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Friday, 14 July
02:54
The Four Things to Consider About Ancestry DNA testing Waking Science
We have all heard about the ancestry DNA test before. There are commercials that play telling us that it is possible to find out about our heritage, where we come from, and what we are made of.
The cool thing about a DNA test is that there are more reasons to take one than you may have realized. There are 4 things in particular you should consider when checking out one of these DNA tests regarding ancestry.
1. The Test Process
Depending on which kit you go with, one may be easier
to use than the others. Some require additional steps or even
additional costs which means that you are paying not only for the
testing device but even more to use it the right way.
There are some kits that come with both the kit and lab processing fee already included in the price. All you have to do is follow the directions and return the pre-paid mailer before you can receive your results about your ancestry.
2. What Kind of Test?
Another major thing to consider is that there are
different types of test. The three main ones are the Y-DNA test,
the autosomal DNA test, and the mitochondrial ancestry DNA test. It is
important to know which kind of test that you are going to be
taking.
The autosomal DNA test is the most rich in information, being able to trace both family lines instead of just one like the others are capable of. With a deeper result comes a higher cost but it can be worth it find out where you come from on both sides of the family tree.
3. What Comes in the Test?
Not all test kits are created equally, so it helps to
know what kind of kit you are getting. As mentioned previously,
the...
01:28
Strong Bones Need Strontium Dr. Tenpenny
Weve all heard about the benefits of calcium for bone health and bone density, but have you heard of strontium? Strontium is a naturally-occurring alkaline earth metal that is []
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Thursday, 13 July
20:00
University cuts anesthesiology researchers funding amid four retractions Retraction Watch
An anesthesiologist who had his funding revoked for fabricating data has earned a fourth retraction for publishing the same data in two Springer Nature journals.
Wen-fei Tan, an anesthesiologist at The First Hospital of China Medical University in Shenyang, is the first author of the recently retracted paper Changes in the first postoperative night bispectral index of patients after thyroidectomy with different types of primary anesthetic management: a randomized controlled trial, published in the Journal of Clinical Monitoring and Computing (JCMC), a Springer Nature journal, in 2017. It has been cited four times, according to Clarivates Web of Science.
The retraction notice states:
Concerns have been raised that part of the trace Fig. 2A is identical with part of the trace for Group Post in Fig. 2b of a different article by some of the same authors [1] which has now been retracted [2]. The Editor-in-Chief no longer has confidence in the data presented. Wen-fei Tan disagrees with this retraction. Zhi-lin Wang, Hong Ma, Feng Jin and Huang-wei Lu have not responded to correspondence from the Publisher about this retraction.
The other article mentioned in the notice, Preoperative versus postoperative...
17:00
Part 1/10 The Grand Debunk of the antivaxxer book Turtles All the Way Down Science-Based Medicine
This book written by "Anonymous", edited by Children's Health Defense lawyer Mary Holland and Children's Health Defense Publisher Liaison and Thinking Moms Revolution co-founder Zoey OToole, and published by "The Turtles Team" purports to use only mainstream references to prove its points. But the book employs all the standard tropes in a master class of science denial and antivax tactics and techniques.
The post Part 1/10 The Grand Debunk of the antivaxxer book Turtles All the Way Down first appeared on Science-Based Medicine.12:02
Flavonoids from seabuckthorn mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons. GreenMedInfo
PMID: Phytomedicine. 2023 Jul ;115:154832. Epub 2023 Apr 18. PMID: 37121059 Abstract Title: Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons: Signaling via PI3K/Akt and ERK pathways. Abstract: BACKGROUND: Various brain disorders, including neurodegenerative diseases and major depressive disorders, threaten an increasing number of patients. Seabuckthorn, a fruit from Hippophae rhamnoides L., is an example of "medicine food homology". The fruit has enriched flavonoids that reported to have benefits in treating cognitive disorders. However, the studies on potential functions of Seabuckthorn and/or its flavonoid-enriched fraction in treating neurodegenerative disorders are limited.PURPOSE: This study aimed to determine the ability and mechanism of the flavonoid-enriched fraction of Seabuckthorn (named as SBF) in mimicking the neurotrophic functions in inducing neurite outgrowth of cultured neurons.METHODS: Cultured PC12 cell line, SH-SY5Y cell line and primary neurons (cortical and hippocampal neurons isolated from E17-19 SD rat embryos) were the employed models to evaluate SBF in inducing neurite outgrowth by comparing to the effects of NGF and BDNF. Immuno-fluorescence staining was applied to identify the morphological change during the neuronal differentiation. Luciferase assay was utilized for analyzing the transcriptional regulation of neurofilaments and cAMP/CREB-mediated gene. Western blot assay was conducted to demonstrate the expressions of neurofilaments and phosphorylated proteins.RESULTS: The application of SBF induced neuronal cell differentiation, and this differentiating activation was blocked by the inhibitors of PI3K/Akt and ERK pathways. Additionally, SBF showed synergy with neurotrophic factors in stimulating the neurite outgrowth of cultured neurons. Moreover, the major flavonoids within SBF, i.e., isorhamnetin, quercetin and kaempferol, could account for the neurotrophic activities of SBF.CONCLUSION: Seabuckthorn flavonoids mimicked neurotrophic functions in inducing neuronal cell differentiation via activating PI3K/Akt and ERK pathways. The results suggest the beneficial functions of Seabuckthorn as a potential health food supplement in treating various brain disorders, e.g., neurodegenerative diseases.
12:00
Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study. GreenMedInfo
PMID: Front Nutr. 2023 ;10:1136590. Epub 2023 Feb 9. PMID: 36845055 Abstract Title: Prediction of active marker of seabuckthorn polysaccharides for prevention and treatment of cervical cancer and mechanism study. Abstract: OBJECTIVE: To predict the target of Seabuckthorn polysaccharides in the prevention and treatment of cervical cancer, and to explore its multi-target and multi-pathway mechanism.METHODS: Using the Swisstarget database, a total of 61 potential targets of polysaccharide active components were obtained. Cervical cancer related targets were obtained from the GeneCards database. The correlation score was greater than 5 targets for 2727; 15 intersection targets of active ingredients and disease were obtained by Venn diagram. Cytoscape3.6.0 software was used to construct the Polysaccharide composition-Target-Disease Network and Protein-Protein Interaction Networks (PPI). Cytoscape3.6.0 software was used for visualization and network topology analysis to obtain core targets. Kyoto encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) were analyzed using Metascape database. SailVina and PyMOL software were used for molecular docking to verify binding strength.RESULTS: A total of 15 core targets were obtained for cervical cancer. These targets are significantly enriched in HIF-1 signaling pathway, Galactose metabolism, EGFR tyrosine kinase inhibitor resistance, growth factor receptor binding, carbohydrate binding, protein homodimerization activity and other GO and KEGG entries; Molecular docking showed that ADA and GLB1 were well bound to Glucose, D-Mannose, and Galactose.CONCLUSION: The effect of seabuckthorn polysaccharides on the prevention and treatment of cervical cancer is characterized by multi-component, multi-target and multi-pathway, which provides scientific basis for further research on the activity of seabuckthorn polysaccharides.
11:50
Total phenolic and total flavonoid content, individual phenolic compounds and antioxidant activity in sweet rowanberry cultivars. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Apr 12 ;12(4). Epub 2023 Apr 12. PMID: 37107288 Abstract Title: Total Phenolic and Total Flavonoid Content, Individual Phenolic Compounds and Antioxidant Activity in Sweet Rowanberry Cultivars. Abstract: Sweet rowanberry and its cultivars represent a less-known fruit species with significant antioxidant activity, mostly promoted by polyphenolic compounds. This paper examined sevencultivars and evaluated their total polyphenolic and flavonoid content, as well as the content of individual polyphenolic compounds from the group of phenolic acids and flavonoids. It also determined their antioxidant activity using DPPH, ACW and ACL. Furthermore, to reflect the distribution of the contribution to antioxidant activity, correlations between antioxidant activity and the contents of ascorbic acid, vitamin E and individual phenolic compounds were established. The highest total phenolic content of 8307.4 mg kgwas determined in 'Granatina', with the main contribution of phenolic acid content of 7001.7 mg kgand a significantly lower total flavonoid content of 1304.6 mg kg. Flavanols represented the most abundant group of flavonoids, with catechin being the second most frequent flavanol with the highest content of 633.67 mg kgin 'Granatina'. Flavonols were represented by rutin and quercetin. 'Businka' displayed a significant vitamin E content of 4.77 mg kg, and 'Alaja Krupnaja' had the highest vitamin C level of 7.89 g kg. These results emphasize their potential health and nutritional benefits and, thus, their promising and valuable role in the food processing industry.
10:27
Autism Is Rapacious and Will Bankrupt Education, Social Security and Families Age of Autism The Rebel Alliance!
Cheery, yes? And true.
By Anne Dachel
Im starting to see stories in the news that are a preview of how
everything will eventually collapse. This is inevitable. We
cant have this level of disability among our kids everywhere and
not have the cost eventually bankrupt us.
Loss of Brain Trust is about whats happening in our schools. You cant have tens of thousands of kids on waitlists for ASD diagnoses, you cant be building whole schools for autistic students, you cant have counties in England going into huge deficit spending because of the cost of special education, and you cant have autism rates at 5 percent of students (like in CA, NI, and Ireland) and not have it permanently change society.
I have long said that it wont be until the COST OF AUTISM buries us that well finally honestly address the CAUSE OF AUTISM.
Imagine what will happen in the next few years as more and more and more disabled kids leave school with no place to go. Imagine what will happen as aging parents can no longer care for these adult children.
In 2014 the U.K. officially extended special education to age 25. Im guessing that was done because there is simply nothing for all these disabled young adults after leaving school. It was Britains attempt to kick can down the road.
While Im mostly focused on EDUCATION on Loss of Brain Trust, I cant help but notice the stories about ADULT SERVICES and that growing crisis. THIS IS WHAT WILL COLLAPSE THE HOUSE OF LIES ABOUT AUTISM.
Weve bought into the REALLY BIG LIE ABOUT AUTISMthat there has always been autism everywhere like we see in our children, we just didnt notice, or we just called it something else.
Its the perpetual official explanation every time the rate leaps upward.
Of course if that were true, we would have experience dealing with autism. Weve had IDEA for almost 50 years now, so we would have had these kids in school, even if we didnt call their disability AUTISM.
QUESTION: If autism has always been here, why do we have to train health care staff, EMTs, police, fire fighters, and teachers etc. to deal with autism?
That...
10:00
Pig Beans The Latest GMO Frankenfood Articles
As expected, more and ever-wilder transgenic foods are being produced. Among the latest is Piggy Sooy, a soybean genetically engineered to contain pig protein.1,2 According to Moolec, the U.K.-based company that developed this latest Frankenfood, pig genes were spliced into conventional soya to create a soybean with 26.6% animal protein.
The exact pig genes used is a trade secret. As a result of this genetic engineering, the interior flesh of the soybean is also a rosy flesh color. The company is also working on developing a pea plant that produces beef protein. Moolec claims these transgenic hybrids will provide similar taste, texture and nutritional value as meat, without the high cost of cultured or lab-grown meat alternatives. According to New Atlas:3
Farmers will raise the plants via conventional agricultural practices. Once the beans have been harvested and processed again, via conventional techniques their proteins will go into meat substitutes and other products ...
As is the case with lab-grown pork, it is hoped that commercial adoption of Piggy Sooy could ultimately eliminate the raising and slaughtering of pigs, along with the associated ethical and environmental concerns.
Moolec has developed a unique, successful, and patentable platform for the expression of highly valuable proteins in the seeds of economically important crops such as soybeans, says the company's chief science officer, Amit Dhingra.
This achievement opens up a precedent for the entire scientific community that is looking to achieve high levels of protein expression in seeds via molecular farming. There's currently no word on when foods containing the proteins may be available to consumers.
US Authorizes Cultured Chicken
Lab-grown chicken is also heading toward our plates. June 21, 2023, the U.S. Department of Agriculture (USDA) authorized the sale of cell-cultivated chicken meaning chicken meat grown from stem cells in a bioreactor from Good Meat and Upside Foods.4,5
Both plan on rolling out their synthetic chicken to high-end r...
Robots for Elders: A Trojan Horse? Articles
This story is about a new market grab and a new brand of hype. Let us take a good look at the shiny marketing brochure for "eldercare technology." It seems like the important investors, perched high, are very excited about the opportunity to squeeze more profits out of the demographic and health crises that they have previously created with their own hands and to "monetize" the elders like captured pets, while pretending that they are doing it for the elders own good.
Ehm, who are our house experts on monetizing manufactured woes? The WEF folks! In 2021, they inquired: "Ageing: Looming crisis or booming opportunity?" Seemingly, the decline in health and fertility rates is a looming crisis for us, lowly peasants but it sure is a booming opportunity for their crew!
The proverbial owners of everything are saying that "by 2050, the number of adults over the age of 65 globally will double, reaching a staggering 1.6 billion, with the largest growth in the developing world. This growth will be one of the greatest social, economic, and political transformations of our time, that will impact existing healthcare, government and social systems." (Yay, new normal, hooray!) They continue:
"We can begin to make investments in our support systems (enabled and scaled by technology) that encompass a coordinated response from governments, society, academia, and the private sector.
To truly bring the holistic services needed to market, device makers, developers, enterprises such as retirement homes and insurance companies, civil society, policy-makers, and academia should come together to develop a unified platform that includes Internet of Things and Artificial Intelligence [emphasis mine]."
Sure, when one has a hammer, everything is a nail! Meanwhile, the WEF story lists the following areas of eldercare technology:
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Robots |
Telemedicine |
|
Tablets for communication and entertainment |
"Smart" platforms that integrate electronic medical records (EMRs) and electronic health records with AI and analytics (yay!!) |
|
Wearables |
Voice, touch, motion, and other assistive technologies |
|
Connected IoT devices and sensors |
Technologies for safety (monitoring... |
Peril on Your Plate: Effects of GE and Chemical Agriculture Articles
Editor's Note: This article is a reprint. It was originally published June 23, 2018.
After being told by her doctor that genetically engineered (GE) food and pesticides could be responsible for her son's food allergies, Ekaterina Yakovleva set out to investigate. Her quest for answers was captured by the Russian Times in the featured film, "The Peril on Your Plate: Genetic Engineering and Chemical Agriculture."
The film shows Yakovleva and her team traveling the world to meet "the people who lift the lid on the perils of GMOs and the chemicals used in the industry," as well as proponents of GMOs who argue that genetic engineering is a "high-tech" solution to feeding the world's growing population.
Advocates for genetic engineering tell Yakovleva that the technology is beneficial to farmers in that it increases resistance to pests and disease, as well as produces higher yields. But Yakovleva isn't convinced.
She learns nothing could be further from the truth after witnessing the devastation caused by mass farmer suicides in India as a result of the failure of Monsanto's Bt cotton. Yakovleva visits the U.K. where she meets Lady Margaret, Countess of Mar, a member of the House of Lords and a former farmer who suffered from chemical use, and then to the U.S. where she meets with Zen Honeycutt of Moms Across America about the link between GMOs, pesticides and chronic disease in humans.
What Is Genetic Engineering?
In order to better understand genetic engineering and its impact on human health, Yakovleva starts to research the technique and how it's used. She learns that genetic engineering enables DNA to be transferred not only between different kinds of plants, but even between different kingdoms, meaning scientists can take DNA from an insect or animal and insert it into the genome of a plant.
Many GMO proponents claim that genetic engineering is just an extension of natural breeding methods, and just as safe. Nothing could be further from the truth on both counts. Genetic engineering is radically different from conventional breeding techniques used to improve a crop. For starters, it's a laboratory-based technique allowing scientists to create a food that could never be created by nature.
Claire Robinson, editor of GM Watch and co-author of the book, "GMO Myths and Truths: A Citizen's Guide to the Evidence on the Safety and Efficacy of Genetically Modified Foods and Crops," says:
"Genetic engineering enables DNA to be transferred not only between different kinds of plants, but even between different kingdoms. You can take DNA from an insect, an animal, a virus or a bacterium, and insert it into the genome of a food crop plant. This is actually a very imprecise p...
09:34
Therapeutic treatment with pycnogenol attenuates ischemic brain injury. GreenMedInfo
PMID: J Integr Neurosci. 2023 Feb 10 ;22(2):26. PMID: 36992594 Abstract Title: Therapeutic Treatment with PycnogenolAttenuates Ischemic Brain Injury in Gerbils Focusing on Cognitive Impairment, Neuronal Death, BBB Leakage and Neuroinflammation in the Hippocampus. Abstract: BACKGROUND: A gerbil model of ischemia and reperfusion (IR) injury in the forebrain has been developed for studies on mechanisms, prevention and therapeutic strategies of IR injury in the forebrain. Pycnogenol(PYC), a standardized extract of French maritime pine tree (Aiton) has been exploited as an additive for dietary supplement. In the present study, we investigated the neuroprotective effects of post-treatment with PYC and its therapeutic mechanisms in gerbils.METHODS: The gerbils were given sham and IR operation and intraperitoneally injected with vehicle and Pycnogenol(25, 50 and 100 mg/kg, respectively) immediately, at 24 hours and 48 hours after sham and IR operation. Through 8-arm radial maze test and passive avoidance test, each spatial memory and short-term memory function was assessed. To examine the neuroprotection of Pycnogenol, we conducted cresyl violet staining, immunohistochemistry for neuronal nuclei, and Fluoro-Jade B histofluorescence. Moreover, we carried out immunohistochemistry for immunoglobulin G (IgG) to investigate blood-brain barrier (BBB) leakage and interleukin-1(IL-1) to examine change in pro-inflammatory cytokine.RESULTS: We found that IR-induced memory deficits were significantly ameliorated when 100 mg/kg Pycnogenolwas treated. In addition, treatment with 100 mg/kg Pycnogenol, not 25 mg/kg nor 50 mg/kg, conferred neuroprotective effect against IR injury. For its mechanisms, we found that 100 mg/kg Pycnogenolsignificantly reduced BBB leakage and inhibited the expression of IL-1.CONCLUSIONS: Therapeutic treatment (post-treatment) with Pycnogenolafter IR effectively attenuated ischemic brain injury in gerbils. Based on these results, we suggest that PYC can be employed as an important material for ischemic drugs.
09:31
The neuroprotective effects of the combined extract of mulberry fruit and mulberry leaf against hydrogen peroxide-induced cytotoxicity. GreenMedInfo
PMID: BMC Complement Med Ther. 2023 Apr 13 ;23(1):117. Epub 2023 Apr 13. PMID: 37055744 Abstract Title: The neuroprotective effects of the combined extract of mulberry fruit and mulberry leaf against hydrogen peroxide-induced cytotoxicity in SH-SY5Y Cells. Abstract: The prevalence of dementia is increasing, and most of the causes are related to neuronal cell death. Unfortunately, no effective strategy is available for protecting against this condition. Based on the use of the synergistic concept together with the positive modulation effect of both mulberry fruit and mulberry leaf on dementia, we hypothesized that the combined extract of mulberry fruit and mulberry leaf (MFML) should mitigate neuronal cell death. Neuronal cell damage was induced in SH-SY5Y cells by exposure to hydrogen peroxide at a dose of 200 M. SH-SY5Y cells were given MFML at doses of 62.5 and 125 g/mL before induced cytotoxicity. Then, the cell viability was determined via MTT assay, and the possible underlying mechanisms were investigated via the alterations of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), nuclear factor-B (NF-B), and tumor necrosis factor-alpha (TNF-), together with apoptotic factors including (B-cell lymphoma 2) BCL2, Casapase-3 and Caspase-9. The results showed that MFML significantly enhanced cell viability. It also significantly decreased MDA level, NF-B, TNF-, Casapase-3, Caspase-9, but increased SOD, GSH-Px and BCL2. These data demonstrated the neuroprotective effect of MFML. The possible underlying mechanisms might occur partly via the improvement of the inappropriate apoptotic mechanisms via BCL2, Casapase-3 and Caspase-9 together with the decrease in neurodegeneration induced by the reduction of inflammation and oxidative stress. In conclusion, MFML is a potential neuroprotectant candidate against neuronal cell injury. However, toxicity, animal studies, and clinical trials are essential to confirm these benefits.
09:05
Mulberry extract ameliorates T2DM-related symptoms. GreenMedInfo
PMID: J Ethnopharmacol. 2023 Sep 15 ;313:116475. Epub 2023 Apr 27. PMID: 37120060 Abstract Title: Mulberry extract ameliorates T2DM-related symptoms via AMPK pathway in STZ-HFD-induced C57BL/6J mice. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Mulberry (Morus alba L.) is not only a tasty food but also a beneficial medicinal substance that has been historically used to treat diabetes, as recorded in Tang Ben Cao. Recent research on animal models has shown that the ethyl acetate extract of Morus alba L. fruits (EMF) has hypoglycemic and hypolipidemic properties. However, there is a lack of documentation on the specific mechanisms through which EMF exerts its hypoglycemic effects.OBJECTIVE OF THE STUDY: This study aimed to investigate the impact of EMF on L6 cells and C57/BL6J mice and to elucidate the potential mechanisms underlying its effects. The findings of this study can contribute to the existing evidence for the application of EMF as a therapeutic drug or dietary supplement in the management of type 2 diabetes mellitus (T2DM).MATERIALS AND METHODS: The UPLC-Q-TOF-MS technique was utilized to gather MS data. Masslynx 4.1 software in conjunction with the SciFinder database and other relevant references were used to analyze and identify the chemical composition of EMF. A series of in vitro investigations including MTT assay, glucose uptake assay and Western blot analysis were performed using an L6 cell model stably expressing IRAP-mOrange after EMF treatment. In vivo investigations were performed on a STZ-HFD co-induced T2DM mouse model, which included assessments of body composition, biochemical tests, histopathological analysis, and Western blot analysis.RESULTS: MTT results revealed that EMF had no toxic effects on the cells at various concentrations. When EMF was administered to L6 cells, there was an increase in glucose transporter type 4 (GLUT4) translocation activity and a significant dose-dependent enhancement of glucose uptake by L6 myotubes. EMF treatment led to a marked increase in P-AMPK levels and GLUT4 expression in the cells, but these effects were reversed by an AMPK inhibitor (Compound C). In diabetic mice with STZ-HFD-induced diabetes, EMF treatment improved oral glucose tolerance, hyperglycemia, and hyperinsulinemia. Furthermore, EMF supplementation significantly reduced insulin resistance (IR) in diabetic mice, as evaluated using a steady-state model of the insulin resistance index. Histopathological sections demonstrated that acute EMF treatment reduced hepatic steatosis, pancreatic damage, and adipocyte hypertrophy. Western blot analysis demonstrated that EMF treatment also reduced abnormally high PPARexpression, elevated the level of p-AMPK and p-ACC, and augmented the abundance of GLUT4 in insulin-sensitive peripheral tissues.SUMMARY: The results suggest tha...
08:58
Artificial intelligence and mental health: The latest Chipur
Would you bare your soul to a robot or bond with a chatbot? How bout trusting a machine learning diagnosis? Artificial intelligence and mental health: fantastic things are happening. Heres the latest
The post Artificial intelligence and mental health: The latest first appeared on Chipur.
08:54
The prebiotic effects of an extract with antioxidant properties from Morus alba contribute to ameliorate high-fat diet-induced obesity. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Apr 21 ;12(4). Epub 2023 Apr 21. PMID: 37107352 Abstract Title: The Prebiotic Effects of an Extract with Antioxidant Properties fromL. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice. Abstract: Obesity is a global health issue, in which modifications in gut microbiota composition have a key role. Different therapeutic strategies are being developed in combination with diet and exercise, including the use of plant extracts, such as those obtained fromL. leaves. Recent studies have revealed their anti-inflammatory and antioxidant properties. The aim of the present work was to evaluate whether the beneficial effects ofL. leaf extract in high-fat diet-induced obesity in mice is correlated with its impact on gut microbiota. The extract reduced body weight gain and attenuated lipid accumulation, as well as increased glucose sensitivity. These effects were associated with an amelioration of the obesity-associated inflammatory status, most probably due to the described antioxidant properties of the extract. Moreover,L. leaf extract mitigated gut dysbiosis, which was evidenced by the restoration of the/ratio and the decrease in plasma lipopolysaccharide (LPS) levels. Specifically, the extract administration reducedand increasedabundance, these effects being correlated with the beneficial effects exerted by the extract on the obesity-associated inflammation. In conclusion, anti-obesogenic effects ofL. leaf extract may be mediated through the amelioration of gut dysbiosis.
08:22
Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma. GreenMedInfo
PMID: Phytomedicine. 2023 Jun ;114:154765. Epub 2023 Mar 16. PMID: 37004403 Abstract Title: Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway. Abstract: BACKGROUD: Flavonoids have a variety of biological activities, such as anti-inflammation, anti-tumor, anti-thrombosis and so on. Morusinol, as a novel isoprene flavonoid extracted from Morus alba root barks, has the effects of anti-arterial thrombosis and anti-inflammatory in previous studies. However, the anti-cancer mechanism of morusinol remains unclear.PURPOSE: In present study, we mainly studied the anti-tumor effect of morusinol and its mode of action in melanoma.METHODS: The anti-cancer effect of morusinol on melanoma were evaluated by using the MTT, EdU, plate clone formation and soft agar assay. Flow cytometry was used for detecting cell cycle and apoptosis. The-H2AX immunofluorescence and the alkaline comet assay were used to detect DNA damage and the Western blotting analysis was used to investigate the expressions of DNA-damage related proteins. Ubiquitination and turnover of CHK1 were also detected by using the immunoprecipitation assay. The cell line-derived xenograft (CDX) mouse models were used in vivo to evaluate the effect of morusinol on tumorigenicity.RESULTS: We demonstrated that morusinol not only had the ability to inhibit cell proliferation, but also induced cell cycle arrest at G0/G1 phase, caspase-dependent apoptosis and DNA damage in human melanoma cells. In addition, morusinol effectively inhibited the growth of melanoma xenografts in vivo. More strikingly, CHK1, which played an important role in maintaining the integrity of cell cycle, genomic stability and cell viability, was down-regulated in a dose- and time-dependent manner after morusinol treatment. Further research showed that CHK1 was degraded by the ubiquitin-proteasome pathway. Whereafter, morusinol-induced cell cycle arrest, apoptosis and DNA damage were partially salvaged by overexpressing CHK1 in melanoma cell lines. Herein, further experiments demonstrated that morusinol increased the sensitivity of dacarbazine (DTIC) to chemotherapy for melanoma in vitro and in vivo.CONCLUSION: Morusinol induces CHK1 degradation through the ubiquitin-proteasome pathway, thereby inducing cell cycle arrest, apoptosis and DNA damage response in melanoma. Our study firstly provided a theoretical basis for morusinol to be a candidate drug for clinical treatment of cancer, such as melanoma, alone or combinated with dacarbazine.
08:07
Morus alba fruit diet ameliorates cognitive deficit in mouse model of streptozotocin-induced memory impairment. GreenMedInfo
PMID: Metab Brain Dis. 2023 Jun ;38(5):1657-1669. Epub 2023 Mar 22. PMID: 36947332 Abstract Title: Morus alba fruit diet ameliorates cognitive deficit in mouse model of streptozotocin-induced memory impairment. Abstract: Mounting evidence shows that dietary intake of fruits with polyphenols is beneficial to improve impaired memory functions. This study explored the preventive as well as therapeutic effects of diet enriched with Morus alba fruits extract (DEMA) in streptozotocin (STZ) induced mouse model of memory impairment. The study consisted of two facets: one aspect consisted of pretreatment of animals with DEMA for two weeks followed by STZ (i.c.v) intervention and the second phase involved induction of dementia with STZ (i.c.v) followed by treatment with DEMA for 14 days. Cognitive functions of animals were measured by Morris Water Maze test and to delineate the associated mechanism of action, brain biochemical estimations (acetyl-cholinesterase activity, myeloperoxidase activity, thiobarbituric acid reactive species, superoxide dismutase activity, reduced glutathione and nitrite/nitrate) and histopathological studies (haematoxylin and eosin staining) were performed. Pre- and post- treatment with DEMA significantly prevented and attenuated, respectively, the detrimental effects of STZ on mice brain. The results demonstrated that dietary modification, by incorporation of M. alba fruits, reduces the incidence and aids in treatment of memory disorder in mice by reducing central cholinergic activity, decreasing oxidative stress and preventing neurodegeneration.
08:05
Evaluation of the anticancer potential of Morus nigra and Ocimum basilicum mixture against different cancer cell lines. GreenMedInfo
PMID: Biomed Res Int. 2023 ;2023:9337763. Epub 2023 Apr 19. PMID: 37124934 Abstract Title: Evaluation of the Anticancer Potential ofandMixture against Different Cancer Cell Lines: An In Vitro Evaluation. Abstract: (M) and(O) mixture (MO2) extract was extracted using hexane (MO2H), chloroform (MO2C), ethyl acetate (MO2E), and methanol (MO2M) in a Soxhlet apparatus. The cytotoxicity was evaluated using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The ICvalues of the MO2C-treated cancer cells were 11.31g/mL (MDA-MB-231), 15.45g/mL (MCF-7), 18.9g/mL (HepG2), 26.33g/mL (Huh-7), 30.17g/mL (LoVo), and 36.76g/mL (HCT116). MO2C-treated cells showed cellular and nuclear morphological alterations like chromatin condensation and formation of apoptotic bodies as observed using light and fluorescent microscopy. The antioxidant and anti-inflammatory properties were investigated in vitro using 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and egg albumin denaturation assays. It was evident that the MO2M extract exhibited the highest antioxidant activity (18.13%), followed by the MO2E extract (12.25%), MO2C extract (9.380%), and MO2H extract (6.31%). The highest inhibition percentage of albumin denaturation was observed in MO2H (28.54%), followed by MO2M (4.32%) at 0.2 and 0.1mg/mL concentrations, respectively. The compounds identified using gas chromatography-mass spectrometry (GC-MS) analysis for MO2C extract were-trans-bergamotene, germacrene D, selin-4,7(11)-diene, 2 tridecen-1-ol, and 2-decen-1-ol. The present study reveals that MO2C has promising anticancer activity and may serve as a potent polyherbal extract in cancer treatment.
08:02
Phytochemical characterization, antioxidant activity and antihypertensive evaluation of Ocimum basilicum. GreenMedInfo
PMID: Heliyon. 2023 Apr ;9(4):e14644. Epub 2023 Mar 23. PMID: 37064472 Abstract Title: Phytochemical characterization, antioxidant activity and antihypertensive evaluation ofL. in l-NAME induced hypertensive rats and its correlation analysis. Abstract: (basil) is an aromatic culinary herb that has shown a great potential in therapeutic world. It has many promising pharmacological activities that make it centre for investigations for many researchers. Current study has been planned to determine chemical constituents of basil leaves extracts and theirandantioxidant andantihypertensive potential. GC-MS studies of non-polar extracts showed presence of 75 compounds including monoterpenes, hydrocarbons, sesquiterpenes, triterpenes, phyto-sterols and phthalates. Higher percentages of fatty acids were also identified. The major compounds include linalool (7.65%), terpineol (1.42%),-cadinol (13.55%), methyl palmitate (14.24%), palmitic acid (14.31%), linolenic acid (1.30%) and methyl linolenate (17.72%). Electron spray ionization mass spectrometry ESI-HRMS/MS of the polar extracts revealed the presence of alkaloids, phenolic acid, amino acid, coumarin, lignin, flavanoid and terpene derivative. Total phenolic content and total flavonoid content were determined using spectrophotometric technique and calculated as gallic acid equivalents GAE/g dry weight and rutin equivalent RE/g of dry weight respectively. The highest phenolic content and flavonoid content were found in ethyl acetate extract 9.40 mg GAE/g and 15.9 mg RE/g of dry weight. All the extracts showed significant antioxidant activity in DPPH and ABTS cation decolorization assays. Dichloromethane extract possess the highest DPPH scavenging activity, i.e., 64.12% 0.23 at concentration of 4 mg/ml. Moreover instudies all the extracts showed prominent effect by inhibiting AAPS induce oxidation in Human erythrocytes being 69.24% 0.18 in dichloromethane extract, 64.44% 0.04 in ethyl acetate and 53.33% 0.09 in acetone extract. The methanol extract ofexhibited significant decrease in systolic blood pressure in l-Name induced hypertensive rats at the dose of 50 mg/kg for 28 days. Total phenolic content had a higher linear correlation (r = 0.678) with antihypertensive activity, with a level of significance 95% showing that phenolic compounds in the leaves of the plant has important role in inhibiting l -NAME induced hypertension while flavonoid compounds may play a key role in the antioxidant activities of the plant, through synergism. Conclusively,leaves with bioactive metabolites are a potential source for the development of antihypertensive drugs.
07:41
Dose-dependent dual effect of Morus nigra extract on urinary parameters of hypertensive rats. GreenMedInfo
PMID: Chem Biodivers. 2023 May ;20(5):e202300017. Epub 2023 May 2. PMID: 37071473 Abstract Title: Dose-Dependent Dual Effect of Morus nigra L. Extract on Urinary Parameters of Hypertensive Rats. Abstract: This study investigated the diuretic and antiurolithic effects of the hydroalcoholic extract obtained from Morus nigra L. leaves (HEMN) in female hypertensive rats. The rats were treated orally with vehicle (VEH), hydrochlorothiazide (HCTZ), or HEMN. After 8 h, the urine was analyzed. Besides, the precipitation of calcium oxalate (CaOx) was induced in the urine. The HEMN, at a dose of 0.03mg/g, increased the volume of urine compared to the VEH-treated group and increased the urinary content of Cl, without altering the excretion of Naand K. Besides, HENM reduced the elimination of Cain the urine. On the other hand, at a dose of 0.1mg/g, it significantly reduced the volume of urine excreted, thus suggesting an antidiuretic effect dependent on the dose used. Similarly, HEMN at concentrations of 1 and 3mg/mL reduced CaOx crystals' formation in monohydrate and dihydrate forms. However, with the increase in the concentration of HEMN to 10mg/mL, a significant increase in the formation of CaOx crystals was found. In conclusion, M. nigra extract has a dose-dependent dual effect on urinary parameters, which may have a diuretic and antiurolithic effect at lower doses or the opposite effect at higher doses.
06:53
Polysaccharides extracted from mulberry fruits antioxidant effect of ameliorating H2O2-induced liver injury. GreenMedInfo
PMID: BMC Complement Med Ther. 2023 Apr 12 ;23(1):112. Epub 2023 Apr 12. PMID: 37046263 Abstract Title: Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating HO-induced liver injury in HepG2 cells. Abstract: BACKGROUND: Mori Fructus is an economical and readily available traditional Chinese medicine and food. Polysaccharides in Mori Fructus have clear antioxidant activity and have been found to alleviate oxidative stress (OS)-induced liver damage in experimental studies. The mechanism of regulation of cellular antioxidant activity by mulberry polysaccharides has been suggested to be Nrf2, but it is not clear whether the Nrf2 pathway is mediated by activation of other targets, and the exact process of effects in hepatocytes has yet to be elucidated.METHODS: In this study, the basic characterization of total polysaccharides extracted from mulberry fruits (Morus nigra Linn.) was analyzed. A model of oxidative damage induced by HOin HepG2 cells was established. The levels of cellular oxidation-related markers, including ROS, SOD and Gpx, were then examined. Furthermore, Q-PCR and Western-blot were used to detect the expression of genes and proteins related to the PI3K/Akt-mediated Nrf2 signaling pathway.RESULTS: The results showed that a total mulberry polysaccharides (TMP) has a molecular weight of 57.5 kDa with a pyranose ring mainly composed of glucose (48.81%), galactose (22.79%) and mannose (18.2%). TMP reduced the accumulation of ROS in HepG2 cells after HOtreatment and modulated the activity of SOD and Gpx. Q-PCR and Western-blot showed that TMP could up-regulate the expression of p-PI3K, p-AKT, Nrf2, NQO1 and HO-1.CONCLUSIONS: This study demonstrates that TMP can reduce ROS accumulation in HO-treated HepG2 cells and restore cell viability by activating the PI3K/AKT-mediated Nrf2 pathway. TMP may be a potent antioxidant agent that could slow down oxidative damage to the liver.
06:48
Comprehensive analysis of antioxidant and hepatoprotective properties of Morus nigra. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Feb 4 ;12(2). Epub 2023 Feb 4. PMID: 36829941 Abstract Title: Comprehensive Analysis of Antioxidant and Hepatoprotective Properties ofL. Abstract: The framework of this study was a comprehensive investigation ofL. extracts, with the aim to establish the correlation between chemical composition and antioxidant/hepatoprotective activity of a series of black mulberry extracts obtained from aerial parts of the plant. Black mulberry leaf (MLEE), bark (MBEE), juice (MJ) and fresh fruit (MFEE) extracts were obtained using the conventional Soxhlet extraction, while the supercritical COextraction procedure was employed for preparation of the seed oil (MSO). Analysis of the chemical composition was performed using spectrophotometric, HPLC and GC methods. For the evaluation of antioxidant activity, in vitro FRAP and DPPH assays were applied. In Haan strain NMRI mice with streptozotocin-induced oxidative stress, in vivo antioxidant activity and liver tissue integrity were examined. The content of polyphenolic compounds was the highest in MBEE (68.30.7 mgGAE/g) with the most abundant compounds being polyphenolic acids, followed by MLEE (23.40.5 mgGAE/g) with the flavonoids isoquercetin and rutin being present in a significant amount. An analysis of MSO revealed a high content of-linoleic acid. The highest antioxidant activity in vitro (FRAP and DPPH) was observed for MLEE, MBEE and MSO. Beneficial effects were confirmed in vivo, with lower values of hepatosomatic index, potentiation of the activity of the enzymes superoxide dismutase and catalase, a lower rate of lipid peroxidation and reduced positivity for the P450 enzyme in animals treated with MLEE, MBEE and MSO. Black mulberry leaf and bark extracts as well as seed oil exhibited significant antioxidant activity. Apart from the confirmed biological properties of the fruit and leaf extracts, the observed activities of black mulberry seed oil and bark extract imply its importance as a sustainable source of phytochemicals.
06:11
Water fluoridation fires up opponents in New Plymouth Fluoride Action Network
There were passionate scenes at the New Plymouth council chambers as councillors came under attack for allowing fluoride to be put back in the districts water supply.
Anti-fluoride placards were erected outside and several speakers railed against the government decision to fluoridate water supplies, while a lone supporter of the move struggled to get heard.
New Plymouths drinking water has not been fluoridated since 2011, when the council voted to remove it from the citys supply.
Fluoride did not feature on Tuesdays council agenda, but that did not stop those upset at its reintroduction next month from making themselves heard.
Kane Titchener from Fluoride Free New Zealand travelled from Te Awamutu for the council meeting.
The accountant likened its effects to those of lead in paint and petrol.
Its time that we listened and stopped fluoridation, he said.
Chris Lind speaks at a New Plymouth District Council meeting Photo: RNZ / Robin Martin
Colleen Jones warned councillors that under the Health Act, they were ultimately responsible for providing clean, safe water.
People have a right to decide appropriately to their own needs and values, Jones said.
Chris Lind wondered whether the council had done its due diligence.
One of the key things I have to question here is your quality assurance department and your health and safety department have they done a risk review on this and has that risk review been put out for public consultation as an end user by the public?
James Kemp speaks at the council meeting. Photo: RNZ / Robin Martin
James Kemp took aim at the former director-general of health, Sir Ashley Bloomfield.
I cant believe we are having this conversation weve already voted in this area no. Bloomfield has stitched you all up and buggered off, Kemp said.
Frust...
06:06
Work underway on Dubbo fluoride repair Fluoride Action Network
The tender for the refurbishment of the fluoride dosing system at the John Gilbert Water Treatment Plant (JGWTP) in Dubbo has been awarded by Dubbo Regional Council (DRC).
Following a comprehensive evaluation process, the council resolved to engage TWS Evolution at the tendered amount of $1,192,101. This decision has been finalised with all requisite documentation assessed by NSW Public Works and the Department of Planning and Environment (Water Group).
The design phase has been initiated and is expected to span approximately 12 weeks. Upon completion and approval of the design, work will commence at the JGWTP with a targeted completion date set for the end of April 2024.
Since the failure of the citys fluoridation equipment in January 2019, Dubbos residents have been without fluoride in their water supply. Despite the JGWTP staff alerting the councils leadership at the time, no immediate corrective action was undertaken.
The issue was not fully addressed until April 2022 when the newly appointed council leadership became aware of the lack of fluoride. Subsequent to this, meetings were held with NSW Health, DPE Water and NSW Public Works to comprehend the magnitude of the problem and formulate an effective solution.
I once again extend my apologies to the public for this significant breach of trust. In January 2019, the community should have been notified about the lack of fluoride in the water supply. This oversight not only represents a breach of public trust but also, according to Section 6B of the Fluoridation of Public Water Supplies Act 1957, the unauthorised discontinuation of fluoridation is a breach of the Act, Dubbo Regional Council Mayor Mathew Dickerson said.
Transparency is paramount and it should have been vital that the public be informed about the situation.
The council initially aimed to reintroduce fluoride into the water supply by June 2023. However, in collaboration with NSW Public Works, DPE Water and NSW Health it became evident that the project was more complex and time-consuming than initially estimated. Further, the decision was made to implement a different fluoride dosing method compared to the one previously used at the JGWTP.
I apologise to the public for not meeting our target date. The project was substantially larger than initially estimated, but it was crucial that we execute this correctly for the future residents of Dubbo, Clr Dickerson said.
The affected water supply includes potable town water from the JGWTP which serves Dubbo, Wongarbon, Eumungerie, Ballimore, Mogriguy and Brocklehurst.
Water fluoridation refers to the process of adjusting the fluoride concentration in drinking water to an optimal level that helps mitigate tooth decay. Dubbos water supply currently only includes natural fluoridation.
...
06:06
Hydroethanolic extract of Morus nigra Leaves: A dual PPAR-/ agonist with anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7. GreenMedInfo
PMID: Plants (Basel). 2022 Nov 17 ;11(22). Epub 2022 Nov 17. PMID: 36432875 Abstract Title: Hydroethanolic Extract of Morus nigra L. Leaves: A Dual PPAR-/Agonist with Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7. Abstract: Inhibition of systemic inflammation has been a beneficial strategy in treating several non-communicable diseases, which represent one of the major causes of mortality in the world. The Peroxisome Proliferator-Activated Receptors (PPAR) are interesting pharmacological targets, since they can act both through the metabolic and anti-inflammatory pathways.L. has flavonoids in its chemical composition with recognized anti-oxidant activity and often associated with anti-inflammatory activity. Therefore, this study aimed to evaluate the hydroethanolic extract ofleaves' ability to activate PPAR and promote anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated murine macrophage cells. The leaf extract was prepared by cold maceration, and the chemical profile was obtained by HPLC-DAD. Activation of PPARandwas evaluated by the luciferase reporter assay. The anti-inflammatory activity was assessed by measuring the reactive oxygen species (ROS), nitric oxide (NO), and Tumor Necrosis Factor-(TNF-) in RAW 264.7 cells after stimulation with LPS from. The HPLC-DAD analysis identified two major compounds: rutin and isoquercitrin. The extract showed agonist activity for the two types of PPAR,and, although its major compounds, rutin and isoquercitrin, did not significantly activate the receptors. In addition, the extract significantly reduced the production of ROS, NO, and TNF-. Treatment with the specific PPAR-antagonist, GW 6471, was able to partially block the anti-inflammatory effect caused by the extract.
05:59
Study Debunks the Theory that Depression is Caused by a Chemical Imbalance in the Brain Americas Problem with Criminal Drug Dealers Medical Kidnap
by Brian Shilhavy
Editor, Health Impact News
America has a huge drug addiction problem, where drug dealers are literally destroying this country.
No, I am not referring to fentanyl, meth, crack, heroin, or any other illegal street drug and the people who push them.
I am referring to the much larger drug addiction problem with drugs that are distributed by a much larger drug dealer network: FDA-approved and authorized prescription drugs.
This is, by far, the largest criminal organization in the world. The pharmaceutical drugs distributed by medical doctors and purchased in drug stores that are on the corner of every city and town in America, are what is destroying this country.
These drugs are the leading cause of death in the United States, and their drug dealers are the largest class of criminal organizations in the world. See:
Pharmaceutical Industry is the Leading Cause of Death in U.S., and the Largest Criminal Group in the World
The worst offenders among these drug pushers, are the fake doctors called psychiatrists, where 1 out every 5 of these doctors are arrested on criminal charges, where 40% of all women in psychiatric wards are raped, and where a child is 3 times more likely to be sexually molested by a psychiatrist than by a stranger or registered sex offender.
For references to sources that back up these statistics, please see:
Sexual...
05:59
Study Debunks the Theory that Depression is Caused by a Chemical Imbalance in the Brain Americas Problem with Criminal Drug Dealers Vaccine Impact
by Brian Shilhavy
Editor, Health Impact News
America has a huge drug addiction problem, where drug dealers are literally destroying this country.
No, I am not referring to fentanyl, meth, crack, heroin, or any other illegal street drug and the people who push them.
I am referring to the much larger drug addiction problem with drugs that are distributed by a much larger drug dealer network: FDA-approved and authorized prescription drugs.
This is, by far, the largest criminal organization in the world. The pharmaceutical drugs distributed by medical doctors and purchased in drug stores that are on the corner of every city and town in America, are what is destroying this country.
These drugs are the leading cause of death in the United States, and their drug dealers are the largest class of criminal organizations in the world. See:
Pharmaceutical Industry is the Leading Cause of Death in U.S., and the Largest Criminal Group in the World
The worst offenders among these drug pushers, are the fake doctors called psychiatrists, where 1 out every 5 of these doctors are arrested on criminal charges, where 40% of all women in psychiatric wards are raped, and where a child is 3 times more likely to be sexually molested by a psychiatrist than by a stranger or registered sex offender.
For references to sources that back up these statistics, please see:
Sexual...
05:56
Ameliorating effect of the total flavonoids of Morus nigra on prediabetic mice based on regulation of inflammation and insulin sensitization. GreenMedInfo
PMID: J Agric Food Chem. 2022 Oct 5 ;70(39):12484-12501. Epub 2022 Sep 23. PMID: 36150176 Abstract Title: Ameliorating Effect of the Total Flavonoids ofL. on Prediabetic Mice Based on Regulation of Inflammation and Insulin Sensitization. Abstract: Prediabetes is a critical stage characterized by insulin resistance.L., an edible plant, is widely used in food and nutritive supplements and exhibits various pharmacological activities; however, its therapeutic effects and mechanisms on prediabetes have rarely been reported. In this research, the major components of total flavonoids ofL. (TFM) were identified, and TFM treatment was found to reduce prediabetes progressing to type 2 diabetes mellitus (T2DM) from 93.75 to 18.75%. The microbiota and next-generation sequencing combined with western blotting in vivo and in vitro demonstrated that TFM and its components ameliorated insulin resistance mediated by the suppressor of cytokine signaling and protein tyrosine phosphatase 1B, which benefited by maintaining intestinal homeostasis and restraining plasma levels of inflammatory factors. This study confirmed the T2DM prevention effect of TFM and revealed the underlying mechanism, setting the stage for the design of functional foods for diabetes prevention.
05:28
Study Debunks the Theory that Depression is Caused by a Chemical Imbalance in the Brain Americas Problem with Criminal Drug Dealers Health Impact News
by Brian Shilhavy
Editor, Health Impact News
America has a huge drug addiction problem, where drug dealers are literally destroying this country.
No, I am not referring to fentanyl, meth, crack, heroin, or any other illegal street drug and the people who push them.
I am referring to the much larger drug addiction problem with drugs that are distributed by a much larger drug dealer network: FDA-approved and authorized prescription drugs.
This is, by far, the largest criminal organization in the world. The pharmaceutical drugs distributed by medical doctors and purchased in drug stores that are on the corner of every city and town in America, are what is destroying this country.
These drugs are the leading cause of death in the United States, and their drug dealers are the largest class of criminal organizations in the world. See:
Pharmaceutical Industry is the Leading Cause of Death in U.S., and the Largest Criminal Group in the World
The worst offenders among these drug pushers, are the fake doctors called psychiatrists, where 1 out every 5 of these doctors are arrested on criminal charges, where 40% of all women in psychiatric wards are raped, and where a child is 3 times more likely to be sexually molested by a psychiatrist than by a stranger or registered sex offende...
05:10
Vitamin D supplements evidence about safety and effectiveness Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
A lot of medical research on vitamin D supplements don't provide much evidence that it is useful in treating any disease.
02:57
Where Have All the Liberals Gone? GreenMedInfo
Opening comments to the general public to ask a question, in sincerity: what changed the minds of society's former First Amendment advocates?
02:52
Where Have All the Liberals Gone? GreenMedInfo
Originally published on www.racket.news by Matt
Taibbi
Opening comments to the general public to ask a question, in sincerity: what changed the minds of society's former First Amendment advocates?
Go Back:30 Days | 7 Days | 2 Days | 1 Day
Wednesday, 12 July
21:59
FDA Approves Leqembi for Alzheimers Science-Based Medicine
FDA upgrades Leqembi for AD from accelerated to traditional approval based on latest clinical data.
The post FDA Approves Leqembi for Alzheimers first appeared on Science-Based Medicine.20:01
We Have a Neck: Psychiatrist James Greenblatt on The Links Between Body and Brain Mad In America
James Greenblatt is an innovator and longtime authority in the fields of integrative medicine and functional psychiatry, focusing on nutrition and other natural modes of treatment for people in distressincluding teens with eating disorders and children and adults diagnosed with ADHD.
Hes the author of eight books, most recently on antidepressant withdrawal, and the founder of the website PsychiatryRedefined.orgwhere he works to educate his colleagues/professionals on the science and practice of functional, integrative, and metabolic psychiatry.
Greenblatt serves as Chief Medical Officer and Vice President of Medical Services at Walden Behavioral Care, which is based in Massachusetts. He teaches at the Tufts University School of Medicine and the Dartmouth College School of Medicine.
The transcript below has been edited for length and clarity. Listen to the audio of the interview here.
Amy Biancolli: Dr. Greenblatt, welcome. Glad to have you here today.
James Greenblatt: Thank you, Amy. Its good to be with you.
Biancolli: I have a lot of questions today, because youve done so much interesting work. But for a start, for our listeners, could you define functional medicine and integrative psychiatry? And how do those approaches differ from conventional psychiatry? What do people need to know going into this conversation about what you do and how it differs?
Greenblatt: Good start. We can have three buckets here. Conventional psychiatry, were all quite aware of, is pretty much a symptomatic-based polypharmacy treatment model. We have one tool and its a medicine for a symptom. The second, third and fourth medicine, I think were all aware of that, and the limitations of that. We throw in psychotherapy, but the model is medications.
Integrative medicine, which has gained steam over the last 30 years, includes the terms like mindfulness and yoga and lifestyle and exercise, and diet. All these terms that the consumers had to push forward and finally have been embraced by our medical establishmentand thats great news. We have mindfulness trainings at Harvard and Stanford, and we have lifestyle fellowships for doctors, but...
20:00
Patients Express Anger at Doctors Ignorance About Antidepressant Withdrawal Effects Mad In America
Despite the astonishing increase in the prescribing and long-term use of antidepressants, many medical professionals remain ignorant of how to support patients in safely discontinuing antidepressant drugs and navigating withdrawal symptoms.
A recently published study highlights the frustration felt by antidepressant users who have suffered from a lack of professional support and suggestions for how doctors and healthcare systems can better support people coming off of antidepressants.
Although helpful for some, antidepressants can have adverse side effects prompting many to discontinue their antidepressants. This process, however, is described as severely challenging because of antidepressant withdrawal or the physical and emotional symptoms that can emerge days, weeks or months after stopping antidepressants, which sometimes surpass the problems for which the drugs were prescribed.
This difficult process and the well-documented lack of support by health professionals have forced patients to seek advice from online peer support groups, where people share their lived experiences of antidepressant withdrawal and provide support to others.
The need for support is not surprising since it is estimated that approximately half of the tens of millions of people taking antidepressants will experience withdrawal symptoms when they try to reduce or come off them, write researchers John Read, Mark Horowitz, Joanna Moncrieff, and Stevie Lewis, who has experience of withdrawal from antidepressants and is a member of The Lived Experience Advisory Panel for Prescribed Drug Dependence.
To inform health services about which supports are
most needed during the process of reducing or discontinuing
antidepressants, an anonymous survey was administered to members of
online withdrawal support groups. Seven hundred eight members
completed the following sentence: A public health service to help
people come off antidepressants should include.
The team of researchers reviewed al...
20:00
The new retraction record holder is a German anesthesiologist, with 184 Retraction Watch
The German anesthesiologist Joachim Boldt has lost 20 more papers since January 2023, earning him the top spot in our leaderboard, with 184 retractions.
Boldt, readers may recall, was once one of the leading international figures in perioperative medicine. His work, particularly studies involving the use of fluid management during surgery, helped inform clinical guidelines that, thanks to his misdeeds, some experts believe may have put patients at risk for serious harm and even death.
Boldt has vaulted over another anesthesiologist, Yoshitaka Fujii, to take the crown (more on that in a moment) although one might fairly ask: Why did it take so long?
The bulk of the recently retracted papers appeared in Intensive Care Medicine, a European title published by Springer Nature. Since March, the journal has pulled 15 articles by Boldt, whose misdeeds including but not limited to fabrication of data and lack of ethics approval in his clinical trials first came to light in 2010. Five more came in the journal Chest.
Heres one notice, for Right ventricular function and cardiac surgery, which Intensive Care Medicine published in June 1988. (Note that the statement from Justus Liebig University dates to 2020.)
The Editor-in-Chief h...
10:36
Vasorelaxant effect of Moroccan Cannabis sativa threshing residues on rat mesenteric arterial bed is endothelium and muscarinic receptors dependent. GreenMedInfo
PMID: Evid Based Complement Alternat Med. 2023 ;2023:1265103. Epub 2023 Apr 20. PMID: 37123084 Abstract Title: Vasorelaxant Effect of MoroccanThreshing Residues on Rat Mesenteric Arterial Bed is Endothelium and Muscarinic Receptors Dependent. Abstract: INTRODUCTION: Ethanolic fraction of Moroccanthreshing residues (EFCS) was evaluated for its vasorelaxant activity. The current work aims to identify the active metabolites in the ethanolic fraction of the EFCS and illustrate their mechanism of action.METHODS: Free radical scavenging capacity of EFCS was assessed using DPPH method. The EFCS vasodilation activities in phenylephrine-precontracted isolated rat mesenteric arterial beds were investigated in presence of L-NAME (nitric oxide synthase inhibitor), indomethacin (cyclooxygenase inhibitor), potassium channel blockers (namely tetraetylamonium, barium chloride, and glibenclamide), and atropine. Nitric oxide vascular release was measured by electron paramagnetic resonance (EPR) using a spin trap in rat aortic rings.RESULTS: EFCS induced dose-dependent vasorelaxation on mesenteric vascular bed. Incubation of the preparations with L-NAME, ODQ (a soluble guanylyl cyclase inhibitor), or potassium channel blockers reduced the fall of perfusion pressure caused by EFCS. Endothelial denudation or atropine abolished the EFCS's vasorelaxant effect, suggesting involvement of muscarinic receptors and endothelium-relaxing factors. The extract induced nitric oxide release in aortic rings in a similar manner as acetylcholine suggesting an effect of EFCS on the muscarinic receptor and the conductance arteries. Chemical investigation of EFCS identified potential active components namely apigenin and derivatives of luteolin skeleton and also additional components such as neophytadiene, squalene, and-sitosterol. In conclusion, the vasorelaxant effect of EFCS on rat mesenteric arterial bed, which is dependent of muscarinic receptor activation, nitric oxide, and EDHF, can account for potential therapeutic use against high blood pressure related cardiovascular diseases.
10:13
Medical cannabis is effective for cancer-related pain: Quebec Cannabis Registry results. GreenMedInfo
PMID: BMJ Support Palliat Care. 2023 May 2. Epub 2023 May 2. PMID: 37130724 Abstract Title: Medical cannabis is effective for cancer-related pain: Quebec Cannabis Registry results. Abstract: OBJECTIVES: To evaluate the safety and effectiveness of medical cannabis (MC) in reducing pain and concurrent medications in patients with cancer.METHODS: This study analysed data collected from patients with cancer who were part of the Quebec Cannabis Registry. Brief Pain Inventory (BPI), revised Edmonton Symptom Assessment System (ESAS-r) questionnaires, total medication burden (TMB) and morphine equivalent daily dose (MEDD) recorded at 3-month, 6-month, 9-month and 12-month follow-ups were compared with baseline values. Adverse events were also documented at each follow-up visit.RESULTS: This study included 358 patients with cancer. Thirteen out of 15 adverse events reported in 11 patients were not serious; 2 serious events (pneumonia and cardiovascular event) were considered unlikely related to MC. Statistically significant decreases were observed at 3-month, 6-month and 9-month follow-up for BPI worst pain (5.50.7 baseline, 3.60.7, 3.60.7, 3.60.8; p
10:00
Media Continue to Lie About Gene Therapy Jab Articles
While the COVID-19 shots are referred to as vaccines, they do not meet the classical definition of a vaccine. Health authorities needed to change the definition1 to accommodate the COVID shots and shut down the argument that, as experimental gene therapies, they may be riskier than traditional vaccines.
Meanwhile, based on the U.S. Food and Drug Administrations definition2,3 of gene therapy theyre clearly gene therapies, and both Moderna4 and BioNTech5 acknowledge this in their Securities and Exchange Commission (SEC) registration statements.
In a 2014 paper,6 BioNTech founder Ugur Sahin also stated that One would expect the classification of an mRNA drug to be a biologic, gene therapy or somatic cell therapy.
Publicly, however, drug makers, regulators and, of course, the media, have been going to great lengths to make sure people dont think of them that way. Now, a peer-reviewed paper7,8 has weighed in on the controversy, stressing that mRNA COVID shots should be labeled as gene therapy.
mRNA Shots Are Gene Therapy, but Not Regulated as Such
As noted in this paper, published in the International Journal of Molecular Science, June 22, 2023:
COVID-19 vaccines were developed and approved rapidly in response to the urgency created by the pandemic. No specific regulations existed at the time they were marketed. The regulatory agencies therefore adapted them as a matter of urgency.
Now that the pandemic emergency has passed, it is time to consider the safety issues associated with this rapid approval. The mode of action of COVID-19 mRNA vaccines should classify them as gene therapy products (GTPs), but they have been excluded by regulatory agencies.9
Some of the tests they have undergone as vaccines have produced non-compliant results in terms of purity, quality and batch homogeneity. The wide and persistent biodistribution of mRNAs and their protein products, incompletely studied due to their classification as vaccines, raises safety issues.
Post-marketing studies have shown that mRNA passes into breast milk and could have adverse effects on breast-fed babies. Long-term expression, integrat...
What Causes Eye Floaters and Are They Dangerous? Articles
From time to time, most people notice small black dots or squiggly lines in their eyes that float across their vision. In a study1 of 603 people, 76% reported that they see floaters and 33% said it caused a noticeable impairment in their vision.
For some people, floaters can also appear like little cobwebs that come and go across their visual field. While most of the time floaters are only a nuisance, sometimes they can be a sign of a more serious eye condition.
These little specks in your visual field move as your eye moves. This means when you attempt to look directly at them, they seem to float away. As your eyes stop moving, they may float back into vision again. Nearly everyone will see floaters as they age, but some people have a higher risk of floaters.2 This includes people who are typically over the age of 50, nearsighted, have diabetes or have had surgery to correct cataracts.
Floaters are most obvious to a person when they are looking at a bright white object. This might include light-colored walls, the snow or a computer screen. The floaters appear as black flecks that may initially look like flies or spiders moving at the very edge of their peripheral vision.
How Do Eye Floaters Form?
The eye has two chambers that are commonly referred to as the front and the back of the eye. At the front of the eye is the cornea, which is the dome-shaped portion. Behind the cornea is a chamber filled with fluid called aqueous humor. The definition of humor is bodily fluid. The body continually produces aqueous humor that maintains pressure in the eye. This happens when the same amount of fluid is leaving the eye as is being produced.
The back of the eye is located between the lens and the retina. This is called the vitreous cavity and it is filled with vitreous humor. Vitreous humor is a gel-like substance that is more viscous than aqueous humor but continues to allow light penetration. With age, vitreous humor thins and may loosen from the retina. Floaters form when tiny collagen strands of vitreous stick together and cast a shadow over the retina. It is the shadow you see as a floater.
The vitreous humor may detach from the retina, called posterior vitreous detachment. In this case, a person experiences acute flashes and floaters, which require immediate medical attention. Flashes may look like a camera flashing or lightning.
On their own, floaters are common and do not typically need to be treated. However, when floaters and flashes appear together, it is a serious condition. Vitreous humor makes up approximately 80% of the volume of the eye and helps maintain the shape of the eye. Dr. Sarah Brewer told Mirror:3
...Baking Soda Inexpensive Treatment for Autoimmune Diseases Articles
Editor's Note: This article is a reprint. It was originally published May 7, 2018.
Baking soda (sodium bicarbonate or NaHCO3), popularized by Arm & Hammer more than 150 years ago, is a staple in many homes for baking and cleaning purposes, but this inexpensive ingredient also has a number of medicinal uses and benefits. It rates right up there with hydrogen peroxide as one of the most inexpensive and safe health tools around, so it makes sense to learn all you can about the many uses of baking soda.
It's commonly known to have alkalinizing, antacid and electrolyte replacement properties.1 When taken internally, baking soda is thought to raise the pH of your blood. This appears to be the basic premise behind its recommended use against colds and influenza symptoms, recounted in a 1924 Arm & Hammer booklet on the medical uses of baking soda.2,3
Long-distance runners have also engaged in a practice known as "soda doping" taking baking soda capsules before races to enhance performance a measure thought to work similarly to carbohydrate loading. In this case, by increasing the pH of your blood, this practice is thought to offset the acidity produced in muscles during intense activity. While I do not suggest or recommend you try this at home, use of baking soda has also been shown to improve speed among swimmers.4
Research5 has also shown drinking baking soda solution can help pregnant women who are having a slow or difficult labor to avoid C-sections in about 20% of cases by neutralizing acid in their womb. This could spell the difference between life and death in developing countries and/or instances where C-section is not an option.
Baking Soda May Be an Inexpensive Treatment
More recently, research funded by the National Institutes of Health suggests baking soda may be an effective treatment adjunct for rheumatoid arthritis (RA) and other autoimmune diseases. According to this study,6,7 led by renal physiologist Paul O'Connor and published in The Journal of Immunology, drinking a solution of water and baking soda appears to prime your immune system against inflammation.
Baking soda dose is about 1/2 tsp to 1 tsp a few times a day. I personally take 3/4 tsp three times a day in a four ounce glass of orange juice. You need to stir the orange juice for a chemical reaction to occur and you...
09:44
Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It Medical Kidnap
by Brian Shilhavy
Editor, Health Impact News
I was able to view the recently released movie Sound of Freedom in a local theater last night, which amazingly was sold out in a Monday evening showing more than a week after the films release.
The film stars Jim Caviezel playing the part of Tim Ballard, a former Special Agent for the Department of Homeland Security who was assigned to the Internet Crimes Against Children (ICAC) Task Force, and started his own organization, Operation Underground Railroad, a nonprofit focused on rescuing trafficked children.
The production of this film reportedly began more than 5 years ago, and since at least 2021, I have seen numerous interviews and articles about Jim Caviezel talking about this film along with such topics as adrenochrome, Satanic ritual abuse, organ harvesting, and other such dark topics that we have covered for the better part of a decade here at Health Impact News.
While this is definitely a good film that I recommend everyone to watch if they get a chance to, be forewarned that none of these darker topics are even addressed in this film, nor is there any real call to action with practical advice on how to actually stop child trafficking.
When I was about to leave the theater as the credits starting rolling, the screen put up a timer stating that there was a special message by Jim Caviezel after the credits.
Ah, maybe this is where Caviezel will draw in these other topics, I thought, and give some practical advice about how to stop all this.
But he didnt.
The only call to action was to get more people to view the film, with an opportunity for people to scan a QR code and donate money so that others could view the film who could not afford to.
There are some copies of this special message from Caviezel on the Internet now, and it is about 2 minutes long:
It is truly unfortunate that this film is being advertised as a Right Wing Conservative Christian film by those in the media (I dont think Caviezel or Ballard see it that w...
09:44
Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It Vaccine Impact
by Brian Shilhavy
Editor, Health Impact News
I was able to view the recently released movie Sound of Freedom in a local theater last night, which amazingly was sold out in a Monday evening showing more than a week after the films release.
The film stars Jim Caviezel playing the part of Tim Ballard, a former Special Agent for the Department of Homeland Security who was assigned to the Internet Crimes Against Children (ICAC) Task Force, and started his own organization, Operation Underground Railroad, a nonprofit focused on rescuing trafficked children.
The production of this film reportedly began more than 5 years ago, and since at least 2021, I have seen numerous interviews and articles about Jim Caviezel talking about this film along with such topics as adrenochrome, Satanic ritual abuse, organ harvesting, and other such dark topics that we have covered for the better part of a decade here at Health Impact News.
While this is definitely a good film that I recommend everyone to watch if they get a chance to, be forewarned that none of these darker topics are even addressed in this film, nor is there any real call to action with practical advice on how to actually stop child trafficking.
When I was about to leave the theater as the credits starting rolling, the screen put up a timer stating that there was a special message by Jim Caviezel after the credits.
Ah, maybe this is where Caviezel will draw in these other topics, I thought, and give some practical advice about how to stop all this.
But he didnt.
The only call to action was to get more people to view the film, with an opportunity for people to scan a QR code and donate money so that others could view the film who could not afford to.
There are some copies of this special message from Caviezel on the Internet now, and it is about 2 minutes long:
It is truly unfortunate that this film is being advertised as a Right Wing Conservative Christian film by those in the media (I dont think Caviezel or Ballard see it that w...
09:40
Retinal vascular occlusion may not be a coincidental finding after COVID-19 vaccination. GreenMedInfo
PMID: NPJ Vaccines. 2023 May 2 ;8(1):64. Epub 2023 May 2. PMID: 37130882 Abstract Title: Risk assessment of retinal vascular occlusion after COVID-19 vaccination. Abstract: Coronavirus disease 2019 (COVID-19) vaccines are associated with several ocular manifestations. Emerging evidence has been reported; however, the causality between the two is debatable. We aimed to investigate the risk of retinal vascular occlusion after COVID-19 vaccination. This retrospective cohort study used the TriNetX global network and included individuals vaccinated with COVID-19 vaccines between January 2020 and December 2022. We excluded individuals with a history of retinal vascular occlusion or those who used any systemic medication that could potentially affect blood coagulation prior to vaccination. To compare the risk of retinal vascular occlusion, we employed multivariable-adjusted Cox proportional hazards models after performing a 1:1 propensity score matching between the vaccinated and unvaccinated cohorts. Individuals with COVID-19 vaccination had a higher risk of all forms of retinal vascular occlusion in 2 years after vaccination, with an overall hazard ratio of 2.19 (95% confidence interval 2.00-2.39). The cumulative incidence of retinal vascular occlusion was significantly higher in the vaccinated cohort compared to the unvaccinated cohort, 2 years and 12 weeks after vaccination. The risk of retinal vascular occlusion significantly increased during the first 2 weeks after vaccination and persisted for 12 weeks. Additionally, individuals with first and second dose of BNT162b2 and mRNA-1273 had significantly increased risk of retinal vascular occlusion 2 years following vaccination, while no disparity was detected between brand and dose of vaccines. This large multicenter study strengthens the findings of previous cases. Retinal vascular occlusion may not be a coincidental finding after COVID-19 vaccination.
09:31
This study presents a rare case of spontaneous regression of advanced transverse colon cancer. GreenMedInfo
PMID: Surg Case Rep. 2023 Apr 25 ;9(1):64. Epub 2023 Apr 25. PMID: 37095273 Abstract Title: Spontaneous regression of advanced transverse colon cancer with deficient mismatch repair: a case report. Abstract: BACKGROUND: Spontaneous regression (SR) of cancer occurs in 1 in 60,000-100,000 patients. This phenomenon has been reported in almost all cancer types, most commonly neuroblastoma, renal cell carcinoma, malignant melanoma, and lymphoma/leukemia. However, SR in colorectal cancer (CRC) is extremely rare, particularly in advanced cases. Hence, this report describes a very rare case of spontaneous regression of advanced transverse colon cancer.CASE PRESENTATION: A 76-year-old female with anemia was diagnosed with a type II well-differentiated adenocarcinoma in the middle transverse colon. Two months later, a second colonoscopy examination was performed for preoperative marking, and it revealed tumor shrinkage and a shift to type 0-IIc morphology. Endoscopic tattooing was then performed, followed by a laparoscopic partial resection of the transverse colon with D3 lymph node dissection. However, the resected specimen contained no tumor, and colonoscopy showed no tumor remnants in the remaining colon. Histopathological examination revealed mucosal regeneration and a mucus nodule in between the submucosal and muscular layers, with no cancer cells detected. Immunohistochemical analysis revealed the loss of MutL homolog 1 (MLH1) and postmeiotic segregation increased 2 (PMS2) expression in the cancer cells of biopsied specimens, suggesting deficient mismatch repair (dMMR). The patient continues to be followed up until 6 years postoperatively, and no recurrence has been observed. In this study, we also reviewed similar reported cases of spontaneous regression of cancer involving dMMR.CONCLUSION: This study presents a rare case of spontaneous regression of advanced transverse colon cancer wherein dMMR is strongly involved. However, further accumulation of similar cases is needed to elucidate this phenomenon and to develop new treatment strategies for CRC.
09:26
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. GreenMedInfo
PMID: Commun Biol. 2023 Apr 22 ;6(1):444. Epub 2023 Apr 22. PMID: 37087494 Abstract Title: Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Abstract: Immunodeficient mice reconstituted with a human immune system (HIS mice) give rise to human T cells, which make them an attractive system to study human immune responses to tumors. However, such HIS mice typically exhibit sub-optimal responses to immune challenges as well as fail to develop antigen-specific B or T cell memory. Here we report HIS mice mediate spontaneous regression of human B cell lymphoma Raji. Tumor regression was dependent on CD4+ and CD8+ T cell responses and resulted in T cell memory. The T cell memory elicited was mainly Raji-specific, however some level of cross-protection was also elicited to a related B cell lymphoma cell line Ramos. Single-cell RNAseq analysis indicated activation of CD8+ T cells in regressing Raji tumors as well as clonal expansion of specific T cell receptors (TCRs). Cloning of TCRs from Raji-infiltrating T cells into a Jurkat reporter cell line showed reactivity specific for Raji tumor cells. Overall, we report a platform for studying in vivo human T cell tumor immunity by highlighting spontaneous Raji tumor regression, clonal TCR expansion, and T cell memory in HIS mice.
09:22
Spontaneous cancer remission after COVID-19. GreenMedInfo
PMID: J Transl Med. 2023 Apr 21 ;21(1):273. Epub 2023 Apr 21. PMID: 37085802 Abstract Title: Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment. Abstract: Early in the COVID-19 pandemic, it emerged that the risk of severe outcomes was greater in patients with co-morbidities, including cancer. The huge effort undertaken to fight the pandemic, affects the management of cancer care, influencing their outcome. Despite the high fatality rate of COVID-19 disease in cancer patients, rare cases of temporary or prolonged clinical remission from cancers after SARS-CoV-2 infection have been reported. We have reviewed sixteen case reports of COVID-19 disease with spontaneous cancer reduction of progression. Fourteen cases of remission following viral infections and two after anti-SARS-CoV-2 vaccination. The immune response to COVID-19, may be implicated in both tumor regression, and progression. Specifically, we discuss potential mechanisms which include oncolytic and priming hypotheses, that may have contributed to the cancer regression in these cases and could be useful for future options in cancer treatment.
08:48
Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It Health Impact News
by Brian Shilhavy
Editor, Health Impact News
I was able to view the recently released movie Sound of Freedom in a local theater last night, which amazingly was sold out in a Monday evening showing more than a week after the films release.
The film stars Jim Caviezel playing the part of Tim Ballard, a former Special Agent for the Department of Homeland Security who was assigned to the Internet Crimes Against Children (ICAC) Task Force, and started his own organization, Operation Underground Railroad, a nonprofit focused on rescuing trafficked children.
The production of this film reportedly began more than 5 years ago, and since at least 2021, I have seen numerous interviews and articles about Jim Caviezel talking about this film along with such topics as adrenochrome, Satanic ritual abuse, organ harvesting, and other such dark topics that we have covered for the better part of a decade here at Health Impact News.
While this is definitely a good film that I recommend everyone to watch if they get a chance to, be forewarned that none of these darker topics are even addressed in this film, nor is there any real call to action with practical advice on how to actually stop child trafficking.
When I was about to leave the theater as the credits starting rolling, the screen put up a timer stating that there was a special message by Jim Caviezel after the credits.
Ah, maybe this is where Caviezel will draw in these other topics, I thought, and give some practical advice about how to stop all this.
But he didnt.
The only call to action was to get more people to view the film, with an opportunity for people to scan a QR code and donate money so that others could view the film who could not afford to.
There are some copies of this special message from Caviezel on the Internet now, and it is about 2 minutes long:
...
08:35
Rutin orotects fibroblasts from UVA radiation. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Mar 28 ;12(4). Epub 2023 Mar 28. PMID: 37107196 Abstract Title: Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway. Abstract: This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h of UVA exposure). These effects are related to rutin's ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 signaling pathway results in an increase in reduced glutathione and Bcl2/Bax ratio, and the subsequent protection of mitochondrial respiratory capacity. These results demonstrate how rutin may play a potentially cytoprotective role against UVA-induced skin damage through a purely antiapoptotic mechanism.
08:14
Rutin could be a potential agent for muscle loss such as sarcopenia. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Mar 3 ;12(3). Epub 2023 Mar 3. PMID: 36978887 Abstract Title: Rutin Prevents Dexamethasone-Induced Muscle Loss in C2C12 Myotube and Mouse Model by Controlling FOXO3-Dependent Signaling. Abstract: One of the causes of sarcopenia is that homeostasis between anabolism and catabolism breaks down due to muscle metabolism changes. Rutin has shown antioxidant and anti-inflammatory effects in various diseases, but there are few studies on the effect on muscle loss with aging. The effect of rutin on muscle loss was evaluated using dexamethasone-induced muscle loss C2C12 myoblast and mouse model. In the group treated with dexamethasone, the muscle weight of gastrocnemius (GA), tibialis anterior (TA), and extensor digitorum longus (EDL) in the mouse model were significantly decreased (
08:00
Happy Hour with Bishop Leon Benjamin Dr. Tenpenny
07-11-2023 Listen to audio here: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-11-23-HHr-LeonBenjamin.mp4 About my guest: A native of Richmond, VA, Pastor []
07:57
Potential treatment options for neuroblastoma with polyphenols. GreenMedInfo
PMID: Biomolecules. 2023 Mar 20 ;13(3). Epub 2023 Mar 20. PMID: 36979499 Abstract Title: Potential Treatment Options for Neuroblastoma with Polyphenols through Anti-Proliferative and Apoptotic Mechanisms. Abstract: Neuroblastoma (NB) is an extracranial tumor of the peripheral nervous system arising from neural crest cells. It is the most common malignancy in infants and the most common extracranial solid tumor in children. The current treatment for high-risk NB involves chemotherapy and surgical resection followed by high-dose chemotherapy with autologous stem-cell rescue and radiation treatment. However, those with high-risk NB are susceptible to relapse and the long-term side effects of standard chemotherapy. Polyphenols, including the sub-class of flavonoids, contain more than one aromatic ring with hydroxyl groups. The literature demonstrates their utility in inducing the apoptosis of neuroblastoma cells, mostly in vitro and some in vivo. This review explores the use of various polyphenols outlined in primary studies, underlines the pathways involved in apoptotic activity, and discusses the dosage and delivery of these polyphenols. Primary studies were obtained from multiple databases with search the terms "neuroblastoma", "flavonoid", and "apoptosis". The in vitro studies showed that polyphenols exert an apoptotic effect on several NB cell lines. These polyphenols include apigenin, genistein, didymin, rutin, quercetin, curcumin, resveratrol, butein, bisphenols, and various plant extracts. The mechanisms of the therapeutic effects include calpain-dependent pathways, receptor-mediated apoptosis, and, notably, and most frequently, mitochondrial apoptosis pathways, including the mitochondrial proteins Bax and Bcl-2. Overall, polyphenols demonstrate potency in decreasing NB proliferation and inducing apoptosis, indicating significant potential for further in vivo research.
07:50
Serious Concerns Over Australias Landmark Psilocybin, MDMA Ruling Mad In America
From Australian Broadcasting Corporation: Over the six months that Andrew was undergoing therapy, Australias peak medical regulator was evaluating an application to reclassify psilocybin and MDMA (the compound in Ecstasy) as medicines. It had knocked back a similar proposal just the year before. So when it decided in February to become the first country in the world to approve such a change, it shocked even those who had proposed it.
. . . As recently as October last year, the TGA ruled that there was insufficient evidence to down-schedule the drugs. But just months later, in February, it did a spectacular 180-degree turn and approved psychiatrists to use MDMA for PTSD and psilocybin for treatment-resistant depression.
That move divided the psychiatric community. It went against the advice from the peak bodies for doctors, psychiatrists and psychologists, respectively. And Background Briefing can reveal it went against the advice of the TGAs own advisory committee. I have serious concerns about how that decision was reached, a person involved in the deliberations told Background Briefing. So, what caused the typically conservative TGA to change its mind, in a matter of months?
***
Back to Around the Web
The post Serious Concerns Over Australias Landmark Psilocybin, MDMA Ruling appeared first on Mad In America.
07:18
Determination of Rutin's antitumoral effect on EAC solid tumor. GreenMedInfo
PMID: Med Oncol. 2023 Mar 27 ;40(5):131. Epub 2023 Mar 27. PMID: 36971893 Abstract Title: Determination of Rutin's antitumoral effect on EAC solid tumor by AgNOR count and PI3K/AKT/mTOR signaling pathway. Abstract: Rutin is one of the flavonoids found in fruits and vegetables. The PI3K/AKT/mTOR signaling pathway is critical for the life cycle at the cellular level. In current study, we purposed to demonstrate the antitumoral effect of rutin at different doses through the mTOR-signaling pathway and argyrophilic nucleolar regulatory region. EAC cells were injected subcutaneously into the experimental groups. 25 and 50 mg/kg Rutin were injected intraperitoneally to the animals with solid tumors for 14 days. Immunohistochemical, Real-time PCR and AgNOR analyzes were actualized on the taken tumors. When the rutin given groups and the tumor group were compared, the tumor size increase was detected to be statistically significant (p
07:15
Rutin improves diabetes-induced muscle atrophy. GreenMedInfo
PMID: Pak J Pharm Sci. 2023 Jan ;36(1):217-221. PMID: 36967515 Abstract Title: Rutin improves diabetes-induced muscle atrophy in mice. Abstract: Muscle atrophy is a common complication in diabetes mellitus. Rutin has multiple biologic and therapeutic effects both in diabetic complications and muscle functions. However, no researches have implied prevention and treatment of rutin on muscle atrophy in diabetes mellitus. Our data demonstrated that rutin increased myocyte area and weight of gastrocnemius to promote muscular strength (p
06:55
Rutin impedes human low-density lipoprotein from non-enzymatic glycation. GreenMedInfo
PMID: Int J Biol Macromol. 2023 May 31 ;238:124151. Epub 2023 Mar 22. PMID: 36963546 Abstract Title: Rutin impedes human low-density lipoprotein from non-enzymatic glycation: A mechanistic insight against diabetes-related disorders. Abstract: Glycation of human low-density protein (LDL) has an essential contribution to cardiovascular diseases. Natural compounds like rutin have been extensively studied in preventing glycation-induced oxidative stress. This study examined rutin's anti-glycation potential with glycated LDL utilizing spectroscopic and in silico methods. Glycated LDL treated with rutin, showed around 80 % inhibition in advanced glycation end-product production. Carbonyl content and lipid peroxidation like assays were used to establish the development of oxidative stress. Rutin was seen to lower the generation of oxidative stress in a dose-dependent manner. Using thioflavin-T assay and electron microscopy, rutin was suggested to restore the structural disturbances in glycated LDL. Moreover, CD spectroscopy suggested reinstation of secondary structure of glycated LDL treated with rutin. Mechanistic insights between rutin and LDL were observed through spectroscopic measures. Molecular docking study confirmed the LDL-rutin binding with a binding energy of -10.0 kcal/mol. The rutin-LDL complex was revealed to be highly stable by molecular dynamics simulation, with RMSD, RMSF, Rg, SASA, and the secondary structure of LDL remaining essentially unchanged during the simulation period. Our study suggests that rutin possesses strong anti-glycating properties, which can be useful in therapeutics, as glycated LDL has an important role in atherosclerotic cardiovascular diseases.
06:52
New study shows the links between BMI and risk of death Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
A new study has examined whether BMI categories are linked to higher risk of death, the overweight category did not lead to excess deaths.
06:41
The role of natural flavonoids as telomerase inhibitors in suppressing cancer growth. GreenMedInfo
PMID: Pharmaceuticals (Basel). 2023 Apr 17 ;16(4). Epub 2023 Apr 17. PMID: 37111362 Abstract Title: The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth. Abstract: Cancer is a complex and multifaceted group of diseases characterized by the uncontrolled growth and spread of abnormal cells. While cancer can be challenging and life-altering, advances in research and development have led to the identification of new promising anti-cancer targets. Telomerase is one such target that is overexpressed in almost all cancer cells and plays a critical role in maintaining telomere length, which is essential for cell proliferation and survival. Inhibiting telomerase activity can lead to telomere shortening and eventual cell death, thus presenting itself as a potential target for cancer therapy. Naturally occurring flavonoids are a class of compounds that have already been shown to possess different biological properties, including the anti-cancer property. They are present in various everyday food sources and richly present in fruits, nuts, soybeans, vegetables, tea, wine, and berries, to name a few. Thus, these flavonoids could inhibit or deactivate telomerase expression in cancer cells by different mechanisms, which include inhibiting the expression of hTERT, mRNA, protein, and nuclear translocation, inhibiting the binding of transcription factors to hTERT promoters, and even telomere shortening. Numerous cell line studies and in vivo experiments have supported this hypothesis, and this development could serve as a vital and innovative therapeutic option for cancer. In this light, we aim to elucidate the role of telomerase as a potential anti-cancer target. Subsequently, we have illustrated that how commonly found natural flavonoids demonstrate their anti-cancer activity via telomerase inactivation in different cancer types, thus proving the potential of these naturally occurring flavonoids as useful therapeutic agents.
06:38
Epigallocatechin-3-gallate alleviates liver oxidative damage caused by iron overload. GreenMedInfo
PMID: Nutrients. 2023 Apr 21 ;15(8). Epub 2023 Apr 21. PMID: 37111212 Abstract Title: Epigallocatechin-3-Gallate Alleviates Liver Oxidative Damage Caused by Iron Overload in Mice through Inhibiting Ferroptosis. Abstract: Ferroptosis, a form of regulated cell death, has been widely explored as a novel target for the treatment of diseases. The failure of the antioxidant system can induce ferroptosis. Epigallocatechin-3-Gallate (EGCG) is a natural antioxidant in tea; however, whether EGCG can regulate ferroptosis in the treatment of liver oxidative damage, as well as the exact molecular mechanism, is unknown. Here, we discovered that iron overload disturbed iron homeostasis in mice, leading to oxidative stress and damage in the liver by activating ferroptosis. However, EGCG supplementation alleviated the liver oxidative damage caused by iron overload by inhibiting ferroptosis. EGCG addition increased NRF2 and GPX4 expression and elevated antioxidant capacity in iron overload mice. EGCG administration attenuates iron metabolism disorders by upregulating FTH/L expression. Through these two mechanisms, EGCG can effectively inhibit iron overload-induced ferroptosis. Taken together, these findings suggest that EGCG is a potential ferroptosis suppressor, and may be a promising therapeutic agent for iron overload-induced liver disease.
06:29
EGCG attenuates CA1 neuronal death in the rat hippocampus following status epilepticus. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Apr 20 ;12(4). Epub 2023 Apr 20. PMID: 37107343 Abstract Title: EGCG Attenuates CA1 Neuronal Death by Regulating GPx1, NF-B S536 Phosphorylation and Mitochondrial Dynamics in the Rat Hippocampus following Status Epilepticus. Abstract: Epigallocatechin-3-gallate (EGCG) is an antioxidant that directly scavenges reactive oxygen species (ROS) and inhibits pro-oxidant enzymes. Although EGCG protects hippocampal neurons from status epilepticus (SE, a prolonged seizure activity), the underlying mechanisms are not fully understood. As the preservation of mitochondrial dynamics is essential for cell viability, it is noteworthy to elucidate the effects of EGCG on impaired mitochondrial dynamics and the related signaling pathways in SE-induced CA1 neuronal degeneration, which are yet unclear. In the present study, we found that EGCG attenuated SE-induced CA1 neuronal death, accompanied by glutathione peroxidase-1 (GPx1) induction. EGCG also abrogated mitochondrial hyperfusion in these neurons by the preservation of extracellular signal-regulated kinase 1/2 (ERK1/2)-dynamin-related protein 1 (DRP1)-mediated mitochondrial fission, independent of c-Jun-terminal kinase (JNK) activity. Furthermore, EGCG abolished SE-induced nuclear factor-B (NF-B) serine (S) 536 phosphorylation in CA1 neurons. ERK1/2 inhibition by U0126 diminished the effect of EGCG on neuroprotection and mitochondrial hyperfusion in response to SE without affecting GPx1 induction and NF-B S536 phosphorylation, indicating that the restoration of ERK1/2-DRP1-mediated fission may be required for the neuroprotective effects of EGCG against SE. Therefore, our findings suggest that EGCG may protect CA1 neurons from SE insults through GPx1-ERK1/2-DRP1 and GPx1-NF-B signaling pathways, respectively.
06:11
Epigallocatechin-3-gallate inhibits atrial fibrosis and reduces the occurrence and maintenance of atrial fibrillation. GreenMedInfo
PMID: Cardiovasc Drugs Ther. 2023 Mar 31. Epub 2023 Mar 31. PMID: 37000367 Abstract Title: Epigallocatechin-3-Gallate Inhibits Atrial Fibrosis and Reduces the Occurrence and Maintenance of Atrial Fibrillation and its Possible Mechanisms. Abstract: BACKGROUND: Atrial fibrosis is one of the main causes of the onset and recurrence of atrial fibrillation (AF), for which there is no effective treatment. The aim of this study was to investigate the effect and mechanism of epigallocatechin-3-gallate (EGCG) on AF in rats.METHODS: The rat model of AF was established by rapid pacing induction after angiotensin-II (Ang-II) induced atrial fibrosis to verify the relationship between atrial fibrosis and the AF. The expression levels of TGF-/Smad3 pathway molecules and lysyl oxidase (LOX) in AF were detected. Subsequently, EGCG was used to intervene Ang-II-induced atrial fibrosis to explore the role of EGCG in the treatment of AF and its inhibitory mechanism on fibrosis. It was further verified that EGCG inhibited the production of collagen and the expression of LOX through the TGF-/Smad3 pathway at the cellular level.RESULTS: The results showed that the induction rate and maintenance time of AF in rats increased with the increase of the degree of atrial fibrosis. Meanwhile, the expressions of Col I, Col III, molecules related to TGF-/Smad3 pathway, and LOX increased significantly in the atrial tissues of rats in the Ang-II induced group. EGCG could reduce the occurrence and maintenance time of AF by inhibiting the degree of Ang-induced rat atrial fibrosis. Cell experiments confirmed that EGCG could reduce the synthesis of collagen and the expression of LOX in cardiac fibroblast induced by Ang-II. The possible mechanism is to down-regulate the expression of genes and proteins related to the TGF-/Smad3 pathway.CONCLUSION: EGCG could downregulate the expression levels of collagen and LOX by inhibiting the TGF-/Smad3 signaling pathway, alleviating Ang-II-induced atrial fibrosis, which in turn inhibited the occurrence and curtailed the duration of AF.
06:02
Preventing persistence of HPV infection with natural molecules. GreenMedInfo
PMID: Pathogens. 2023 Mar 6 ;12(3). Epub 2023 Mar 6. PMID: 36986338 Abstract Title: Preventing Persistence of HPV Infection with Natural Molecules. Abstract: Human papillomavirus (HPV) infection is one the most common sexually transmitted infections worldwide. In most cases, the infection is temporary and asymptomatic; however, when persistent, it may lead to lesions that can evolve into cancer in both women and men. Nowadays, prophylactic vaccination is the primary preventive strategy for HPV infections, but vaccines do not cover all types of HPV strains. Scientific research has uncovered the beneficial role of some natural supplements in preventing persistent HPV infections or treating HPV-related lesions. We review the current insight into the roles of natural molecules in HPV infection with a special focus on epigallocatechin gallate (EGCG), folic acid, vitamin B12, and hyaluronic acid (HA). Specifically, EGCG from green tea extracts plays a critical role in suppressing HPV oncogenes and oncoproteins (E6/E7), which are responsible for HPV oncogenic activity and cancer development. Folic acid and vitamin B12 are essential vitamins for multiple functions in the body, and accumulating evidence suggests their importance in maintaining a high degree of methylation of the HPV genome, thus decreasing the likelihood of causing malignant lesions. HA, due to its re-epithelizing property, may prevent HPV virus entry in damaged mucosa and epithelia. Thereby, based on these premises, the combination of EGCG, folic acid, vitamin B12, and HA may be a very promising therapeutic approach to prevent HPV persistence.
06:00
Ep 492 Imagine Feeling Great and not tired Dr Ron Unfiltered Uncensored
Do you wake up tired? Are you losing hair? Are you having trouble losing weight? If this is you, tune in and hear about your thyroid and how this gland and toxins influence the powerhouses of your cells, the mitochondria.
05:38
Hyaluronic acid accelerates re-epithelialization and healing of acute cutaneous wounds. GreenMedInfo
PMID: Eur Rev Med Pharmacol Sci. 2023 Apr ;27(3 Suppl):37-45. PMID: 37129334 Abstract Title: Hyaluronic acid accelerates re-epithelialization and healing of acute cutaneous wounds. Abstract: OBJECTIVE: Hyaluronic acid has been efficient in ameliorating and supporting recovery in both chronic and acute lesions. The aim of this study was to assess the effectiveness of hyaluronic acid-based cream and gauze pads in cutaneous wounds.PATIENTS AND METHODS: This retrospective and prospective study examines the use of a 0.2% hyaluronic acid cream or gauze-pads application (Connettivina Bio). 85 patients participated in the study and were affected by wounds of different etiologies, comprising superficial trauma wounds (20), surgical sutures (15), first- and second-degree burns (15), dermabrasions (30) and ulcers of different etiologies (5). We analyzed the healing process in terms of progression and wound quality. Moreover, we performed biopsies (not on all patients) to evaluate the grade of re-epithelialization.RESULTS: We observed a reduction in the mean surface area of the wounds, precisely 456 mm2 at baseline to 147 mm2 after six weeks with an average 80% decrease in the wound surface area. No fibrin tissue was observed, and a small amount of exudate was noted in 91% of wounds. Hyaluronic acid cream and gauze-pads-based treatments were well tolerated by patients. All groups showed a decrease of inflammation with a progressive increase of collagen fibers and granulation tissue.CONCLUSIONS: The treatment with hyaluronic acid 0.2% yielded remarkable outcomes in the re-epithelialization of superficial wounds and provided favorable recovery and tolerance for patients.
05:30
Fluoride set to enter New Plymouths water supply after instruction from the Director-General of Health Fluoride Action Network
New equipment enabling fluoride to be added to the New Plymouth water supply is being put through its paces, after the Director-General of Health instructed NPDC to add fluoride by the end of July this year.
The Health (Fluoridation of Drinking Water) Amendment Bill passed in the Beehive in November 2021, removed the decision for water fluoridation away from councils to the Director-General of Health, because it is a medical issue.
The Director General of the Ministry of Health has instructed us to put fluoride into the water supply for 26,000 homes across the district and weve been testing the equipment to ensure were on track to go live at the end of this month, says NPDC Three Waters
Manager Mark Hall.
The specialised equipment allowing water to be dosed with fluoride costs around $200,000 and has been paid for by the Ministry of Health.
The New Plymouth water supply services homes and businesses in Omata, New Plymouth, Bell Block, Waitara, Lepperton, Tikorangi, Onaero and Urenui.
Ministry of Health advice is that fluoride is a natural substance that helps to prevent tooth decay.
Fluoride has no taste or smell so residents will not notice any difference to their drinking water.
NPDC has not been advised by the Ministry if the Inglewood, ??kura and ?kato water supplies will also need fluoridating in the future.
Fast facts
- NPDC provides four public water supplies across the district.
- NPDC is one of 14 councils given the directive to add fluoride by the end of the month.
- The New Plymouth supply was fluoridated until 2011 following a decision by the elected council to remove it. The remaining three supplies have never been fluoridated.
- The districts four water supplies provide about 28 million litres of water per day to just under 28,000 homes and businesses.
- About 90% of that volume comes from the New Plymouth Water Treatment Plant.
Caption: NPDCs Clive Fleming installs some of the equipment that will introduce fluoride into New Plymouths water supply the end of this month.
FREQUENTLY ASKED QUESTIONS
Why do we need fluoridated water?
The Ministry of Health (MOH) considers fluoride in drinking water as a safe and effective way to prevent tooth decay among Kiwis.
The passing of the Health (Fluoridation of Drinking Water) Amendm...
05:13
Hyaluronic acid-based nanosystems for CD44 mediated anti-inflammatory and antinociceptive activity. GreenMedInfo
PMID: Int J Mol Sci. 2023 Apr 14 ;24(8). Epub 2023 Apr 14. PMID: 37108462 Abstract Title: Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity. Abstract: The nervous and immune systems go hand in hand in causing inflammation and pain. However, the two are not mutually exclusive. While some diseases cause inflammation, others are caused by it. Macrophages play an important role in modulating inflammation to trigger neuropathic pain. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a well-known ability to bind with the cluster of differentiation 44 (CD44) receptor on classically activated M1 macrophages. Resolving inflammation by varying the molecular weight of HA is a debated concept. HA-based drug delivery nanosystems such as nanohydrogels and nanoemulsions, targeting macrophages can be used to relieve pain and inflammation by loading antinociceptive drugs and enhancing the effect of anti-inflammatory drugs. This review will discuss the ongoing research on HA-based drug delivery nanosystems regarding their antinociceptive and anti-inflammatory effects.
04:54
Vitamin B12 alleviates myocardial ischemia/reperfusion injury. GreenMedInfo
PMID: Biomed Pharmacother. 2023 Jul ;163:114761. Epub 2023 Apr 29. PMID: 37126929 Abstract Title: Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Abstract: AIM: To examine the protective effect of vitamin B12 against myocardial ischemia/reperfusion (I/R) injury and elucidate its underlying mechanism of action.METHODS: Mice were subjected to myocardial I/R injury by left anterior descending coronary artery (LAD) occlusion followed by 24 h reperfusion. Cardiac function and injury were evaluated by echocardiography, triphenyl tetrazolium chloride (TTC) and cardiac troponin T (cTnT) staining, and measuring lactate dehydrogenase (LDH) levels. In addition, various molecular and biochemical methods, as well as RNA sequencing were used to determine the effects and mechanism of action of vitamin B12 on I/R injury.RESULTS: We found that high doses of vitamin B12 inhibited myocardial I/R injury. Furthermore, our data indicated that vitamin B12 supplementation alleviated cardiac dysfunction and injury by mitigating oxidative stress and apoptosis through downregulation of Nox2, the Ac-SOD2/SOD2 and Bax/Bcl-2 ratios and cleaved caspase-3 expression, and upregulation of SIRT3 expression and AMPK activity. However, these effects were largely reversed following treatment with the SIRT3 inhibitor, 3-TYP. Our RNA-sequencing data further demonstrated that vitamin B12 supplementation reduced inflammation during I/R injury.CONCLUSION: High doses of vitamin B12 supplements improved myocardial I/R injury by suppressing the accumulation of reactive oxygen species and apoptosis of myocardial tissue through modulation of the SIRT3/AMPK signaling pathway, while reducing inflammation. Our findings suggested that vitamin B12 administered at high doses could be a potential therapy for myocardial I/R damage.
04:28
Vitamin B12 is a potential strategy and treatment for epilepsy and other related epileptogenesis activities. GreenMedInfo
PMID: Cureus. 2023 Mar ;15(3):e35929. Epub 2023 Mar 9. PMID: 37050999 Abstract Title: The Effect of High-Dose Methyl Vitamin B12 Therapy on Epileptogenesis in Rats: An In Vivo Study. Abstract: Introduction Epileptogenesis has been considered one of the most prevalent diseases affecting significant numbers of individuals worldwide. Since vitamin B12 has been reported to possess antiepileptic effects, this supports that vitamin B12 deficiency is correlated to seizure occurrence. Hence, this study aimed to evaluate the neuroprotective effects of vitamin B12 injection on pentylenetetrazole (PTZ)-induced rats. Methods The study was performed using 40 adult female Sprague-Dawley rats (~250 g). A 45 mg/kg PTZ was intraperitoneally injected into rat models to induce seizure effects. Different groups of rat models received methyl vitamin B12 therapy at different dosages, a low dosage of 45g/kg and a high dosage of 85g/kg, at different pre-treatment periods, one day and two weeks prior to PTZ injection. A control group, which received only PTZ injection, served as a reference. The seizure latency, seizure intensity, and differences in the quality of seizures and their characteristics, from simple twitches to complete seizures, were observed after 30 minutes of PTZ injection. Results In general, the latency to convulsion significantly increased when vitamin B12 pre-treatment was employed. The longest latency time (LT) of 520.6373.83 seconds was observed when a high dosage of vitamin B12 at 85g/kg was injected one day prior to PTZ inoculation, which was significantly higher than that of the control group at 176.8862.67 seconds (P
02:41
Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19. GreenMedInfo
PMID: Front Immunol. 2023 ;14:1048790. Epub 2023 Mar 13. PMID: 36993968 Abstract Title: Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19methyl-dependent changes in epigenetic markings. Abstract: COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory genesmethyl-dependent epigenetic mechanisms. In this work, whole blood cultures from moderate or severe COVID-19 patients were used to assess the potential of B12 as adjuvant drug. The vitamin normalized the expression of a panel of inflammatory genes still dysregulated in the leukocytes despite glucocorticoid therapy during hospitalization. B12 also increased the flux of the sulfur amino acid pathway, that regulates the bioavailability of methyl. Accordingly, B12-induced downregulation ofstrongly and negatively correlated with the hypermethylation of CpGs in its regulatory regions. Transcriptome analysis revealed that B12 attenuates the effects of COVID-19 on most inflammation-related pathways affected by the disease. As far as we are aware, this is the first study to demonstrate that pharmacological modulation of epigenetic markings in leukocytes favorably regulates central components of COVID-19 physiopathology.
02:33
High burden of vitamin B12 deficiency among adults and elderly. GreenMedInfo
PMID: J Nepal Health Res Counc. 2023 Mar 10 ;20(3):702-707. Epub 2023 Mar 10. PMID: 36974860 Abstract Title: High Burden of Vitamin B12 Deficiency among Adults and Elderly. Abstract: BACKGROUND: Deficiency of vitamin-B12 is widespread. Adults and the elderly are particularly susceptible to vitamin-B12 deficiency. This study investigated the burden of vitamin-B12 deficiency and insufficiency among adults and the elderly attending a tertiary care hospital in Nepal.METHODS: This is a retrospective chart review conducted at Dhulikhel hospital. We reviewed records of 1615 patients investigating Vitamin-B12 level (pmol/L) at the clinical biochemistry laboratory from laboratory management database MIDAS between June 2020 and December 2021. Vitamin-B12 level was measured using enzyme immunoassay in Abbott Architect i1000SR analyzer. The categorical variables are presented as frequency and percentage; and numerical variables as means and standard deviations, or median and Interquartile range. Pearson Chi-square test was used to determine association between categorical variables. Mann Whitney test and Kruskal Wallis H test were used to compare Vitamin-B12 level by categories.RESULTS: There were 1454 participants of which 33.5% of the patients were deficient, 27.9% were borderline deficient, while 38.7% had adequate vitamin B12 levels. Young adults(170.4 pmol/L) had a lower median vitamin B12 level than middle-aged adults (183.7pmol/L) and the elderly population (247.9pmol/L) (P
Tuesday, 11 July
23:00
Morning Coffee Jul 11 Dr. Tenpenny
07-11-2023 Audio Track: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-11-23-MorningCoffee.mp4 If you enjoyed this show, and want to join us live for []
09:00
On Your Health-Jul 10 2023 Robert Workman & Bill Bathgate Dr. Tenpenny
07-10-2023 Listen to audio of interview here. Click on the video below to watch this episode: https://drtenpenny.b-cdn.net/2023/07-10-23-OYH-EMF.mp4 Do you experience any of these symptoms? Are you aware of []
00:04
Millions Against Medical Mandates Presents The Truth Trilogy Video Series Age of Autism The Rebel Alliance!
Today, we present Truth Trilogy from Millions Against Medical
Mandates. The three video topics are FOOD, TOXINS and VACCINES.
From MAMM:
The Truth Trilogy is a series
like no other!
Thanks to the support from the Centner foundation, MAM was able to
curate the most relevant information related to the toxic truth
about food, environmental toxins, and vaccines.
Focused on solutions, yet covering all the relevant facts, this
series serves to both educate and enlighten.
We offer this at no charge and ask that you share it widely. It can
be used in classrooms, discussion groups, and for patient education
at health and wellness centers, etc.
The Truth Trilogy is meant to be
a progressive series with each presentation designed to build on
the next.
Please enjoy and share this series with people
who may not be as awakened, or as informed, as you are - so
together we can create a healthier tomorrow!
VIEW THE SERIES
HERE
The Toxic Truth About Food
Whats all this talk about the importance of whole, unprocessed, organic food in order to maximize your health, strengthen your immune system to fight off infections (any infection!) and prevent chronic illness? Is it true? Is improving your diet really worth the effort?
Unequivocally.the answer to these questions is YES!
In this entertaining and educational, hour-long presentation, we (a nurse, a teacher, and a masters level holistic nutritionist) will take you on a journey. We will go back in time and discover how our food lost its nutritional value, and how the food and chemical industries used clever advertising, propaganda, and persuas...