begin to lose their
optimal functioning. It is a natural means of growing older, and
should be expected at some point in our lives. One of the most
unfortunate side effects of this ageing is that, sometimes, disease
may be associated with it. When it comes to hearing loss,
otosclerosis is one of the biggest factors to be aware of.
Our ears are made of tiny bones in and around the lobe, as well as deep inside the body part too. The middle part of the ear, which is comprised of the eardrum, may be susceptible to this diseases. Once it is acquired, the tiny bones located here are harder to move, resulting in some form of hearing loss.
Cause #2: Menieres Disease
As mentioned previously, our ears are comprised of
different sets of tiny bones. While the middle part of the ear may
be vulnerable to otosclerosis, the inner area can also be targeted.
Usually, this part may be susceptible to what is known as Menieres
disease. Located in the inner ear, you may begin to hear a
consistent ringing in the ear if you are in your thirties.
Menieres disease can lead you to also being sensitive to loud noises in general. For those who suffer from the worst parts of the disease, you may experience dizziness at some poi...
01:44
How to Safely Mark a Queen Bee The Healthy Home Economist
How to safely mark a queen bee so that you know how old she is and to more easily identify her during periodic hive wellness checks. My beehive adventure continues following the requeening of my beehive and the untimely retirement of her predecessor, Aurora. It was time to mark the new queen, which I aptly
The post How to Safely Mark a Queen Bee appeared first on The Healthy Home Economist.
01:37
5 Essential Nutrients for Strong Bones Healthy Holistic Living
Everyone is cognizant of the importance of maintaining bone health. Yet, most people still associate this with consuming dairy products such as milk or cheese. While calcium is crucial, it is only one of the myriad nutrients needed for bone health. In fact, plant-based foods are comprehensive powerhouses, providing all the vitamins and minerals required for healthy bones.
Contrary to the widespread belief propagated by the dairy
industry that milk is indispensable for bone health, its not
entirely accurate. Ultra-pasteurized foods may even have adverse
effects, and its estimated that up to 65% of the global population
have some form of lactose intolerance 1. Moreover, depending on calcium
supplements isnt always the best option. A noteworthy study found
that calcium in supplement form augments the risk of heart disease,
whereas dietary calcium lowered this risk 2.
Given these findings, its imperative to source your calcium and other nutrients from plant-based foods. Lets delve into the key vitamins and minerals necessary for bone health, the plant-based sources to obtain them from, and the health benefits they provide.
Vital Vitamins and Minerals for Bone Health
1. Calcium
Calcium, in conjunction with collagen, forms about 99% of your bone tissue 3. Its thus essential to include calcium-rich foods in your diet.
Broccoli is a plant-based food thats abundant in calcium, with one cup con...