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Wednesday, 12 July
21:59
FDA Approves Leqembi for Alzheimers Science-Based Medicine
FDA upgrades Leqembi for AD from accelerated to traditional approval based on latest clinical data.
The post FDA Approves Leqembi for Alzheimers first appeared on Science-Based Medicine.20:01
We Have a Neck: Psychiatrist James Greenblatt on The Links Between Body and Brain Mad In America
James Greenblatt is an innovator and longtime authority in the fields of integrative medicine and functional psychiatry, focusing on nutrition and other natural modes of treatment for people in distressincluding teens with eating disorders and children and adults diagnosed with ADHD.
Hes the author of eight books, most recently on antidepressant withdrawal, and the founder of the website PsychiatryRedefined.orgwhere he works to educate his colleagues/professionals on the science and practice of functional, integrative, and metabolic psychiatry.
Greenblatt serves as Chief Medical Officer and Vice President of Medical Services at Walden Behavioral Care, which is based in Massachusetts. He teaches at the Tufts University School of Medicine and the Dartmouth College School of Medicine.
The transcript below has been edited for length and clarity. Listen to the audio of the interview here.
Amy Biancolli: Dr. Greenblatt, welcome. Glad to have you here today.
James Greenblatt: Thank you, Amy. Its good to be with you.
Biancolli: I have a lot of questions today, because youve done so much interesting work. But for a start, for our listeners, could you define functional medicine and integrative psychiatry? And how do those approaches differ from conventional psychiatry? What do people need to know going into this conversation about what you do and how it differs?
Greenblatt: Good start. We can have three buckets here. Conventional psychiatry, were all quite aware of, is pretty much a symptomatic-based polypharmacy treatment model. We have one tool and its a medicine for a symptom. The second, third and fourth medicine, I think were all aware of that, and the limitations of that. We throw in psychotherapy, but the model is medications.
Integrative medicine, which has gained steam over the last 30 years, includes the terms like mindfulness and yoga and lifestyle and exercise, and diet. All these terms that the consumers had to push forward and finally have been embraced by our medical establishmentand thats great news. We have mindfulness trainings at Harvard and Stanford, and we have lifestyle fellowships for doctors, but...
20:00
Patients Express Anger at Doctors Ignorance About Antidepressant Withdrawal Effects Mad In America
Despite the astonishing increase in the prescribing and long-term use of antidepressants, many medical professionals remain ignorant of how to support patients in safely discontinuing antidepressant drugs and navigating withdrawal symptoms.
A recently published study highlights the frustration felt by antidepressant users who have suffered from a lack of professional support and suggestions for how doctors and healthcare systems can better support people coming off of antidepressants.
Although helpful for some, antidepressants can have adverse side effects prompting many to discontinue their antidepressants. This process, however, is described as severely challenging because of antidepressant withdrawal or the physical and emotional symptoms that can emerge days, weeks or months after stopping antidepressants, which sometimes surpass the problems for which the drugs were prescribed.
This difficult process and the well-documented lack of support by health professionals have forced patients to seek advice from online peer support groups, where people share their lived experiences of antidepressant withdrawal and provide support to others.
The need for support is not surprising since it is estimated that approximately half of the tens of millions of people taking antidepressants will experience withdrawal symptoms when they try to reduce or come off them, write researchers John Read, Mark Horowitz, Joanna Moncrieff, and Stevie Lewis, who has experience of withdrawal from antidepressants and is a member of The Lived Experience Advisory Panel for Prescribed Drug Dependence.
To inform health services about which supports are
most needed during the process of reducing or discontinuing
antidepressants, an anonymous survey was administered to members of
online withdrawal support groups. Seven hundred eight members
completed the following sentence: A public health service to help
people come off antidepressants should include.
The team of researchers reviewed al...
20:00
The new retraction record holder is a German anesthesiologist, with 184 Retraction Watch
The German anesthesiologist Joachim Boldt has lost 20 more papers since January 2023, earning him the top spot in our leaderboard, with 184 retractions.
Boldt, readers may recall, was once one of the leading international figures in perioperative medicine. His work, particularly studies involving the use of fluid management during surgery, helped inform clinical guidelines that, thanks to his misdeeds, some experts believe may have put patients at risk for serious harm and even death.
Boldt has vaulted over another anesthesiologist, Yoshitaka Fujii, to take the crown (more on that in a moment) although one might fairly ask: Why did it take so long?
The bulk of the recently retracted papers appeared in Intensive Care Medicine, a European title published by Springer Nature. Since March, the journal has pulled 15 articles by Boldt, whose misdeeds including but not limited to fabrication of data and lack of ethics approval in his clinical trials first came to light in 2010. Five more came in the journal Chest.
Heres one notice, for Right ventricular function and cardiac surgery, which Intensive Care Medicine published in June 1988. (Note that the statement from Justus Liebig University dates to 2020.)
The Editor-in-Chief has retracted th...
10:36
Vasorelaxant effect of Moroccan Cannabis sativa threshing residues on rat mesenteric arterial bed is endothelium and muscarinic receptors dependent. GreenMedInfo
PMID: Evid Based Complement Alternat Med. 2023 ;2023:1265103. Epub 2023 Apr 20. PMID: 37123084 Abstract Title: Vasorelaxant Effect of MoroccanThreshing Residues on Rat Mesenteric Arterial Bed is Endothelium and Muscarinic Receptors Dependent. Abstract: INTRODUCTION: Ethanolic fraction of Moroccanthreshing residues (EFCS) was evaluated for its vasorelaxant activity. The current work aims to identify the active metabolites in the ethanolic fraction of the EFCS and illustrate their mechanism of action.METHODS: Free radical scavenging capacity of EFCS was assessed using DPPH method. The EFCS vasodilation activities in phenylephrine-precontracted isolated rat mesenteric arterial beds were investigated in presence of L-NAME (nitric oxide synthase inhibitor), indomethacin (cyclooxygenase inhibitor), potassium channel blockers (namely tetraetylamonium, barium chloride, and glibenclamide), and atropine. Nitric oxide vascular release was measured by electron paramagnetic resonance (EPR) using a spin trap in rat aortic rings.RESULTS: EFCS induced dose-dependent vasorelaxation on mesenteric vascular bed. Incubation of the preparations with L-NAME, ODQ (a soluble guanylyl cyclase inhibitor), or potassium channel blockers reduced the fall of perfusion pressure caused by EFCS. Endothelial denudation or atropine abolished the EFCS's vasorelaxant effect, suggesting involvement of muscarinic receptors and endothelium-relaxing factors. The extract induced nitric oxide release in aortic rings in a similar manner as acetylcholine suggesting an effect of EFCS on the muscarinic receptor and the conductance arteries. Chemical investigation of EFCS identified potential active components namely apigenin and derivatives of luteolin skeleton and also additional components such as neophytadiene, squalene, and-sitosterol. In conclusion, the vasorelaxant effect of EFCS on rat mesenteric arterial bed, which is dependent of muscarinic receptor activation, nitric oxide, and EDHF, can account for potential therapeutic use against high blood pressure related cardiovascular diseases.
10:13
Medical cannabis is effective for cancer-related pain: Quebec Cannabis Registry results. GreenMedInfo
PMID: BMJ Support Palliat Care. 2023 May 2. Epub 2023 May 2. PMID: 37130724 Abstract Title: Medical cannabis is effective for cancer-related pain: Quebec Cannabis Registry results. Abstract: OBJECTIVES: To evaluate the safety and effectiveness of medical cannabis (MC) in reducing pain and concurrent medications in patients with cancer.METHODS: This study analysed data collected from patients with cancer who were part of the Quebec Cannabis Registry. Brief Pain Inventory (BPI), revised Edmonton Symptom Assessment System (ESAS-r) questionnaires, total medication burden (TMB) and morphine equivalent daily dose (MEDD) recorded at 3-month, 6-month, 9-month and 12-month follow-ups were compared with baseline values. Adverse events were also documented at each follow-up visit.RESULTS: This study included 358 patients with cancer. Thirteen out of 15 adverse events reported in 11 patients were not serious; 2 serious events (pneumonia and cardiovascular event) were considered unlikely related to MC. Statistically significant decreases were observed at 3-month, 6-month and 9-month follow-up for BPI worst pain (5.50.7 baseline, 3.60.7, 3.60.7, 3.60.8; p
10:00
Baking Soda Inexpensive Treatment for Autoimmune Diseases Articles
Editor's Note: This article is a reprint. It was originally published May 7, 2018.
Baking soda (sodium bicarbonate or NaHCO3), popularized by Arm & Hammer more than 150 years ago, is a staple in many homes for baking and cleaning purposes, but this inexpensive ingredient also has a number of medicinal uses and benefits. It rates right up there with hydrogen peroxide as one of the most inexpensive and safe health tools around, so it makes sense to learn all you can about the many uses of baking soda.
It's commonly known to have alkalinizing, antacid and electrolyte replacement properties.1 When taken internally, baking soda is thought to raise the pH of your blood. This appears to be the basic premise behind its recommended use against colds and influenza symptoms, recounted in a 1924 Arm & Hammer booklet on the medical uses of baking soda.2,3
Long-distance runners have also engaged in a practice known as "soda doping" taking baking soda capsules before races to enhance performance a measure thought to work similarly to carbohydrate loading. In this case, by increasing the pH of your blood, this practice is thought to offset the acidity produced in muscles during intense activity. While I do not suggest or recommend you try this at home, use of baking soda has also been shown to improve speed among swimmers.4
Research5 has also shown drinking baking soda solution can help pregnant women who are having a slow or difficult labor to avoid C-sections in about 20% of cases by neutralizing acid in their womb. This could spell the difference between life and death in developing countries and/or instances where C-section is not an option.
Baking Soda May Be an Inexpensive Treatment
More recently, research funded by the National Institutes of Health suggests baking soda may be an effective treatment adjunct for rheumatoid arthritis (RA) and other autoimmune diseases. According to this study,6,7 led by renal physiologist Paul O'Connor and published in The Journal of Immunology, drinking a solution of water and baking soda appears to prime your immune system against inflammation.
Baking soda dose is about 1/2 tsp to 1 tsp a few times a day. I personally take 3/4 tsp three times a day in a four ounce glass of orange juice. You need to stir the orange juice for a chemical reaction to occur and you...
Media Continue to Lie About Gene Therapy Jab Articles
While the COVID-19 shots are referred to as vaccines, they do not meet the classical definition of a vaccine. Health authorities needed to change the definition1 to accommodate the COVID shots and shut down the argument that, as experimental gene therapies, they may be riskier than traditional vaccines.
Meanwhile, based on the U.S. Food and Drug Administrations definition2,3 of gene therapy theyre clearly gene therapies, and both Moderna4 and BioNTech5 acknowledge this in their Securities and Exchange Commission (SEC) registration statements.
In a 2014 paper,6 BioNTech founder Ugur Sahin also stated that One would expect the classification of an mRNA drug to be a biologic, gene therapy or somatic cell therapy.
Publicly, however, drug makers, regulators and, of course, the media, have been going to great lengths to make sure people dont think of them that way. Now, a peer-reviewed paper7,8 has weighed in on the controversy, stressing that mRNA COVID shots should be labeled as gene therapy.
mRNA Shots Are Gene Therapy, but Not Regulated as Such
As noted in this paper, published in the International Journal of Molecular Science, June 22, 2023:
COVID-19 vaccines were developed and approved rapidly in response to the urgency created by the pandemic. No specific regulations existed at the time they were marketed. The regulatory agencies therefore adapted them as a matter of urgency.
Now that the pandemic emergency has passed, it is time to consider the safety issues associated with this rapid approval. The mode of action of COVID-19 mRNA vaccines should classify them as gene therapy products (GTPs), but they have been excluded by regulatory agencies.9
Some of the tests they have undergone as vaccines have produced non-compliant results in terms of purity, quality and batch homogeneity. The wide and persistent biodistribution of mRNAs and their protein products, incompletely studied due to their classification as vaccines, raises safety issues.
Post-marketing studies have shown that mRNA passes into breast milk and could have adverse effects on breast-fed babies. Long-term expression, integrat...
What Causes Eye Floaters and Are They Dangerous? Articles
From time to time, most people notice small black dots or squiggly lines in their eyes that float across their vision. In a study1 of 603 people, 76% reported that they see floaters and 33% said it caused a noticeable impairment in their vision.
For some people, floaters can also appear like little cobwebs that come and go across their visual field. While most of the time floaters are only a nuisance, sometimes they can be a sign of a more serious eye condition.
These little specks in your visual field move as your eye moves. This means when you attempt to look directly at them, they seem to float away. As your eyes stop moving, they may float back into vision again. Nearly everyone will see floaters as they age, but some people have a higher risk of floaters.2 This includes people who are typically over the age of 50, nearsighted, have diabetes or have had surgery to correct cataracts.
Floaters are most obvious to a person when they are looking at a bright white object. This might include light-colored walls, the snow or a computer screen. The floaters appear as black flecks that may initially look like flies or spiders moving at the very edge of their peripheral vision.
How Do Eye Floaters Form?
The eye has two chambers that are commonly referred to as the front and the back of the eye. At the front of the eye is the cornea, which is the dome-shaped portion. Behind the cornea is a chamber filled with fluid called aqueous humor. The definition of humor is bodily fluid. The body continually produces aqueous humor that maintains pressure in the eye. This happens when the same amount of fluid is leaving the eye as is being produced.
The back of the eye is located between the lens and the retina. This is called the vitreous cavity and it is filled with vitreous humor. Vitreous humor is a gel-like substance that is more viscous than aqueous humor but continues to allow light penetration. With age, vitreous humor thins and may loosen from the retina. Floaters form when tiny collagen strands of vitreous stick together and cast a shadow over the retina. It is the shadow you see as a floater.
The vitreous humor may detach from the retina, called posterior vitreous detachment. In this case, a person experiences acute flashes and floaters, which require immediate medical attention. Flashes may look like a camera flashing or lightning.
On their own, floaters are common and do not typically need to be treated. However, when floaters and flashes appear together, it is a serious condition. Vitreous humor makes up approximately 80% of the volume of the eye and helps maintain the shape of the eye. Dr. Sarah Brewer told Mirror:3
...09:44
Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It Medical Kidnap
by Brian Shilhavy
Editor, Health Impact News
I was able to view the recently released movie Sound of Freedom in a local theater last night, which amazingly was sold out in a Monday evening showing more than a week after the films release.
The film stars Jim Caviezel playing the part of Tim Ballard, a former Special Agent for the Department of Homeland Security who was assigned to the Internet Crimes Against Children (ICAC) Task Force, and started his own organization, Operation Underground Railroad, a nonprofit focused on rescuing trafficked children.
The production of this film reportedly began more than 5 years ago, and since at least 2021, I have seen numerous interviews and articles about Jim Caviezel talking about this film along with such topics as adrenochrome, Satanic ritual abuse, organ harvesting, and other such dark topics that we have covered for the better part of a decade here at Health Impact News.
While this is definitely a good film that I recommend everyone to watch if they get a chance to, be forewarned that none of these darker topics are even addressed in this film, nor is there any real call to action with practical advice on how to actually stop child trafficking.
When I was about to leave the theater as the credits starting rolling, the screen put up a timer stating that there was a special message by Jim Caviezel after the credits.
Ah, maybe this is where Caviezel will draw in these other topics, I thought, and give some practical advice about how to stop all this.
But he didnt.
The only call to action was to get more people to view the film, with an opportunity for people to scan a QR code and donate money so that others could view the film who could not afford to.
There are some copies of this special message from Caviezel on the Internet now, and it is about 2 minutes long:
It is truly unfortunate that this film is being advertised as a Right Wing Conservative Christian film by those in the media (I dont think Caviezel or Ballard see it that way though), whe...
09:44
Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It Vaccine Impact
by Brian Shilhavy
Editor, Health Impact News
I was able to view the recently released movie Sound of Freedom in a local theater last night, which amazingly was sold out in a Monday evening showing more than a week after the films release.
The film stars Jim Caviezel playing the part of Tim Ballard, a former Special Agent for the Department of Homeland Security who was assigned to the Internet Crimes Against Children (ICAC) Task Force, and started his own organization, Operation Underground Railroad, a nonprofit focused on rescuing trafficked children.
The production of this film reportedly began more than 5 years ago, and since at least 2021, I have seen numerous interviews and articles about Jim Caviezel talking about this film along with such topics as adrenochrome, Satanic ritual abuse, organ harvesting, and other such dark topics that we have covered for the better part of a decade here at Health Impact News.
While this is definitely a good film that I recommend everyone to watch if they get a chance to, be forewarned that none of these darker topics are even addressed in this film, nor is there any real call to action with practical advice on how to actually stop child trafficking.
When I was about to leave the theater as the credits starting rolling, the screen put up a timer stating that there was a special message by Jim Caviezel after the credits.
Ah, maybe this is where Caviezel will draw in these other topics, I thought, and give some practical advice about how to stop all this.
But he didnt.
The only call to action was to get more people to view the film, with an opportunity for people to scan a QR code and donate money so that others could view the film who could not afford to.
There are some copies of this special message from Caviezel on the Internet now, and it is about 2 minutes long:
It is truly unfortunate that this film is being advertised as a Right Wing Conservative Christian film by those in the media (I dont think Caviezel or Ballard see it that way though), whe...
09:40
Retinal vascular occlusion may not be a coincidental finding after COVID-19 vaccination. GreenMedInfo
PMID: NPJ Vaccines. 2023 May 2 ;8(1):64. Epub 2023 May 2. PMID: 37130882 Abstract Title: Risk assessment of retinal vascular occlusion after COVID-19 vaccination. Abstract: Coronavirus disease 2019 (COVID-19) vaccines are associated with several ocular manifestations. Emerging evidence has been reported; however, the causality between the two is debatable. We aimed to investigate the risk of retinal vascular occlusion after COVID-19 vaccination. This retrospective cohort study used the TriNetX global network and included individuals vaccinated with COVID-19 vaccines between January 2020 and December 2022. We excluded individuals with a history of retinal vascular occlusion or those who used any systemic medication that could potentially affect blood coagulation prior to vaccination. To compare the risk of retinal vascular occlusion, we employed multivariable-adjusted Cox proportional hazards models after performing a 1:1 propensity score matching between the vaccinated and unvaccinated cohorts. Individuals with COVID-19 vaccination had a higher risk of all forms of retinal vascular occlusion in 2 years after vaccination, with an overall hazard ratio of 2.19 (95% confidence interval 2.00-2.39). The cumulative incidence of retinal vascular occlusion was significantly higher in the vaccinated cohort compared to the unvaccinated cohort, 2 years and 12 weeks after vaccination. The risk of retinal vascular occlusion significantly increased during the first 2 weeks after vaccination and persisted for 12 weeks. Additionally, individuals with first and second dose of BNT162b2 and mRNA-1273 had significantly increased risk of retinal vascular occlusion 2 years following vaccination, while no disparity was detected between brand and dose of vaccines. This large multicenter study strengthens the findings of previous cases. Retinal vascular occlusion may not be a coincidental finding after COVID-19 vaccination.
09:31
This study presents a rare case of spontaneous regression of advanced transverse colon cancer. GreenMedInfo
PMID: Surg Case Rep. 2023 Apr 25 ;9(1):64. Epub 2023 Apr 25. PMID: 37095273 Abstract Title: Spontaneous regression of advanced transverse colon cancer with deficient mismatch repair: a case report. Abstract: BACKGROUND: Spontaneous regression (SR) of cancer occurs in 1 in 60,000-100,000 patients. This phenomenon has been reported in almost all cancer types, most commonly neuroblastoma, renal cell carcinoma, malignant melanoma, and lymphoma/leukemia. However, SR in colorectal cancer (CRC) is extremely rare, particularly in advanced cases. Hence, this report describes a very rare case of spontaneous regression of advanced transverse colon cancer.CASE PRESENTATION: A 76-year-old female with anemia was diagnosed with a type II well-differentiated adenocarcinoma in the middle transverse colon. Two months later, a second colonoscopy examination was performed for preoperative marking, and it revealed tumor shrinkage and a shift to type 0-IIc morphology. Endoscopic tattooing was then performed, followed by a laparoscopic partial resection of the transverse colon with D3 lymph node dissection. However, the resected specimen contained no tumor, and colonoscopy showed no tumor remnants in the remaining colon. Histopathological examination revealed mucosal regeneration and a mucus nodule in between the submucosal and muscular layers, with no cancer cells detected. Immunohistochemical analysis revealed the loss of MutL homolog 1 (MLH1) and postmeiotic segregation increased 2 (PMS2) expression in the cancer cells of biopsied specimens, suggesting deficient mismatch repair (dMMR). The patient continues to be followed up until 6 years postoperatively, and no recurrence has been observed. In this study, we also reviewed similar reported cases of spontaneous regression of cancer involving dMMR.CONCLUSION: This study presents a rare case of spontaneous regression of advanced transverse colon cancer wherein dMMR is strongly involved. However, further accumulation of similar cases is needed to elucidate this phenomenon and to develop new treatment strategies for CRC.
09:26
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. GreenMedInfo
PMID: Commun Biol. 2023 Apr 22 ;6(1):444. Epub 2023 Apr 22. PMID: 37087494 Abstract Title: Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model. Abstract: Immunodeficient mice reconstituted with a human immune system (HIS mice) give rise to human T cells, which make them an attractive system to study human immune responses to tumors. However, such HIS mice typically exhibit sub-optimal responses to immune challenges as well as fail to develop antigen-specific B or T cell memory. Here we report HIS mice mediate spontaneous regression of human B cell lymphoma Raji. Tumor regression was dependent on CD4+ and CD8+ T cell responses and resulted in T cell memory. The T cell memory elicited was mainly Raji-specific, however some level of cross-protection was also elicited to a related B cell lymphoma cell line Ramos. Single-cell RNAseq analysis indicated activation of CD8+ T cells in regressing Raji tumors as well as clonal expansion of specific T cell receptors (TCRs). Cloning of TCRs from Raji-infiltrating T cells into a Jurkat reporter cell line showed reactivity specific for Raji tumor cells. Overall, we report a platform for studying in vivo human T cell tumor immunity by highlighting spontaneous Raji tumor regression, clonal TCR expansion, and T cell memory in HIS mice.
09:22
Spontaneous cancer remission after COVID-19. GreenMedInfo
PMID: J Transl Med. 2023 Apr 21 ;21(1):273. Epub 2023 Apr 21. PMID: 37085802 Abstract Title: Spontaneous cancer remission after COVID-19: insights from the pandemic and their relevance for cancer treatment. Abstract: Early in the COVID-19 pandemic, it emerged that the risk of severe outcomes was greater in patients with co-morbidities, including cancer. The huge effort undertaken to fight the pandemic, affects the management of cancer care, influencing their outcome. Despite the high fatality rate of COVID-19 disease in cancer patients, rare cases of temporary or prolonged clinical remission from cancers after SARS-CoV-2 infection have been reported. We have reviewed sixteen case reports of COVID-19 disease with spontaneous cancer reduction of progression. Fourteen cases of remission following viral infections and two after anti-SARS-CoV-2 vaccination. The immune response to COVID-19, may be implicated in both tumor regression, and progression. Specifically, we discuss potential mechanisms which include oncolytic and priming hypotheses, that may have contributed to the cancer regression in these cases and could be useful for future options in cancer treatment.
08:48
Sound of Freedom Film Falls Short of Revealing Who are the Ones Trafficking Children and How to Stop It Health Impact News
by Brian Shilhavy
Editor, Health Impact News
I was able to view the recently released movie Sound of Freedom in a local theater last night, which amazingly was sold out in a Monday evening showing more than a week after the films release.
The film stars Jim Caviezel playing the part of Tim Ballard, a former Special Agent for the Department of Homeland Security who was assigned to the Internet Crimes Against Children (ICAC) Task Force, and started his own organization, Operation Underground Railroad, a nonprofit focused on rescuing trafficked children.
The production of this film reportedly began more than 5 years ago, and since at least 2021, I have seen numerous interviews and articles about Jim Caviezel talking about this film along with such topics as adrenochrome, Satanic ritual abuse, organ harvesting, and other such dark topics that we have covered for the better part of a decade here at Health Impact News.
While this is definitely a good film that I recommend everyone to watch if they get a chance to, be forewarned that none of these darker topics are even addressed in this film, nor is there any real call to action with practical advice on how to actually stop child trafficking.
When I was about to leave the theater as the credits starting rolling, the screen put up a timer stating that there was a special message by Jim Caviezel after the credits.
Ah, maybe this is where Caviezel will draw in these other topics, I thought, and give some practical advice about how to stop all this.
But he didnt.
The only call to action was to get more people to view the film, with an opportunity for people to scan a QR code and donate money so that others could view the film who could not afford to.
There are some copies of this special message from Caviezel on the Internet now, and it is about 2 minutes long:
...
08:35
Rutin orotects fibroblasts from UVA radiation. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Mar 28 ;12(4). Epub 2023 Mar 28. PMID: 37107196 Abstract Title: Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway. Abstract: This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h of UVA exposure). These effects are related to rutin's ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 signaling pathway results in an increase in reduced glutathione and Bcl2/Bax ratio, and the subsequent protection of mitochondrial respiratory capacity. These results demonstrate how rutin may play a potentially cytoprotective role against UVA-induced skin damage through a purely antiapoptotic mechanism.
08:14
Rutin could be a potential agent for muscle loss such as sarcopenia. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Mar 3 ;12(3). Epub 2023 Mar 3. PMID: 36978887 Abstract Title: Rutin Prevents Dexamethasone-Induced Muscle Loss in C2C12 Myotube and Mouse Model by Controlling FOXO3-Dependent Signaling. Abstract: One of the causes of sarcopenia is that homeostasis between anabolism and catabolism breaks down due to muscle metabolism changes. Rutin has shown antioxidant and anti-inflammatory effects in various diseases, but there are few studies on the effect on muscle loss with aging. The effect of rutin on muscle loss was evaluated using dexamethasone-induced muscle loss C2C12 myoblast and mouse model. In the group treated with dexamethasone, the muscle weight of gastrocnemius (GA), tibialis anterior (TA), and extensor digitorum longus (EDL) in the mouse model were significantly decreased (
08:00
Happy Hour with Bishop Leon Benjamin Dr. Tenpenny
07-11-2023 Listen to audio here: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-11-23-HHr-LeonBenjamin.mp4 About my guest: A native of Richmond, VA, Pastor []
07:57
Potential treatment options for neuroblastoma with polyphenols. GreenMedInfo
PMID: Biomolecules. 2023 Mar 20 ;13(3). Epub 2023 Mar 20. PMID: 36979499 Abstract Title: Potential Treatment Options for Neuroblastoma with Polyphenols through Anti-Proliferative and Apoptotic Mechanisms. Abstract: Neuroblastoma (NB) is an extracranial tumor of the peripheral nervous system arising from neural crest cells. It is the most common malignancy in infants and the most common extracranial solid tumor in children. The current treatment for high-risk NB involves chemotherapy and surgical resection followed by high-dose chemotherapy with autologous stem-cell rescue and radiation treatment. However, those with high-risk NB are susceptible to relapse and the long-term side effects of standard chemotherapy. Polyphenols, including the sub-class of flavonoids, contain more than one aromatic ring with hydroxyl groups. The literature demonstrates their utility in inducing the apoptosis of neuroblastoma cells, mostly in vitro and some in vivo. This review explores the use of various polyphenols outlined in primary studies, underlines the pathways involved in apoptotic activity, and discusses the dosage and delivery of these polyphenols. Primary studies were obtained from multiple databases with search the terms "neuroblastoma", "flavonoid", and "apoptosis". The in vitro studies showed that polyphenols exert an apoptotic effect on several NB cell lines. These polyphenols include apigenin, genistein, didymin, rutin, quercetin, curcumin, resveratrol, butein, bisphenols, and various plant extracts. The mechanisms of the therapeutic effects include calpain-dependent pathways, receptor-mediated apoptosis, and, notably, and most frequently, mitochondrial apoptosis pathways, including the mitochondrial proteins Bax and Bcl-2. Overall, polyphenols demonstrate potency in decreasing NB proliferation and inducing apoptosis, indicating significant potential for further in vivo research.
07:50
Serious Concerns Over Australias Landmark Psilocybin, MDMA Ruling Mad In America
From Australian Broadcasting Corporation: Over the six months that Andrew was undergoing therapy, Australias peak medical regulator was evaluating an application to reclassify psilocybin and MDMA (the compound in Ecstasy) as medicines. It had knocked back a similar proposal just the year before. So when it decided in February to become the first country in the world to approve such a change, it shocked even those who had proposed it.
. . . As recently as October last year, the TGA ruled that there was insufficient evidence to down-schedule the drugs. But just months later, in February, it did a spectacular 180-degree turn and approved psychiatrists to use MDMA for PTSD and psilocybin for treatment-resistant depression.
That move divided the psychiatric community. It went against the advice from the peak bodies for doctors, psychiatrists and psychologists, respectively. And Background Briefing can reveal it went against the advice of the TGAs own advisory committee. I have serious concerns about how that decision was reached, a person involved in the deliberations told Background Briefing. So, what caused the typically conservative TGA to change its mind, in a matter of months?
***
Back to Around the Web
The post Serious Concerns Over Australias Landmark Psilocybin, MDMA Ruling appeared first on Mad In America.
07:18
Determination of Rutin's antitumoral effect on EAC solid tumor. GreenMedInfo
PMID: Med Oncol. 2023 Mar 27 ;40(5):131. Epub 2023 Mar 27. PMID: 36971893 Abstract Title: Determination of Rutin's antitumoral effect on EAC solid tumor by AgNOR count and PI3K/AKT/mTOR signaling pathway. Abstract: Rutin is one of the flavonoids found in fruits and vegetables. The PI3K/AKT/mTOR signaling pathway is critical for the life cycle at the cellular level. In current study, we purposed to demonstrate the antitumoral effect of rutin at different doses through the mTOR-signaling pathway and argyrophilic nucleolar regulatory region. EAC cells were injected subcutaneously into the experimental groups. 25 and 50 mg/kg Rutin were injected intraperitoneally to the animals with solid tumors for 14 days. Immunohistochemical, Real-time PCR and AgNOR analyzes were actualized on the taken tumors. When the rutin given groups and the tumor group were compared, the tumor size increase was detected to be statistically significant (p
07:15
Rutin improves diabetes-induced muscle atrophy. GreenMedInfo
PMID: Pak J Pharm Sci. 2023 Jan ;36(1):217-221. PMID: 36967515 Abstract Title: Rutin improves diabetes-induced muscle atrophy in mice. Abstract: Muscle atrophy is a common complication in diabetes mellitus. Rutin has multiple biologic and therapeutic effects both in diabetic complications and muscle functions. However, no researches have implied prevention and treatment of rutin on muscle atrophy in diabetes mellitus. Our data demonstrated that rutin increased myocyte area and weight of gastrocnemius to promote muscular strength (p
06:55
Rutin impedes human low-density lipoprotein from non-enzymatic glycation. GreenMedInfo
PMID: Int J Biol Macromol. 2023 May 31 ;238:124151. Epub 2023 Mar 22. PMID: 36963546 Abstract Title: Rutin impedes human low-density lipoprotein from non-enzymatic glycation: A mechanistic insight against diabetes-related disorders. Abstract: Glycation of human low-density protein (LDL) has an essential contribution to cardiovascular diseases. Natural compounds like rutin have been extensively studied in preventing glycation-induced oxidative stress. This study examined rutin's anti-glycation potential with glycated LDL utilizing spectroscopic and in silico methods. Glycated LDL treated with rutin, showed around 80 % inhibition in advanced glycation end-product production. Carbonyl content and lipid peroxidation like assays were used to establish the development of oxidative stress. Rutin was seen to lower the generation of oxidative stress in a dose-dependent manner. Using thioflavin-T assay and electron microscopy, rutin was suggested to restore the structural disturbances in glycated LDL. Moreover, CD spectroscopy suggested reinstation of secondary structure of glycated LDL treated with rutin. Mechanistic insights between rutin and LDL were observed through spectroscopic measures. Molecular docking study confirmed the LDL-rutin binding with a binding energy of -10.0 kcal/mol. The rutin-LDL complex was revealed to be highly stable by molecular dynamics simulation, with RMSD, RMSF, Rg, SASA, and the secondary structure of LDL remaining essentially unchanged during the simulation period. Our study suggests that rutin possesses strong anti-glycating properties, which can be useful in therapeutics, as glycated LDL has an important role in atherosclerotic cardiovascular diseases.
06:52
New study shows the links between BMI and risk of death Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
A new study has examined whether BMI categories are linked to higher risk of death, the overweight category did not lead to excess deaths.
06:41
The role of natural flavonoids as telomerase inhibitors in suppressing cancer growth. GreenMedInfo
PMID: Pharmaceuticals (Basel). 2023 Apr 17 ;16(4). Epub 2023 Apr 17. PMID: 37111362 Abstract Title: The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth. Abstract: Cancer is a complex and multifaceted group of diseases characterized by the uncontrolled growth and spread of abnormal cells. While cancer can be challenging and life-altering, advances in research and development have led to the identification of new promising anti-cancer targets. Telomerase is one such target that is overexpressed in almost all cancer cells and plays a critical role in maintaining telomere length, which is essential for cell proliferation and survival. Inhibiting telomerase activity can lead to telomere shortening and eventual cell death, thus presenting itself as a potential target for cancer therapy. Naturally occurring flavonoids are a class of compounds that have already been shown to possess different biological properties, including the anti-cancer property. They are present in various everyday food sources and richly present in fruits, nuts, soybeans, vegetables, tea, wine, and berries, to name a few. Thus, these flavonoids could inhibit or deactivate telomerase expression in cancer cells by different mechanisms, which include inhibiting the expression of hTERT, mRNA, protein, and nuclear translocation, inhibiting the binding of transcription factors to hTERT promoters, and even telomere shortening. Numerous cell line studies and in vivo experiments have supported this hypothesis, and this development could serve as a vital and innovative therapeutic option for cancer. In this light, we aim to elucidate the role of telomerase as a potential anti-cancer target. Subsequently, we have illustrated that how commonly found natural flavonoids demonstrate their anti-cancer activity via telomerase inactivation in different cancer types, thus proving the potential of these naturally occurring flavonoids as useful therapeutic agents.
06:38
Epigallocatechin-3-gallate alleviates liver oxidative damage caused by iron overload. GreenMedInfo
PMID: Nutrients. 2023 Apr 21 ;15(8). Epub 2023 Apr 21. PMID: 37111212 Abstract Title: Epigallocatechin-3-Gallate Alleviates Liver Oxidative Damage Caused by Iron Overload in Mice through Inhibiting Ferroptosis. Abstract: Ferroptosis, a form of regulated cell death, has been widely explored as a novel target for the treatment of diseases. The failure of the antioxidant system can induce ferroptosis. Epigallocatechin-3-Gallate (EGCG) is a natural antioxidant in tea; however, whether EGCG can regulate ferroptosis in the treatment of liver oxidative damage, as well as the exact molecular mechanism, is unknown. Here, we discovered that iron overload disturbed iron homeostasis in mice, leading to oxidative stress and damage in the liver by activating ferroptosis. However, EGCG supplementation alleviated the liver oxidative damage caused by iron overload by inhibiting ferroptosis. EGCG addition increased NRF2 and GPX4 expression and elevated antioxidant capacity in iron overload mice. EGCG administration attenuates iron metabolism disorders by upregulating FTH/L expression. Through these two mechanisms, EGCG can effectively inhibit iron overload-induced ferroptosis. Taken together, these findings suggest that EGCG is a potential ferroptosis suppressor, and may be a promising therapeutic agent for iron overload-induced liver disease.
06:29
EGCG attenuates CA1 neuronal death in the rat hippocampus following status epilepticus. GreenMedInfo
PMID: Antioxidants (Basel). 2023 Apr 20 ;12(4). Epub 2023 Apr 20. PMID: 37107343 Abstract Title: EGCG Attenuates CA1 Neuronal Death by Regulating GPx1, NF-B S536 Phosphorylation and Mitochondrial Dynamics in the Rat Hippocampus following Status Epilepticus. Abstract: Epigallocatechin-3-gallate (EGCG) is an antioxidant that directly scavenges reactive oxygen species (ROS) and inhibits pro-oxidant enzymes. Although EGCG protects hippocampal neurons from status epilepticus (SE, a prolonged seizure activity), the underlying mechanisms are not fully understood. As the preservation of mitochondrial dynamics is essential for cell viability, it is noteworthy to elucidate the effects of EGCG on impaired mitochondrial dynamics and the related signaling pathways in SE-induced CA1 neuronal degeneration, which are yet unclear. In the present study, we found that EGCG attenuated SE-induced CA1 neuronal death, accompanied by glutathione peroxidase-1 (GPx1) induction. EGCG also abrogated mitochondrial hyperfusion in these neurons by the preservation of extracellular signal-regulated kinase 1/2 (ERK1/2)-dynamin-related protein 1 (DRP1)-mediated mitochondrial fission, independent of c-Jun-terminal kinase (JNK) activity. Furthermore, EGCG abolished SE-induced nuclear factor-B (NF-B) serine (S) 536 phosphorylation in CA1 neurons. ERK1/2 inhibition by U0126 diminished the effect of EGCG on neuroprotection and mitochondrial hyperfusion in response to SE without affecting GPx1 induction and NF-B S536 phosphorylation, indicating that the restoration of ERK1/2-DRP1-mediated fission may be required for the neuroprotective effects of EGCG against SE. Therefore, our findings suggest that EGCG may protect CA1 neurons from SE insults through GPx1-ERK1/2-DRP1 and GPx1-NF-B signaling pathways, respectively.
06:11
Epigallocatechin-3-gallate inhibits atrial fibrosis and reduces the occurrence and maintenance of atrial fibrillation. GreenMedInfo
PMID: Cardiovasc Drugs Ther. 2023 Mar 31. Epub 2023 Mar 31. PMID: 37000367 Abstract Title: Epigallocatechin-3-Gallate Inhibits Atrial Fibrosis and Reduces the Occurrence and Maintenance of Atrial Fibrillation and its Possible Mechanisms. Abstract: BACKGROUND: Atrial fibrosis is one of the main causes of the onset and recurrence of atrial fibrillation (AF), for which there is no effective treatment. The aim of this study was to investigate the effect and mechanism of epigallocatechin-3-gallate (EGCG) on AF in rats.METHODS: The rat model of AF was established by rapid pacing induction after angiotensin-II (Ang-II) induced atrial fibrosis to verify the relationship between atrial fibrosis and the AF. The expression levels of TGF-/Smad3 pathway molecules and lysyl oxidase (LOX) in AF were detected. Subsequently, EGCG was used to intervene Ang-II-induced atrial fibrosis to explore the role of EGCG in the treatment of AF and its inhibitory mechanism on fibrosis. It was further verified that EGCG inhibited the production of collagen and the expression of LOX through the TGF-/Smad3 pathway at the cellular level.RESULTS: The results showed that the induction rate and maintenance time of AF in rats increased with the increase of the degree of atrial fibrosis. Meanwhile, the expressions of Col I, Col III, molecules related to TGF-/Smad3 pathway, and LOX increased significantly in the atrial tissues of rats in the Ang-II induced group. EGCG could reduce the occurrence and maintenance time of AF by inhibiting the degree of Ang-induced rat atrial fibrosis. Cell experiments confirmed that EGCG could reduce the synthesis of collagen and the expression of LOX in cardiac fibroblast induced by Ang-II. The possible mechanism is to down-regulate the expression of genes and proteins related to the TGF-/Smad3 pathway.CONCLUSION: EGCG could downregulate the expression levels of collagen and LOX by inhibiting the TGF-/Smad3 signaling pathway, alleviating Ang-II-induced atrial fibrosis, which in turn inhibited the occurrence and curtailed the duration of AF.
06:02
Preventing persistence of HPV infection with natural molecules. GreenMedInfo
PMID: Pathogens. 2023 Mar 6 ;12(3). Epub 2023 Mar 6. PMID: 36986338 Abstract Title: Preventing Persistence of HPV Infection with Natural Molecules. Abstract: Human papillomavirus (HPV) infection is one the most common sexually transmitted infections worldwide. In most cases, the infection is temporary and asymptomatic; however, when persistent, it may lead to lesions that can evolve into cancer in both women and men. Nowadays, prophylactic vaccination is the primary preventive strategy for HPV infections, but vaccines do not cover all types of HPV strains. Scientific research has uncovered the beneficial role of some natural supplements in preventing persistent HPV infections or treating HPV-related lesions. We review the current insight into the roles of natural molecules in HPV infection with a special focus on epigallocatechin gallate (EGCG), folic acid, vitamin B12, and hyaluronic acid (HA). Specifically, EGCG from green tea extracts plays a critical role in suppressing HPV oncogenes and oncoproteins (E6/E7), which are responsible for HPV oncogenic activity and cancer development. Folic acid and vitamin B12 are essential vitamins for multiple functions in the body, and accumulating evidence suggests their importance in maintaining a high degree of methylation of the HPV genome, thus decreasing the likelihood of causing malignant lesions. HA, due to its re-epithelizing property, may prevent HPV virus entry in damaged mucosa and epithelia. Thereby, based on these premises, the combination of EGCG, folic acid, vitamin B12, and HA may be a very promising therapeutic approach to prevent HPV persistence.
06:00
Ep 492 Imagine Feeling Great and not tired Dr Ron Unfiltered Uncensored
Do you wake up tired? Are you losing hair? Are you having trouble losing weight? If this is you, tune in and hear about your thyroid and how this gland and toxins influence the powerhouses of your cells, the mitochondria.
05:38
Hyaluronic acid accelerates re-epithelialization and healing of acute cutaneous wounds. GreenMedInfo
PMID: Eur Rev Med Pharmacol Sci. 2023 Apr ;27(3 Suppl):37-45. PMID: 37129334 Abstract Title: Hyaluronic acid accelerates re-epithelialization and healing of acute cutaneous wounds. Abstract: OBJECTIVE: Hyaluronic acid has been efficient in ameliorating and supporting recovery in both chronic and acute lesions. The aim of this study was to assess the effectiveness of hyaluronic acid-based cream and gauze pads in cutaneous wounds.PATIENTS AND METHODS: This retrospective and prospective study examines the use of a 0.2% hyaluronic acid cream or gauze-pads application (Connettivina Bio). 85 patients participated in the study and were affected by wounds of different etiologies, comprising superficial trauma wounds (20), surgical sutures (15), first- and second-degree burns (15), dermabrasions (30) and ulcers of different etiologies (5). We analyzed the healing process in terms of progression and wound quality. Moreover, we performed biopsies (not on all patients) to evaluate the grade of re-epithelialization.RESULTS: We observed a reduction in the mean surface area of the wounds, precisely 456 mm2 at baseline to 147 mm2 after six weeks with an average 80% decrease in the wound surface area. No fibrin tissue was observed, and a small amount of exudate was noted in 91% of wounds. Hyaluronic acid cream and gauze-pads-based treatments were well tolerated by patients. All groups showed a decrease of inflammation with a progressive increase of collagen fibers and granulation tissue.CONCLUSIONS: The treatment with hyaluronic acid 0.2% yielded remarkable outcomes in the re-epithelialization of superficial wounds and provided favorable recovery and tolerance for patients.
05:13
Hyaluronic acid-based nanosystems for CD44 mediated anti-inflammatory and antinociceptive activity. GreenMedInfo
PMID: Int J Mol Sci. 2023 Apr 14 ;24(8). Epub 2023 Apr 14. PMID: 37108462 Abstract Title: Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity. Abstract: The nervous and immune systems go hand in hand in causing inflammation and pain. However, the two are not mutually exclusive. While some diseases cause inflammation, others are caused by it. Macrophages play an important role in modulating inflammation to trigger neuropathic pain. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a well-known ability to bind with the cluster of differentiation 44 (CD44) receptor on classically activated M1 macrophages. Resolving inflammation by varying the molecular weight of HA is a debated concept. HA-based drug delivery nanosystems such as nanohydrogels and nanoemulsions, targeting macrophages can be used to relieve pain and inflammation by loading antinociceptive drugs and enhancing the effect of anti-inflammatory drugs. This review will discuss the ongoing research on HA-based drug delivery nanosystems regarding their antinociceptive and anti-inflammatory effects.
04:54
Vitamin B12 alleviates myocardial ischemia/reperfusion injury. GreenMedInfo
PMID: Biomed Pharmacother. 2023 Jul ;163:114761. Epub 2023 Apr 29. PMID: 37126929 Abstract Title: Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Abstract: AIM: To examine the protective effect of vitamin B12 against myocardial ischemia/reperfusion (I/R) injury and elucidate its underlying mechanism of action.METHODS: Mice were subjected to myocardial I/R injury by left anterior descending coronary artery (LAD) occlusion followed by 24 h reperfusion. Cardiac function and injury were evaluated by echocardiography, triphenyl tetrazolium chloride (TTC) and cardiac troponin T (cTnT) staining, and measuring lactate dehydrogenase (LDH) levels. In addition, various molecular and biochemical methods, as well as RNA sequencing were used to determine the effects and mechanism of action of vitamin B12 on I/R injury.RESULTS: We found that high doses of vitamin B12 inhibited myocardial I/R injury. Furthermore, our data indicated that vitamin B12 supplementation alleviated cardiac dysfunction and injury by mitigating oxidative stress and apoptosis through downregulation of Nox2, the Ac-SOD2/SOD2 and Bax/Bcl-2 ratios and cleaved caspase-3 expression, and upregulation of SIRT3 expression and AMPK activity. However, these effects were largely reversed following treatment with the SIRT3 inhibitor, 3-TYP. Our RNA-sequencing data further demonstrated that vitamin B12 supplementation reduced inflammation during I/R injury.CONCLUSION: High doses of vitamin B12 supplements improved myocardial I/R injury by suppressing the accumulation of reactive oxygen species and apoptosis of myocardial tissue through modulation of the SIRT3/AMPK signaling pathway, while reducing inflammation. Our findings suggested that vitamin B12 administered at high doses could be a potential therapy for myocardial I/R damage.
04:28
Vitamin B12 is a potential strategy and treatment for epilepsy and other related epileptogenesis activities. GreenMedInfo
PMID: Cureus. 2023 Mar ;15(3):e35929. Epub 2023 Mar 9. PMID: 37050999 Abstract Title: The Effect of High-Dose Methyl Vitamin B12 Therapy on Epileptogenesis in Rats: An In Vivo Study. Abstract: Introduction Epileptogenesis has been considered one of the most prevalent diseases affecting significant numbers of individuals worldwide. Since vitamin B12 has been reported to possess antiepileptic effects, this supports that vitamin B12 deficiency is correlated to seizure occurrence. Hence, this study aimed to evaluate the neuroprotective effects of vitamin B12 injection on pentylenetetrazole (PTZ)-induced rats. Methods The study was performed using 40 adult female Sprague-Dawley rats (~250 g). A 45 mg/kg PTZ was intraperitoneally injected into rat models to induce seizure effects. Different groups of rat models received methyl vitamin B12 therapy at different dosages, a low dosage of 45g/kg and a high dosage of 85g/kg, at different pre-treatment periods, one day and two weeks prior to PTZ injection. A control group, which received only PTZ injection, served as a reference. The seizure latency, seizure intensity, and differences in the quality of seizures and their characteristics, from simple twitches to complete seizures, were observed after 30 minutes of PTZ injection. Results In general, the latency to convulsion significantly increased when vitamin B12 pre-treatment was employed. The longest latency time (LT) of 520.6373.83 seconds was observed when a high dosage of vitamin B12 at 85g/kg was injected one day prior to PTZ inoculation, which was significantly higher than that of the control group at 176.8862.67 seconds (P
02:41
Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19. GreenMedInfo
PMID: Front Immunol. 2023 ;14:1048790. Epub 2023 Mar 13. PMID: 36993968 Abstract Title: Vitamin B12 attenuates leukocyte inflammatory signature in COVID-19methyl-dependent changes in epigenetic markings. Abstract: COVID-19 induces chromatin remodeling in host immune cells, and it had previously been shown that vitamin B12 downregulates some inflammatory genesmethyl-dependent epigenetic mechanisms. In this work, whole blood cultures from moderate or severe COVID-19 patients were used to assess the potential of B12 as adjuvant drug. The vitamin normalized the expression of a panel of inflammatory genes still dysregulated in the leukocytes despite glucocorticoid therapy during hospitalization. B12 also increased the flux of the sulfur amino acid pathway, that regulates the bioavailability of methyl. Accordingly, B12-induced downregulation ofstrongly and negatively correlated with the hypermethylation of CpGs in its regulatory regions. Transcriptome analysis revealed that B12 attenuates the effects of COVID-19 on most inflammation-related pathways affected by the disease. As far as we are aware, this is the first study to demonstrate that pharmacological modulation of epigenetic markings in leukocytes favorably regulates central components of COVID-19 physiopathology.
02:33
High burden of vitamin B12 deficiency among adults and elderly. GreenMedInfo
PMID: J Nepal Health Res Counc. 2023 Mar 10 ;20(3):702-707. Epub 2023 Mar 10. PMID: 36974860 Abstract Title: High Burden of Vitamin B12 Deficiency among Adults and Elderly. Abstract: BACKGROUND: Deficiency of vitamin-B12 is widespread. Adults and the elderly are particularly susceptible to vitamin-B12 deficiency. This study investigated the burden of vitamin-B12 deficiency and insufficiency among adults and the elderly attending a tertiary care hospital in Nepal.METHODS: This is a retrospective chart review conducted at Dhulikhel hospital. We reviewed records of 1615 patients investigating Vitamin-B12 level (pmol/L) at the clinical biochemistry laboratory from laboratory management database MIDAS between June 2020 and December 2021. Vitamin-B12 level was measured using enzyme immunoassay in Abbott Architect i1000SR analyzer. The categorical variables are presented as frequency and percentage; and numerical variables as means and standard deviations, or median and Interquartile range. Pearson Chi-square test was used to determine association between categorical variables. Mann Whitney test and Kruskal Wallis H test were used to compare Vitamin-B12 level by categories.RESULTS: There were 1454 participants of which 33.5% of the patients were deficient, 27.9% were borderline deficient, while 38.7% had adequate vitamin B12 levels. Young adults(170.4 pmol/L) had a lower median vitamin B12 level than middle-aged adults (183.7pmol/L) and the elderly population (247.9pmol/L) (P
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23:00
Morning Coffee Jul 11 Dr. Tenpenny
07-11-2023 Audio Track: If you prefer to watch rather than listen, click on the video below: https://drtenpenny.b-cdn.net/2023/07-11-23-MorningCoffee.mp4 If you enjoyed this show, and want to join us live for []
20:15
Editorial board member dropped from journal site after Retraction Watch-Undark report links him to paper mill Retraction Watch
The journal Scientific Reports removed a scientist linked to paper mill activity from its editorial board last year, but didnt take his name off the web page until last month, after a Retraction Watch-Undark story pointed out his association.
The former editorial board member, Masoud Afrand, is an assistant professor of engineering at the Islamic Azad University in Iran.
In our story, Alexander Magazinov, a scientific sleuth and software engineer based in Kazakhstan, cited Afrand as an example of researchers seemingly associated with paper mills who manage to get editorial positions at reputable journals. Afrand, he said:
was likely part of a paper mill operation for a special issue in Mathematical Methods in the Applied Sciences, where Afrand was cited over 130 times.
At the time our story was published, on June 21, Afrand was listed as an editorial board member for mechanical engineering at Scientific Reports, a Springer Nature title.
About a week later, a commenter noted that Afrand was no longer on the website, although he had been in a snapshot of the webpage from June 20 in the Internet Archives Wayback Machine.
Magazinov replied that he had emailed the journal about Afrand on May 31, 2022. He wrote:
Why it should take a dedicated journalist to get things done, is beyond my understanding.
Rafal Marszalek, chief editor of Scientific Reports, told us that while Afrand had been listed as an editorial bo...
20:00
Prolonged Negative Impacts of Benzodiazepine Use Revealed in New Study Mad In America
A study recently published in PLOS One emphasizes the prolonged negative impacts of benzodiazepine use. According to participants, symptoms such as fatigue, anxiety, and memory loss often persisted for at least a year. Some respondents reported grappling with these after-effects long after stopping the drug. Furthermore, numerous participants revealed that they experienced adverse life events due to their use of benzodiazepines.
The study, led by Alexis D. Ritvo from the University of Colorado School of Medicine, noted:
More than half of the respondents who experienced low energy, distractedness, memory loss, nervousness, anxiety, and other symptoms stated that these symptoms lasted a year or longer. These symptoms were often reported as de novo and distinct from the symptoms for which the benzodiazepines were originally prescribed. A subset of respondents stated that symptoms persisted even after benzodiazepines had been discontinued for a year or more. Adverse life consequences were reported by many respondents as well.
The current work aimed to investigate symptoms and
adverse life events associated with benzodiazepine use. To achieve
this goal, the authors used data from previous research in which
1,207 benzodiazepine users completed an anonymous survey about
symptoms and adverse life consequences they attributed to their use
of benzodiazepines.
The participants were recruited from benzodiazepine support groups and health/wellness...
10:00
Can Ginger Help With Diabetes? Articles
The number of people with diagnosed diabetes has grown to epidemic numbers.1 Complications from diabetes include retinopathy, heart attack, stroke, diabetic nephropathy, nerve damage and sexual problems in men and women.2 The number of people exposed to these risks rises dramatically each year.
In 2004,3 experts estimated the global number of people with diabetes was projected to rise from 171 million in 2000 to 366 million in 2030. However, the International Diabetes Federation4 estimated there were 151 million people with diabetes across the world in 2000 and cited 536 million in 2021. This is over 150 million more than experts estimated would be diagnosed 9 years later in 2030.
The growing number of people with diabetes and obesity has the pharmaceutical industry scrambling to identify drug interventions. FDA approval5 for the most recent of those drugs Wegovy (semaglutide) was released with the hope it would increase weight loss.
Wegovy reportedly works by suppressing a person's natural appetite, which is supposed to lead to eating fewer calories and subsequently losing weight.6 Novo Nordisk, manufacturer of Wegovy, has limited the number of doses patients are allowed to use since the demand for the drug is currently outpacing the company's ability to manufacture it.7
The medication comes with a boxed warning of the risk for thyroid C-cell tumors, including medullary thyroid carcinoma, in animal models. Serious side effects from the drug include anxiety, blurred vision, confusion, depression, difficulty swallowing, seizures, slurred speech and trouble breathing.8 Wegovy cites more possible side effects including pancreatitis, low blood sugar, kidney failure, increased heart rate and thoughts of suicide.
As the pharmaceutical industry develops drugs that require more drugs to treat the side effects of the first drug, researchers have also discovered that antioxidants like ginger can help lower blood sugar, reduce insulin resistance and improve insulin sensitivity. Combining this with behavior modification strategies to help you eat less and exercise more, including ginger in your daily regimen, may be all that's needed to achieve your goals.
Ginger Lowers Blood Sugar and Improves Insulin Sensitivity
Why Pfizer Stopped COVID Vax Trial Articles
No randomized trial data are available for use of the COVID-19 shot in pregnant women, and Pfizer cut its pregnancy trial short.1 But this doesnt stop the U.S. Centers for Disease Control and Prevention from recommending COVID-19 injections for everyone 6 months and older, including people who are pregnant, breastfeeding, trying to get pregnant now, or those who might become pregnant in the future.2
Not having any good data didnt seem to bother the CDC, Dr. Martin Makary, a professor at Johns Hopkins University School of Medicine, wrote in Tablet.3 He and a team of scientists petitioned the U.S. Food and Drug Administration to add a disclaimer to the shots label about the lack of trial data on its safety in pregnant women. The FDA declined, stating that this information wouldnt be relevant.
Pregnant women, however, do need to know about the shots lack of testing during pregnancy its the foundation of informed consent. Theyd also likely be interested to know why Pfizer stopped its pregnancy trial early and has yet to make the results it did find public.
Pfizer Stopped COVID Jab Pregnancy Trial, Withholds Data
In February 2021, Pfizer launched a randomized, placebo-controlled, observer-blind study to evaluate the safety of its COVID-19 shot BNT162b2 in healthy pregnant women. The injections were set to take place between 24 and 34 weeks gestation, with participants randomized 1-to-1 to receive a COVID-19 shot or placebo.4 But while the study was initially set to enroll 4,000 women,5 Pfizer only signed up 349, then stopped enrollment entirely.6
Most concerning, Makary explained, the pregnancy outcomes of those who participated in the trial, and their babies, are still not public today, nearly two years later.7 Pregnant and breastfeeding women were excluded from Pfizers and Modernas phase III clinical trials,8 but in April 2021, CDC director Dr. Rochelle Walensky announced, "CDC recommends that pregnant people receive the COVID-19 vaccine."9
The American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM) soon echoed this statement, recommending pregnant women get injected, as did the UKs Royal College of...
WiFried Is Wireless Technology Dooming a Generation? Articles
Editor's Note: This article is a reprint. It was originally published March 31, 2018.
Most people today live in a sea of radiofrequencies (RF), emitted from wireless technologies of all kinds, from routers to smartphones, tablets, baby monitors, TVs, appliances, smart meters and more. In the featured ABC program "Wi-Fried," originally aired in 2016, Maryanne Demasi, Ph.D., investigates the alleged safety of mobile devices.
According to many experts, chronic, heavy exposure could be having severe repercussions for our health, especially that of children, who are now being exposed even before birth.
As noted by Devra Davis, Ph.D., an epidemiologist and author of the book, "Disconnect: The Truth About Cell Phone Radiation," children have never before been exposed to this level of pulsed radiation, and it's still too early to determine the exact extent of the harm. Still, mounting evidence suggests harm is indeed occurring, so it would be foolish to wait until we're in the midst of a global catastrophe.
External Interference Can Disrupt Natural Bioelectric Signals
While a number of different devices contribute to the overall radiation burden, those kept closest to your body on a regular basis, such as your cellphone, are of greatest concern. Worldwide, there are more than 6 billion cellphone subscriptions. In other words, we're rapidly nearing total saturation, where every single person on the planet has one of these devices.
Many of these mobile phones are smartphones, with apps that frequently receive and transmit pulsed electromagnetic signals. The human body also has natural electromagnetic fields (EMFs), as many of your bodily processes involves the transmission of electric signals, and as noted by Demasi, "External interference can disrupt those signals."
In a 2016 article, Jerry Phillips, Ph.D., a biochemist and director of the Excel Science Center at the University of Colorado, explained how living cells react to RF radiation:1
"The signal couples with cells, although nobody really knows what the nature of that coupling is. Some effects of that reaction can be things like movement of calcium across membranes, the production of free radicals or a change in the expression of genes in the cell.
Suddenly important proteins are being expressed at times and places and in amounts that they shouldn't be, and that has a dramatic effect on the function of the cells. And some of these changes are consistent with what's seen when cells undergo
When you consider t...
09:00
On Your Health-Jun 12 2023 Robert Workman & Bill Bathgate Dr. Tenpenny
07-10-2023 Listen to audio of interview here. Click on the video below to watch this episode: https://drtenpenny.b-cdn.net/2023/07-10-23-OYH-EMF.mp4 In this episode of On Your Health my two guests blow []
08:02
Forced Psychiatry Is Expanding At Societys Peril Mad In America
From The Globe and Mail: A researcher, scholar and gifted philosopher-poet, Erin Soros has garnered two National Magazine Awards, a CBC Literary Award, and a Simon Fraser University residency.
She also has a history of serious trauma.
This May, Ms. Soros won a Writers Union of Canada award for her account of seeking mental-health help in 2022, and then getting detained in a Vancouver psychiatric hospital, where she was threatened, stripped, tied down with four-point restraints, and forcibly tranquillized. She described this involuntary care as unnecessary, brutal, traumatizing, and like institutionalized rape.
During the research for my book, I interviewed hundreds of ordinary, intelligent people like Ms. Soros who have experienced forced psychiatric treatment overstretched single parents, struggling university students, war refugees, sexual assault victims, and those whod recently lost spouses or jobs and many of them shared similar stories and perspectives. After being committed by apparently well-intentioned, risk-averse or overprotective psychiatric professionals, declining psychotropic drugs became evidence of lack of insight into their need for treatment; security guards, restraints and forced drugging often followed. I also found mental-health law powers being increasingly used in social or institutional management: Staff in schools, foster and group homes, workplaces and government agencies, housing, long-term care facilities, and mental-health hotlines often get disruptive, distressed or protesting people forcibly taken to psychiatric hospitals.
When politicians, pundits and others call for expanding involuntary commitment, is this what they a...
07:18
The MTHFR gene and vaccines just the scientific facts Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
An anti-vaccine trope that keeps reappearing is that vaccines somehow cause harm to the MTHFR gene. Except science says they are unrelated.
07:02
Humans have genetically modified crops for 10,000 years Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
According to scientific research, humans have genetically modified food crops for over 10,000 years. GMOs are not recent advances.
06:41
Coffee boosts mental alertness, and its not just the caffeine Skeptical Raptor
The Skeptical Raptor, stalking pseudoscience in the internet jungle.
New research shows confirms that coffee boosts alertness, but surprisingly, it's not just caffeine that is involved.
03:22
03:00
Critical Psychiatry Textbook, Chapter 8: Depression and Mania (Affective Disorders) (Part Eleven) Mad In America
Editors Note: Over the next several months, Mad in Gtzsches book, Critical Psychiatry Textbook. In this blog, he discusses the harmful effects of lithium and anti-epileptic drugs used for bipolar disorder. Each Monday, a new section of the book is published, and all chapters are archived here.
Harms of lithium
Lithium is a highly toxic drug that requires tight monitoring of the serum level. The FDA warns that lithium toxicity can occur at doses close to therapeutic levels.437
This fact was ignored in a textbook which claimed that lithium is generally well-tolerated, and that its harms are few and well known.18:115 It that were true, it is surprising that 40% of the patients interrupt the treatment prematurely, which the book mentioned on the same page.18:115
Another textbook respected the evidence. It mentioned
that the most common adverse effects are polydipsia, polyuria,
weight increase, hand tremor, gastrointestinal symptoms such as
nausea, dyspepsia, and diarrhoea, minor oedema, and skin reactions,
and that mental harms include difficulty concentrating, affected
memory, and decreased vitality and creativity.17:662 The
book noted that long-term harms are more serious: up to 10% of the
patients have morphological changes in their kidneys, 1% have
irreversible kidney damage, and hypothyroidism and teratogenicity
occur in rare cases.17:662 A third textbook confirmed
the risk of malformations.16:301
In package inserts, patients and their families are warned that the patient must discontinue lithium therapy and contact the doctor if they experience diarrhoea, vomiting, tremor, mild ataxia (not explained even though few patients k...
01:25
00:04
Millions Against Medical Mandates Presents The Truth Trilogy Video Series Age of Autism The Rebel Alliance!
Today, we present Truth Trilogy from Millions Against Medical
Mandates. The three video topics are FOOD, TOXINS and VACCINES.
From MAMM:
The Truth Trilogy is a series
like no other!
Thanks to the support from the Centner foundation, MAM was able to
curate the most relevant information related to the toxic truth
about food, environmental toxins, and vaccines.
Focused on solutions, yet covering all the relevant facts, this
series serves to both educate and enlighten.
We offer this at no charge and ask that you share it widely. It can
be used in classrooms, discussion groups, and for patient education
at health and wellness centers, etc.
The Truth Trilogy is meant to be
a progressive series with each presentation designed to build on
the next.
Please enjoy and share this series with people
who may not be as awakened, or as informed, as you are - so
together we can create a healthier tomorrow!
VIEW THE SERIES
HERE
The Toxic Truth About Food
Whats all this talk about the importance of whole, unprocessed, organic food in order to maximize your health, strengthen your immune system to fight off infections (any infection!) and prevent chronic illness? Is it true? Is improving your diet really worth the effort?
Unequivocally.the answer to these questions is YES!
In this entertaining and educational, hour-long presentation, we (a nurse, a teacher, and a masters level holistic nutritionist) will take you on a journey. We will go back in time and discover how our food lost its nutritional value, and how the food and chemical industries used clever advertising, propaganda, and persuas...
Monday, 10 July
23:41
A Picture Says A Thousand Words, A Thousand Pictures Scream Age of Autism The Rebel Alliance!
By Kim Rossi
Yesterday, at 6:15am, I woke to the sound of my daughter's bed
moving around the floor. Uh oh! The Exorcist, you might worry?
No. We couldn't get that lucky. There's no priest to
call with autism. I knew instantly that she was looking for one of
her dozen papers. And that my morning was fully underway.
Many years ago, she started requesting screen shots of YouTube
videos. Mostly classic Sesame Street, Elmo's World, Blue's Clues,
Between The Lions and Jay Jay the Jet Plane. Think PBS Kids back in
1998. Printing full sized photos was costing a fortune in ink. A
smart, young staffer suggested I copy the photos into WORD, shrink
them, and then print them much smaller. "GREAT!" And then, autism
took over. The idea worked SO WELL that my daughter began asking
for more, and more, and more. They serve a purpose for her. There
is an order that you or I can't see. And she KNOWS when she
is missing one paper, and often when a single, tiny photo falls
off.
And we're back to the bed moving around her floor. "Where's
the cat? Where's the cat?" Sometimes I can find the 1/4" square
with tape on the floor. Mostly I have to pray she can give me
enough information to find the video clip and print a new
picture. Yesterday, I got lucky. Buy a Power ball lottery
ticket lucky. She said, "Cat. Sesame Street. Moon." AH HA!
That's "Hey Diddle Diddle" from Sesame Street with Edgar Turtle who
plays the banjo! Sure enough, I pulled up the video, she smiled and
said, "CAT." Cat-astrophe averted!
Few people understand the level of detail it takes to help an
autistic person. Most AofA readers know. Tell me something only you
can do for your child. And how you hope to translate it for someone
else.
And the dish ran away with the spoon.
KIM
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Order today, from Skyhorse Publishing.