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Saturday, 22 July
11:24
Can Iron Deficiency Cause Low Milk Supply? Renee Kam IBCLC BellyBelly
Have you been diagnosed with iron deficiency recently?
Are you breastfeeding and concerned iron deficiency can cause low milk supply?
Women who are breastfeeding are more likely to have low iron after birth.
This due to depletion during pregnancy and childbirth.
Can lron Deficiency Cause Low Milk Supply?
After birth, vaginal bleeding for six weeks can also leave new mothers lower in iron.
This is a vulnerable time as you establish breastfeeding and your milk supply settles.
Its common for there to be a few challenges along the way as you and your baby become skilled at breastfeeding.
Worrying about iron deficiency affecting your milk supply the last thing you need to worry about.
What Is Iron Deficiency?
Iron deficiency can occur naturally due to increased blood volume during pregnancy.
However, there is also a greater demand for iron during pregnancy.
From both the growing baby and the placenta.
During birth, its also common to lose some blood which further reduces available iron.
This leads to abnormally low levels of red blood cells or haemoglobin. This means your blood isnt able to carry as much oxygen to your muscles and tissues.
Symptoms of iron deficiency include:
- Dizziness
- Weakness
- Fatigue
- Headaches
- Shortness of breath
- Feeling cold
If low iron levels arent corrected, this can lead to anaemia.
Iron deficiency anemia is a much more severe form of iron deficiency.
You can be mildly, moderately or severely iron deficient. Iron deficiency anaemia is a more severe form of iron deficiency. This can also be mild, moderate or severe.
Iron deficiency is the most common cause of anaemia in pregnancy.
You can read more in Anaemia During Pregnancy | Causes, Symptoms and Treatment.
Iron-deficiency anaemia during pregnancy occurs in around 20% of women in developed countries.
So, can iron-deficiency anaemia be a problem for milk supply?
Iron Deficiency Anaemia May Impact Milk Supply
It is currently not clear whether iron deficiency anaemia may affect milk supply.
There is only a small amount of observational evidence available for us to look at.
These small studies suggest anaemia may be responsible for low milk supply and the cessation of breastfeeding.
However there is a link between low iron and immune function, which can...
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Friday, 21 July
17:41
Why Are Prenatal Diabetes Tests Taking Place Too Late? Fiona Peacock BellyBelly
Gestational diabetes is a type of diabetes that affects women during pregnancy, prenatal diabetes tests help to identify this early.
Women who suffer from gestational diabetes have an increased risk of developing Type 2 diabetes in later life.
Gestational diabetes is believed to affect as many as one in five women during pregnancy.
If left untreated, the condition can be serious, causing complications such as stillbirth. But when managed well, problems are much less likely.
Why does prenatal diabetes tests occur so late in pregnancy?
Leading scientists are now warning prenatal diabetes tests are occurring too late during pregnancy.
Screening usually takes place around 28 weeks to determine whether the mother has developed gestational diabetes. However, a recent study concluded that 28 weeks was too late, in many cases.
The University of Cambridge study looked at over 4,000 women and found that, in many cases, at 28 weeks, the developing baby had already been affected by gestational diabetes. Gestational diabetes causes an increase of sugar in the mothers bloodstream, and this can lead to a babys rapid growth inside the womb.
Mothers with gestational diabetes are more likely to have large babies. During birth, larger babies suffer increased risks, such as bone fractures. Bigger babies might also be at a higher risk of obesity and diabetes in later life.
The new study published in the journal Diabetes Care found that excessive fetal growth had often already kicked in by the time the prenatal diabetes tests occurred around week 28. Women who tested positive for gestational diabetes at 28 weeks were twice as likely to give birth to big babies when compared with other women.
Current guidelines state that screening should occur between Weeks 24 and 28. Screening is most commonly carried out at 28 weeks, during a routine prenatal appointment. This study, however, raises the question as to whether 28 weeks is too late. More research is needed to pinpoint the optimal time for the screening to be carried out.
Recommended Reading:
For more information on gestational diabetes, be sure to check out BellyBellys articles:
Gestational Diabetes Symptoms 4 You Need To Know
Why Gestational Diabetes Is Highly Likely Due To Your Diet.
09:19
Resveratrol reliefs DEHP-induced defects during human decidualization. "IndyWatch Feed Health"
PMID: Ecotoxicol Environ Saf. 2023 Jun 15 ;258:114931. Epub 2023 Apr 28. PMID: 37121080 Abstract Title: Resveratrol reliefs DEHP-induced defects during human decidualization. Abstract: Di-(2-Ethylhexyl) phthalate (DEHP) is widely used as an additive in many plastic products. Studies have revealed that DEHP persistent exposure can affect embryonic development and lead to adverse female reproductive disorders. The establishment of pregnancy involves extensive changes in the endometrial tissue, including massive extracellular matrix (ECM) remodeling. Decidualization of the endometrium provides a suitable environment for subsequent growth by causing changes in the morphology of the uterine stromal cells, is a key process in human pregnancy. Resveratrol (RSV) is a natural polyphenolic plant antitoxin with a wide range of pharmacological effects. Growing evidence indicates that RSV has therapeutic effects on certain female reproductive disorders. In this study, the effect of DEHP on cell viability was investigated by cell proliferation assay. Cell decidualization was induced in vitro, and the downregulation of molecules associated with decidualization was confirmed through quantitative real-time PCR and western blot analysis. Immunofluorescence analysis revealed alteration in cell morphology, and found that administration of DEHP sufficiently induced ERentry into the nucleus. The effect of DEHP on cells was fully verified by RNA-seq analysis. Interestingly, an upregulation of decidual molecules was observed after rescue with RSV, which was confirmed by RNA-seq transcriptome analysis and quantitative real-time PCR assay. Additionally, the expression of ECM remodeling-related genes was significantly restored by RSV administration. The study revealed the potential mechanisms of DEHP-induced decidualization defects and the functional relieving roles of RSV while providing a perspective therapeutic candidate for alleviating the DEHP-induced deficiencies in decidualization.
05:59
Effect of Tinospora cordifolia on gestational diabetes mellitus and its complications. "IndyWatch Feed Health"
PMID: Women Health. 2023 ;63(5):359-369. Epub 2023 Apr 20. PMID: 37080903 Abstract Title: Effect ofon gestational diabetes mellitus and its complications. Abstract: Ayurvedic system of medicine uses giloy or guduchi, also known as(TC), to treat diabetes and related diseases like hyperglycemia and hyperlipididemia. However, its usage in gestational diabetes mellitus (GDM) is not well studied. The primary objective of the study was to examine the effects of water extract of TC called satva, essential oil, and hydroalcoholic (HA) extract on GDM and its complications and to explore their mechanism of action using mice model. We used streptozotocin-induced diabetes in pregnant mice as murine model and tested TC preparations for anti-GDM activities. Blood glucose, insulin, litter size, and placental weight were assessed. ELISA method was used to measure plasma insulin level to compute homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and homeostatic model assessment for assessing beta cell function (HOMA-Beta) levels to estimate insulin resistance, insulin sensitivity, and beta cell function respectively. TC-treated groups had significantly higher serum insulin levels, QUICKI, average litter size, and lower placental weight (
Thursday, 20 July
21:47
Link "IndyWatch Feed Nthamerica"
I know that guy! Thats Marc Tessier-Lavigne! Hes about my age, and we shared similar interests we were both interested in axon guidance, and I followed his work avidly some years ago. He was publishing about netrins, signaling molecules that affect the trajectory of growing neurons, while I was studying growing neurons in grasshopper embryos. I met him several times, I attended talks he gave at various meetings, it was hard to avoid Tessier-Lavigne.
Our careers followed very different paths, though. I ended up teaching at a small liberal arts college, while he got a position at UCSF, and then was CSO at Genentech, and then was president of Rockefeller University, was on the boards of various pharmaceutical companies, and finally was president of Stanford University. He was a major go-getter, running gigantic factory-style labs, getting regularly published in Science and Nature and Cell. It was a life that looked horrible to me, just as my life of obscurity and teaching would have looked horrible to him, if ever he had deigned to notice me.
Why would I have disliked the prestigious path he took in science? Because he turned himself into a manager, a guy who was disconnected from the science that was being done in his massively well-funded labs. Ick. Id rather play at the bench and help students get enthusiastic about doing science.
I may have chosen wisely, because now Tessier-Lavigne has been compelled to resign as an investigation found evidence of fraud in his work. Yikes. This is bad.
The Board of Trustees inquiry stopped short of accusing Tessier-Lavigne who has been Stanfords president since 2016 of fraud, saying theres no evidence he personally engaged in research misconduct.
However, it was concluded that five papers on which Tessier-Lavigne was a principal author included work from some members of labs overseen by Dr. Tessier-Lavigne who had either engaged in inappropriate manipulation of research data or engaged in deficient scientific practices, resulting in significant flaws in those papers.
When the issues emerged, Tessier-Lavigne took insufficient steps to correct mistakes in the scientific record, the boards report said.
This is what happens when you become an over-worked administrator with your fingers in too many pies. That does not excuse him he has his name on so many papers, and getting a...
21:19
Over 700 Babies Left to Die After Botched Abortions in Australia "IndyWatch Feed World"
READ MORE AT CALDRON POOL Its been said, the true
measure of any society can...
12:43
Neonatal exposure to bisphenol analogues disrupts genital development in male mice. "IndyWatch Feed Health"
PMID: Environ Pollut. 2023 Aug 1 ;330:121783. Epub 2023 May 8. PMID: 37164221 Abstract Title: Neonatal exposure to bisphenol analogues disrupts genital development in male mice. Abstract: The public concern and governmental regulations on bisphenol A (BPA) have stimulated the development and production of alternative analogues to replace BPA in a myriad of applications. Given the endocrine disrupting activities of BPA and potentially other analogues, the present study investigated and compared the effects of neonatal exposure to BPA, BPB, BPE, BPF, and BPS on the genital development in male mice. Pups were injected subcutaneously on the right shoulder in the mornings of postnatal days P0.5, P2, P4, and P6, resulting in a low dose of 0.05 g/g body weight (bw)/day and a high dose of 10 g/g bw/day. Mice were sacrificed at predetermined time and evaluated for gene expression levels (3 days after birth or P3), steroid hormone levels (P5), and morphological changes (P21). The results demonstrated that BPA, BPB, BPE, or BPF significantly shortened glans penis length and anogenital distance, while BPS didn't. Testis weight and anogenital distance were also significantly affected by BPA, BPE or BPF. The results also revealed that bisphenol analogues exposure significantly reduced testosterone levels, and altered the expression levels of developmental genes networks in developing penis of mice. Our data demonstrate that selected bisphenol analogues may possess similar endocrine disrupting effects compared to BPA, and exposure to these analogues could affect reproductive development of male mice. This raises the concern on the environmental and health safety of bisphenol analogues applied as industrial BPA replacements.
02:35
Progress in embryo analysis! "IndyWatch Feed Nthamerica"
Our new development in spider development is pretty basic stuff. Were dechorionating embryos! That is, stripping off a thin membrane surrounding the embryo, so we can do staining and fixation and various other things. Its a standard invertebrate technique it turns out you can remove it by just washing them in bleach. Look, it works! This is a Parasteatoda embryo.
Were still tinkering with the timing of the treatment. Five minutes is way too long, which basically dissolved the whole embryo. All it takes is a brief wash to break the chorion down. Were also working out methods for manipulating them theyre tiny! Just pipetting them into a solution is a great way to lose them. Were now using a cut off microfuge tube to make a cylinder that we cap with a sheet of fine nylon mesh, to lower them into the solution. Of course, then we have to separate the embryos from the mesh. Fortunately, we opened up one egg sac and 140 embryos rolled out, so we have lots of material to experiment on.
The next question is whether they survive our abuse. Weve got some of them sitting under a microscope, time-lapsing their response. Well see if they growor die and fall apart.